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Michael Knowles, MD, Pulmonology, Chapel Hill, NC, University of North Carolina Hospitals

MichaelRKnowlesMD

Pulmonology • Chapel Hill, NC

Pleural Disease

Professor, Medicine, University of North Carolina at Chapel Hill School of Medicine

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Education & Training

  • Duke University Hospital
    Duke University HospitalResidency, Internal Medicine, 1973 - 1975
  • Ohio State University Hospital
    Ohio State University HospitalResidency, Internal Medicine, 1971 - 1973
  • University of North Carolina at Chapel Hill School of Medicine
    University of North Carolina at Chapel Hill School of MedicineClass of 1971

Certifications & Licensure

  • NC State Medical License
    NC State Medical License 1971 - 2023
  • MD State Medical License
    MD State Medical License 1975 - 1978
  • OH State Medical License
    OH State Medical License 1972 - 1974
  • American Board of Internal Medicine Internal Medicine
  • American Board of Internal Medicine Pulmonary Disease

Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Mutation of CFAP57, a Protein Required for the Asymmetric Targeting of a Subset of Inner Dynein Arms in Chlamydomonas, Causes Primary Ciliary Dyskinesia  
    Michael Knowles, MD, PLOS Genetics

Authored Content

  • Analysis of a Large Cohort of Cystic Fibrosis Patients with Severe Liver Disease Indicates Lung Function Decline Does Not Significantly Differ from That of the General Cystic Fibrosis PopulationOctober 2018

Press Mentions

  • Consortium Spotlight: Advancing Discoveries in Mucociliary Clearance Diseases
    Consortium Spotlight: Advancing Discoveries in Mucociliary Clearance DiseasesMarch 11th, 2022
  • Portlaoise Hospital's X-ray Team Hit the Mark in Health Watchdog's New Review
    Portlaoise Hospital's X-ray Team Hit the Mark in Health Watchdog's New ReviewJune 25th, 2020
  • Help Is at Hand for Covid-19 Staff Stress Says Portlaoise Hospital Manager
    Help Is at Hand for Covid-19 Staff Stress Says Portlaoise Hospital ManagerApril 29th, 2020
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Grant Support

  • Pathogenesis Of PCD Lung DiseaseNational Heart, Lung, And Blood Institute2004–2012
  • Genetic Disorder Of Mucocilary ClearanceNational Heart, Lung, And Blood Institute2009–2011
  • Molecular Phenotypes For Cystic Fibrosis Lung DiseaseNational Heart, Lung, And Blood Institute2008–2011
  • Gene Modifiers In CF Lung DiseaseNational Heart, Lung, And Blood Institute2001–2010
  • Association Of Genotype And Circulating Levels Of Tgf?1 In Cystic Fibrosis PANational Center For Research Resources2008
  • RARE Genetic Disorders Of The AirwaysNational Center For Research Resources2007–2008
  • Genetic Modifiers Of CF Liver DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2004–2008
  • Genetic Mutations In Patients With Primary Ciliary Dyskinesia And FamilyNational Center For Research Resources2004–2008
  • Genetic Disorders Of Mucociliary Clearance: RARE Diseases: Pcd, Cf, &PhaNational Center For Research Resources2004–2008
  • Genetic Disorders Of Mucociliary ClearanceNational Center For Research Resources2004–2008
  • Genetic Modifiers Of Inherited Liver DiseaseNational Center For Research Resources2007
  • Gene Modifiers In Cystic Fibrosis Lung DiseaseNational Center For Research Resources2007
  • Measurement Of Airway Transepithelial Potential Difference In CFNational Center For Research Resources2005–2007
  • Multicenter Study Of Nontuberculous Mycobacteria In PTS With Cystic FibrosisNational Center For Research Resources1999–2002
  • Airway Inflammation &Mediators In Chronic BronchitisNational Center For Research Resources1999–2002
  • Airway Surface Liquid Composition Of Humans In VivoNational Heart, Lung, And Blood Institute1998–2002
  • Measurement Of Airway Transepithelial Potential Difference In Cystic FibrosisNational Center For Research Resources1996–2002
  • Nontuberculous Mycobacteria In PTS W/ Cystic FibrosisNational Center For Research Resources2000
  • Glucocorticoids &Mineralocorticoids On Electrical Potential DifferenceNational Center For Research Resources2000
  • CPX In Adult W/ Mild To Moderately Severe Cystic FibrosisNational Center For Research Resources2000
  • Airway Transepithelial Potential Difference In CFNational Center For Research Resources2000
  • Human Respiratory Epithelial Function In VivoNational Heart, Lung, And Blood Institute1995–2000
  • Measurement Of Airway Electrical Potential DifferenceNational Center For Research Resources1996–1999
  • Gene Transfer In Vivo In Cystic Fibrosis PatientsNational Heart, Lung, And Blood Institute1996–1997
  • Gene Transfer In Cystic Fibrosis Using E1 Deleted AdenovirusNational Center For Research Resources1996–1997
  • Acute Safety And Efficacy Of Aerosolized Nucleotides As Therapy For CFNational Center For Research Resources1995–1996
  • Pharmacokinetics Of Amiloride Administration In Cyctic Fibrosis PatientsNational Center For Research Resources1995
  • Acute Effects Of Aerosolized Amiloride In Cystic Fibrosis And Normal SubjectsNational Center For Research Resources1995
  • Clinical Investigator AwardNational Heart, Lung, And Blood Institute1985

Hospital Affiliations

Dr. Michael Knowles, Dr. Michael Knowles, MD, Dr. M Knowles, Dr. Michael R Knowles