MichaelJosephRogersMDFAAD

PubMed

• A Class III Semaphorin (Sema3e) Inhibits Mouse Osteoblast Migration and Decreases Osteoclast Formation In Vitro.
  Hughes, A., Kleine-Albers, J., Helfrich, M.H., Ralston, S.H., Rogers, M.J.> ;Calcif Tissue Int. 2012 Feb
• Influence of bone affinity on the skeletal distribution of fluorescently-labeled bisphosphonates in vivo.
  Roelofs, A.J., Stewart, C.A., Sun, S., Blazewska, K.M., Kashemirov, B.A., McKenna, C.E., Russell, R.G., Rogers, M.J., Lundy, M.W., Ebetino, F.H., Coxon, F.P.> ;J Bone Miner Res. 2012 Apr
• Isolation and purification of rabbit osteoclasts.
  Coxon, F.P., Rogers, M.J., Crockett, J.C.> ;Methods Mol Biol. 2012
• Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth.
  Moriceau, G., Roelofs, A.J., Brion, R., Redini, F., Ebetion, F.H., Rogers, M.J., Heymann, D.> ;Cancer. 2012 Feb 1
• Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors.
  B?a?ewska, K. M.,Ni, F.,Haiges, R.,Kashemirov, B. A.,Coxon, F. P.,Stewart, C. A.,Baron, R.,Rogers, M. J.,Seabra, M. C.,Ebetino, F. H.,McKenna, C. E.> ;Eur J Med Chem. 2011 Oct
• The regulation of osteoclast function and bone resorption by small GTPases.
  Itzstein, C., Coxon, F.P., Rogers, M.J.> ;Small Gtpases. 2011 5
• Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.
  Taylor, A., Mules, E.H., Seabra, M.C., Helfrich, M.H., Rogers, M.J., Coxon, F.P.> ;Small Gtpases. 2011 5
• Signal peptide mutations in rank prevent downstream activation of NFκB.
  Crockett, J.C., Mellis, D.J., Shennan, K.I., Duthie, A., Greenhorn, J., Wilkinson, D.I., Ralston, S.H., Helfrich, M.H., Rogers, M.J.> ;J Bone Miner Res. 2011 Aug
• Synthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs.
  Sun, S., B?a?ewska, K. M., Kashemirov, B. A., Roelofs, A. J., Coxon, F. P., Rogers, M. J., Ebetino, F. H., McKenna, M. J., McKenna, C. E.> ;Phosphorus Sulfur Silicon Relat Elem. 2011 Apr
• The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates.
  Coxon, F.P., Taylor, A., Stewart, C.A., Baron, R., Seabra, M.C., Ebetino, F.H., Rogers, M.J.> ;Bone. 2011 Jul
• Biochemical and molecular mechanisms of action of bisphosphonates.
  Rogers, M. J., Crockett, J. C., Coxon, F. P., Mönkkönen, J.> ;Bone. 2011 Jul
• Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts.
  Hocking, L.J., Mellis, D.J., McCabe, P.S., Helfrich, M.H., Rogers, M.J.> ;Biochem Biophys Res Commun. 2010 Nov 19
• Fluvastatin does not prevent the acute-phase response to intravenous zoledronic acid in post-menopausal women.
  Thompson, K., Keech, F., McLernon, D.J., Vinod, K., May, R.J., Simpson, W.G., Rogers, M.J., Reid, D.M.> ;Bone. 2011 Jul
• Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imi...
  McKenna, C. E., Kashemirov, B. A., B?azewska, K. M., Mallard-Favier, I., Stewart, C. A., Rojas, J., Lundy, M. W., Ebetino, F. H., Baron, R. A., Dunford, J. E., Kirsten...> ;J Med Chem. 2010 May 13
• Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo.
  Roelofs, A.J., Coxon, F.P., Ebetino, F.H., Lundy, M.W., Henneman, Z.J., Nancollas, G.H., Sun, S., Blazewska, K.M., Bala, J.F., Kashemirov, B.A., Khalid, A.B., McKenna,...> ;J Bone Miner Res. 2010 Mar
• The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.
  Guenther, A., Gordon, S., Tiemann, M., Burger, R., Bakker, F., Green, J.R., Baum, W., Roelofs, A.J., Rogers, M.J., Gramatzki, M.> ;Int J Cancer. 2010-01-01
• Activation of gammadelta T Cells by Bisphosphonates.
  Thompson, K., Roelofs, A.J., Jauhiainen, M., Mönkkönen, H., Mönkkönen, J., Rogers, M.J.> ;Adv Exp Med Biol. 2010-01-01
• Fluorescent Risedronate Analogs Reveal Bisphosphonate Uptake by Bone Marrow Monocytes and Localization Around Osteocytes In Vivo.
  Roelofs, A.J., Coxon, F.P., Ebetino, F.H., Lundy, M.W., Henneman, Z.J., Nancollas, G.H., Sun, S., Blazewska, K.M., Lynn F Bala, J., Kashemirov, B.A., Khalid, A.B., McK...> ;J Bone Miner Res. 2009-10-12
• The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.
  Whyte, L.S., Ryberg, E., Sims, N.A., Ridge, S.A., Mackie, K., Greasley, P.J., Ross, R.A., Rogers, M.J.> ;Proc Natl Acad Sci U S A. 2009-09-22
• The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts.
  Hirbe, A.C., Roelofs, A.J., Floyd, D.H., Deng, H., Becker, S.N., Lanigan, L.G., Apicelli, A.J., Xu, Z., Prior, J.L., Eagleton, M.C., Piwnica-Worms, D., Rogers, M.J., W...> ;Bone. 2009-05-01
• Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.
  Baron, R. A., Tavaré, R., Figueiredo, A. C., B?azewska, K. M., Kashemirov, B. A., McKenna, C. E., Ebetino, F. H., Taylor, A., Rogers, M. J., Coxon, F. P., Seabra, M. C.> ;J Biol Chem. 2009-03-13
• Fluorescently labeled risedronate and related analogues: "magic linker" synthesis.
  Kashemirov, B.A., Bala, J.F., Chen, X., Ebetino, F.H., Xia, Z., Russell, R.G., Coxon, F.P., Roelofs, A.J., Rogers, M.J., McKenna, C.E.> ;Bioconjug Chem. 2008-12-01
• Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo.
  Fournier, P. G., Daubiné, F., Lundy, M. W., Rogers, M. J., Ebetino, F. H., Clézardin, P.> ;Cancer Res. 2008-11-01
• Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations.
  Guerrini, M.M., Sobacchi, C., Cassani, B., Abinun, M., Kilic, S.S., Pangrazio, A., Moratto, D., Mazzolari, E., Clayton-Smith, J., Orchard, P., Coxon, F.P., Helfrich, M...> ;Am J Hum Genet. 2008 Jul
• Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells.
  Coxon, F.P., Thompson, K., Roelofs, A.J., Ebetino, F.H., Rogers, M.J.> ;Bone. 2008 May
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