MichaelE.PacoldMD

PubMed

• 7 citations
  Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma.
  Guisheng Zhao, Patrick Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin S Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri, Javad N...> ;Acta Neuropathologica Communications. 2022 Oct 23
• 3 citations
  Resurrecting essential amino acid biosynthesis in mammalian cells.
  Julie Trolle, Ross M McBee, Andrew Kaufman, Sudarshan Pinglay, Henri Berger, Sergei German, Liyuan Liu, Michael J Shen, Xinyi Guo, J Andrew Martin, Michael E Pacold, D...> ;Elife. 2022 Sep 27
• 4 citations
  Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.
  Alcida Karz, Maya Dimitrova, Kevin Kleffman, Christopher Alvarez-Breckenridge, Michael B Atkins, Adrienne Boire, Marcus Bosenberg, Priscilla Brastianos, Daniel P Cahil...> ;Pigment Cell & Melanoma Research. 2022 Nov 1
• 21 citations
  The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway
  Robert S. Banh, Esther S. Kim, Quentin Spillier, Douglas E. Biancur, Keisuke Yamamoto, Albert S. W. Sohn, Guangbin Shi, Drew R. Jones, Alec C. Kimmelman, Michael E. Pa...> ;Nature. 2021 Sep 1
• 112 citations
  Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer.
  Robert S. Banh, Douglas E. Biancur, Keisuke Yamamoto, Albert S. W. Sohn, Beth Walters, Miljan Kuljanin, Ajami Gikandi, Huamin Wang, Joseph D. Mancias, Robert J. Schnei...> ;Cell. 2020 Nov 25
• 20 citations
  Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
  Lynne Chantranupong, Jessica L. Saulnier, Wengang Wang, Drew R. Jones, Michael E. Pacold, Bernardo L. Sabatini> ;Elife. 2020 Oct 12
• 70 citations
  Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy
  Lin Wu, Kate E.R. Hollinshead, Yuhan Hao, Christy Au, Lina Kroehling, Charles Ng, Woan Yu Lin, Dayi Li, Hernandez Moura Silva, Jong Shin, Juan J. Lafaille, Richard Pos...> ;Cell. 2020 Aug 6
• 1 citations
  The uninhibited pathway is not worth studying.
  Michael E. Pacold> ;Nature Chemical Biology. 2020 Jun 22
• 120 citations
  Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
  Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger Liang, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino B. Ferraro, Grant M. Fische...> ;Cancer Discovery. 2020 Sep 1
• 128 citations
  SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.
  Nora Kory, Gregory A. Wyant, Gyan Prakash, Jelmi uit de Bos, Francesca Bottanelli, Michael E. Pacold, Sze Ham Chan, Caroline A. Lewis, Timothy C. Wang, Heather R. Keys...> ;Science. 2018 Nov 16
• 17 citations
  Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
  Jason M. Rohde, Kyle R. Brimacombe, Li Liu, Michael E. Pacold, Adam Yasgar, Dorian M. Cheff, Tobie D. Lee, Ganesha Rai, Bolormaa Baljinnyam, Zhuyin Li, Anton Simeonov,...> ;Bioorganic & Medicinal Chemistry. 2018 May 1
• 10 citations
  Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
  Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan, Jason M. Rohde, Caroline A. Lewis, Lotteke J Y M Swier, Richard Possemato, Walter W. Chen, Lucas B. Sullivan, Bria...> ;Nature Chemical Biology. 2016 Jul 19
• 68 citations
  Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes.
  Ravi V. Shah, Venkatesh L. Murthy, Michael E. Pacold, Kirsty Danielson, Kahraman Tanriverdi, Martin G. Larson, Kristina Hanspers, Alexander R. Pico, Eric Mick, Jared P...> ;Diabetes Care. 2017 Feb 9
• 331 citations
  A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
  Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan, Jason M. Rohde, Caroline A. Lewis, Lotteke J Y M Swier, Richard Possemato, Walter W. Chen, Lucas B. Sullivan, Bria...> ;Nature Chemical Biology. 2016 Jun 1
• 300 citations
  Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
  Robert A. Saxton, Kevin E. Knockenhauer, Rachel L. Wolfson, Lynne Chantranupong, Michael E. Pacold, Timothy C. Wang, Thomas U. Schwartz, David M. Sabatini> ;Science. 2016 Jan 1
• 255 citations
  SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
  Dohoon Kim, Brian P. Fiske, Kıvanç Birsoy, Elizaveta Freinkman, Kenjiro Kami, Richard Possemato, Yakov Chudnovsky, Michael E. Pacold, Walter W. Chen, Jason R. Cantor, ...> ;Nature. 2015 Apr 16
• 163 citations
  Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.
  Yoav D. Shaul, Elizaveta Freinkman, William C. Comb, Jason R. Cantor, Wai Leong Tam, Prathapan Thiru, Dohoon Kim, Naama Kanarek, Michael E. Pacold, Walter W. Chen, Bri...> ;Cell. 2014 Aug 28
• 844 citations
  Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
  Schraga Schwartz, Maxwell R. Mumbach, Marko Jovanovic, Timothy C. Wang, Karolina Maciag, G. Guy Bushkin, Philipp Mertins, Dmitry Ter-Ovanesyan, Naomi Habib, Davide Cac...> ;Cell Reports. 2014 Jul 10
• 232 citations
  Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor†
  Sang Min Lim, Kenneth D. Westover, Scott B. Ficarro, Rane A. Harrison, Hwan Geun Choi, Michael E. Pacold, Martin Carrasco, John C. Hunter, Nam Doo Kim, Ting Xie, Taebo...> ;Angewandte Chemie. 2014 Jan 3
• 22 citations
  Supportive and palliative radiation oncology service: Impact of a dedicated service on palliative cancer care
  Yolanda D. Tseng, Monica Krishnan, Joshua Jones, Adam Sullivan, Daniel P. Gorman, Allison Taylor, Michael Edward Pacold, Barbara Kalinowski, Harvey J. Mamon, Janet L. ...> ;Practical Radiation Oncology. 2013 Oct 1
• 340 citations
  mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
  Seong A. Kang, Michael E. Pacold, Christopher L. Cervantes, Daniel Lim, Hua Jane Lou, Kathleen Ottina, Nathanael S. Gray, Benjamin E. Turk, Michael B. Yaffe, David M. ...> ;Science. 2013 Jul 26
• 240 citations
  The bromodomain protein Brd4 insulates chromatin from DNA damage signalling
  Scott R. Floyd, Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, Jonathan Rameseder, Michael J. Lee, Emily J. Blake, An...> ;Nature. 2013 Jun 13
• 96 citations
  Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery.
  Shrirang Karve, Michael E. Werner, Rohit Sukumar, Natalie D. Cummings, Jonathan Copp, Edina C. Wang, Chenxi Li, Manish Sethi, Ronald C. Chen, Michael E. Pacold, Andrew...> ;Proceedings of the National Academy of Sciences of the United States of America. 2012 May 22
• 1090 citations
  Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
  Richard Possemato, Kevin Marks, Yoav D. Shaul, Michael E. Pacold, Dohoon Kim, Kıvanç Birsoy, Shalini Sethumadhavan, Hin-Koon Woo, Hyun Gyung Jang, Abhishek K. Jha, Wal...> ;Nature. 2011 Aug 18
• 10 citations
  Slow self-activation enhances the potency of viridin prodrugs.
  Joseph Blois, Hushan Yuan, Adam W. Smith, Michael E. Pacold, Ralph Weissleder, Lewis C. Cantley, Lee Josephson> ;Journal of Medicinal Chemistry. 2008 Aug 14
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Journal Articles

• SFXN1 Is a Mitochondrial Serine Transporter Required for One-Carbon Metabolism  
  Michael E Pacold, Science Magazine