MichaelRobertSavonaMD

PubMed

• Clonal Hematopoiesis and Inflammation in the VasculaturE (CHIVE): a prospective, longitudinal cohort and biorepository.
  Morgan L Shannon, Jonathan Brett Heimlich, Sydney Olson, Ariana Debevec, Zachary Copeland, Ashwin Kishtagari, Caitlyn Vlasschaert, Christina A Snider, Alexander J Silv...> ;Blood Advances. 2024 Apr 12
• Cost-Effective and Scalable Clonal Hematopoiesis Assay Provides Insight into Clonal Dynamics.
  Taralynn Mack, Caitlyn Vlasschaert, Kelly von Beck, Alexander J Silver, J Brett Heimlich, Hannah Poisner, Jessica Ulloa, Andrew L Sochacki, Cosmin A Bejan, Yaomin Xu, ...> ;The Journal of Molecular Diagnostics. 2024 Apr 6
• CLO24-079: Results From Phase 3 Trial of Imetelstat, a First-in-Class Telomerase Inhibitor, in Patients With Red Blood Cell Transfusion Dependent (RBC-TD) Non-del(5q) ...
  Yazan Madanat, Michael R Savona, Mikkael A Sekeres, Uwe Platzbecker, Valeria Santini, Pierre Fenaux, Maria Diez-Campelo, David Valcárcel, Tymara Berry, Souria Doughert...> ;Journal of the National Comprehensive Cancer Network. 2024 Apr 5
• 3 citations
  Multiomic Profiling of Human Clonal Hematopoiesis Reveals Genotype and Cell-Specific Inflammatory Pathway Activation.
  Jonathan Brett Heimlich, Pawan Bhat, Alyssa Parker, Matthew T Jenkins, Caitlyn Vlasschaert, Jessica Ulloa, Joseph Van Amburg, Chad R Potts, Sydney Olson, Alexander J S...> ;Blood Advances. 2024 Mar 20
• A randomized, double-blind study of zinpentraxin alfa in patients with myelofibrosis who were previously treated with or ineligible for ruxolitinib: Stage 2 of a phase...
  Verstovsek, S., Talpaz, M., Wadleigh, M., Isidori, A., Te Boekhorst, P., Savona, M., Bose, P., Pozdnyakova, O., Mesa, R., El-Galaly, T., O'Sullivan, J., Gamel, K., Hig...> ;Haematologica. 2024 Jan 25
• 1 citations
  Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk.
  Ashwin Kishtagari, M A Wasay Khan, Yajing Li, Caitlyn Vlasschaert, Naimisha Marneni, Alexander J Silver, Kelly von Beck, Travis Spaulding, Shannon Stockton, Christina ...> ;Blood Cancer Journal. 2024 Jan 15
• 3 citations
  Oral decitabine-cedazuridine versus intravenous decitabine for myelodysplastic syndromes and chronic myelomonocytic leukaemia (ASCERTAIN): a registrational, randomised...
  Garcia-Manero, G., McCloskey, J., Griffiths, E., Yee, K., Zeidan, A., Al-Kali, A., Deeg, H., Patel, P., Sabloff, M., Keating, M., Zhu, N., Gabrail, N., Fazal, S., Maly...> ;The Lancet. Haematology. 2024 Jan 1
• TLR3 agonism augments CD47 inhibition in acute myeloid leukemia.
  Ramsey, H., Gorska, A., Smith, B., Monteith, A., Fuller, L., Arrate, M., Savona, M.> ;Haematologica. 2023 Dec 28
• 4 citations
  Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge): a multinational, ra...
  Platzbecker, U., Santini, V., Fenaux, P., Sekeres, M., Savona, M., Madanat, Y., Díez-Campelo, M., Valcárcel, D., Illmer, T., Jonášová, A., Bělohlávková, P., Sherman, L...> ;Lancet. 2024 Jan 20
• 1 citations
  LAIR-1 agonism as a therapy for acute myeloid leukemia.
  Rustin R Lovewell, Junshik Hong, Subhadip Kundu, Carly M Fielder, Qianni Hu, Kwang Woon Kim, Haley E Ramsey, Agnieszka E Gorska, Londa S Fuller, Linjie Tian, Priyanka ...> ;The Journal of Clinical Investigation. 2023 Nov 15
• 4 citations
  Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Cons...
  Maximilian Stahl, Jan Philipp Bewersdorf, Zhuoer Xie, Matteo Giovanni Della Porta, Rami Komrokji, Mina L Xu, Omar Abdel-Wahab, Justin Taylor, David P Steensma, Daniel ...> ;Blood Reviews. 2023 Nov 1
• Genomic Data Heterogeneity across Molecular Diagnostic Laboratories: A Real-World Connect Myeloid Disease Registry Perspective on Variabilities in Genomic Assay Method...
  Jay L Patel, Harry P Erba, Michael R Savona, David L Grinblatt, Maria Clark, Tyler C Clive, Trevor B Smart, Adeola Y Makinde, Irene S DeGutis, Edward Yu, Julie M Eggin...> ;The Journal of Molecular Diagnostics. 2023 Aug 1
• 2 citations
  PheMIME: An Interactive Web App and Knowledge Base for Phenome-Wide, Multi-Institutional Multimorbidity Analysis.
  Siwei Zhang, Nick Strayer, Tess Vessels, Karmel Choi, Geoffrey W Wang, Yajing Li, Cosmin A Bejan, Ryan S Hsi, Alexander G Bick, Digna R Velez Edwards, Michael R Savona...> ;Medrxiv. 2023 Jul 30
• 4 citations
  An agenda to advance research in myelodysplastic syndromes: a TOP 10 priority list from the first international workshop in MDS.
  Maximilian Stahl, Omar Abdel-Wahab, Andrew H Wei, Michael R Savona, Mina L Xu, Zhuoer Xie, Justin Taylor, Daniel Starczynowski, Guillermo F Sanz, David A Sallman, Vale...> ;Blood Advances. 2023 Jun 27
• 1 citations
  Phase 1/2 Study of the Pan-PIM Kinase Inhibitor INCB053914 Alone or in Combination With Standard-of-Care Agents in Patients With Advanced Hematologic Malignancies.
  Manish R Patel, William Donnellan, Michael Byrne, Adam S Asch, Amer M Zeidan, Maria R Baer, Amir T Fathi, Andrew T Kuykendall, Fred Zheng, Chris Walker, Lulu Cheng, Ci...> ;Clinical Lymphoma, Myeloma & Leukemia. 2023 Sep 1
• Transplantation Referral Patterns for Patients with Newly Diagnosed Higher-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia at Academic and Community Sites in...
  Benjamin Tomlinson, Marcos de Lima, Christopher R Cogle, Michael A Thompson, David L Grinblatt, Daniel A Pollyea, Rami S Komrokji, Gail J Roboz, Michael R Savona, Mikk...> ;Transplantation and Cellular Therapy. 2023 Jul 1
• 4 citations
  Patient-specific comorbidities as prognostic variables for survival in myelofibrosis.
  Sochacki, A., Bejan, C., Zhao, S., Patel, A., Kishtagari, A., Spaulding, T., Silver, A., Stockton, S., Pugh, K., Dorand, R., Bhatta, M., Strayer, N., Zhang, S., Snider...> ;Blood Advances. 2023 Mar 14
• 6 citations
  Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1International Workshop on MDS (iwMDS) Of t...
  Jan Philipp Bewersdorf, Zhuoer Xie, Rafael Bejar, Uma Borate, Jacqueline Boultwood, Andrew M Brunner, Rena Buckstein, Hetty E Carraway, Jane E Churpek, Naval G Daver, ...> ;Blood Reviews. 2023 Jul 1
• Nanoparticle STING Agonist Reprograms the Bone Marrow to an Antitumor Phenotype and Protects Against Bone Destruction.
  David C Florian, Natalie E Bennett, Mateusz Odziomek, Jessalyn J Baljon, Mohamed Wehbe, Alyssa R Merkel, Melissa A Fischer, Michael R Savona, Julie A Rhoades, Scott A ...> ;Cancer Research Communications. 2023 Feb 1
• 28 citations
  A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets.
  Caitlyn Vlasschaert, Taralynn Mack, J Brett Heimlich, Abhishek Niroula, Md Mesbah Uddin, Joshua Weinstock, Brian Sharber, Alexander J Silver, Yaomin Xu, Michael Savona...> ;Blood. 2023 May 4
• 12 citations
  Targeting RARA overexpression with tamibarotene, a potent and selective RARα agonist, is a novel approach in AML.
  Stéphane de Botton, Thomas Cluzeau, Carlos Vigil, Rachel J Cook, Philippe Rousselot, David A Rizzieri, Jane L Liesveld, Pierre Fenaux, Thorsten Braun, Anne Banos, Jose...> ;Blood Advances. 2023 May 9
• 1 citations
  Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk.
  Dalton L Greenwood, Haley E Ramsey, Phuong T T Nguyen, Andrew R Patterson, Kelsey Voss, Jackie E Bader, Ayaka Sugiura, Zachary A Bacigalupa, Samuel Schaefer, Xiang Ye,...> ;Immunohorizons. 2022 Dec 1
• 14 citations
  Longer-term benefit of luspatercept in transfusion-dependent lower-risk myelodysplastic syndromes with ring sideroblasts.
  Zeidan, A., Platzbecker, U., Garcia-Manero, G., Sekeres, M., Fenaux, P., DeZern, A., Greenberg, P., Savona, M., Jurcic, J., Verma, A., Mufti, G., Buckstein, R., Santin...> ;Blood. 2022 Nov 17
• 1 citations
  Differences in classification schemata for myelodysplastic/myeloproliferative overlap neoplasms.
  Mrinal M Patnaik, Amer M Zeidan, Eric Padron, Uwe Platzbecker, David A Sallman, Amy E DeZern, Rafael Bejar, Mikkael Sekeres, Justin Taylor, Richard F Little, Jan P Bew...> ;Leukemia. 2022 Dec 1
• 13 citations
  Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes.
  Amer M Zeidan, Jan Philipp Bewersdorf, Rena Buckstein, Mikkael A Sekeres, David P Steensma, Uwe Platzbecker, Sanam Loghavi, Jacqueline Boultwood, Rafael Bejar, John M ...> ;Leukemia. 2022 Dec 1
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Abstracts/Posters

• Results of PAC203: A Randomized Phase 2 Dose-Finding Study and Determination of the Recommended Dose of Pacritinib
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Pevonedistat, a Nedd-8 Activating Enzyme Inhibitor, Upregulates NOXA to Increase Effectiveness of Azacitidine and Venetoclax in Preclinical Models of Acute Myelogenous...
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Diagnostic Testing Patterns and Concordance with World Health Organization (WHO) Criteria for Patients (Pts) with Newly Diagnosed (ND) Myelodysplastic Syndromes (MDS) ...
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Patient Specific Comorbidities Impact Overall Survival in Myelofibrosis
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Pharmacokinetic Exposure Equivalence and Preliminary Efficacy and Safety from a Randomized Cross over Phase 3 Study (ASCERTAIN study) of an Oral Hypomethylating Agent ...
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Geno-Clinical Model for the Diagnosis of Bone Marrow Myeloid Neoplasms
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• JAK2V617F Clonal Hematopoiesis Stratifies By Peripheral Blood Counts.
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Nascent Transcript and Single Cell Rnaseq Analysis Defines the Mechanism of Action of the LSD1 Inhibitor INCB059872 in Myeloid Leukemia
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Developmental Plasticity of Acute Myeloid Leukemia Mediates Resistance to Venetoclax-Based Therapy
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Oral Azacitidine and Cedazuridine Approximate Azacitidine Efficacy in a Murine Model
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Venetoclax-Based Salvage Therapy for Post-Hematopoietic Cell Transplantation Relapse in Acute Myeloid Leukemia
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Bone Marrow Morphologic Findings in Patients Receiving IDH Inhibitor Therapy in Combination with Intensive Induction Chemotherapy: Challenges with Interpretation of th...
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• The VITAL Trial: Phase II Trial of Vosaroxin and Infusional Cytarabine for Frontline Treatment of acute Myeloid LeukemiaClinically Relevant Abstract
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Landmark Response and Survival Analyses from 206 AML Patients Treated with Guadecitabine in a Phase 2 Study Demonstrate the Importance of Adequate Treatment Duration t...
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Variable Response to BCL2 Inhibition in MDS Is Enhanced across MDS Subtypes with Synergistic Combination of BCL2+MCL1 Inhibition
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Preliminary Results from a Phase II Study of the Combination of Pevonedistat and Azacitidine in the Treatment of MDS and MDS/MPN after Failure of DNA Methyltransferase...
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• TP53 State Dictates Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• CUL1: Novel Therapeutic Target in Myeloid Neoplasms Harboring -7/Del(7q)
  Michael R. Savona, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

• Abnl Marro: An International Cooperative Trial for Patients with MDS/MPN Overlap Syndromes 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• Landmark Response and Survival Analyses from 102 MDS and CMML Patients Treated with Guadecitabine in a Phase 2 Study Showing That Maximum Response and Survival Is Best... 
  61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
• Translating Pathophysiological Advances Into Innovative Treatments for Myelodysplastic Syndromes and Related Myeloid Neoplasms 
  60th American Society of Hematology Annual Meeting - 11/30/2018