MichaelIsakoffMD

Pediatric Hematology & Oncology • Hartford, CT

Professor, Pediatrics, University of Connecticut SOM

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Office
282 Washington St
Hartford, CT 06106
Phone+1 860-545-9630

Fax+1 860-545-9622
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Summary

Dr. Michael Isakoff is a pediatric hematologist/oncologist in Hartford, CT and is affiliated with multiple hospitals in the area, including Connecticut Children's Medical Center and Hartford Hospital. He received his medical degree from NYU School of Medicine and has been in practice 18 years. He is experienced in pediatric sarcomas and pediatric hematology / oncology.

Education & Training

Children's Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 2002 - 2005
Yale-New Haven Medical CenterResidency, Pediatrics, 1999 - 2002
New York University School of MedicineClass of 1999

Certifications & Licensure

CT State Medical License 2005 - 2024
MA State Medical License 2002 - 2024
ME State Medical License Active through 2016
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Start of enrollment: 2001 Oct 18
Active, not recruiting
Phase 3
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors Start of enrollment: 2004 Mar 25
Recruiting
Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Start of enrollment: 2007 Mar 26
Active, not recruiting
Phase 3
Combination Chemotherapy, Autologous Stem Cell Transplant, and/or Radiation Therapy in Treating Young Patients With Extraocular Retinoblastoma Start of enrollment: 2008 Feb 04
Active, not recruiting
Phase 3
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies Start of enrollment: 2008 Jul 17
Recruiting
Neuropsychological and Behavioral Testing in Younger Patients With Cancer Start of enrollment: 2009 Feb 27
Recruiting
Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer Start of enrollment: 2003 Oct 13
Completed
Study of Kidney Tumors in Younger Patients Start of enrollment: 2006 Feb 27
Recruiting
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Start of enrollment: 2008 Feb 04
Completed
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Start of enrollment: 2000 Nov 06
Recruiting
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma Start of enrollment: 1999 Mar 15
Completed
Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Start of enrollment: 2004 Feb 16
Completed
Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor Start of enrollment: 2009 Jul 13
Active, not recruiting
Phase 3
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 14
Active, not recruiting
Phase 3
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Start of enrollment: 2010 May 07
Active, not recruiting
Phase 3
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Start of enrollment: 2010 Aug 09
Completed
Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin Start of enrollment: 2010 Oct 04
Active, not recruiting
Phase 1
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Start of enrollment: 2010 Aug 09
Active, not recruiting
Phase 3
Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Start of enrollment: 2010 Nov 22
Completed
Phase 2
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Start of enrollment: 2010 Nov 22
Active, not recruiting
Phase 3
Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia Start of enrollment: 2011 Apr 04
Completed
Phase 3
Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Start of enrollment: 2011 May 01
Completed
Not Applicable
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Jun 20
Active, not recruiting
Phase 3
Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor Start of enrollment: 2011 Aug 01
Completed
Phase 2
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum Start of enrollment: 2012 Feb 01
Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission Start of enrollment: 2012 Feb 21
Active, not recruiting
Phase 3
Intergroup Trial for Children or Adolescents With B-Cell NHL or B-AL: Evaluation of Rituximab Efficacy and Safety in High Risk Patients Start of enrollment: 2012 Jun 01
Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Start of enrollment: 2012 Jun 27
Active, not recruiting
Phase 2
Sorafenib and Topotecan in Refractory/Recurrent Pediatric Malignancies Start of enrollment: 2013 Jan 01
Completed
Phase 1
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma Start of enrollment: 2013 Feb 12
Completed
Phase 2
Blood Sample Markers of Reproductive Hormones in Assessing Ovarian Reserve in Younger Patients With Newly Diagnosed Lymphomas Start of enrollment: 2013 Jun 17
Active, not recruiting
Chlorhexidine Gluconate Cleansing in Preventing Central Line Associated Bloodstream Infection and Acquisition of Multi-drug Resistant Organisms in Younger Patients With Cancer or Undergoing Donor Stem Cell Transplant Start of enrollment: 2013 Nov 04
Completed
Phase 3
Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma Start of enrollment: 2013 Nov 13
Active, not recruiting
Phase 2
Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma Start of enrollment: 2014 Aug 01
Completed
Phase 2
Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer Start of enrollment: 2009 Sep 01
Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma Start of enrollment: 2016 Oct 25
Recruiting
Phase 2
Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Cancer Start of enrollment: 2017 Nov 29
Recruiting
Phase 3
Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory Neuroblastoma Start of enrollment: 2019 Jul 08
Active, not recruiting
Phase 2
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia Start of enrollment: 2019 Jul 03
Recruiting
Phase 3
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Publications & Presentations

PubMed

Bilateral tonic pupils secondary to anti-GD2 antibody therapy for neuroblastoma.
Christopher M Edwards, Daniel Elefant, Michael S Isakoff, Majida A Gaffar> ;Journal of AAPOS. 2024 Apr 1
Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial.
Giselle L Saulnier Sholler, Genevieve Bergendahl, Elizabeth C Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B Nagulapally, Karl Dykema, Valerie I Brown, Michael...> ;Genome Medicine. 2024 Feb 12
2 citations
Eflornithine as Postimmunotherapy Maintenance in High-Risk Neuroblastoma: Externally Controlled, Propensity Score-Matched Survival Outcome Comparisons.
Javier Oesterheld, William Ferguson, Jacqueline M Kraveka, Genevieve Bergendahl, Thomas Clinch, Elizabeth Lorenzi, Don Berry, Randal K Wada, Michael S Isakoff, Don E E...> ;Journal of Clinical Oncology. 2024 Jan 1
Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board.
Ajay Gupta, Richard F Riedel, Chirag Shah, Scott C Borinstein, Michael S Isakoff, Rashmi Chugh, Jeremy M Rosenblum, Erin S Murphy, Shauna R Campbell, Catherine M Alber...> ;Cancer. 2023 Nov 1
A phase II trial of nifurtimox combined with topotecan and cyclophosphamide for refractory or relapsed neuroblastoma and medulloblastoma.
Don Eslin, Peter E Zage, Genevieve Bergendahl, Elizabeth Lewis, William Roberts, Jacqueline Kraveka, Deanna Mitchell, Michael S Isakoff, Jawhar Rawwas, Randal K Wada, ...> ;International Journal of Cancer. 2023 Sep 1
1 citations
Joint Adult and Pediatric Working Group as a Successful Platform to Strengthen Adolescent and Young Adult (AYA) Clinical Trial Collaboration: A Report from the NCTN/SA...
Susan L Whiteway, Aaron R Weiss, Safia K Ahmed, Wendy A Allen-Rhoades, Viswatej Avutu, Kenneth Cardona, Lara E Davis, Elizabeth J Davis, Daniel J Indelicato, Michael S...> ;Journal of Adolescent and Young Adult Oncology. 2023 Oct 1
3 citations
A pilot study of genomic-guided induction therapy followed by immunotherapy with difluoromethylornithine maintenance for high-risk neuroblastoma.
Jacqueline M Kraveka, Elizabeth C Lewis, Genevieve Bergendahl, William Ferguson, Javier Oesterheld, Elizabeth Kim, Abhinav B Nagulapally, Karl J Dykema, Valerie I Brow...> ;Cancer Reports. 2022 Nov 1
5 citations
A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma.
Giselle Saulnier-Sholler, Dan G Duda, Genevieve Bergendahl, David Ebb, Matija Snuderl, Theodore W Laetsch, Jennifer Michlitsch, Derek Hanson, Michael S Isakoff, Kevin ...> ;Clinical Cancer Research. 2022 Sep 15
11 citations
Phase 2 study of anti-disialoganglioside antibody, dinutuximab, in combination with GM-CSF in patients with recurrent osteosarcoma: A report from the Children's Oncolo...
Pooja Hingorani, Mark Krailo, Allen Buxton, Paul Hutson, Paul M Sondel, Mitchell Diccianni, Alice Yu, Carol D Morris, Richard B Womer, Brian Crompton, R Lor Randall, L...> ;European Journal of Cancer. 2022 Sep 1
Pelvic Lymphovascular Malformation Presenting as a Vulvar Mass in an Adolescent Female.
Rhea Sindvani, Michael Isakoff, Elena Tunitsky-Bitton> ;Journal of Pediatric and Adolescent Gynecology. 2022 Oct 1
8 citations
Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion
Sara A. Byron, William P.D. Hendricks, Abhinav Nagulapally, Jacqueline M. Kraveka, William S. Ferguson, Valerie I. Brown, Don E Eslin, Deanna Mitchell, Albert Corneliu...> ;Cancer Research. 2021 Oct 5
6 citations
Charting a path for prioritization of novel agents for clinical trials in osteosarcoma: A report from the Children's Oncology Group New Agents for Osteosarcoma Task Fo...
Sarah B. Whittle, Katharine Offer, Ryan D. Roberts, Amy K. LeBlanc, Cheryl A. London, Robbie G. Majzner, Alex Yee-Chen Huang, Peter J. Houghton, E. Alejandro Sweet Cor...> ;Pediatric Blood & Cancer. 2021 Jun 16
13 citations
Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.
Javier Oesterheld, Damon R. Reed, Bhuvana A. Setty, Michael S. Isakoff, Patrick A. Thompson, Hong Yin, Masanori Hayashi, David M. Loeb, Tiffany Smith, Rikesh J Makanji...> ;Pediatric Blood & Cancer. 2020 Jul 1
25 citations
An evolutionary framework for treating pediatric sarcomas
Damon R. Reed, Jonathan Metts, Mariyah Pressley, Brooke L. Fridley, Masanori Hayashi, Michael S. Isakoff, David M. Loeb, Rikesh J Makanji, Ryan D. Roberts, Matteo Truc...> ;Cancer. 2020 Jun 1
2 citations
Primary Cutaneous Follicle Center Lymphoma in a 16-Year-old boy With Crohn Disease Exposed to Infliximab and Methotrexate.
Wael N Sayej, Michael S Isakoff, Joseph A DiGiuseppe, Douglas Moote, Fabiola Balarezo, Christine Finck, Jeffrey S Hyams> ;Journal of Pediatric Gastroenterology and Nutrition. 2020 Feb 1
49 citations
Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children's Oncology Group (COG) New Agents for Ewing Sarcoma Task Force.
Kelly M. Bailey, Carrye R. Cost, Ian J. Davis, Julia Glade-Bender, Patrick J. Grohar, Peter J. Houghton, Michael S. Isakoff, Elizabeth Stewart, Nadia N. Laack, Jason T...> ;F1000research. 2019 Apr 15
310 citations
Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort
Sigbjørn Smeland, Stefan S. Bielack, Jeremy Whelan, Mark L. Bernstein, Pancras C.W. Hogendoorn, Mark Krailo, Richard Gorlick, Katherine A. Janeway, Fiona C. Ingleby, J...> ;European Journal of Cancer. 2019 Mar 1
19 citations
A phase II study of eribulin in recurrent or refractory osteosarcoma: A report from the Children's Oncology Group
Michael S. Isakoff, Robert E. Goldsby, Doojduen Villaluna, Mark Krailo, Pooja Hingorani, Anderson B. Collier, Carol D. Morris, E. Anders Kolb, John J. Doski, Richard B...> ;Pediatric Blood & Cancer. 2019 Feb 1
28 citations
Factors influencing survival after recurrence in osteosarcoma: A report from the Children's Oncology Group.
Holly Spraker-Perlman, Donald A. Barkauskas, Mark Krailo, Paul A. Meyers, Cindy L. Schwartz, John J. Doski, Richard Gorlick, Katherine A. Janeway, Michael S. Isakoff> ;Pediatric Blood & Cancer. 2019 Jan 1
56 citations
Consensus and controversies regarding the treatment of rhabdomyosarcoma.
Scott C. Borinstein, Diana Steppan, Masanori Hayashi, David M. Loeb, Michael S. Isakoff, Odion Binitie, Andrew S. Brohl, Julia A. Bridge, Mark J. Stavas, Eric T. Shino...> ;Pediatric Blood & Cancer. 2018 Feb 1
98 citations
Treatment Pathway of Bone Sarcoma in Children, Adolescents, and Young Adults
Damon R. Reed, Masanori Hayashi, Lars M. Wagner, Odion Binitie, Diana Steppan, Andrew S. Brohl, Eric T. Shinohara, Julia A. Bridge, David M. Loeb, Scott C. Borinstein,...> ;Cancer. 2017 Jun 15
276 citations
Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, in...
Neyssa Marina, Sigbjørn Smeland, Stefan S. Bielack, Mark L. Bernstein, Gordana Jovic, Mark Krailo, Jane Hook, Carola A.S. Arndt, Henk van den Berg, Bernadette Brennan,...> ;The Lancet. Oncology. 2016 Oct 1
8 citations
Rapid Protocol Enrollment in Osteosarcoma: A Report From the Children's Oncology Group
Michael S. Isakoff, Robert E. Goldsby, Doojduen Villaluna, Mark Krailo, Richard Gorlick, John J. Doski, Richard B. Womer, Katherine A. Janeway> ;Pediatric Blood & Cancer. 2016 Feb 1
12 citations
Pediatric phase I trial of oral sorafenib and topotecan in refractory or recurrent pediatric solid malignancies.
Damon R. Reed, Leo Mascarenhas, Kathleen Manning, Gregory A. Hale, John M. Goldberg, Jonathan Gill, Eric Sandler, Michael S. Isakoff, Tiffany Smith, Jamie T. Caracciol...> ;Cancer Medicine. 2016 Feb 1
12 citations
Clinical features and outcomes of infants with Ewing sarcoma under 12 months of age
Thalia Wong, Robert E. Goldsby, Rosanna Wustrack, Thomas Cash, Michael S. Isakoff, Steven G. DuBois> ;Pediatric Blood & Cancer. 2015 Nov 1
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Press Mentions

American Red Cross Urging People to Donate Blood Amidst National ShortageJune 21st, 2021
Doctors Concerned About Shortage of Childhood Cancer Treatment DrugOctober 15th, 2019

Hospital Affiliations

Connecticut Children's Medical CenterHartford, Connecticut
Hartford HospitalHartford, Connecticut

MichaelIsakoffMD

Dr. Isakoff is on Doximity

Summary

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Press Mentions

Hospital Affiliations

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