MichaelW.ZindaMD

PubMed

• 31 citations
  Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer
  Zebin Wang, Shaun E. Grosskurth, Tony Cheung, Philip Petteruti, Jingwen Zhang, Xin Wang, Wenxian Wang, Farzin Gharahdaghi, Jiaquan Wu, Nancy Su, Ryan T. Howard, Michel...> ;Cancer Research. 2018 Dec 1
• 38 citations
  BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors.
  Garrett W. Rhyasen, Yi Yao, Jingwen Zhang, Austin Dulak, Lillian Castriotta, Kelly Jacques, Wei Zhao, Farzin Gharahdaghi, Maureen Hattersley, Paul Lyne, Edwin Clark, M...> ;Plos One. 2018 Jul 23
• 27 citations
  Generation of stable PDX derived cell lines using conditional reprogramming
  Alexandra Borodovsky, Travis J. McQuiston, Daniel Stetson, Ambar Ahmed, David Whitston, Jingwen Zhang, Michael Grondine, Deborah Lawson, Sharon S. Challberg, Michael Z...> ;Molecular Cancer. 2017 Dec 6
• 120 citations
  Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS.
  Sarah Ross, Alexey S. Revenko, Lyndsey Hanson, Rebecca Ellston, Anna Staniszewska, Nicky Whalley, Sanjay K. Pandey, Mitchell Revill, Claire Rooney, Linda K. Buckett, S...> ;Science Translational Medicine. 2017 Jun 14
• 106 citations
  AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies
  Garrett W. Rhyasen, Maureen Hattersley, Yi Yao, Austin Dulak, Wenxian Wang, Philip Petteruti, Ian L. Dale, Scott Boiko, Tony Cheung, Jingwen Zhang, Shenghua Wen, Lilli...> ;Molecular Cancer Therapeutics. 2016 Nov 1
• 9 citations
  Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.
  Adriana E. Tron, Erika Krasnickas Keeton, Minwei Ye, Matias Casás-Selves, Huawei Chen, Keith Dillman, Rosemary E. Gale, Chloe Stengel, Michael Zinda, David C. Linch, Z...> ;Leukemia & Lymphoma. 2016 May 17
• 50 citations
  JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors.
  Sizhi P. Gao, Qing Chang, Ninghui Mao, Laura Daly, Robert Vogel, Tyler Chan, Shu Hui Liu, Eirini Bournazou, Erez Schori, Haiying Zhang, Monica Red Brewer, William Pao,...> ;Science Signaling. 2016 Mar 29
• 15 citations
  Identification of azabenzimidazoles as potent JAK1 selective inhibitors
  Melissa Vasbinder, Marat Alimzhanov, Martin Augustin, Geraldine Bebernitz, Kirsten Bell, Claudio Chuaqui, Tracy L. Deegan, Andrew D. Ferguson, Kelly Goodwin, Dennis Hu...> ;Bioorganic & Medicinal Chemistry Letters. 2016 Jan 1
• 49 citations
  Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors
  Barry R. Davies, Nin Guan, Armelle Logie, Claire Crafter, Lyndsey Hanson, Vivien Jacobs, Neil H. James, Philippa Dudley, Kelly Jacques, Brendon Ladd, Celina M. D'Cruz,...> ;Molecular Cancer Therapeutics. 2015 Nov 1
• 54 citations
  The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient–Derived Xenograft Models
  Alwin Schuller, Evan Barry, Rhys D.O. Jones, Ryan E. Henry, Melanie M. Frigault, Garry Beran, David Linsenmayer, Maureen Hattersley, Aaron Smith, Joanne Wilson, Stefan...> ;Clinical Cancer Research. 2015 Mar 16
• 32 citations
  Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation
  Lei Gu, Pooja Talati, Paraskevi Vogiatzi, Ana L. Romero-Weaver, Junaid Abdulghani, Zhiyong Liao, Benjamin E. Leiby, David T. Hoang, Tuomas Mirtti, Kalle Alanen, Michae...> ;Molecular Cancer Therapeutics. 2014 May 1
• 45 citations
  Pharmacologic Inhibition of Jak2–Stat5 Signaling By Jak2 Inhibitor AZD1480 Potently Suppresses Growth of Both Primary and Castrate-Resistant Prostate Cancer
  Lei Gu, Zhiyong Liao, David T. Hoang, Ayush Dagvadorj, Shilpa Gupta, Shauna Blackmon, Elyse Ellsworth, Pooja Talati, Benjamin E. Leiby, Michael Zinda, Costas D. Lallas...> ;Clinical Cancer Research. 2013 Oct 15
• 428 citations
  The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors
  Michael Hedvat, Dennis Huszar, Andreas Herrmann, Joseph M. Gozgit, Anne Schroeder, Adam Sheehy, Ralf Buettner, David Proia, Claudia M. Kowolik, Hong Xin, Brian Armstro...> ;Cancer Cell. 2009 Dec 8
• Join now to see all