MichaelA.RosenzweigMD

Oncology • Duarte, CA

Hematologic Oncology

Assistant Professor

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Office
Division of Myeloma
1500 East Duarte Road
Duarte, CA 91010
Phone+1 626-256-4673

Fax+1 626-389-3060
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Education & Training

Memorial Sloan Kettering Cancer CenterFellowship, Blood & Bone Marrow Transplant, 2009 - 2011
Boston University Medical CenterFellowship, Hematology and Medical Oncology, 2006 - 2009
Boston University Medical CenterResidency, Internal Medicine, 2001 - 2004
University of Arizona College of MedicineClass of 2001

Certifications & Licensure

CA State Medical License 2011 - 2025
NC State Medical License 2021 - 2022
NY State Medical License 2009 - 2013
MA State Medical License 2004 - 2011
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Clinical Trials

A Safety Study of Carfilzomib in Patients With Previously-Treated Systemic Light Chain Amyloidosis Start of enrollment: 2013 Feb 01
Completed
Phase 1
The PRONTO Study, a Global Phase 2b Study of NEOD001 in Previously Treated Subjects With Light Chain (AL) Amyloidosis Start of enrollment: 2016 Mar 01
Completed
Phase 2
Leflunomide in Treating Patients With High-Risk Smoldering Multiple Myeloma Start of enrollment: 2019 Dec 11
Withdrawn
Phase 2
Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma Start of enrollment: 2020 Oct 08
Active, not recruiting
Early Phase 1
Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma Start of enrollment: 2020 Nov 27
Recruiting
Phase 2
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Publications & Presentations

PubMed

Clonal Hematopoiesis and Cardiovascular Disease in Patients With Multiple Myeloma Undergoing Hematopoietic Cell Transplant.
June-Wha Rhee, Raju Pillai, Tianhui He, Alysia Bosworth, Sitong Chen, Liezl Atencio, Artem Oganesyan, Kelly Peng, Tati Guzman, Kara Lukas, Brianna Sigala, Aleksi Iukur...> ;JAMA Cardiology. 2024 Jan 1
Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic Cell Transplant...
Flavia Chiuppesi, Sandra Ortega-Francisco, Miguel-Angel Gutierrez, Jing Li, Minh Ly, Katelyn Faircloth, Jada Mack-Onyeike, Corinna La Rosa, Sandra Thomas, Qiao Zhou, J...> ;Vaccines. 2023 Sep 15
Using a Modified Delphi Panel to Estimate Health Service Utilization for Patients with Advanced and Non-Advanced Systemic Light Chain Amyloidosis.
Morie Gertz, Rafat Abonour, Sarah N Gibbs, Muriel Finkel, Heather Landau, Suzanne Lentzsch, Grace Lin, Anuj Mahindra, Tiffany Quock, Cara Rosenbaum, Michael Rosenzweig...> ;Clinicoeconomics and Outcomes Research. 2023 Jan 1
Leflunomide Confers Rapid Recovery from COVID-19 and is Coupled with Temporal Immunologic Changes.
Ada Alice Dona, James F Sanchez, Joycelynne M Palmer, Timothy W Synold, Flavia Chiuppesi, Sandra Thomas, Enrico Caserta, Mahmoud Singer, Theophilus Tandoh, Arnab Chowd...> ;Journal of Immunological Sciences. 2023 Jan 1
2 citations
Functional SARS-CoV-2-specific T cells of donor origin in allogeneic stem cell transplant recipients of a T-cell-replete infusion: A prospective observational study.
Corinna La Rosa, Flavia Chiuppesi, Yoonsuh Park, Qiao Zhou, Dongyun Yang, Ketevan Gendzekhadze, Minh Ly, Jing Li, Teodora Kaltcheva, Sandra Ortega Francisco, Miguel-An...> ;Frontiers in Immunology. 2023 Jan 1
2 citations
Health-related quality of life in patients with light chain amyloidosis treated with bortezomib, cyclophosphamide, and dexamethasone ± daratumumab: Results from the AN...
Vaishali Sanchorawala, Giovanni Palladini, Monique C Minnema, Arnaud Jaccard, Hans C Lee, Simon Gibbs, Peter Mollee, Christopher Venner, Jin Lu, Stefan Schönland, Mosh...> ;American Journal of Hematology. 2022 Jun 1
6 citations
Amyloidosis with Cardiac Involvement: Identification, Characterization, and Management.
Faizi Jamal, Michael Rosenzweig> ;Current Hematologic Malignancy Reports. 2021 Jun 9
19 citations
ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells
Latika Singh, Eric S. Muise, Anannya Bhattacharya, Jeff Grein, Sarah Javaid, Peter Stivers, Jun Zhang, Yujie Qu, Barbara Joyce-Shaikh, Andrey Loboda, Chunsheng Zhang, ...> ;Molecular Cancer Research. 2021 Apr 1
20 citations
Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells.
Yun Wang, Long Cui, Peter Georgiev, Latika Singh, Yanyan Zheng, Ying Yu, Jeff Grein, Chunsheng Zhang, Eric S. Muise, David L. Sloman, Heidi Ferguson, Hongshi Yu, Crist...> ;Oncoimmunology. 2021 Mar 18
20 citations
CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma
Hadas Lewinsky, Emine Gulsen Gunes, Keren David, Lihi Radomir, Matthias P. Kramer, Bianca Pellegrino, Michal Perpinial, Jing Chen, Ting-Fang He, Anthony Mansour, Kun Y...> ;JCI Insight. 2021 Feb 22
69 citations
Bortezomib, lenalidomide, and dexamethasone with or without elotuzumab in patients with untreated, high-risk multiple myeloma (SWOG-1211): primary analysis of a random...
, , , , , , , , , , , , , , , , > ;The Lancet. Haematology. 2021 Jan 1
48 citations
Daratumumab induces mechanisms of immune activation through CD38+ NK cell targeting.
Domenico Viola, Ada Dona, Enrico Caserta, Estelle Troadec, Francesca Besi, Tinisha McDonald, Lucy Ghoda, Emine Gulsen Gunes, James F. Sanchez, Jihane Khalife, Marianna...> ;Leukemia. 2021 Jan 1
4 citations
Liver and Gastrointestinal Involvement: Update.
Michael Rosenzweig, Efstathios Kastritis> ;Hematology/oncology Clinics of North America. 2020 Dec 31
24 citations
Identifying CD38+ cells in patients with multiple myeloma: first-in-human imaging using copper-64–labeled daratumumab
Amrita Krishnan, Vikram Adhikarla, Erasmus Poku, Joycelynne M. Palmer, Ammar Chaudhry, Van Eric Biglang-awa, Nicole Bowles, Nitya Nathwani, Michael Rosenzweig, Firooze...> ;Blood Advances. 2020 Oct 27
4 citations
Liver and Gastrointestinal Involvement
Michael Rosenzweig, Raymond L. Comenzo> ;Hematology/oncology Clinics of North America. 2020 Oct 1
3 citations
Glucocorticoid receptor expression in multiple myeloma patients is a predictor of survival.
Alex E. Pozhitkov, Michael Rosenzweig, Flavia Pichiorri, Emine Gulsen Gunes, Ralf Buettner, Jonathan J Keats, Steven T. Rosen> ;Leukemia & Lymphoma. 2020 Sep 13
122 citations
Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: Safety run-in results of ANDROMEDA
Giovanni Palladini, Efstathios Kastritis, Mathew S. Maurer, Jeffrey A. Zonder, Monique C. Minnema, Ashutosh D. Wechalekar, Arnaud Jaccard, Hans C. Lee, Naresh Bumma, J...> ;Blood. 2020 Jul 2
6 citations
Toxicities Associated With Metformin/Ritonavir Combination Treatment in Relapsed/Refractory Multiple Myeloma
Nitya Nathwani, Joycelynne Palmer, Timothy W. Synold, Behrouz Salehian, Michael Rosenzweig, James F. Sanchez, Samantha N. Hammond, Kehinde Adekola, Valeria Tomarchio, ...> ;Clinical Lymphoma, Myeloma & Leukemia. 2020 May 29
12 citations
Repurposing leflunomide for relapsed/refractory multiple myeloma: a phase 1 study.
Michael Rosenzweig, Joycelynne Palmer, Ni-Chun Tsai, Tim Synold, Xiwei Wu, Shu Tao, Samantha N. Hammond, Ralf Buettner, Lupe Duarte, Myo Htut, Chatchada Karanes, Nitya...> ;Leukemia & Lymphoma. 2020 Apr 8
14 citations
Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting
Ralf Buettner, Corey Morales, Enrico Caserta, Estelle Troadec, Emine Gulsen Gunes, Domenico Viola, Jihane Khalife, Hongzhi Li, Jonathan J Keats, Austin Christofferson,...> ;Blood Advances. 2019 Apr 9
38 citations
Daratumumab induces CD38 internalization and impairs myeloma cell adhesion
Jayeeta Ghose, Domenico Viola, Cesar Terrazas, Enrico Caserta, Estelle Troadec, Jihane Khalife, Emine Gulsen Gunes, James F. Sanchez, Tinisha McDonald, Guido Marcucci,...> ;Oncoimmunology. 2018 Jul 23
1 citations
Phase I/II trial of the oral regimen ixazomib, pomalidomide, and dexamethasone in relapsed/refractory multiple myeloma.
Amrita Krishnan, Prashant Kapoor, Joycelynne M Palmer, Ni-Chun Tsai, Shaji Kumar, Sagar Lonial, Myo Htut, Chatchada Karanes, Nitya Nathwani, Michael Rosenzweig, Firooz...> ;Leukemia. 2018 Jul 1
11 citations
Atypical Presentation of Gelsolin Amyloidosis in a Man of African Descent with a Novel Mutation in the Gelsolin Gene.
Karlos Z. Oregel, Geoffrey Shouse, Cyrus D. Oster, Freddy Martinez, Jun Wang, Michael Rosenzweig, Jeremy Deisch, Chien-Shing Chen, Gayathri Nagaraj> ;The American Journal of Case Reports. 2018 Mar 30
Phase I/II Trial of the Oral Regimen Ixazomib, Pomalidomide, and Dexamethasone in relapsed/refractory Multiple Myeloma
Michael Rosenzweig, Prashant Kapoor, Sagar Lonial, George Somlo, Amrita Krishnan, Shaji Kumar, Myo Htut, Stephen J Forman, Chatchada Karanes, Nitya Nathwani, Jesus G B...> ;Nature. 2018 Feb 24
15 citations
Preclinical data support leveraging CS1 chimeric antigen receptor T-cell therapy for systemic light chain amyloidosis
Michael Rosenzweig, Ryan Urak, Miriam Walter, Laura Lim, James F. Sanchez, Amrita Krishnan, Stephen J. Forman, Xiuli Wang> ;Cytotherapy. 2017 Jul 1
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Abstracts/Posters

First-in-Human Imaging of Multiple Myeloma Using Copper-64-Labeled Daratumumab: Preliminary Results
Michael Rosenzweig, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Press Mentions

Recommendations from FDA-AACR Workshop to Increase African American Representation in Multiple Myeloma Clinical TrialsApril 9th, 2021
Novel Approaches Emerge in AL AmyloidosisApril 27th, 2018
Working TogetherOctober 10th, 2017