MichaelAPackDO

PubMed

• Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish.
  Zhao X, Lorent K, Wilkins BJ, Marchione DM, Gillespie K, Waisbourd-Zinman O, So J, Koo KA, Shin D, Porter JR, Wells RG, Blair I, Pack M> ;Hepatology. 2016-09-01
• Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish.
  Abrams J, Einhorn Z, Seiler C, Zong AB, Sweeney HL, Pack M> ;Dis Model Mech. 2016-05-01
• Biliatresone, a Reactive Natural Toxin from Dysphania glomulifera and D. littoralis: Discovery of the Toxic Moiety 1,2-Diaryl-2-Propenone.
  Koo KA, Lorent K, Gong W, Windsor P, Whittaker SJ, Pack M, Wells RG, Porter JR> ;Chem. Res. Toxicol.. 2015-08-17
• 98 citations
  Identification of a plant isoflavonoid that causes biliary atresia.
  Kristin Lorent, Weilong Gong, Kyung A. Koo, Orith Waisbourd-Zinman, Sara Karjoo, Xiao Zhao, Ian M Sealy, Ross Kettleborough, Derek L. Stemple, Peter A. Windsor, Stephe...> ;Science Translational Medicine. 2015 May 6
• A novel keratin18 promoter that drives reporter gene expression in the intrahepatic and extrahepatic biliary system allows isolation of cell-type specific transcripts ...
  Wilkins BJ, Gong W, Pack M> ;Gene Expr. Patterns. 2014-03-01
• Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1).
  Valvezan, A. J.,Huang, J.,Lengner, C. J.,Pack, M.,Klein, P. S.> ;Dis Model Mech. 2013 Oct 2
• Zebrafish models of human liver development and disease.
  Wilkins, B. J.,Pack, M.> ;Compr Physiol. 2013 Jul
• Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid.
  Walters JW, Anderson JL, Bittman R, Pack M, Farber SA> ;Chem. Biol.. 2012-07-27
• Smooth muscle tension induces invasive remodeling of the zebrafish intestine.
  Seiler C, Davuluri G, Abrams J, Byfield FJ, Janmey PA, Pack M> ;PLoS Biol.. 2012-01-01
• DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia.
  Matthews RP, Eauclaire SF, Mugnier M, Lorent K, Cui S, Ross MM, Zhang Z, Russo P, Pack M> ;Hepatology. 2011-03-01
• Identification of novel inhibitors of dietary lipid absorption using zebrafish.
  Clifton JD, Lucumi E, Myers MC, Napper A, Hama K, Farber SA, Smith AB, Huryn DM, Diamond SL, Pack M> ;PLoS ONE. 2010-08-25
• CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
  Zheng, X., Xu, C., Di Lorenzo, A., Kleaveland, B., Zou, Z., Seiler, C., Chen, M., Cheng, L., Xiao, J., He, J., Pack, M.A., Sessa, W.C., Kahn, M.L.> ;J Clin Invest. 2010 Aug
• Decreased levels of the RNA splicing factor Prpf3 in mice and zebrafish do not cause photoreceptor degeneration.
  Graziotto, J.J., Inglehearn, C.F., Pack, M.A., Pierce, E.A.> ;Invest Ophthalmol Vis Sci. 2008 Sep
• Analysis of the zebrafish proteome during embryonic development.
  Lucitt, M.B., Price, T.S., Pizarro, A., Wu, W., Yocum, A.K., Seiler, C., Pack, M.A., Blair, I.A., Fitzgerald, G.A., Grosser, T.> ;Mol Cell Proteomics. 2008 May
• Prostaglandin E synthases in zebrafish.
  Pini, B., Grosser, T., Lawson, J.A., Price, T.S., Pack, M.A., FitzGerald, G.A.> ;Arterioscler Thromb Vasc Biol. 2005 Feb
• Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas.
  Lin, J.W., Biankin, A.V., Horb, M.E., Ghosh, B., Prasad, N.B., Yee, N.S., Pack, M.A., Leach, S.D.> ;Dev Biol. 2004 Oct 15
• Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas.
  Lin, J.W., Biankin, A.V., Horb, M.E., Ghosh, B., Prasad, N.B., Yee, N.S., Pack, M.A., Leach, S.D.> ;Dev Biol. 2004 Jun 15
• Developmental expression of functional cyclooxygenases in zebrafish.
  Grosser, T., Yusuff, S., Cheskis, E., Pack, M.A., FitzGerald, G.A.> ;Proc Natl Acad Sci U S A. 2002 Jun 11
• p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis.
  Wilkins, B. J.,Lorent, K.,Matthews, R. P.,Pack, M.> ;PLoS ONE. 2013 Oct 23
• Analysis of small molecule metabolism in zebrafish.
  Ho, S. Y., Pack, M., Farber, S. A.> ;Methods Enzymol. 2003
• Genetic analysis of digestive physiology using fluorescent phospholipid reporters.
  Farber, S. A., Pack, M., Ho, S. Y., Johnson, I. D., Wagner, D. S., Dosch, R., Mullins, M. C., Hendrickson, H. S., Hendrickson, E. K., Halpern, M. E.> ;Science. 2001 May 18
• Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish.
  Matthews, R. P., Lorent, K., Pack, M.> ;Dev Dyn. 2008 Jan
• Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells.
  Inaba, K., Turley, S., Yamaide, F., Iyoda, T., Mahnke, K., Inaba, M., Pack, M., Subklewe, M., Sauter, B., Sheff, D., Albert, M., Bhardwaj, N., Mellman, I., Steinman, R...> ;J Exp Med. 1998 Dec 7
• Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure.
  Ho, S. Y., Lorent, K., Pack, M., Farber, S. A.> ;Cell Metab. 2006 Apr
• Zebrafish as a model for pancreatic cancer research.
  Yee, N. S., Pack, M.> ;Methods Mol Med. 2005
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