MichaelDouglasMeyerMD

PubMed

• In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
  Malysz, J., Anderson, D. J., Grønlien, J. H., Ji, J., Bunnelle, W. H., Håkerud, M., Thorin-Hagene, K., Ween, H., Helfrich, R., Hu, M., Gubbins, E., Gopalakrishnan, S.,...> ;J Pharmacol Exp Ther. 2010 Sep 1
• Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.
  Frost, J.M., Dart, M.J., Tietje, K.R., Garrison, T.R., Grayson, G.K., Daza, A.V., El-Kouhen, O.F., Yao, B.B., Hsieh, G.C., Pai, M., Zhu, C.Z., Chandran, P., Meyer, M.D.> ;J Med Chem. 2010-01-14
• Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substit...
  Bunnelle, W. H., Tietje, K. R., Frost, J. M., Peters, D., Ji, J., Li, T., Scanio, M. J., Shi, L., Anderson, D. J., Dyhring, T., Grønlien, J. H., Ween, H., Thorin-Hagen...> ;J Med Chem. 2009-07-23
• Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazo...
  Yao, B.B., Hsieh, G., Daza, A.V., Fan, Y., Grayson, G.K., Garrison, T.R., El Kouhen, O., Hooker, B.A., Pai, M., Wensink, E.J., Salyers, A.K., Chandran, P., Zhu, C.Z., ...> ;J Pharmacol Exp Ther. 2009-01-01
• Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.
  Frost, J.M., Dart, M.J., Tietje, K.R., Garrison, T.R., Grayson, G.K., Daza, A.V., El-Kouhen, O.F., Miller, L.N., Li, L., Yao, B.B., Hsieh, G.C., Pai, M., Zhu, C.Z., Ch...> ;J Med Chem. 2008 Mar 27
• Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.
  Ji, J., Schrimpf, M.R., Sippy, K.B., Bunnelle, W.H., Li, T., Anderson, D.J., Faltynek, C., Surowy, C.S., Dyhring, T., Ahring, P.K., Meyer, M.D.> ;J Med Chem. 2007 Nov 1
• Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathw...
  Bitner, R.S., Bunnelle, W.H., Anderson, D.J., Briggs, C.A., Buccafusco, J., Curzon, P., Decker, M.W., Frost, J.M., Gronlien, J.H., Gubbins, E., Li, J., Malysz, J., Mar...> ;J Neurosci. 2007 Sep 26
• Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.
  Bunnelle, W.H., Daanen, J.F., Ryther, K.B., Schrimpf, M.R., Dart, M.J., Gelain, A., Meyer, M.D., Frost, J.M., Anderson, D.J., Buckley, M., Curzon, P., Cao, Y., Puttfar...> ;J Med Chem. 2007 Jul 26
• Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.
  Frost, J.M., Bunnelle, W.H., Tietje, K.R., Anderson, D.J., Rueter, L.E., Curzon, P., Surowy, C.S., Ji, J., Daanen, J.F., Kohlhaas, K.L., Buckley, M.J., Henry, R.F., Dy...> ;J Med Chem. 2006 Dec 28
• Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors.
  Briggs, C.A., Gubbins, E.J., Marks, M.J., Putman, C.B., Thimmapaya, R., Meyer, M.D., Surowy, C.S.> ;Mol Pharmacol. 2006 Jul
• High- and low-sensitivity subforms of alpha4beta2 and alpha3beta2 nAChRs.
  Briggs, C.A., Gubbins, E.J., Putman, C.B., Thimmapaya, R., Meyer, M.D., Surowy, C.S.> ;J Mol Neurosci. 2006
• Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenocepto...
  Altenbach, R.J., Khilevich, A., Kolasa, T., Rohde, J.J., Bhatia, P.A., Patel, M.V., Searle, X.B., Yang, F., Bunnelle, W.H., Tietje, K., Bayburt, E.K., Carroll, W.A., M...> ;J Med Chem. 2004 Jun 3
• N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to p...
  Altenbach, R.J., Khilevich, A., Meyer, M.D., Buckner, S.A., Milicic, I., Daza, A.V., Brune, M.E., O'Neill, A.B., Gauvin, D.M., Cain, J.C., Nakane, M., Holladay, M.W., ...> ;J Med Chem. 2002 Sep 26
• 6-Chloropyridazin-3-yl derivatives active as nicotinic agents: synthesis, binding, and modeling studies.
  Toma, L., Quadrelli, P., Bunnelle, W.H., Anderson, D.J., Meyer, M.D., Cignarella, G., Gelain, A., Barlocco, D.> ;J Med Chem. 2002 Aug 29
• Conformationally constrained nicotines: polycyclic, bridged, and spiro-annulated analogues as novel ligands for the nicotinic acetylcholine receptor.
  Ullrich, T., Krich, S., Binder, D., Mereiter, K., Anderson, D.J., Meyer, M.D., Pyerin, M.> ;J Med Chem. 2002 Aug 29
• Preclinical pharmacology of fiduxosin, a novel alpha(1)-adrenoceptor antagonist with uroselective properties.
  Hancock, A.A., Buckner, S.A., Brune, M.E., Esbenshade, T.A., Ireland, L.M., Katwala, S., Milicic, I., Meyer, M.D., Kerwin, J.F., Williams, M.> ;J Pharmacol Exp Ther. 2002 Feb
• Effect of fiduxosin, an antagonist selective for alpha(1A)- and alpha(1D)-adrenoceptors, on intraurethral and arterial pressure responses in conscious dogs.
  Brune, M.E., Katwala, S.P., Milicic, I., Witte, D.G., Kerwin, J.F., Meyer, M.D., Hancock, A.A., Williams, M.> ;J Pharmacol Exp Ther. 2002 Feb
• Modeling of relationships between pharmacokinetics and blockade of agonist-induced elevation of intraurethral pressure and mean arterial pressure in conscious dogs tre...
  Witte, D.G., Brune, M.E., Katwala, S.P., Milicic, I., Stolarik, D., Hui, Y., Marsh, K.C., Kerwin, J.F., Meyer, M.D., Hancock, A.A.> ;J Pharmacol Exp Ther. 2002 Feb
• Extension of corpus luteum lifespan and reduction of uterine secretion of prostaglandin F2 alpha of cows in response to recombinant interferon-tau.
  Meyer, M. D., Hansen, P. J., Thatcher, W. W., Drost, M., Badinga, L., Roberts, R. M., Li, J., Ott, T. L., Bazer, F. W.> ;J Dairy Sci. 1995 Sep
• SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.
  Schrimpf, M. R., Sippy, K. B., Briggs, C. A., Anderson, D. J., Li, T., Ji, J., Frost, J. M., Surowy, C. S., Bunnelle, W. H., Gopalakrishnan, M., Meyer, M. D.> ;Bioorg Med Chem Lett. 2012 Feb 15
• A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic effi...
  Ji, J., Bunnelle, W. H., Anderson, D. J., Faltynek, C., Dyhring, T., Ahring, P. K., Rueter, L. E., Curzon, P., Buckley, M. J., Marsh, K. C., Kempf-Grote, A., Meyer, M. D.> ;Biochem Pharmacol. 2007 Oct 15
• In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?
  Yao, B. B., Mukherjee, S., Fan, Y., Garrison, T. R., Daza, A. V., Grayson, G. K., Hooker, B. A., Dart, M. J., Sullivan, J. P., Meyer, M. D.> ;Br J Pharmacol. 2006 Sep
• ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes.
  Buckner, S. A., Milicic, I., Daza, A. V., Meyer, M. D., Altenbach, R. J., Williams, M., Sullivan, J. P., Brioni, J. D.> ;Eur J Pharmacol. 2002 Aug 2
• Spinal mechanisms underlying A-85380-induced effects on acute thermal pain.
  Rueter, L. E., Meyer, M. D., Decker, M. W.> ;Brain Res. 2000 Jul 28
• Actions of A-131701, a novel, selective antagonist for alpha-1A compared with alpha-1B adrenoceptors on intraurethral and blood pressure responses in conscious dogs an...
  Hancock, A. A., Brune, M. E., Witte, D. G., Marsh, K. C., Katwala, S., Milicic, I., Ireland, L. M., Crowell, D., Meyer, M. D., Kerwin, J. F.> ;J Pharmacol Exp Ther. 1998 May
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