MichaelJOmbrelloMDFACR
Pediatric Rheumatology • Bethesda, MDJuvenile Rheumatoid Arthritis and Related Rheumatology, Pediatric Systemic Pain and Inflammatory Syndromes and Related Rheumatology, Pediatric Vasculitis Rheumatology
Principal Investigator, Head of the Translational Genetics and Genomics Section, and Combined Adult and Pediatric Rheumatologist at the National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health
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Office
10 Center Drive
Building 10, Room 12N248A, MSC 1560
Bethesda, MD 20892Phone+1 301-435-4037- Is this information wrong?
Summary
- Clinically trained and board certified in both adult and pediatric rheumatology, I obtained postdoctoral training in advanced genetic and genomic techniques in the laboratory of Dan Kastner. I now lead a translational research group that, by employing contemporary genetics, genomics and bioinformatics approaches, seeks to identify the underpinnings of both Mendelian and genetically-complex forms of autoinflammatory and autoimmune diseases. At this time, the primary focus of my group is investigating systemic arthritis, a rare, severe, and poorly understood condition that may affect people of all ages. When present in children it is called systemic juvenile idiopathic arthritis, whereas when present in adults it is called Adult-onset Still's disease.
Education & Training
St Louis University School of MedicineFellowship, Rheumatology, 2006 - 2009- St Louis University School of MedicineFellowship, Pediatric Rheumatology, 2006 - 2009
- St Louis University School of MedicineResidency, Internal Medicine/Pediatrics, 2002 - 2006
- Saint Louis University School of MedicineClass of 2002
Certifications & Licensure
MO State Medical License 2009 - 2025
Awards, Honors, & Recognition
- Young Physician Scientist Award American Society of Clinical Investigation, 2018
- Best Genetics and Pathogenesis Abstract (to Victoria Arthur) Pediatric Rheumatology Symposium, American College of Rheumatology, 2017
- Pediatric Rheumatology European Society Early Career Investigator Travel Award Childhood Arthritis Rheumatology Research Alliance (CARRA), 2016
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Clinical Trials
Publications & Presentations
PubMed
- 2 citationsPLCG2-associated immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants.Kathleen Baysac, Guangping Sun, Hiroto Nakano, Elizabeth G Schmitz, Anthony C Cruz, Charles Fisher, , Emily Mace, Joshua D Milner, Ombrello, A. K., Ombrello, A. K., Bi...> ;The Journal of Allergy and Clinical Immunology. 2024 Jan 1
- 42 citationsSevere delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles.Vivian E. Saper, Michael J. Ombrello, Adriana H. Tremoulet, Gonzalo Montero-Martín, Sampath Prahalad, Scott W. Canna, Chisato Shimizu, Gail H. Deutsch, Serena Y Tan, E...> ;Annals of the Rheumatic Diseases. 2021 Nov 17
- 11 citationsElevated serum gasdermin D N-terminal implicates monocyte and macrophage pyroptosis in adult-onset Still's disease.Hideto Nagai, Yohei Kirino, Hiroto Nakano, Yosuke Kunishita, Riko Henmi, Ann Marie Szymanski, Ryusuke Yoshimi, Michael J. Ombrello, Hideaki Nakajima> ;Rheumatology. 2021 Aug 2
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Press Mentions
- Nobody Has My Condition But MeJanuary 23rd, 2023
CC Grand Rounds: Adventures in Autoinflammatory Genetics: From Genetically Complex Syndromes to Mendelian Diseases: 1) Systemic Juvenile Idiopathic Arthritis: One Name, Many Faces and 2) the Deficiency of Adenosine Deaminase 2: A Master of MimicryJanuary 23rd, 2020
My Experience at the 2019 Rheumatology Research Workshop: Opportunity to Meet Peers & Role ModelsDecember 13th, 2019- Join now to see all
Grant Support
- Genetics and pathophysiology of systemic juvenile idiopathic arthritis and other complex autoinflammatory diseasesNational Institute of Arthritis and Musculoskeletal and Skin Disease2014–2023
Committees
- Voting member, Juvenile Idiopathic Arthritis Treatment Guideline Development Committee 2017 - 2022
- Committee Member, Early Career Investigator Subcommittee of the Committee on Research, American College of Rheumatology 2016 - 2020
Professional Memberships
- American College of RheumatologyFellow (FACR)
- Childhood Arthritis and Rheumatology Research AllianceMember
- International Childhood Arthritis Genetics ConsortiumMember
- Fellow
- International Society of Systemic Auto-Inflammatory DiseasesMember
Hospital Affiliations
NIH Clinical CenterBethesda, Maryland
External Links
- NIAMS Translational Genetics and Genomics Unit websitehttp://tinyurl.com/NIAMS-TGGU/
- LabTV Videohttps://www.youtube.com/watch?v=Oyzsw5PucJM
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