MichaelAWeissMD

PubMed

• 21 citations
  Evolution of insulin at the edge of foldability and its medical implications.
  Nischay K. Rege, Ming Liu, Yanwu Yang, Balamurugan Dhayalan, Nalinda P. Wickramasinghe, Yen-Shan Chen, Leili Rahimi, Huan Guo, Leena Haataja, Jinhong Sun, Faramarz Ism...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Nov 5
• 28 citations
  Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin.
  Orit Weil‐Ktorza, Nischay K. Rege, Shifra Lansky, Deborah E. Shalev, Gil Shoham, Michael A. Weiss, Norman Metanis> ;Chemistry. 2019 Jun 26
• 28 citations
  A thing of beauty: Structure and function of insulin's "aromatic triplet".
  Michael A. Weiss, Michael C. Lawrence> ;Diabetes, Obesity & Metabolism. 2018 Sep 19
• 117 citations
  Biosynthesis, structure, and folding of the insulin precursor protein.
  Ming Liu, Michael A. Weiss, Anoop Arunagiri, Jing Yong, Nischay Rege, Jinhong Sun, Leena Haataja, Randal J. Kaufman, Peter Arvan> ;Diabetes, Obesity & Metabolism. 2018 Sep 19
• 11 citations
  Structure-Based Stabilization of Insulin as a Therapeutic Protein Assembly via Enhanced Aromatic-Aromatic Interactions.
  Nischay Rege, Nalinda P. Wickramasinghe, Alisar N. Tustan, Nelson B. Phillips, Vivien C. Yee, Faramarz Ismail-Beigi, Michael A. Weiss> ;The Journal of Biological Chemistry. 2018 Jun 7
• 22 citations
  An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
  Michael D. Glidden, Khadijah Aldabbagh, Nelson B. Phillips, Kelley Carr, Yen Shan Chen, Jonathan Whittaker, Manijeh Phillips, Nalinda P. Wickramasinghe, Nischay Rege, ...> ;The Journal of Biological Chemistry. 2018 Jan 5
• 9 citations
  Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
  Michael D. Glidden, Yanwu Yang, Nicholas A. Smith, Nelson B. Phillips, Kelley Carr, Nalinda P. Wickramasinghe, Faramarz Ismail-Beigi, Michael C. Lawrence, Brian J. Smi...> ;The Journal of Biological Chemistry. 2018 Jan 5
• Erratum: Glucose-responsive insulin by molecular and physical design.
  Naveed A. Bakh, Abel B. Cortinas, Michael A. Weiss, Robert Langer, Daniel G. Anderson, Zhen Gu, Sanjoy Dutta, Michael S. Strano> ;Nature Chemistry. 2018 Jan 1
• 73 citations
  Glucose-responsive insulin by molecular and physical design
  Naveed A. Bakh, Abel B. Cortinas, Michael A. Weiss, Robert Langer, Daniel G. Anderson, Zhen Gu, Sanjoy Dutta, Michael S. Strano> ;Nature Chemistry. 2017 Sep 22
• 31 citations
  Development of glucose-responsive 'smart' insulin systems.
  Nischay K. Rege, Nelson B. Phillips, Michael A. Weiss> ;Current Opinion in Endocrinology, Diabetes, and Obesity. 2017 Aug 1
• 9 citations
  Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin
  Balamurugan Dhayalan, Kalyaneswar Mandal, Nischay K. Rege, Michael A. Weiss, Simon H. Eitel, Thomas Meier, Ralph O. Schoenleber, Stephen B. H. Kent> ;Chemistry. 2017 Jan 31
• 17 citations
  Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.
  Krystel El Hage, Vijay Pandyarajan, Nelson B. Phillips, Brian J. Smith, John G. Menting, Jonathan Whittaker, Michael C. Lawrence, Markus Meuwly, Michael A. Weiss> ;The Journal of Biological Chemistry. 2016 Dec 30
• 7 citations
  Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.
  Joseph D. Racca, Yen Shan Chen, Yanwu Yang, Nelson B. Phillips, Michael A. Weiss> ;The Journal of Biological Chemistry. 2016 Oct 14
• 18 citations
  Contribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.
  Vijay Pandyarajan, Nelson B. Phillips, Nischay K. Rege, Michael C. Lawrence, Jonathan Whittaker, Michael A. Weiss> ;The Journal of Biological Chemistry. 2016 Jun 17
• 17 citations
  Efficient Total Chemical Synthesis of 13C=18O Isotopomers of Human Insulin for Isotope‐Edited FTIR
  Balamurugan Dhayalan, Ann Fitzpatrick, Kalyaneswar Mandal, Jonathan Whittaker, Michael A. Weiss, Andrei Tokmakoff, Stephen B. H. Kent> ;Chembiochem. 2016 Mar 2
• 79 citations
  Higher-resolution structure of the human insulin receptor ectodomain: Multi-modal inclusion of the insert domain
  Tristan I. Croll, Brian J. Smith, Mai B. Margetts, Jonathan Whittaker, Michael A. Weiss, Colin W. Ward, Michael C. Lawrence> ;Structure. 2016 Mar 1
• 20 citations
  Competitive inhibition of the endoplasmic reticulum signal peptidase by non-cleavable mutant preprotein cargos
  Jingqiu Cui, Wei Chen, Jinhong Sun, Huan Guo, Rachel Madley, Yi Xiong, Xingyi Pan, Hongliang Wang, Andrew W. Tai, Michael A. Weiss, Peter Arvan, Ming Liu> ;The Journal of Biological Chemistry. 2015 Nov 20
• 2 citations
  Remembering Donald F. Steiner
  Michael A. Weiss, Shu Jin Chan> ;Frontiers in Endocrinology. 2015 Apr 30
• 20 citations
  Aromatic Anchor at an Invariant Hormone-Receptor Interface FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN
  Vijay Pandyarajan, Brian J. Smith, Nelson B. Phillips, Linda Whittaker, Gabriella P. Cox, Nalinda P. Wickramasinghe, John G. Menting, Zhuli Wan, Jonathan Whittaker, Fa...> ;The Journal of Biological Chemistry. 2014 Dec 12
• 10 citations
  Structure-Function Relationships in Human Testis-determining Factor SRY AN AROMATIC BUTTRESS UNDERLIES THE SPECIFIC DNA-BENDING SURFACE OF A HIGH MOBILITY GROUP (HMG) BOX
  Joseph D. Racca, Yen Shan Chen, James D. Maloy, Nalinda P. Wickramasinghe, Nelson B. Phillips, Michael A. Weiss> ;The Journal of Biological Chemistry. 2014 Nov 21
• 11 citations
  Deciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin.
  Michal Avital-Shmilovici, Jonathan Whittaker, Michael A. Weiss, Stephen B. H. Kent> ;The Journal of Biological Chemistry. 2014 Aug 22
• 18 citations
  Biophysical optimization of a therapeutic protein by nonstandard mutagenesis: studies of an iodo-insulin derivative.
  Vijay Pandyarajan, Nelson B. Phillips, Gabriela P. Cox, Yanwu Yang, Jonathan Whittaker, Faramarz Ismail-Beigi, Michael A. Weiss> ;The Journal of Biological Chemistry. 2014 Aug 22
• 110 citations
  Protective hinge in insulin opens to enable its receptor engagement.
  John G. Menting, Yanwu Yang, Shu Jin Chan, Nelson B. Phillips, Brian J. Smith, Jonathan Whittaker, Nalinda P. Wickramasinghe, Linda Whittaker, Vijay Pandyarajan, Zhu L...> ;Proceedings of the National Academy of Sciences of the United States of America. 2014 Aug 19
• 33 citations
  Endoplasmic reticulum oxidoreductin-1α (Ero1α) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress.
  Jordan J. Wright, Julia Birk, Leena Haataja, Ming Liu, Thomas Ramming, Michael A. Weiss, Christian Appenzeller-Herzog, Peter Arvan> ;The Journal of Biological Chemistry. 2013 Oct 25
• 21 citations
  Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold
  Yen Shan Chen, Joseph D. Racca, Nelson B. Phillips, Michael A. Weiss> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Sep 17
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