MichaelC.MyersDO

PubMed

• A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney ...
  Shah, P.P., Wang, T., Kaletsky, R.L., Myers, M.C., Purvis, J.E., Jing, H., Huryn, D.M., Greenbaum, D.C., Smith, A.B., Bates, P., Diamond, S.L.> ;Mol Pharmacol. 2010 Aug
• Identification of novel inhibitors of dietary lipid absorption using zebrafish.
  Clifton, J.D., Lucumi, E., Myers, M.C., Napper, A., Hama, K., Farber, S.A., Smith, A.B., Huryn, D.M., Diamond, S.L., Pack, M.> ;PLoS One. 2010
• Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L.
  Shah, P.P., Myers, M.C., Beavers, M.P., Purvis, J.E., Jing, H., Grieser, H.J., Sharlow, E.R., Napper, A.D., Huryn, D.M., Cooperman, B.S., Smith, A.B., Diamond, S.L.> ;Mol Pharmacol. 2008 Jul
• Molecular docking of cathepsin L inhibitors in the binding site of papain.
  Beavers, M.P., Myers, M.C., Shah, P.P., Purvis, J.E., Diamond, S.L., Cooperman, B.S., Huryn, D.M., Smith, A.B.> ;J Chem Inf Model. 2008 Jul
• HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.
  Johnston, P.A., Phillips, J., Shun, T.Y., Shinde, S., Lazo, J.S., Huryn, D.M., Myers, M.C., Ratnikov, B.I., Smith, J.W., Su, Y., Dahl, R., Cosford, N.P., Shiryaev, S.A...> ;Assay Drug Dev Technol. 2007 Dec
• Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions.
  Hara, T., Durell, S.R., Myers, M.C., Appella, D.H.> ;J Am Chem Soc. 2006 Feb 15
• Catalytic conjugate additions of carbonyl anions under neutral aqueous conditions.
  Myers, M.C., Bharadwaj, A.R., Milgram, B.C., Scheidt, K.A.> ;J Am Chem Soc. 2005 Oct 26
• A new family of small molecules to probe the reactivation of mutant p53.
  Myers, M. C.,Wang, J.,Iera, J. A.,Bang, J. K.,Hara, T.,Saito, S.,Zambetti, G. P.,Appella, D. H.> ;J Am Chem Soc. 2005 May 4
• Peptide nucleic acids with a flexible secondary amine in the backbone maintain oligonucleotide binding affinity.
  Myers, M.C., Pokorski, J.K., Appella, D.H.> ;Org Lett. 2004 Dec 9
• A cyclopentane conformational restraint for a peptide nucleic acid: design, asymmetric synthesis, and improved binding affinity to DNA and RNA.
  Myers, M.C., Witschi, M.A., Larionova, N.V., Franck, J.M., Haynes, R.D., Hara, T., Grajkowski, A., Appella, D.H.> ;Org Lett. 2003 Jul 24
• Regioselective organocadmium alkylations of substituted quinones.
  Aponick, A., Buzdygon, R.S., Tomko, R.J., Fazal, A.N., Shughart, E.L., McMaster, D.M., Myers, M.C., Pitcock, W.H., Wigal, C.T.> ;J Org Chem. 2002 Jan 11
• Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor.
  Myers, M. C., Shah, P. P., Diamond, S. L., Huryn, D. M., Smith, A. B.> ;Bioorg Med Chem Lett. 2008 Jan 1
• Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biologica...
  Myers, M. C., Napper, A. D., Motlekar, N., Shah, P. P., Chiu, C. H., Beavers, M. P., Diamond, S. L., Huryn, D. M., Smith, A. B.> ;Bioorg Med Chem Lett. 2007 Sep 1
• Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.
  Myers, M. C., Shah, P. P., Beavers, M. P., Napper, A. D., Diamond, S. L., Smith, A. B., Huryn, D. M.> ;Bioorg Med Chem Lett. 2008 Jun 15
• Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors.
  Liu, Z., Myers, M. C., Shah, P. P., Beavers, M. P., Benedetti, P. A., Diamond, S. L., Smith, A. B., Huryn, D. M.> ;Comb Chem High Throughput Screen. 2010 May
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