NathalieCRiouxMD

PubMed

• 1 citations
  Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers.
  David B Freeman, Tamara D Hopkins, Peter J Mikochik, Joseph P Vacca, Hua Gao, Adel Naylor-Olsen, Sonali Rudra, Huixu Li, Marius S Pop, Rosa A Villagomez, Christina Lee...> ;Journal of Medicinal Chemistry. 2023 Dec 14
• A comprehensive evaluation in clinic and physiologically-based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interactio...
  Ziping Yang, Nathalie Rioux, Ludwig Vincent, Hannah M Jones, David Cha, Andrew Plummer, David Wilfret, Brian P Kearney> ;CPT. 2023 Oct 1
• 3 citations
  Metabolic disposition of H3B-8800, an orally available small-molecule splicing modulator, in rats, monkeys, and humans.
  Nathalie Rioux, Sherri Smith, Federico Colombo, Amy Kim, W. George Lai, Darrell Nix, Y Amy Siu, Joanne Schindler, Pete Smith> ;Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2020 Jan 6
• 155 citations
  Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
  Fedoriw Andrew Mark, Satyajit R. Rajapurkar, Shane W. O'Brien, Sarah Gerhart, Lorna Helen Mitchell, Nicholas D. Adams, Nathalie Rioux, Trupti Lingaraj, Scott Ribich, M...> ;Cancer Cell. 2019 Jul 8
• 56 citations
  Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
  Xiaoling Puyang, Craig Furman, Zheng Guo Zhu, Zhenhua J. Wu, Deepti Banka, Kiran Aithal, Sergei Agoulnik, David M. Bolduc, Silvia Buonamici, Benjamin Caleb, Subhasree ...> ;Cancer Discovery. 2018 Jul 10
• 38 citations
  Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
  Michael Thomenius, Jennifer Totman, Darren Martin Harvey, Lorna Helen Mitchell, Thomas V. Riera, Kat Cosmopoulos, Alexandra R. Grassian, Christine Klaus, Megan Alene C...> ;Plos One. 2018 Jun 1
• 81 citations
  H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma
  Jaya Julie Joshi, Heather Coffey, Erik Corcoran, Jennifer Tsai, Chia-Ling Huang, Kana Ichikawa, Sudeep Prajapati, Ming-Hong Hao, Suzanna L. Bailey, Jeremy Wu, Victoria...> ;Cancer Research. 2017 Dec 15
• 25 citations
  Physiologically-Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development
  Nathalie Rioux, Nigel J. Waters> ;Drug Metabolism and Disposition. 2016 Jul 1
• 60 citations
  Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
  Lorna Helen Mitchell, P. Ann Boriack-Sjodin, Sherri Smith, Michael Thomenius, Nathalie Rioux, Michael John Munchhof, James Edward John Mills, Christine Klaus, Jennifer...> ;ACS Medicinal Chemistry Letters. 2016 Feb 11
• 92 citations
  Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.
  Kenneth W. Duncan, Nathalie Rioux, P. Ann Boriack-Sjodin, Michael John Munchhof, Lawrence A. Reiter, Christina R. Majer, Lei Jin, L. Danielle Johnston, Elayne Chan-Pen...> ;ACS Medicinal Chemistry Letters. 2016 Feb 11
• 366 citations
  A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
  Elayne Chan-Penebre, Kristy G Kuplast, Christina R. Majer, P. Ann Boriack-Sjodin, Tim J. Wigle, L. Danielle Johnston, Nathalie Rioux, Michael John Munchhof, Lei Jin, S...> ;Nature Chemical Biology. 2015 Jun 1
• 90 citations
  Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
  Lorna Helen Mitchell, A.E Drew, Scott Ribich, Nathalie Rioux, K.K. Swinger, Suzanne L. Jacques, Trupti Lingaraj, P.A Boriack-Sjodin, Nigel J. Waters, Tim J. Wigle, O M...> ;ACS Medicinal Chemistry Letters. 2015 Apr 8
• 94 citations
  EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity
  John Emmerson Campbell, Kevin Wayne Kuntz, Sarah K. Knutson, Natalie Warholic, Heike Keilhack, Tim J. Wigle, Alejandra Raimondi, Christine Klaus, Nathalie Rioux, Akira...> ;ACS Medicinal Chemistry Letters. 2015 Mar 18
• 63 citations
  Inhibition of Lung Tumorigenesis by Nsaids: A Working Hypothesis
  Andre Castonguay, Nathalie Rioux, Caroline Duperron, Guylaine Jalbert> ;Experimental Lung Research. 1998 Jul 1
• 18 citations
  Recovery From 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Immunosuppression in A/J Mice by Treatment With Nonsteroidal Antiinflammatory Drugs
  Nathalie Rioux, Andre Castonguay, Dietrich Hoffmann> ;Journal of the National Cancer Institute. 1997 Jun 18
• 71 citations
  Inhibition of lung tumourigenesis by sulindac: comparison of two experimental protocols.
  Andre Castonguay, Nathalie Rioux> ;Carcinogenesis. 1997 Mar 1
• Induction of COX expression by a tobacco carcinogen: implication in lung cancer chemoprevention.
  Rioux, N., Castonguay, A.> ;Inflamm Res. 1999 Dec
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