MichaelJ.BarberMDPhD

Cardiology • Colorado Springs, CO

Cardiac Electrophysiology, Exercise Physiology and Cardiac Rehabilitation

Medical Director, Vascular Center of Colorado

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Office
3314 Mesa Road
Colorado Springs, CO 80904
Phone+1 719-428-2202

Fax+1 719-231-2250
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Education & Training

Duke University HospitalFellowship, Cardiovascular Disease, 1987 - 1990
University of Virginia Medical CenterResidency, Internal Medicine, 1984 - 1987
Indiana University School of MedicineClass of 1984
Loyola University of ChicagoPhD, Cardiovascular physiology, 1976 - 1980
Wabash CollegeA.B., Biology/Chemistry, Cum laude, 1972 - 1976

Certifications & Licensure

CO State Medical License 1993 - 2025
NC State Medical License 1987 - 1992
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

Fellow, Heart Rhythm Society (FHRS)
Fellow American Heart Association (FAHA)
CMS Meaningful Use Stage 1 Certification NextGen Ambulatory EHR, NextGen Healthcare, 2013
Whos Who in Medicine and Healthcare Marquis Whos Who
Fellow (FACC) American College of Cardiology
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Publications & Presentations

PubMed

27 citations
Aminolevulinate synthase: lysine 313 is not essential for binding the pyridoxal phosphate cofactor but is essential for catalysis.
Gloria C. Ferreira, Usha Vajapey, Osama I. Hafez, Gregory A. Hunter, Michael J. Barber> ;Protein Science. 2008 Dec 31
12 citations
Expression and characterization of a functional canine variant of cytochrome b5 reductase.
Glenn William Roma, Louis J. Crowley, Michael J. Barber> ;Archives of Biochemistry and Biophysics. 2006 Aug 1
15 citations
Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding.
M.J. Percy, Louis J. Crowley, J. Boudreaux, Michael J. Barber> ;Archives of Biochemistry and Biophysics. 2006 Mar 1
18 citations
Identification and characterization of the novel FAD-binding lobe G75S mutation in cytochrome b5 reductase: An aid to determine recessive congenital methemoglobinemia ...
M.J. Percy, Louis J. Crowley, David I. Roper, Tom Vulliamy, D.M. Layton, Michael J. Barber> ;Blood Cells, Molecules & Diseases. 2006 Jan 1
14 citations
Mutagenesis of Glycine 179 modulates both catalytic efficiency and reduced pyridine nucleotide specificity in cytochrome b5 reductase.
Glenn William Roma, Louis J. Crowley, C. Ainsley Davis, Michael J. Barber> ;Biochemistry. 2005 Oct 18
17 citations
Recessive congenital methaemoglobinaemia: functional characterization of the novel D239G mutation in the NADH-binding lobe of cytochrome b5 reductase.
M.J. Percy, Louis J. Crowley, C.A. Davis, Mary Frances McMullin, G.A. Savage, J. Hughes, Corrina McMahon, R.J.M. Quinn, Owen P. Smith, Michael J. Barber, Terence R.J. ...> ;British Journal of Haematology. 2005 Jun 1
15 citations
Cytochrome b5 reductase: Role of the si-face residues, proline 92 and tyrosine 93, in structure and catalysis
Christopher C. Marohnic, Louis J. Crowley, C. Ainsley Davis, Eugene T. Smith, Michael J. Barber> ;Biochemistry. 2005 Feb 22
21 citations
Cytochrome b5 reductase: the roles of the recessive congenital methemoglobinemia mutants P144L, L148P, and R159*.
C. Ainsley Davis, Louis J. Crowley, Michael J. Barber> ;Archives of Biochemistry and Biophysics. 2004 Nov 15
12 citations
Cytochrome b5 oxidoreductase: expression and characterization of the original familial ideopathic methemoglobinemia mutations E255- and G291D.
C. Ainsley Davis, Michael J. Barber> ;Archives of Biochemistry and Biophysics. 2004 May 15
11 citations
Voltammetric simulations of multiple electron transfer/proton transfer coupled reactions: flavin adenine dinucleotide as a model system.
Eugene T. Smith, C. Ainsley Davis, Michael J. Barber> ;Analytical Biochemistry. 2003 Dec 1
13 citations
The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site.
Maria C. Bewley, C. Ainsley Davis, Christopher C. Marohnic, David Taormina, Michael J. Barber> ;Biochemistry. 2003 Nov 18
32 citations
Engineering and characterization of a NADPH-utilizing cytochrome b5 reductase
Christopher C. Marohnic, Maria C. Bewley, Michael J. Barber> ;Biochemistry. 2003 Sep 30
3 citations
Heterologous expression of enzymopenic methemoglobinemia variants using a novel NADH:cytochrome c reductase fusion protein.
C. Ainsley Davis, Michael J. Barber> ;Protein Expression and Purification. 2003 Jul 1
6 citations
Biotin sulfoxide reductase: Tryptophan 90 is required for efficient substrate utilization
Veronica V. Pollock, Richard C. Conover, Michael K. Johnson, Michael J. Barber> ;Archives of Biochemistry and Biophysics. 2003 Jan 15
13 citations
Bacterial expression of the molybdenum domain of assimilatory nitrate reductase: production of both the functional molybdenum-containing domain and the nonfunctional t...
Veronica V. Pollock, Richard C. Conover, Michael K. Johnson, Michael J. Barber> ;Archives of Biochemistry and Biophysics. 2002 Jul 15
8 citations
Synthesis and bacterial expression of a gene encoding the heme domain of assimilatory nitrate reductase
Michael J. Barber, Shawn K. Desai, Christopher C. Marohnic, Hector H. Hernandez, Veronica V. Pollock> ;Archives of Biochemistry and Biophysics. 2002 Jun 1
15 citations
Heterologous Expression of an Endogenous Rat Cytochrome b5/Cytochrome b5 Reductase Fusion Protein: Identification of Histidines 62 and 85 as the Heme Axial Ligands
C. Ainsley Davis, Ish K. Dhawan, Michael K. Johnson, Michael J. Barber> ;Archives of Biochemistry and Biophysics. 2002 Apr 1
65 citations
The structure and biochemistry of NADH-dependent cytochrome b5 reductase are now consistent.
Maria C. Bewley, Christopher C. Marohnic, Michael J. Barber> ;Biochemistry. 2001 Nov 13
3 citations
Production of a Recombinant Hybrid Hemoflavoprotein: Engineering a Functional NADH:Cytochrome c Reductase
Michael J. Barber, Gregory B. Quinn> ;Protein Expression and Purification. 2001 Nov 1
7 citations
Assimilatory nitrate reductase: lysine 741 participates in pyridine nucleotide binding via charge complementarity.
Michael J. Barber, Shawn K. Desai, Christopher C. Marohnic> ;Archives of Biochemistry and Biophysics. 2001 Oct 1
19 citations
Circular Permutation of 5-Aminolevulinate Synthase MAPPING THE POLYPEPTIDE CHAIN TO ITS FUNCTION
Anton V. Cheltsov, Michael J. Barber, Gloria C. Ferreira> ;The Journal of Biological Chemistry. 2001 Jun 1
20 citations
Arginine 91 is not essential for flavin incorporation in hepatic cytochrome b(5) reductase.
Christopher C. Marohnic, Michael J. Barber> ;Archives of Biochemistry and Biophysics. 2001 May 15
13 citations
Substitution of murine ferrochelatase glutamate-287 with glutamine or alanine leads to porphyrin substrate-bound variants
Ricardo Franco, Alice S. Pereira, Pedro Tavares, Arianna Mangravita, Michael J. Barber, Isabel Moura, Gloria C. Ferreira> ;The Biochemical Journal. 2001 May 15
32 citations
Kinetic and mechanistic properties of biotin sulfoxide reductase.
Veronica V. Pollock, Michael J. Barber> ;Biochemistry. 2001 Feb 6
154 citations
Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax.
Tae-Hyoung Kim, Yongge Zhao, Michael J. Barber, Diane K. Kuharsky, Xiao Ming Yin> ;The Journal of Biological Chemistry. 2000 Dec 15
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Press Mentions

Elite Athletes Have Super-Low Resting Heart Rates, but That Doesn’t Mean You Need to Shoot for 40 BPMDecember 21st, 2018

Professional Memberships

American College of Cardiology - ACC
Member