MiriamBornhorstMD

Pediatric Hematology & Oncology • Chicago, IL

Cancer Genetics/Cancer Risk Assessment, Pediatric Neuro-Oncology

Physician

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Office
225 E Chicago Ave
Chicago, IL 60611
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Education & Training

Children's National Medical Center/George Washington UniversityFellowship, Pediatric Neuro-Oncology, 2014 - 2015
University of Michigan Health SystemFellowship, Pediatric Hematology/Oncology, 2011 - 2014
University of Michigan Health SystemResidency, Pediatrics, 2008 - 2011
Creighton University School of MedicineClass of 2008

Certifications & Licensure

MI State Medical License 2008 - 2027
IL State Medical License 2023 - 2026
VA State Medical License 2021 - 2024
DC State Medical License 2014 - 2024
MD State Medical License 2022 - 2024
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

An Intermediate Access Protocol for Selumetinib for Treatment of Neurofibromatosis Type 1
Approved for marketing
Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1 Start of enrollment: 2018 Jul 12
Active, not recruiting
Not Applicable
MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas Start of enrollment: 2019 Sep 29
Active, not recruiting
Phase 2
Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas Start of enrollment: 2024 Jun 15
Not yet recruiting
Phase 2
Roles: Contact
A Phase II Trial of Poly-ICLC for Low-Grade Gliomas Start of enrollment: 2021 Dec 15
Recruiting
Phase 2
Roles: Contact
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Publications & Presentations

PubMed

A case report of myelodysplastic syndrome in a patient with PTPN11-related Noonan syndrome.
JinJun Cheng, Christina Wiedl, Miriam Bornhorst, David Jacobsohn> ;Pediatric Blood & Cancer. 2024 Apr 11
Zebrafish-A Suitable Model for Rapid Translation of Effective Therapies for Pediatric Cancers.
Debasish Roy, Bavani Subramaniam, Wai Chin Chong, Roger J Packer, Javad Nazarian, Miriam Bornhorst> ;Cancers. 2024 Mar 30
2 citations
The Brain Tumor Segmentation (BraTS) Challenge 2023:.
Anahita Fathi Kazerooni, Nastaran Khalili, Xinyang Liu, Debanjan Haldar, Zhifan Jiang, Syed Muhammed Anwar, Jake Albrecht, Maruf Adewole, Udunna Anazodo, Hannah Anders...> ;Arxiv. 2024 Mar 8
Early prognostication of overall survival for pediatric diffuse midline gliomas using MRI radiomics and machine learning: a two-center study.
Xinyang Liu, Zhifan Jiang, Holger R Roth, Syed Muhammad Anwar, Erin R Bonner, Aria Mahtabfar, Roger J Packer, Anahita Fathi Kazerooni, Miriam Bornhorst, Marius George ...> ;Medrxiv. 2024 Jan 3
Development and pilot validation of a novel disfigurement severity scale for plexiform neurofibromas in children with neurofibromatosis type 1.
Liny John, Gurbani Singh, Eva Dombi, Pamela L Wolters, Staci Martin, Andrea Baldwin, Seth M Steinberg, Jessica Bernstein, Patricia Whitcomb, Dominique C Pichard, Anne ...> ;Clinical Trials. 2024 Apr 1
1 citations
Optical genome mapping identifies a novel pediatric embryonal tumor with a ZNF532::NUTM1 fusion.
Miriam Bornhorst, Augustine Eze Jr, Surajit Bhattacharya, Ethan Putnam, M Isabel Almira-Suarez, Christopher Rossi, Madhuri Kambhampati, Miguel Almalvez, Mariam Barsegh...> ;The Journal of Pathology. 2023 Jul 1
6 citations
Long-term safety and efficacy of selumetinib in children with neurofibromatosis type 1 on a phase 1/2 trial for inoperable plexiform neurofibromas.
Andrea M Gross, Eva Dombi, Pamela L Wolters, Andrea Baldwin, Anne Dufek, Kailey Herrera, Staci Martin, Joanne Derdak, Kara S Heisey, Patricia M Whitcomb, Seth M Steinb...> ;Neuro-Oncology. 2023 Oct 3
Surveillance imaging and early surgical intervention for improved CNS tumor outcomes in children with Li-Fraumeni syndrome: Children's National Hospital experience and...
Nirali Patel, Kathleen Felton, Surajit Bhattacharya, Maria Isabel Almira-Suarez, Augustine Eze, Joyce Turner, Robert Keating, Chima Oluigbo, Reuven J Schore, Lindsay K...> ;Journal of Neurosurgery. Pediatrics. 2023 Mar 1
Case report: Tisagenlecleucel for treatment of relapsed B- acute lymphoblastic leukemia in a patient withmutation.
Abraham Ipe, Anne Angiolillo, David Jacobsohn, Miriam Bornhorst, Joyce Turner, Anant Vatsayan, Cheng, J.> ;Frontiers in Pediatrics. 2023 Jan 1
4 citations
Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors.
Bonner, E., Harrington, R., Eze, A., Bornhorst, M., Kline, C., Gordish-Dressman, H., Dawood, A., Das, B., Chen, L., Pauly, R., Williams, P., Karlovich, C., Peach, A., ...> ;NPJ Precision Oncology. 2022 Sep 6
6 citations
Risk factors for treatment-refractory and relapsed optic pathway glioma in children with neurofibromatosis type 1.
Chelsea Kotch, Robert Avery, Kelly D Getz, Eric Bouffet, Peter de Blank, Robert Listernick, David H Gutmann, Miriam Bornhorst, Cynthia Campen, Grant T Liu, Richard Apl...> ;Neuro-Oncology. 2022 Aug 1
24 citations
Management of neurofibromatosis type 1-associated plexiform neurofibromas.
Michael J Fisher, Jaishri O Blakeley, Brian D Weiss, Eva Dombi, Shivani Ahlawat, Srivandana Akshintala, Allan J Belzberg, Miriam Bornhorst, Miriam A Bredella, Wenli Ca...> ;Neuro-Oncology. 2022 Nov 2
4 citations
Selumetinib in children with neurofibromatosis type 1 and asymptomatic inoperable plexiform neurofibroma at risk for developing tumor-related morbidity.
Andrea M Gross, Brittany Glassberg, Pamela L Wolters, Eva Dombi, Andrea Baldwin, Michael J Fisher, AeRang Kim, Miriam Bornhorst, Brian D Weiss, Jaishri O Blakeley, Pat...> ;Neuro-Oncology. 2022 Nov 2
21 citations
Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas.
Pooja Panwalkar, Benita Tamrazi, Derek Dang, Chan Chung, Stefan Sweha, Siva Kumar Natarajan, Matthew Pun, Jill Bayliss, Martin P. Ogrodzinski, Drew Pratt, Brendan Mull...> ;Science Translational Medicine. 2021 Oct 6
4 citations
New insights into low grade glioma tumor microenvironment for improved patient management.
Miriam Bornhorst> ;Neuro-Oncology. 2021 Sep 13
9 citations
Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors.
Emmanuelle S. Jecrois, Wang Zheng, Miriam Bornhorst, Yinghua Li, Daniel M. Treisman, Daphine Muguyo, Sharon Huynh, Shayne F. Andrew, Yuan Wang, Jingwen Jiang, Brianna ...> ;Developmental Cell. 2021 Oct 25
2 citations
Biological Treatments of Neurofibromatosis Type 2 and Other Skull Base Disorders.
Scott Raskin, Miriam Bornhorst> ;Otolaryngologic Clinics of North America. 2021 Jun 11
25 citations
Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance.
Carol Durno, Ayse Bahar Ercan, Vanessa Bianchi, Melissa Edwards, Melyssa Aronson, Melissa Galati, Eshetu G. Atenafu, Gadi Abebe-Campino, Abeer Al-Battashi, Musa Alharb...> ;Journal of Clinical Oncology. 2021 May 4
2 citations
Feasibility of magnetic resonance-guided high-intensity focused ultrasound treatment targeting distinct nodular lesions in neurofibromatosis type 1.
Caitlin Tydings, Pavel S. Yarmolenko, Miriam Bornhorst, Eva Dombi, John S. Myseros, Robert F. Keating, James Bost, Karun Sharma, AeRang Kim> ;Neuro-Oncology Advances. 2021 Jan 1
4 citations
A Pediatric Case of Transformed Mycosis Fungoides in a BRCA2 Positive Patient
Andrea M. Gross, Joyce Turner, Anna Y. Kirkorian, Ginette A. Okoye, Dragos C. Luca, Miriam Bornhorst, Shana Jacobs, Kirsten M. Williams, Reuven J. Schore> ;Journal of Pediatric Hematology/oncology. 2020 Jul 1
61 citations
Outcomes of BRAF V600E pediatric gliomas treated with targeted BRAF inhibition
Liana Nobre, Michal Zapotocky, Vijay Ramaswamy, Scott Ryall, Julie Bennett, Daniel Alderete, Julia Balaguer Guill, Lorena V Baroni, Ute Bartels, Abhishek Bavle, Miriam...> ;JCO Precision Oncology. 2020 May 20
222 citations
Selumetinib in Children with Inoperable Plexiform Neurofibromas
Andrea M. Gross, Pamela L. Wolters, Eva Dombi, Andrea Baldwin, Patricia Whitcomb, Michael Fisher, Brian Weiss, Ae Rang Kim, Miriam Bornhorst, Amish C. Shah, Staci Mart...> ;The New England Journal of Medicine. 2020 Mar 18
8 citations
Molecularly Targeted Agents in the Therapy of Pediatric Brain Tumors
Miriam Bornhorst, Eugene Hwang> ;Paediatric Drugs. 2020 Feb 1
2 citations
Somatic Mosaicism of IDH1 R132H Predisposes to Anaplastic Astrocytoma: A Case of Two Siblings.
Sulgi Lee, Madhuri Kambhampati, M Isabel Almira-Suarez, Cheng-Ying Ho, Eshini Panditharatna, Seth I. Berger, Joyce Turner, David Van Mater, Lindsay Kilburn, Roger J. P...> ;Frontiers in Oncology. 2020 Jan 14
2 citations
Clinicopathologic Features of Diencephalic Neuronal and Glioneuronal Tumors
Cheng-Ying Ho, Miriam Bornhorst, M Isabel Almira-Suarez, Kliment Donev, Marjorie Grafe, Heather Gordish-Dressman, Fausto J. Rodriguez> ;Journal of Neuropathology and Experimental Neurology. 2020 Jan 1
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