NathanJohnKlingensmithMD

General Surgery • Atlanta, GA

Trauma Surgery & Surgical Critical Care

Trauma surgery fellow at Grady Memorial Hospital

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Office
80 Jesse Hill Jr drive
Atlanta, GA 30303
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Education & Training

Emory University School of MedicineResidency, Surgery, 2012 - 2017
West Virginia University School of MedicineClass of 2012

Certifications & Licensure

PA State Medical License 2022 - 2024
GA State Medical License 2016 - 2023
American Board of Surgery Surgery
American Board of Surgery Surgical Critical Care

Publications & Presentations

PubMed

European society for trauma and emergency surgery member-identified research priorities in emergency surgery: a roadmap for future clinical research opportunities.
Gary Alan Bass, Lewis Jay Kaplan, Christine Gaarder, Raul Coimbra, Nathan John Klingensmith, Hayato Kurihara, Mauro Zago, Stefano Piero Bernardo Cioffi, Shahin Mohseni...> ;European Journal of Trauma and Emergency Surgery. 2024 Apr 1
CTLA-4 Checkpoint Inhibition Improves Sepsis Survival in Alcohol-Exposed Mice.
Cameron W Paterson, Katherine T Fay, Ching-Wen Chen, Nathan J Klingensmith, Melissa B Gutierrez, Zhe Liang, Craig M Coopersmith, Mandy L Ford> ;Immunohorizons. 2024 Jan 1
1 citations
CHRONIC ETHANOL USE WORSENS GUT PERMEABILITY AND ALTERS TIGHT JUNCTION EXPRESSION IN A MURINE SEPSIS MODEL.
Takehiko Oami, Tetsuya Yumoto, Takashi Shimazui, Sofia Sarmiento, Nathan J Klingensmith, Ching-Wen Chen, Shunsuke Otani, Zhe Liang, Eileen M Burd, Zaid K Mahdi, Mandy ...> ;Shock. 2023 Aug 1
3 citations
Gut Microbiome in Sepsis.
Nathan J Klingensmith, Craig M Coopersmith> ;Surgical Infections. 2023 Apr 1
2 citations
Dispelling Dogma: American Association for Surgery of Trauma Prospective, Multicenter Trial of Index vs Delayed Fasciotomy after Extremity Trauma.
Jane J Keating, Nathan Klingensmith, Alexis M Moren, David J Skarupa, Anthony Loria, Zoe Maher, Sarah A Moore, Michael C Smith, Mark J Seamon> ;Journal of the American College of Surgeons. 2023 May 1
6 citations
Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis.
Nathan J Klingensmith, Katherine T Fay, David A Swift, Julia Mr Bazzano, John D Lyons, Ching-Wen Chen, Mei Meng, Kimberly M Ramonell, Zhe Liang, Eileen M Burd, Charles...> ;JCI Insight. 2022 Aug 22
1 citations
Bullet Embolism into the Common Iliac Artery from a Gunshot Wound to the Heart.
Brendan P Lovasik, Christopher L Nauser, Nathan J Klingensmith, Jonathan H Nguyen> ;The American Surgeon. 2022 May 1
1 citations
Superior Mesenteric Artery and Vein Injuries: Operative Strategies and Outcomes.
Patrick D. Melmer, Brant Clatterbuck, Virginia Parker, Christine Castater, Nathan J. Klingensmith, Christopher R. Ramos, Stephanie Busby, Stuart D Hurst, Deepika Kogan...> ;Vascular and Endovascular Surgery. 2021 Sep 17
16 citations
Overexpression of BCL-2 in the Intestinal Epithelium Prevents Sepsis-Induced Gut Barrier Dysfunction via Altering Tight Junction Protein Expression.
Shunsuke Otani, Takehiko Oami, Benyam P. Yoseph, Nathan J. Klingensmith, Ching-Wen Chen, Zhe Liang, Craig M. Coopersmith> ;Shock. 2020 Sep 1
53 citations
The Gut Microbiome Alters Immunophenotype and Survival From Sepsis
Katherine T. Fay, Nathan J. Klingensmith, Ching-Wen Chen, Wenxiao Zhang, Yini Sun, Kristen N. Morrow, Zhe Liang, Eileen M. Burd, Mandy L. Ford, Craig M. Coopersmith> ;FASEB Journal. 2019 Jul 15
12 citations
Regulators of Intestinal Epithelial Migration in Sepsis.
Mei Meng, Nathan J. Klingensmith, Zhe Liang, John D. Lyons, Katherine T. Fay, Ching-Wen Chen, Mandy L. Ford, Craig M. Coopersmith> ;Shock. 2019 Jan 1
5 citations
Increased mortality in CD43-deficient mice during sepsis.
Katherine T. Fay, Deena B. Chihade, Ching-Wen Chen, Nathan J. Klingensmith, John D. Lyons, Kimberly M. Ramonell, Zhe Liang, Craig M. Coopersmith, Mandy L. Ford> ;Plos One. 2018 Sep 18
15 citations
Chronic Alcohol Ingestion Worsens Survival and Alters Gut Epithelial Apoptosis and CD8+ T Cell Function After Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.
Nathan J. Klingensmith, Katherine T. Fay, John D. Lyons, Ching-Wen Chen, Shunsuke Otani, Zhe Liang, Deena B. Chihade, Eileen M. Burd, Mandy L. Ford, Craig M. Coopersmith> ;Shock. 2019 Apr 1
22 citations
CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis
Kimberly M. Ramonell, Wenxiao Zhang, Annette Hadley, Ching-Wen Chen, Katherine T. Fay, John D. Lyons, Nathan J. Klingensmith, Kevin W. McConnell, Craig M. Coopersmith,...> ;Plos One. 2017 Dec 12
30 citations
Effect of Remote Ischemic Preconditioning on Outcomes in Adult Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Studies.
Jianfeng Xie, Xiwen Zhang, Jingyuan Xu, Zhongheng Zhang, Nathan J. Klingensmith, Songqiao Liu, Chun Pan, Yi Yang, Haibo Qiu> ;Anesthesia and Analgesia. 2017 Nov 1
4 citations
Honokiol Increases CD4+ T Cell Activation and Decreases TNF but Fails to Improve Survival Following Sepsis.
Nathan J. Klingensmith, Ching-Wen Chen, Zhe Liang, Eileen M. Burd, Alton B. Farris, Jack L. Arbiser, Mandy L. Ford, Craig M. Coopersmith> ;Shock. 2017 Oct 1
38 citations
Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis.
Ching-Wen Chen, Rohit Mittal, Nathan J. Klingensmith, Eileen M. Burd, Cox Terhorst, Greg S. Martin, Craig M. Coopersmith, Mandy L. Ford> ;Journal of Immunology. 2017 Sep 15
5 citations
Sepsis reveals compartment-specific responses in intestinal proliferation and apoptosis in transgenic mice whose enterocytes re-enter the cell cycle
John D. Lyons, Nathan J. Klingensmith, Shunsuke Otani, Rohit Mittal, Zhe Liang, Mandy L. Ford, Craig M. Coopersmith> ;FASEB Journal. 2017 Aug 25
30 citations
Myosin Light Chain Kinase Knockout Improves Gut Barrier Function and Confers a Survival Advantage in Polymicrobial Sepsis
C. Adam Lorentz, Zhe Liang, Mei Meng, Ching-Wen Chen, Benyam P. Yoseph, Elise R. Breed, Rohit Mittal, Nathan J. Klingensmith, Alton B. Farris, Eileen M. Burd, Michael ...> ;Molecular Medicine. 2017 Jun 7
91 citations
New insights into the gut as the driver of critical illness and organ failure
Mei Meng, Nathan J. Klingensmith, Craig M. Coopersmith> ;Current Opinion in Critical Care. 2017 Apr 1
14 citations
Fecal microbiota transplantation for multiple organ dysfunction syndrome
Nathan J. Klingensmith, Craig M. Coopersmith> ;Critical Care. 2016 Dec 19
9 citations
Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis.
Lindsay M. Margoles, Rohit Mittal, Nathan J. Klingensmith, John D. Lyons, Zhe Liang, Mara A. Serbanescu, Maylene E. Wagener, Craig M. Coopersmith, Mandy L. Ford> ;Plos One. 2016 Nov 18
25 citations
Epidermal Growth Factor Improves Intestinal Integrity and Survival in Murine Sepsis Following Chronic Alcohol Ingestion.
Nathan J. Klingensmith, Benyam P. Yoseph, Zhe Liang, John D. Lyons, Eileen M. Burd, Lindsay M. Margoles, Michael Koval, Mandy L. Ford, Craig M. Coopersmith> ;Shock. 2017 Feb 1
150 citations
Mechanisms of Intestinal Barrier Dysfunction in Sepsis.
Benyam P. Yoseph, Nathan J. Klingensmith, Zhe Liang, Elise R. Breed, Eileen M. Burd, Rohit Mittal, Jessica A. Dominguez, Benjamin Petrie, Mandy L. Ford, Craig M. Coope...> ;Shock. 2016 Jul 1
221 citations
The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness.
Nathan J. Klingensmith, Craig M. Coopersmith> ;Critical Care Clinics. 2016 Apr 1
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Hospital Affiliations

Grady Health SystemAtlanta, Georgia
Hospital of the University of PennsylvaniaPhiladelphia, Pennsylvania
Penn Presbyterian Medical CenterPhiladelphia, Pennsylvania
Pennsylvania HospitalPhiladelphia, Pennsylvania