NancieJMacIverMD

Pediatric Endocrinology • Durham, NC

Assistant Professor of Pediatrics, Duke University School of Medicine

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Office
2301 Erwin Rd
Durham, NC 27705
Phone(919) 684-3772
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Education & Training

Duke University HospitalFellowship, Pediatric Endocrinology, 2006 - 2009
Duke University HospitalResidency, Pediatrics, 2003 - 2006
Mayo Clinic School of MedicineClass of 2003

Certifications & Licensure

NC State Medical License 2009 - 2021
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Endocrinology

Publications & Presentations

PubMed

Editorial: Nutritional Aspects of Immunity and Immunometabolism in Health and Disease.
Karlsson, E. A., Beck, M. A., MacIver, N. J.> ;Frontiers in immunology. 2020 Nov 3
Targeting T-cell oxidative metabolism to improve influenza survival in a mouse model of obesity
Yazan Alwarawrah, Amanda G. Nichols, William R. Green, William Eisner, Kaitlin Kiernan, Jonathan Warren, Laura P. Hale, Melinda A. Beck, Nancie J. MacIver> ;International Journal of Obesity. 2020 Oct 9
CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism.
Wu, H., Herr, D., MacIver, N. J., Rathmell, J. C., Gerriets, V. A.> ;International immunopharmacology. 2020 Sep 1
PINK1-Dependent Mitophagy Regulates the Migration and Homing of Multiple Myeloma Cells via the MOB1B-Mediated Hippo-YAP/TAZ Pathway.
Fan, S., Price, T., Huang, W., Plue, M., Warren, J., Sundaramoorthy, P., Paul, B., Feinberg, D., MacIver, N., Chao, N., Sipkins, D., Kang, Y.> ;Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2020 Mar 11
A Novel Mechanism for Th17 Inflammation in Human Type 2 Diabetes Mellitus.
Kiernan, K., MacIver, N. J.> ;Trends in endocrinology and metabolism: TEM. 2019 Nov 27
Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.
Lin, K. H., Xie, A., Rutter, J. C., Ahn, Y., Lloyd-Cowden, J. M., Nichols, A. G., Soderquist, R. S., Koves, T. R., Muoio, D. M., MacIver, N. J., Lamba, J. K., Pardee, ...> ;Cell metabolism. 2019 Feb 19
Obesity-Induced Changes in T-Cell Metabolism Are Associated With Impaired Memory T-Cell Response to Influenza and Are Not Reversed With Weight Loss.
Rebeles, J., Green, W. D., Alwarawrah, Y., Nichols, A. G., Eisner, W., Danzaki, K., MacIver, N. J., Beck, M. A.> ;The Journal of infectious diseases. 2018 Dec 12
Viral Infection “Interferes” with Glucose Tolerance
Nancie MacIver, MD> ;Cell Press. 2018 Jul 19
Changes in Nutritional Status Impact Immune Cell Metabolism and Function.
Alwarawrah, Y., Kiernan, K., MacIver, N. J.> ;Frontiers in immunology. 2018 Jun 6
Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate.
MacIver, N. J., Rathmell, J. C.> ;Current opinion in immunology. 2017 Jul 8
3 citations
Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.
Schmidt, E. A., Fee, B. E., Henry, S. C., Nichols, A. G., Shinohara, M. L., Rathmell, J. C., MacIver, N. J., Coers, J., Ilkayeva, O. R., Koves, T. R., Taylor, G. A.> ;The Journal of biological chemistry. 2017 Feb 6
Oxytocin Treatment May Improve Infant Feeding and Social Skills in Prader-Willi Syndrome.
MacIver, N. J.> ;Pediatrics. 2017 Jan 20
6 citations
Nutritional effects on T-cell immunometabolism.
Cohen, S., Danzaki, K., MacIver, N. J.> ;European journal of immunology. 2017 Jan 6
50 citations
Foxp3 and Toll-like receptor signaling balance T<sub>reg</sub> cell anabolic metabolism for suppression.
Gerriets, V. A., Kishton, R. J., Johnson, M. O., Cohen, S., Siska, P. J., Nichols, A. G., Warmoes, M. O., de Cubas, A. A., MacIver, N. J., Locasale, J. W., Turka, L. A...> ;Nature immunology. 2016 Nov 1
Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia
Nancie MacIver, MD> ;The Journal of Immunology.
13 citations
Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature.
Petrovski, S., Parrott, R. E., Roberts, J. L., Huang, H., Yang, J., Gorentla, B., Mousallem, T., Wang, E., Armstrong, M., McHale, D., MacIver, N. J., Goldstein, D. B.,...> ;Journal of clinical immunology. 2016 Apr 15
Increased leptin levels correlate with thyroid autoantibodies in nonobese males.
MacIver, N. J., Thomas, S. M., Green, C. L., Worley, G.> ;Clinical endocrinology. 2015 Oct 8
16 citations
Role of T cells in malnutrition and obesity.
Gerriets, V. A., MacIver, N. J.> ;Frontiers in immunology. 2014 Aug 27
29 citations
Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity
Donte C. Saucillo, Valerie A. Gerriets, John Sheng, Jeffrey C. Rathmell, Nancie J. MacIver> ;Journal of Immunology. 2014 Jan 1
243 citations
Metabolic regulation of T lymphocytes.
MacIver, N. J., Michalek, R. D., Rathmell, J. C.> ;Annual review of immunology. 2013 Jan 10
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Press Mentions

Doctors Studying Why Obesity May Be Tied to Serious COVID-19September 11, 2020 10:42
State Adds 441 Coronavirus Cases, Doctors Study Obesity and COVID-19September 09, 2020 10:52
Doctors Studying Why Obesity Could Make Coronavirus Impact WorseSeptember 09, 2020 10:47
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