MelissaAshleyLyleMDFACC

Cardiology • Jacksonville, FL

Echocardiography, Heart Failure & Transplantation

Physician

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Office
4500 San Pablo Road S
Jacksonville, FL 32224
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Education & Training

Emory University School of MedicineFellowship, Advanced Heart Failure and Transplant Cardiology, 2019 - 2020
Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Cardiovascular Disease, 2016 - 2019
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 2013 - 2016
Mercer University School of MedicineClass of 2013

Certifications & Licensure

FL State Medical License 2020 - 2026
GA State Medical License 2023 - 2025
MN State Medical License 2014 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Fellow of the American College of Cardiology 2020
The Outstanding Clinical Fellow Award in the Cardiovascular Fellowship Training Program Mayo Clinic, 2019
Inductee Alpha Omega Alpha Honor Medical Society, 2013

Publications & Presentations

PubMed

The Veterans Affairs' Dashboard Confessional: Vindication of the VA HF Dashboard.
Melissa A Lyle, Mark N Belkin> ;Journal of Cardiac Failure. 2024 Mar 1
Transcatheter edge-to-edge repair for tricuspid valve regurgitation in apolipoprotein A-I-associated cardiac amyloidosis: case report.
El Sabbagh, A., Alomari, M., Reddy, P., Pollak, P., Lyle, M.> ;European Heart Journal. Case Reports. 2023 Dec 1
Pregnancy Outcomes in Left Ventricular Noncompaction.
Melissa Lyle, William R Miranda, Vaibhav R Vaidya, Carl H Rose, Rowlens M Melduni, Heidi M Connolly, Katie A Young> ;The American Journal of Cardiology. 2023 Dec 15
2 citations
Hereditary transthyretin amyloidosis presenting with spontaneous periorbital purpura: a case report.
Nikita Jhawar, Jordan Reynolds, Raouf Nakhleh, Melissa Lyle> ;European Heart Journal. Case Reports. 2023 Mar 1
26 citations
Sex and gender differences in myocarditis and dilated cardiomyopathy: An update.
DeLisa Fairweather, Danielle J Beetler, Nicolas Musigk, Bettina Heidecker, Melissa A Lyle, Leslie T Cooper Jr, Katelyn A Bruno> ;Frontiers in Cardiovascular Medicine. 2023 Jan 1
1 citations
Migration of intra-aortic balloon pump causing obstruction of the superior mesenteric artery.
Sharan Malkani, Jose Ruiz, Smruti Desai, Smit Paghdar, Parag C Patel, Juan Carlos Leoni Moreno, Melissa Lyle, Maedeh Ganji, Daniel Yip, Rohan M Goswami> ;Journal of Geriatric Cardiology. 2022 Nov 28
Heart transplantation in Val142Ile mutation in the modern era: A single center experience.
Melissa A Lyle, Matthew T Brown, Alanna A Morris, Divya Gupta, J David Vega, Robert T Cole, Kunal N Bhatt> ;Clinical Transplantation. 2022 Nov 1
8 citations
Ventricular arrhythmia burden and implantable cardioverter-defibrillator outcomes in transthyretin cardiac amyloidosis.
Matthew T Brown, Sreeram Yalamanchili, Sean T Evans, Pradhum Ram, Evan A Blank, Melissa A Lyle, Faisal M Merchant, Kunal N Bhatt> ;Pacing and Clinical Electrophysiology. 2022 Apr 1
5 citations
F-FDG/N-ammonia cardiac PET findings in ATTR cardiac amyloidosis.
Kathleen A Young, Melissa Lyle, Andrew N Rosenbaum, Ian C Chang, Grace Lin, Melanie C Bois, Omar F Abou Ezzeddine, Hayan Jouni, Panithaya Chareonthaitawee, Suraj Kapa,...> ;Journal of Nuclear Cardiology. 2023 Apr 1
2 citations
Dramatic Presentation of Cardiac Pleomorphic Liposarcoma.
Nicholas Y. Tan, Maria Najam, Melissa A. Lyle, Joseph J. Maleszewski, Jeremy D. Collins, Kyle W. Klarich> ;Circulation. Cardiovascular Imaging. 2021 Aug 1
1 citations
Failure of intravenous immunoglobulin to improve cardiac function in parvovirus B19-associated chronic dilated cardiomyopathy
Melissa A. Lyle, Leslie T. Cooper> ;European Journal of Heart Failure. 2021 Feb 1
31 citations
Long‐Term Survival of Patients With Left Ventricular Noncompaction
Vaibhav R. Vaidya, Melissa A. Lyle, William R. Miranda, Medhat Farwati, Ameesh Isath, Sri Harsha Patlolla, David O. Hodge, Samuel J. Asirvatham, Suraj Kapa, Abhishek D...> ;Journal of the American Heart Association. 2021 Jan 19
1 citations
Experience With Cardiology-Oriented Outcomes in Critically Ill Patients With Coronavirus Disease 2019.
Randi Connor-Schuler, A Ian Wong, Anand D. Shah, Babar Fiza, Melissa Lyle, Richard P. Ramonell, Maxwell A. Hockstein, George L. Chang, David W. Markham, Charles D. Sea...> ;Critical Care Explorations. 2020 Dec 3
1 citations
Cardiovascular Outcomes in Sarcoidosis
Melissa A. Lyle, Leslie T. Cooper> ;Journal of the American College of Cardiology. 2020 Aug 18
21 citations
Predictive Value of the Get With The Guidelines Heart Failure Risk Score in Unselected Cardiac Intensive Care Unit Patients.
Melissa A. Lyle, Siu Hin Wan, Dennis H. Murphree, Courtney Bennett, Brandon M. Wiley, Gregory W. Barsness, Margaret M. Redfield, Jacob C. Jentzer> ;Journal of the American Heart Association. 2020 Feb 4
A 61-Year-Old Woman With New Pericardial Effusion.
Melissa A. Lyle, Siu Hin Wan, Fletcher A. Miller> ;JAMA Cardiology. 2020 Jan 22
22 citations
Circulating Neprilysin in Patients With Heart Failure and Preserved Ejection Fraction
Melissa A. Lyle, Seethalakshmi R. Iyer, Margaret M. Redfield, Yogesh N.V. Reddy, G. Michael Felker, Thomas P. Cappola, Adrian F. Hernandez, Christopher G. Scott, John ...> ;JACC. Heart Failure. 2020 Jan 1
5 citations
The vasculature in HFpEF vs HFrEF: differences in contractile protein expression produce distinct phenotypes
Melissa A. Lyle, Young Soo Han, Frank V. Brozovich> ;Heliyon. 2020 Jan 1
37 citations
HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half.
Melissa A. Lyle, Frank V. Brozovich> ;Mayo Clinic Proceedings. 2018 Sep 1
29 citations
Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy
Melissa A. Lyle, Jonathan P. Davis, Frank V. Brozovich> ;Frontiers in Physiology. 2017 Aug 23
169 citations
Speaker Introductions at Internal Medicine Grand Rounds: Forms of Address Reveal Gender Bias
Julia A. Files, Anita P. Mayer, Marcia G. Ko, Patricia Friedrich, Michael J. Bryan, Suneela Vegunta, Christopher M. Wittich, Melissa A. Lyle, Ryan Melikian, Trevor Dus...> ;Journal of Women's Health. 2017 May 1
6 citations
Conus artery occlusion causing isolated right ventricular outflow tract infarction: novel application of cardiac magnetic resonance in anterior STEMI
Melissa A. Lyle, Ryan C. Van Woerkom, Marysia S. Tweet, Phillip M. Young, Patricia J.M. Best> ;Cardiovascular Diagnosis and Therapy. 2016 Jun 1
5 citations
Poststernotomy osteomyelitis presenting with severe sepsis and rhabdomyolysis
Eugene M. Tan, Melissa A. Lyle, Kelly Cawcutt, Zelalem Temesgen> ;Case Reports in Medicine. 2016 Apr 10
25 citations
Pulmonary Hypertension in Hereditary Hemorrhagic Telangiectasia
Melissa A. Lyle, Eric R. Fenstad, Michael D. McGoon, Robert P. Frantz, Michael J. Krowka, Garvan C. Kane, Karen L. Swanson> ;Chest. 2016 Feb 1
59-Year-Old Man With Aphasia and Proteinuria.
Melissa A. Lyle, Luke A. Seaburg, Anjali Bhagra> ;Mayo Clinic Proceedings. 2015 Jul 1
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Journal Articles

Cardiovascular Outcomes in Sarcoidosis
Melissa Lyle, MD, JACC: Cardiovascular Imaging

Lectures

Soluble Neprilysin in Patients With Heart Failure With Preserved Ejection Fraction
2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019

Authored Content

Cardiovascular Outcomes in SarcoidosisAugust 2020

Press Mentions

Successful Treatment of Cardiac Amyloidosis Depends on Early DiagnosisAugust 23rd, 2022
Sarcoidoisis Tied to Long-Term Heart RisksAugust 11th, 2020
Heart Transplant Patient Finding Motivation Through Competition, Music and the Mayo Clinic CommunityFebruary 23rd, 2024
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