MichaelWilliamCrowderMD

Emergency Medicine • Dayton, OH

Physician

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Office
327 Forrer Blvd
Dayton, OH 45419
Phone+1 937-299-4499
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Education & Training

Wright State UniversityResidency, Emergency Medicine, 2006 - 2009
David Grant Medical CenterInternship, Transitional Year, 2003 - 2004
Drexel University College of MedicineClass of 2003

Certifications & Licensure

IN State Medical License 2004 - 2025
OH State Medical License 2006 - 2009
American Board of Emergency Medicine Emergency Medicine

Publications & Presentations

PubMed

17 citations
Investigation of Dipicolinic Acid Isosteres for the Inhibition of Metallo-β-Lactamases
Allie Y. Chen, Pei W. Thomas, Zishuo Cheng, Nasa Y. Xu, David L. Tierney, Michael W. Crowder, Walter Fast, Seth M. Cohen> ;Chemmedchem. 2019 Jul 3
20 citations
Investigating the position of the hairpin loop in New Delhi metallo-β-lactamase, NDM-1, during catalysis and inhibitor binding
Mahesh Aitha, Abraham Jon Moller, Indra D. Sahu, Masaki Horitani, David L. Tierney, Michael W. Crowder> ;Journal of Inorganic Biochemistry. 2016 Mar 1
7 citations
Targeting metallo-carbapenemases via modulation of electronic properties of cephalosporins.
Hao Yang, Heather Young, Sophia Yu, L. E. Sutton, Michael W. Crowder> ;The Biochemical Journal. 2014 Dec 1
47 citations
Biochemical, mechanistic, and spectroscopic characterization of metallo-β-lactamase VIM-2.
Mahesh Aitha, Amy R. Marts, Alex Bergstrom, Abraham Jon Moller, Lindsay Moritz, Lucien H. Turner, Jay C. Nix, Robert A. Bonomo, Richard C. Page, David L. Tierney, Mich...> ;Biochemistry. 2014 Nov 25
7 citations
Dilution of dipolar interactions in a spin-labeled, multimeric metalloenzyme for DEER studies
Mahesh Aitha, Timothy K. Richmond, Zhenxin Hu, Alyssa Hetrick, Raquel Reese, Althea Gunther, Robert M. McCarrick, Brian Bennett, Michael W. Crowder> ;Journal of Inorganic Biochemistry. 2014 Jul 1
48 citations
Spectroscopic and Mechanistic Studies of Heterodimetallic Forms of Metallo-β-lactamase NDM‑1
Hao Yang, Mahesh Aitha, Amy R. Marts, Alyssa Hetrick, Brian Bennett, Michael W. Crowder, David L. Tierney> ;Journal of the American Chemical Society. 2014 May 21
18 citations
New β-phospholactam as a carbapenem transition state analog: Synthesis of a broad-spectrum inhibitor of metallo-β-lactamases.
Ke-Wu Yang, Lei Feng, Shao-Kang Yang, Mahesh Aitha, Alecander E. LaCuran, Peter Oelschlaeger, Michael W. Crowder> ;Bioorganic & Medicinal Chemistry Letters. 2013 Nov 1
9 citations
A novel fluorogenic substrate for dinuclear Zn(II)-containing metallo-β-lactamases.
Yin-Lin Zhang, Jian-Min Xiao, Ji-Li Feng, Ke-Wu Yang, Lei Feng, Li-Sheng Zhou, Michael W. Crowder> ;Bioorganic & Medicinal Chemistry Letters. 2013 Mar 15
10 citations
Raman Spectra of Interchanging β lactamase Inhibitor Intermediates on the Millisecond Time Scale
Hossein Heidari Torkabadi, Tao Che, Jingjing Shou, Sivaprakash Shanmugam, Michael W. Crowder, Robert A. Bonomo, Marianne Pusztai-Carey, Paul R. Carey> ;Journal of the American Chemical Society. 2013 Feb 18
2 citations
Novel fluorescent risedronates: Synthesis, photodynamic inactivation and imaging of Bacillus subtilis
Li-Sheng Zhou, Ke-Wu Yang, Lei Feng, Jian-Min Xiao, Cheng-Cheng Liu, Yi-Lin Zhang, Michael W. Crowder> ;Bioorganic & Medicinal Chemistry Letters. 2013 Feb 15
34 citations
Characterization of Zn(II)-responsive ribosomal proteins YkgM and L31 in E. coli.
M. Patrick Hensley, Thusitha S. Gunasekera, J. Allen Easton, Tara K. Sigdel, Stacy A. Sugarbaker, Lindsey Klingbeil, Robert M. Breece, David L. Tierney, Michael W. Cro...> ;Journal of Inorganic Biochemistry. 2012 Jun 1
77 citations
Mechanistic and spectroscopic studies of metallo-β-lactamase NDM-1.
Hao Yang, Mahesh Aitha, Alyssa Hetrick, Timothy K. Richmond, David L. Tierney, Michael W. Crowder> ;Biochemistry. 2012 Apr 25
Zn(II) Binding to Escherichia coli 70S Ribosomes.
Hensley, M.P., Tierney, D.L., Crowder, M.W.> ;Biochemistry. 2011 Nov 22
33 citations
Structural and kinetic studies on metallo-β-lactamase IMP-1.
Dionne H. Griffin, Timothy K. Richmond, Carlo Sanchez, Abraham Jon Moller, Robert M. Breece, David L. Tierney, Brian Bennett, Michael W. Crowder> ;Biochemistry. 2011 Sep 28
8 citations
Converting GLX2-1 into an active glyoxalase II
Pattraranee Limphong, Nicole E. Adams, Matthew F. Rouhier, Ross M. McKinney, Melissa Naylor, Brian Bennett, Christopher A. Makaroff, Michael W. Crowder> ;Biochemistry. 2010 Sep 21
8 citations
The metal ion requirements of Arabidopsis thaliana Glx2-2 for catalytic activity.
Pattraranee Limphong, Ross M. McKinney, Nicole E. Adams, Christopher A. Makaroff, Brian Bennett, Michael W. Crowder> ;Journal of Biological Inorganic Chemistry. 2010 Feb 1
20 citations
Absence of ZnuABC-mediated zinc uptake affects virulence-associated phenotypes of uropathogenic Escherichia coli CFT073 under Zn(II)-depleted conditions.
Thusitha S. Gunasekera, Andrew H. Herre, Michael W. Crowder> ;FEMS Microbiology Letters. 2009 Nov 1
16 citations
Arabidopsis thaliana Mitochondrial Glyoxalase 2-1 Exhibits β-Lactamase Activity
Pattraranee Limphong, George K Nimako, Pei W. Thomas, Walter Fast, Christopher A. Makaroff, Michael W. Crowder> ;Biochemistry. 2009 Sep 15
27 citations
Motion of the zinc ions in catalysis by a dizinc metallo-beta-lactamase.
Robert M. Breece, Zhenxin Hu, Brian Bennett, Michael W. Crowder, David L. Tierney> ;Journal of the American Chemical Society. 2009 Aug 26
33 citations
Differential Binding of Co(II) and Zn(II) to Metallo-beta-Lactamase Bla2 from Bacillus anthracis
Megan J. Hawk, Robert M. Breece, Christine E. Hajdin, Katherine M. Bender, Zhenxin Hu, Alison L. Costello, Brian Bennett, David L. Tierney, Michael W. Crowder> ;Journal of the American Chemical Society. 2009 Aug 5
20 citations
Human Glyoxalase II Contains an Fe(II)Zn(II) Center but Is Active as a Mononuclear Zn(II) Enzyme
Pattraranee Limphong, Ross M. McKinney, Nicole E. Adams, Brian Bennett, Christopher A. Makaroff, Thusitha S. Gunasekera, Michael W. Crowder> ;Biochemistry. 2009 Jun 16
17 citations
Structure and Mechanism of Copper- and Nickel-Substituted Analogues of Metallo-β-lactamase L1†
Zhenxin Hu, Lauren J. Spadafora, Christine E. Hajdin, Brian Bennett, Michael W. Crowder> ;Biochemistry. 2009 Apr 7
18 citations
Molecular dynamic simulations of the metallo-beta-lactamase from Bacteroides fragilis in the presence and absence of a tight-binding inhibitor.
Freddie R. Salsbury, Michael W. Crowder, Stephen F. Kingsmore, Jim J. Huntley> ;Journal of Molecular Modeling. 2009 Feb 1
11 citations
Arabidopsis thaliana GLX2-1 contains a dinuclear metal binding site, but is not a glyoxalase 2.
Pattraranee Limphong, Michael W. Crowder, Brian Bennett, Christopher A. Makaroff> ;The Biochemical Journal. 2009 Jan 1
53 citations
Role of the Zn1 and Zn2 sites in metallo-beta-lactamase L1.
Zhenxin Hu, Gopalraj Periyannan, Brian Bennett, Michael W. Crowder> ;Journal of the American Chemical Society. 2008 Oct 29
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Grant Support

Time-Dependent Structural Studies On Dinuclear Metal Ion Containing EnzymesNational Institute Of General Medical Sciences2010
Zn(Ii) Metallochaperones In E. ColiNational Institute Of General Medical Sciences2006–2007
Characterization Of Metallo-B-LactamasesNational Institute Of General Medical Sciences2002–2005
Metallo Beta Lactamase From X MaltophiliaNational Institute Of Allergy And Infectious Diseases1998–2002
Zinc Containing Beta LactamasesNational Institute Of General Medical Sciences1994
Studies On Zinc-Containing Beta-LactamasesNational Institute Of General Medical Sciences1993

MichaelWilliamCrowderMD

Dr. Crowder is on Doximity

Education & Training

Certifications & Licensure

Publications & Presentations

Grant Support

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