MichaelJForrestPA

PubMed

• 37 citations
  On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cho...
  Douglas G. Johns, Joseph L. Duffy, Timothy S. Fisher, Brian K. Hubbard, Michael J. Forrest> ;Drugs. 2012 Mar 5
• 8 citations
  Chronic Antagonism of the Mineralocorticoid Receptor Ameliorates Hypertension and End Organ Damage in a Rodent Model of Salt-Sensitive Hypertension
  Xiaoyan Zhou, Martin Crook, Wanda Sharif-Rodriguez, Yonghua Zhu, Zadok Ruben, Yi Pan, Olga Urosevic-Price, Li Wang, Amy M. Flattery, Gail Forrest, Daphne Szeto, Huawei...> ;Clinical and Experimental Hypertension. 2011 Nov 29
• 16 citations
  A potent and selective indole N-type calcium channel (Cav2.2) blocker for the treatment of pain
  Sriram Tyagarajan, Prasun K. Chakravarty, Min Park, Bishan Zhou, James B Herrington, Kevin S. Ratliff, Randall M. Bugianesi, Brande S. Williams, Rodolfo Haedo, Andrew ...> ;Bioorganic & Medicinal Chemistry Letters. 2011 Jan 15
• 34 citations
  Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animal...
  Hong C. Shen, Fa-Xiang Ding, Subharekha Raghavan, Qiaolin Deng, Silvi Luell, Michael J. Forrest, Ester Carballo-Jane, Larissa Wilsie, Mihajlo L. Krsmanovic, Andrew K.P...> ;Journal of Medicinal Chemistry. 2010 Feb 25
• 20 citations
  Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.
  Thomas Wisniewski, Ellen K. Bayne, J. Flanagan, Q. Shao, R. Wnek, S. Matheravidathu, Paul A. Fischer, Michael J. Forrest, Larry Peterson, X. Song, Lihu Yang, Julie A. ...> ;Journal of Immunological Methods. 2010 Jan 31
• 6 citations
  A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis.
  Matthew Walker, Barry R. Campbell, Karim Azer, Christopher Tong, Kaijie Fang, Jacquelynn J. Cook, Michael J. Forrest, Kimberly Kempadoo, Samuel D. Wright, Jeffrey Salt...> ;Atherosclerosis. 2009 May 1
• 6 citations
  Discovery of betamethasone 17α-carbamates as dissociated glucocorticoid receptor modulators in the rat
  Amjad Ali, James M. Balkovec, Mark L. Greenlee, Milton L. Hammond, Greg Rouen, Gayle E. Taylor, Monica Einstein, Lan Ge, Georgianna Harris, Terri M. Kelly, Paul Mazur,...> ;Bioorganic & Medicinal Chemistry. 2008 Aug 15
• 227 citations
  Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
  Michael J. Forrest, D Bloomfield, R J Briscoe, Patricia Brown, A‐M Cumiskey, J Ehrhart, James C. Hershey, W.J. Keller, Xiuying Ma, H.E. McPherson, E Messina, Larry Pet...> ;British Journal of Pharmacology. 2008 Aug 1
• 25 citations
  Discovery of Biaryl Anthranilides as Full Agonists for the High Affinity Niacin Receptor
  Hong C. Shen, Fa-Xiang Ding, Silvi Luell, Michael J. Forrest, Ester Carballo-Jane, Kenneth K. Wu, Tsuei-Ju Wu, Kang Cheng, Larissa Wilsie, Mihajlo L. Krsmanovic, Andre...> ;Journal of Medicinal Chemistry. 2007 Nov 10
• 13 citations
  Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists
  Ester Carballo-Jane, Lynn S. Gerckens, Silvi Luell, Allison S. Parlapiano, Michael Wolff, Steven L. Colletti, James R. Tata, Andrew K.P. Taggart, M. Gerard Waters, Jer...> ;Journal of Pharmacological and Toxicological Methods. 2007 Nov 1
• 13 citations
  Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: Synthesis, in vitro profile, molecular modeling studies, and in vivo experiments
  Christopher F. Thompson, Nazia Quraishi, Amjad Ali, Ralph T. Mosley, James R. Tata, Milton L. Hammond, James M. Balkovec, Monica Einstein, Lan Ge, Georgianna Harris, T...> ;Bioorganic & Medicinal Chemistry Letters. 2007 Jun 15
• 7 citations
  Potential role for epidermal Langerhans cells in nicotinic acid-induced vasodilatation in the mouse.
  Ester Carballo-Jane, Tanya Ciecko, Silvi Luell, John Woods, Emanuel Zycband, M. G. Waters, Michael J. Forrest> ;Inflammation Research. 2007 Jun 1
• 77 citations
  Sphingosine-1-Phosphate Agonists Increase Macrophage Homing, Lymphocyte Contacts, and Endothelial Junctional Complex Formation in Murine Lymph Nodes
  Irwin I. Singer, Min Tian, L. Alexandra Wickham, Jeffrey Lin, Scaria S. Matheravidathu, Michael J. Forrest, Suzanne M. Mandala, Elizabeth J. Quackenbush> ;Journal of Immunology. 2005 Dec 1
• Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.
  Li, Z., Chen, W., Hale, J.J., Lynch, C.L., Mills, S.G., Hajdu, R., Keohane, C.A., Rosenbach, M.J., Milligan, J.A., Shei, G., Chrebet, G., Parent, S.A., Bergstrom, J., ...> ;J Med Chem. 2005 Oct 6
• 22 citations
  Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.
  Cameron J. Smith, Amjad Ali, James M. Balkovec, Donald W. Graham, Milton L. Hammond, Gool F. Patel, Gregory P. Rouen, Scott K. Smith, James R. Tata, Monica Einstein, L...> ;Bioorganic & Medicinal Chemistry Letters. 2005 Jun 2
• 32 citations
  Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
  Christopher F. Thompson, Nazia Quraishi, Amjad Ali, James R. Tata, Milton L. Hammond, James M. Balkovec, Monica Einstein, Lan Ge, Georgianna Harris, Theresa M. Kelly, ...> ;Bioorganic & Medicinal Chemistry Letters. 2005 Apr 15
• 23 citations
  Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.
  Kun Liu, Libo Xu, Joel P. Berger, Karen L. MacNaul, Gauchao Zhou, Thomas W. Doebber, Michael J. Forrest, David E. Moller, A. Brian Jones> ;Journal of Medicinal Chemistry. 2005 Apr 7
• 35 citations
  Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists
  Jeffrey J. Hale, George A. Doherty, Leslie Toth, Sander G. Mills, Richard Hajdu, Carol Ann Keohane, Mark Rosenbach, James A. Milligan, Gan-Ju Shei, Gary Chrebet, James...> ;Bioorganic & Medicinal Chemistry Letters. 2004 Jul 5
• 281 citations
  Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes
  Michael J. Forrest, S.-Y. Sun, Richard Hajdu, James D. Bergstrom, Deborah Card, George A. Doherty, Jeffrey J. Hale, Carol Ann Keohane, C. Meyers, James A. Milligan, Sa...> ;The Journal of Pharmacology and Experimental Therapeutics. 2004 May 1
• 49 citations
  Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor: Receptor Binding and in Vivo Activity
  Amjad Ali, Christopher F. Thompson, James M. Balkovec, Donald W. Graham, Milton L. Hammond, Nazia Quraishi, James R. Tata, Monica Einstein, Lan Ge, Georgianna Harris, ...> ;Journal of Medicinal Chemistry. 2004 Apr 2
• 24 citations
  Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation.
  Ester Carballo-Jane, Shilpa Pandit, Joseph C. Santoro, Concetta Freund, Silvi Luell, Georgianna Harris, Michael J. Forrest, Ayesha Sitlani> ;The Journal of Steroid Biochemistry and Molecular Biology. 2004 Feb 1
• 26 citations
  Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.
  Scott D. Edmondson, Anthony Mastracchio, Jiafang He, Christine C. Chung, Michael J. Forrest, Scott Hofsess, Euan Macintyre, Joseph M. Metzger, Naphtali A. O'Connor, Ka...> ;Bioorganic & Medicinal Chemistry Letters. 2003 Nov 17
• 10 citations
  O-Arylmandelic acids as highly selective human PPAR α/γ agonists
  Alan D. Adams, Zao Hu, Derek Von Langen, Adonis Dadiz, Alex Elbrecht, Karen L. MacNaul, Joel P. Berger, Gaochao Zhou, Thomas W. Doebber, Roger Meurer, Michael J. Forre...> ;Bioorganic & Medicinal Chemistry Letters. 2003 Oct 16
• 462 citations
  Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
  Catherine Abbadie, Jill A. Lindia, Anne Marie Cumiskey, Larry Peterson, John S. Mudgett, Ellen K. Bayne, Julie A. DeMartino, D. Euan MacIntyre, Michael J. Forrest> ;Proceedings of the National Academy of Sciences of the United States of America. 2003 Jun 24
• 98 citations
  Sphingosine-1-phosphate Receptor Agonism Impairs the Efficiency of the Local Immune Response by Altering Trafficking of Naive and Antigen-Activated CD4+ T Cells
  Jenny Xie, Naomi Nomura, Sam L. Koprak, Elizabeth J. Quackenbush, Michael J. Forrest, Hugh Rosen> ;Journal of Immunology. 2003 Apr 1
• Join now to see all