Mortimer Poncz MD

Pediatric Hematology & Oncology•Philadelphia, PA

Professor, Pediatrics, Perelman School of Medicine

3401 Civic Center Blvd# ChildrenPhiladelphia, PA 19104
Phone+1 215-590-3535
Fax+1 215-590-3992

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Summary

Dr. Mortimer Poncz is a pediatric hematology and oncology specialist based in Philadelphia, PA. He completed his medical education at the Perelman School of Medicine at the University of Pennsylvania in 1976, followed by a residency in pediatrics and a fellowship in pediatric hematology/oncology at the Children's Hospital of Philadelphia. Dr. Poncz has authored several publications, including research published in high-impact journals such as the Journal of Thrombosis and Haemostasis, Nature Communications, and ACS Nano. He was elected as a member of The American Society for Clinical Investigation in 1991 and has been recognized as a Super Doctor by SuperDoctors.com.

Education & Training

Children's Hospital of PhiladelphiaFellowship, Pediatric Hematology/Oncology, 1979 - 1982
Children's Hospital of PhiladelphiaResidency, Pediatrics, 1976 - 1979
Perelman School of Medicine at the University of PennsylvaniaClass of 1976

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Certifications & Licensure

PA State Medical License 1977 - 2026
NJ State Medical License 1981 - 1991
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Hematology-Oncology

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1991
Super Doctor SuperDoctors.com

Publications & Presentations

PubMed

Non-PF4/heparin-binding, platelet-activating antibodies in heparin-induced thrombocytopenia.
Lu Zhou, Andrew Cao, Wen Zhu, Daniel Villalobos-Garcia, Marisela Marchan
Blood. 2026-07-02
Antiphospholipid syndrome (APS) is a platelet factor 4 (PF4)-centric immunothrombotic disorder.
Conroy O Field, Amrita Sarkar, Khalil Bdeir, Hyunjun Kim, Santosh Kumar Yadav
Blood. 2026-06-30
1 citations
Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients.
Liang Zhao, Sokratis A Apostolidis, Aae Suzuki, Amrita Sarkar, Qian Guo
The Journal of Clinical Investigation. 2026-05-01

Journal Articles

Dynamic Intercellular Redistribution of HIT Antigen Modulates Heparin-Induced Thrombocytopenia
Mortimer Poncz, MD, Blood
Polyreactive IgM Initiates Complement Activation by PF4/heparin Complexes Through the Classical Pathway
Mortimer Poncz, Jennifer B Gilner, Gowthami M Arepally, Blood

Abstracts/Posters

A Novel Approach for Generating Platelet-Delivered FVIII: Role of Transient LRP1 Expression during Megakaryopoiesis
Mortimer Poncz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
A Novel Platelet-Targeting Fibrinolytic Strategy: Endocytosed Urokinase By Megakaryocytes Is Stored in _-Granules and Is Functional In Vivo in a Murine Model of Thromb...
Mortimer Poncz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
The Inherited Platelet Disorder of RUNX1 Haploinsufficiency (Familial Platelet Disorder with Associated Myeloid Malignancy (FPDMM)) Has a Marked Deficiency of Megakary...
Mortimer Poncz, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Press Mentions

Children's Hospital of Philadelphia Appoints New Chief of HematologyJanuary 6th, 2022
Remembering Joel S. Bennett, and MoreAugust 2nd, 2021
J&J and AZ Studying if Modifying COVID-19 Vaccines Can Reduce the Risk of Rare Blood ClotsJuly 13th, 2021

Grant Support

RepSox and its analog for prophylactic intervention in RUNX1 haploinsufficiency FPDMMCHILDREN'S HOSP OF PHILADELPHIA2025–2027
New Mechanistic Insights & Therapeutic Applications of Megakaryocytes/PlateletsCHILDREN'S HOSP OF PHILADELPHIA2020–2027
Pediatric Hematology Research Training ProgramCHILDREN'S HOSP OF PHILADELPHIA1976–2027
Embryonic Stem Cell-Derived Platelets As Cellular TherapeuticsNational Heart, Lung, And Blood Institute2009–2012
Platelet Factor 8 As A Novel Therapy For Hemophilia ANational Heart, Lung, And Blood Institute2011