Michael J Ombrello MD FACR

Juvenile Rheumatoid Arthritis and Related Rheumatology, Pediatric Systemic Pain and Inflammatory Syndromes and Related Rheumatology, Pediatric Vasculitis Rheumatology

Principal Investigator, Head of the Translational Genetics and Genomics Section, and Combined Adult and Pediatric Rheumatologist at the National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health

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10 Center DrBuilding 10, 13C103ABethesda, MD 20892
Phone+1 301-435-4037
Fax+1 314-977-8818

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Summary

Dr. Michael Ombrello is a Pediatric Rheumatologist based in Bethesda, MD, specializing in juvenile rheumatoid arthritis, pediatric systemic pain and inflammatory syndromes, and pediatric vasculitis. He earned his medical degree from Saint Louis University School of Medicine in 2002 and completed his residency and multiple fellowships in Rheumatology at SSM Health/Saint Louis University School of Medicine. He serves as a Principal Investigator at the NIH Clinical Center and has been involved in significant research on autoinflammatory diseases and systemic juvenile idiopathic arthritis. His published work covers complex genetic architectures and immune dysregulation, and he has received several honors, including an NIH Director's Award. Dr. Ombrello is also experienced in conducting clinical trials related to systemic juvenile idiopathic arthritis and adult-onset Still's disease.

Education & Training

SSM Health/Saint Louis University School of MedicineFellowship, Rheumatology, 2006 - 2009
SSM Health/Saint Louis University School of MedicineFellowship, Pediatric Rheumatology, 2006 - 2009
St Louis University School of MedicineResidency, Internal Medicine/Pediatrics, 2002 - 2006
Saint Louis University School of MedicineClass of 2002

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Certifications & Licensure

MO State Medical License 2009 - 2027

Awards, Honors, & Recognition

Young Physician Scientist Award American Society of Clinical Investigation, 2018
Best Genetics and Pathogenesis Abstract (to Victoria Arthur) Pediatric Rheumatology Symposium, American College of Rheumatology, 2017
Pediatric Rheumatology European Society Early Career Investigator Travel Award Childhood Arthritis Rheumatology Research Alliance (CARRA), 2016

Clinical Trials

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions Start of enrollment: 2018 May 21
RECRUITING

Publications & Presentations

PubMed

5 citations
Next generation sequencing analysis reveals complex genetic architecture of childhood-onset systemic lupus erythematosus.
Laura Lewandowski, Linda Hiraki, Christiaan Scott, Ana Barrera-Vargas, Jorge Romo Tena
Lupus Science & Medicine. 2025-06-10
2 citations
Splice site and de novo variants can cause PLCG2-associated immune dysregulation with cold urticaria.
Sophia R Chou, Alexis C Bailey, Kathleen Baysac, Andrew J Oler, Joshua D Milner
The Journal of Allergy and Clinical Immunology. 2025-03-01
1 citations
PLCG2 variants in cherubism.
Jennifer G Chester, Benjamin Carcamo, David A Gudis, Daniel Bustamante, Sidney B Eisig
The Journal of Allergy and Clinical Immunology. 2024-12-01

Press Mentions

Nobody Has My Condition But MeJanuary 23rd, 2023
CC Grand Rounds: Adventures in Autoinflammatory Genetics: From Genetically Complex Syndromes to Mendelian Diseases: 1) Systemic Juvenile Idiopathic Arthritis: One Name, Many Faces and 2) the Deficiency of Adenosine Deaminase 2: A Master of MimicryJanuary 23rd, 2020
My Experience at the 2019 Rheumatology Research Workshop: Opportunity to Meet Peers & Role ModelsDecember 13th, 2019

Grant Support

Genetics and pathophysiology of systemic juvenile idiopathic arthritis and other complex autoinflammatory diseasesNational Institute of Arthritis and Musculoskeletal and Skin Disease2014–2023

Committees

Voting member, Juvenile Idiopathic Arthritis Treatment Guideline Development Committee 2017 - 2022
Committee Member, Early Career Investigator Subcommittee of the Committee on Research, American College of Rheumatology 2016 - 2020