NadineGeorgesRouphaelMD

Infectious Disease • Atlanta, GA

Assistant Professor, Medicine, Emory University School of Medicine

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Office
550 Peachtree St Ne
Atlanta, GA 30308
Phone+1 404-686-1000
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Education & Training

Emory University School of MedicineFellowship, Infectious Disease, 2005 - 2008
Emory University School of MedicineResidency, Internal Medicine, 2002 - 2005
St Joseph's University Medical SchoolClass of 2001

Certifications & Licensure

GA State Medical License 2005 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease

Clinical Trials

Systems Biology of Trivalent Influenza Vaccine (TIV) in Young and Elderly Start of enrollment: 2010 Oct 01
Completed
Not Applicable
Systems Biology of PNEUMOVAX®23 and PREVNAR 13® Start of enrollment: 2014 Apr 01
Completed
Not Applicable
Systems Biology of Zoster Vaccine (ZOSTAVAX®) in Young and Elderly Start of enrollment: 2011 Jul 01
Completed
Not Applicable
Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics Start of enrollment: 2015 Apr 01
Completed
Not Applicable
Immunologic Responses to a Live Attenuated Oral Cholera Vaccine Start of enrollment: 2017 Aug 29
Recruiting
Phase 2
Safety and Efficacy of FMT in Individuals With One or More Recurrences of Clostridium Difficile Associated Disease (CDAD) Start of enrollment: 2019 Jan 11
Terminated
Phase 1, Phase 2
Responses to Rabies Vaccine in Adults With or Without Antibiotics Start of enrollment: 2018 Jul 05
Completed
Phase 4
Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS) Start of enrollment: 2018 Nov 07
Terminated
Phase 4
Durability and Impact of the Seasonal Influenza Vaccine on H5 Induced B Cell Response Start of enrollment: 2018 Oct 11
Completed
Phase 4
Solid Organ Transplant SHINGRIX Start of enrollment: 2020 Jan 30
Terminated
Systems Biology of Zoster Vaccine Start of enrollment: 2019 Nov 14
Completed
Phase 2
Evaluating the Safety and Immunogenicity of HIV-1 BG505 SOSIP.664 gp140 With TLR Agonist and/or Alum Adjuvants in Healthy, HIV-uninfected Adults Start of enrollment: 2020 Jan 13
Active, not recruiting
Phase 1
Immunophenotyping Assessment in a COVID-19 Cohort Start of enrollment: 2020 May 01
Completed
Influenza Human Challenge Model Start of enrollment: 2022 May 24
Recruiting
Phase 1
Roles: Principal Investigator, Contact
Immunology of Ebola Vaccine Start of enrollment: 2024 Jul 01
Not yet recruiting
Phase 2
Roles: Contact, Principal Investigator
Systems Biological Assessment of the Durability of Vaccine Responses Start of enrollment: 2023 Apr 11
Recruiting
Phase 4
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

COVID-19 vaccine efficacy in participants with weakened immune systems from four randomized-controlled trials.
Amy Sherman, Jessica Tuan, Valeria D Cantos, Oladunni Adeyiga, Scott Mahoney, Ana M Ortega-Villa, Amy Tillman, Jennifer Whitaker, Amanda S Woodward Davis, Brett Leav, ...> ;Clinical Infectious Diseases. 2024 Apr 10
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans.
Lilit Grigoryan, Yupeng Feng, Lorenza Bellusci, Lilin Lai, Bushra Wali, Madison Ellis, Meng Yuan, Prabhu S Arunachalam, Mengyun Hu, Sangeeta Kowli, Sheena Gupta, Sofia...> ;Science Immunology. 2024 Apr 5
Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials.
Myra Happe, Amelia R Hofstetter, Jing Wang, Galina V Yamshchikov, LaSonji A Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F...> ;NPJ Vaccines. 2024 Mar 29
A Phase 1, Double-blinded, Placebo-Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of HEV-239 (Hecolin®) Vaccine in Healthy US Adults.
Carol M Kao, Christina A Rostad, Lauren E Nolan, Etza Peters, Jennifer Kleinhenz, Jacob D Sherman, Ashley Tippett, J Wai Kuo Shih, Inci Yildirim, Vivien Agbakoba, Tati...> ;The Journal of Infectious Diseases. 2024 Mar 27
A Phase 2 Clinical Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of Different Prime-Boost Vaccination Schedules of 2013 and 2017 A(H7N9) Inactivated...
Christina A Rostad, Robert L Atmar, Emmanuel B Walter, Sharon Frey, Jeffery L Meier, Amy C Sherman, Lilin Lai, Rachel Tsong, Carol M Kao, Vanessa Raabe, Hana M El Sahl...> ;Clinical Infectious Diseases. 2024 Mar 27
Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 Immunopathology.
Van Phan, H., Tsitsiklis, A., Maguire, C., Haddad, E., Becker, P., Kim-Schulze, S., Lee, B., Chen, J., Hoch, A., Pickering, H., Van Zalm, P., Altman, M., Augustine, A....> ;Medrxiv. 2024 Feb 13
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition.
Yendewa, G., Yendewa, G., Yendewa, G., Yendewa, G., Yendewa, G., Yendewa, G., Yendewa, G., Yendewa, G., Haslund-Gourley, B., Woloszczuk, K., Hou, J., Connors, J., Cusi...> ;Nature Communications. 2024 Jan 9
Host-Microbe Multi-omic Profiling Identifies a Unique Program of COVID-19 Inflammatory Dysregulation in Solid Organ Transplant Recipients.
Langelier, C., Pickering, H., Schaenman, J., Phan, H., Maguire, C., Tsitsiklis, A., Rouphael, N., Higuita, N., Atkinson, M., Breckenridge, S., Fung, M., Messer, W., , ...> ;Research Square. 2023 Dec 20
1 citations
Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial.
Rouphael, N., Branche, A., Diemert, D., Falsey, A., Losada, C., Baden, L., Frey, S., Whitaker, J., Little, S., Kamidani, S., Walter, E., Novak, R., Rupp, R., Jackson, ...> ;The Journal of Infectious Diseases. 2023 Dec 20
Immunogenicity and safety of varying dosages of a fifth-wave influenza A/H7N9 inactivated vaccine given with and without AS03 adjuvant in healthy adults.
Jackson, L., Stapleton, J., Walter, E., Chen, W., Rouphael, N., Anderson, E., Neuzil, K., Winokur, P., Smith, M., Schmader, K., Swamy, G., Thompson, A., Mulligan, M., ...> ;Vaccine. 2024 Jan 12
Phase 1 Open-Label Dose Escalation Trial for the Development of a Human Bacillus Calmette-Guérin Challenge Model for Assessment of Tuberculosis Immunity In Vivo.
Azra Blazevic, Rachel L Edwards, Mei Xia, Christopher S Eickhoff, Fahreta Hamzabegovic, Krystal A Meza, Huan Ning, Janice Tennant, Karla J Mosby, James C Ritchie, Tigi...> ;The Journal of Infectious Diseases. 2023 Nov 29
Natural infection by Zika virus but not DNA vaccination consistently elicits antibodies that compete with two potently neutralising monoclonal antibodies targeting dis...
Teresa C Smith, Daniel O Espinoza, Yerun Zhu, Jaime A Cardona-Ospina, Natalie M Bowman, Sylvia Becker-Dreps, Nadine Rouphael, Alfonso J Rodriguez-Morales, Filemon Buca...> ;Ebiomedicine. 2023 Dec 1
Influenza Vaccine Effectiveness Pre-pandemic Among Adults Hospitalized With Congestive Heart Failure or Chronic Obstructive Pulmonary Disease and Older Adults.
Ashley Tippett, Gabby Ess, Laila Hussaini, Olivia Reese, Luis Salazar, Mary Kelly, Meg Taylor, Caroline Ciric, Amy Keane, Andrew Cheng, Theda Gibson, Wensheng Li, Hui-...> ;Clinical Infectious Diseases. 2024 Apr 10
Corrigendum to "Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study" [eBioMedicine 83 (2022) 104208].
Al Ozonoff, Joanna Schaenman, Naresh Doni Jayavelu, Carly E Milliren, Carolyn S Calfee, Charles B Cairns, Monica Kraft, Lindsey R Baden, Albert C Shaw, Florian Krammer...> ;Ebiomedicine. 2023 Dec 1
1 citations
Priorities and Progress in Gram-negative Bacterial Infection Research by the Antibacterial Resistance Leadership Group.
Michael J Satlin, David van Duin, Pranita D Tamma, Thomas P Lodise, Daria Van Tyne, Keith A Rodvold, Nadine Rouphael, Scott R Evans, Vance G Fowler, Toshimitsu Hamasak...> ;Clinical Infectious Diseases. 2023 Oct 16
Relationship of Heterologous Virus Responses and Outcomes in Hospitalized COVID-19 Patients.
Yael Rosenberg-Hasson, Tyson H Holmes, Joann Diray-Arce, Jing Chen, Ryan Kellogg, Michael Snyder, Patrice M Becker, Al Ozonoff, Nadine Rouphael, Elaine F Reed, , Holde...> ;Journal of Immunology. 2023 Oct 15
2 citations
Efficacy of a monovalent (D614) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, multi-country study.
Gustavo H Dayan, Nadine Rouphael, Stephen R Walsh, Aiying Chen, Nicole Grunenberg, Mary Allen, Johannes Antony, Amit Suresh Bhate, Tatiana Beresnev, Matthew I Bonapart...> ;Eclinicalmedicine. 2023 Oct 1
2 citations
Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, parallel, randomised, modified double-blind, pl...
Gustavo H Dayan, Nadine Rouphael, Stephen R Walsh, Aiying Chen, Nicole Grunenberg, Mary Allen, Johannes Antony, Kwaku Poku Asante, Amit Suresh Bhate, Tatiana Beresnev,...> ;The Lancet. Respiratory Medicine. 2023 Nov 1
Daily fosfomycin versus levofloxacin for complicated urinary tract infections.
Nadine Rouphael, Patricia Winokur, Michael C Keefer, Jessica Traenkner, Ana Drobeniuc, Yohei Doi, Sonal Munsiff, Vance G Fowler, Scott Evans, Randolph E Oler, Bonifrid...> ;Mbio. 2023 Oct 31
Blockade Antibody Responses in Human Subjects Challenged with a New Snow Mountain Virus Inoculum.
Makoto Ibaraki, Lilin Lai, Christopher Huerta, Muktha S Natrajan, Matthew H Collins, Evan J Anderson, Mark J Mulligan, Nadine Rouphael, Christine L Moe, Pengbo Liu> ;Research Square. 2023 Sep 11
8 citations
Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial.
Angela R Branche, Nadine G Rouphael, David J Diemert, Ann R Falsey, Cecilia Losada, Lindsey R Baden, Sharon E Frey, Jennifer A Whitaker, Susan J Little, Evan J Anderso...> ;Nature Medicine. 2023 Sep 1
1 citations
COVID-19 Vaccination Among Patients Receiving Maintenance Renal Replacement Therapy: Immune Response, Real-World Effectiveness, and Implications for the Future.
Nadine Rouphael, Mary Bausch-Jurken> ;The Journal of Infectious Diseases. 2023 Aug 4
6 citations
Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants.
Kirsten E Lyke, Robert L Atmar, Clara Dominguez Islas, Christine M Posavad, Meagan E Deming, Angela R Branche, Christine Johnston, Hana M El Sahly, Srilatha Edupuganti...> ;NPJ Vaccines. 2023 Jul 11
1 citations
Modifiers of COVID-19 vaccine efficacy: Results from four COVID-19 prevention network efficacy trials.
Christine B Turley, LaKesha Tables, Trevon Fuller, Lisa J Sanders, Hyman Scott, Amaran Moodley, Amanda Woodward Davis, Brett Leav, Jacqueline Miller, Kathryn Schoemake...> ;Vaccine. 2023 Jul 25
Efficacy and Durability of Immune Response after Receipt of HPV Vaccines in People Living with HIV.
Cecilia Losada, Hady Samaha, Erin M Scherer, Bahaa Kazzi, Lana Khalil, Ighovwerha Ofotokun, Nadine Rouphael> ;Vaccines. 2023 Jun 5
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Journal Articles

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
Nadine G Rouphael, Phillip A Swanson, Brett Leav, Varun K Phadke, The New England Journal of Medicine

Press Mentions

More COVID-19 Cases but Fewer Working Treatments Against Shifting VirusDecember 16th, 2022
Emory Infectious Disease Leaders Selected for Top Positions and Prestigious Awards by IDSAOctober 20th, 2022
IDSA Honors Notable Leaders in Infectious Diseases at IDOctober 19th, 2022
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