MichalMrugMD

Nephrology • Birmingham, AL

Professor, Medicine, University of Alabama School of Medicine

Join to view full profile

Dr. Mrug is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Mrug's full profile

Already have an account?

Office
700 19th St S
Birmingham, AL 35233
Phone+1 205-933-8101

Fax+1 205-933-4497
Is this information wrong?

Education & Training

University of Alabama Medical CenterFellowship, Nephrology, 2002 - 2004
USA HealthResidency, Internal Medicine, 1999 - 2002
Karlovy University FOMClass of 1995

Certifications & Licensure

AL State Medical License 2002 - 2022
American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012

Publications & Presentations

PubMed

Venglustat, a Novel Glucosylceramide Synthase Inhibitor, in Patients at Risk of Rapidly Progressing ADPKD: Primary Results of a Double-Blind, Placebo-Controlled, Phase...
Ronald T Gansevoort, Ali Hariri, Pascal Minini, Curie Ahn, Arlene B Chapman, Shigeo Horie, Bertrand Knebelmann, Michal Mrug, Albert Cm Ong, York Pc Pei, Vicente E Torr...> ;American journal of kidney diseases : the official journal of the National Kidney Foundation. 2022 Dec 16
A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models.
Zhang Li, Kurt A Zimmerman, Sreelakshmi Cherakara, Phillip H Chumley, James F Collawn, Jun Wang, Courtney J Haycraft, Cheng J Song, Teresa Chacana, Reagan S Andersen, ...> ;Disease models & mechanisms. 2023 Jan 1
The STAGED-PKD 2-Stage Adaptive Study With a Patient Enrichment Strategy and Treatment Effect Modeling for Improved Study Design Efficiency in Patients With ADPKD.
Ronald D Perrone, Ali Hariri, Pascal Minini, Curie Ahn, Arlene B Chapman, Shigeo Horie, Bertrand Knebelmann, Michal Mrug, Albert C M Ong, York P C Pei, Vicente E Torre...> ;Kidney medicine. 2022 Oct 1
Design and Basic Characteristics of a National Patient-Powered Registry in ADPKD.
Elise Hoover, Ronald D Perrone, Chris Rusconi, Beverly Benson, Neera K Dahl, Berenice Gitomer, Amy Manelli, Michal Mrug, Meyeon Park, Stephen L Seliger, Milind A Phadn...> ;Kidney360. 2022 Aug 25
A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice.
Cheng J Song, Zhang Li, Ummey Khalecha Bintha Ahmed, Sarah J Bland, Alex Yashchenko, Shanrun Liu, Ernald J Aloria, Jeremie M Lever, Nancy M Gonzalez, Marisa A Bickel, ...> ;Journal of the American Society of Nephrology : JASN. 2022 Apr 1
Volume Progression and Imaging Classification of Polycystic Liver in Early Autosomal Dominant Polycystic Kidney Disease.
Kyongtae T Bae, Cheng Tao, Robert Feldman, Alan S L Yu, Vicente E Torres, Ronald D Perrone, Arlene B Chapman, Godela Brosnahan, Theodore I Steinman, William E Braun, M...> ;Clinical journal of the American Society of Nephrology : CJASN. 2022 Mar 1
3 citations
Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype.
Sarah R Senum, Ying Sabrina M Li, Katherine A Benson, Giancarlo Joli, Eric Olinger, Sravanthi Lavu, Charles D Madsen, Adriana V Gregory, Ruxandra Neatu, Timothy L Klin...> ;American journal of human genetics. 2022 Jan 6
1 citations
Genetic Testing for Chronic Kidney Diseases: Clinical Utility and Barriers Perceived by Nephrologists
Michal Mrug, Michelle S. Bloom, Christine Seto, Meenakshi Malhotra, Hossein Tabriziani, Philippe Gauthier, Vicki Sidlow, Trudy McKanna, Paul Billings> ;Kidney medicine. 2021 Oct 4
Ly6chi Infiltrating Macrophages Promote Cyst Progression in Injured Conditional Ift88 Mice.
Ernald Jules G. Aloria, Cheng Jack Song, Zhang Li, Mandy J. Croyle, Michal Mrug, Kurt A. Zimmerman, Bradley K. Yoder> ;Kidney. 2021 Jun 24
Autosomal Dominant Polycystic Kidney Disease Does Not Significantly Alter Major COVID-19 Outcomes among Veterans.
Xiangqin Cui, Julia W Gallini, Christine L Jasien, Michal Mrug> ;Kidney360. 2021 Jun 24
Early infiltrating macrophage subtype correlates with late-stage phenotypic outcome in a mouse model of hepatorenal fibrocystic disease
Kurt A. Zimmerman, Cheng Jack Song, Ernald Jules G. Aloria, Zhang Li, Juling Zhou, Sarah J. Bland, Alex Yashchenko, David K. Crossman, Michal Mrug, Bradley K. Yoder> ;Laboratory Investigation. 2021 Jun 22
11 citations
Establishing a Core Outcome Set for Autosomal Dominant Polycystic Kidney Disease: Report of the Standardized Outcomes in Nephrology–Polycystic Kidney Disease (SONG-PKD...
Yeoungjee Cho, Allison Tong, Jonathan C. Craig, Reem A. Mustafa, Arlene B. Chapman, Ronald D. Perrone, Curie Ahn, Kevin J. Fowler, Vicente E. Torres, Ron T. Gansevoort...> ;American Journal of Kidney Diseases. 2021 Feb 1
2 citations
Prognostic Value of Fibroblast Growth Factor 23 in Autosomal Dominant Polycystic Kidney Disease.
Mireille El Ters, Pengcheng Lu, Jonathan D. Mahnken, Jason R. Stubbs, Shiqin Zhang, Darren P. Wallace, Jared J. Grantham, Arlene B. Chapman, Vicente E. Torres, Peter C...> ;Kidney International Reports. 2021 Jan 16
Autosomal Dominant Polycystic Kidney Disease does not significantly alter major COVID-19 outcomes among veterans
Xiangqin Cui, Julia W. Gallini, Christine L. Jasien, Michal Mrug> ;medRxiv. 2020 Nov 29
9 citations
The value of genotypic and imaging information to predict functional and structural outcomes in ADPKD
Sravanthi Lavu, Lisa E. Vaughan, Sarah R. Senum, Timothy L. Kline, Arlene B. Chapman, Ronald D. Perrone, Michal Mrug, William E. Braun, Theodore I. Steinman, Frederic ...> ;JCI insight. 2020 Aug 6
9 citations
Role of chemokines, innate and adaptive immunity.
Kurt A. Zimmerman, Katharina Hopp, Michal Mrug> ;Cellular Signalling. 2020 Sep 1
5 citations
Interferon Regulatory Factor‐5 in Resident Macrophage Promotes Polycystic Kidney Disease
Kurt A. Zimmerman, Jifeng Huang, Lan He, Dustin Z. Revell, Zhang Li, Jung-Shan Hsu, Wayne R. Fitzgibbon, E. Starr Hazard, Gary Hardiman, Michal Mrug, P. Darwin Bell, B...> ;Kidney. 2020 Mar 26
54 citations
Ketosis ameliorates renal cyst growth in polycystic kidney disease
Jacob A. Torres, Samantha L Kruger, Caroline Broderick, Tselmeg Amarlkhagva, Shagun Agrawal, John R. Dodam, Michal Mrug, Leslie A. Lyons, Thomas Weimbs> ;Cell Metabolism. 2019 Dec 3
19 citations
Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease
Jacob A. Torres, Mina Rezaei, Caroline Broderick, Louis Lin, Xiaofang Wang, Bernd Hoppe, Benjamin D. Cowley, Vincenzo Savica, Vicente E. Torres, Saeed R. Khan, Ross P....> ;Journal of Clinical Investigation. 2019 Oct 1
6 citations
Sodium and potassium excretion predict increased depression in urban adolescents.
Sylvie Mrug, Catheryn A. Orihuela, Michal Mrug, Paul W. Sanders> ;Physiological Reports. 2019 Aug 1
23 citations
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Kurt A. Zimmerman, Cheng Jack Song, Zhang Li, Jeremie M. Lever, David K. Crossman, Addison Rains, Ernald Jules G. Aloria, Nancy M. Gonzalez, John Bassler, Juling Zhou,...> ;Journal of The American Society of Nephrology. 2019 Jul 23
10 citations
Growth Pattern of Kidney Cyst Number and Volume in Autosomal Dominant Polycystic Kidney Disease.
Kyongtae T. Bae, Wen Zhou, Chengli Shen, Douglas Landsittel, Zhiyuan Wu, Cheng Tao, Arlene B. Chapman, Vicente E. Torres, Alan S.L. Yu, Michal Mrug, William M. Bennett...> ;Clinical Journal of The American Society of Nephrology. 2019 Jun 7
22 citations
Long-term trajectory of kidney function in autosomal-dominant polycystic kidney disease.
Alan S.L. Yu, Chengli Shen, Douglas Landsittel, Jared J. Grantham, Larry T. Cook, Vicente E. Torres, Arlene B. Chapman, Kyongtae T. Bae, Michal Mrug, Peter C. Harris, ...> ;Kidney International. 2019 May 1
50 citations
Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species.
Kurt A. Zimmerman, Melissa R. Bentley, Jeremie M. Lever, Zhang Li, David K. Crossman, Cheng Jack Song, Shanrun Liu, Michael R. Crowley, James F. George, Michal Mrug, B...> ;Journal of The American Society of Nephrology. 2019 Apr 4
6 citations
Truncating PKHD1 and PKD2 mutations alter energy metabolism
Phillip Chumley, Juling Zhou, Sylvie Mrug, Balu K. Chacko, John M. Parant, Anil K. Challa, Landon Wilson, Taylor F. Berryhill, Stephen Barnes, Robert A. Kesterson, P. ...> ;American Journal of Physiology-renal Physiology. 2019 Mar 1
Join now to see all

Journal Articles

A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan
Ronald D Perrone, Anjay Rastogi, Terry Watnick, Arlene B Chapman, Michal Mrug, Vicente E Torres, Fouad T Chebib, Neera K Dahl, Peter C Harris, Journal of the American Society of Nephrology

Authored Content

Baseline Total Kidney Volume and the Rate of Kidney Growth Are Associated with Chronic Kidney Disease Progression in Autosomal Dominant Polycystic Kidney DiseaseDecember 2017

Press Mentions

Otsuka’s JYNARQUE™ (Tolvaptan) Approved by U.S. FDA as the First Treatment to Slow Kidney Function Decline in Adults at Risk of Rapidly Progressing Autosomal Dominant Polycystic Kidney Disease (ADPKD)April 24th, 2018