NathanIvanShapiroMD

Emergency Medicine • Boston, MA

Associate Professor, Medicine-Beth Israel Deaconess Medical Center, Harvard Medical School

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Office
330 Brookline Ave
Cc2-W
Boston, MA 02215
Phone+1 617-754-2343
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Education & Training

Massachusetts General Hospital/Brigham and Women’s Hospital/Harvard Medical SchoolResidency, Emergency Medicine, 1997 - 2000
Lewis Katz School of Medicine at Temple UniversityClass of 1996

Certifications & Licensure

MA State Medical License 1999 - 2025
RI State Medical License 2005 - 2006
PA State Medical License 2002 - 2006
American Board of Emergency Medicine Emergency Medicine

Clinical Trials

The Utility of Ischemia Modified Albumin (IMA) in Sepsis Start of enrollment: 2007 Mar 01
Completed
Endothelium in Severe Sepsis Start of enrollment: 2008 Mar 01
Completed
Assessment of Acute Disease to Reduce Imaging Costs Start of enrollment: 2010 Jan 01
Completed
Not Applicable
Near Infrared Spectroscopy (St02) Start of enrollment: 2009 Jan 01
Completed
Pilot Study of Bevacizumab (Avastin) in Patients With Septic Shock Start of enrollment: 2010 Feb 01
Withdrawn
Not Applicable
Preemptive Resuscitation for Eradication of Septic Shock Start of enrollment: 2011 Sep 01
Completed
Not Applicable
Procalcitonin Monitoring Sepsis Study Start of enrollment: 2011 Dec 01
Completed
Efficacy and Safety of Ularitide for the Treatment of Acute Decompensated Heart Failure Start of enrollment: 2012 Jul 01
Completed
Phase 3
Rapid Administration of Carnitine in sEpsis Start of enrollment: 2013 Jan 01
Completed
Phase 2
Reoxygenation After Cardiac Arrest (REOX Study) Start of enrollment: 2013 Jun 01
Completed
Hematoma Block for Distal Radius Fracture Start of enrollment: 2014 Aug 01
Recruiting
Not Applicable
Biomarkers in Infection Start of enrollment: 2006 Apr 01
Recruiting
Reoxygenation After Cardiac Arrest II (REOX II Study) Start of enrollment: 2016 Apr 01
Completed
Phase 1
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients Start of enrollment: 2018 Nov 10
Suspended
Early Identification of SEPsis SIGNs in Emergency Department Start of enrollment: 2020 Jul 06
Completed
Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19 Start of enrollment: 2020 Jun 01
Completed
Phase 2
Novel Experimental COVID-19 Therapies Affecting Host Response Start of enrollment: 2021 Jul 15
Completed
Phase 2, Phase 3
Roles: Contact
Pragmatic Trial Examining Oxygenation Prior to Intubation Start of enrollment: 2022 Mar 10
Completed
Not Applicable
Roles: Contact
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Publications & Presentations

PubMed

2 citations
Vaccine Effectiveness Against Influenza A-Associated Hospitalization, Organ Failure, and Death: United States, 2022-2023.
Nathaniel M Lewis, Yuwei Zhu, Ithan D Peltan, Manjusha Gaglani, Tresa McNeal, Shekhar Ghamande, Jay S Steingrub, Nathan I Shapiro, Abhijit Duggal, William S Bender, Le...> ;Clinical Infectious Diseases. 2024 Apr 10
Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults.
Diya Surie, Katharine A Yuengling, Jennifer DeCuir, Yuwei Zhu, Adam S Lauring, Manjusha Gaglani, Shekhar Ghamande, Ithan D Peltan, Samuel M Brown, Adit A Ginde, Amanda...> ;JAMA Network Open. 2024 Apr 1
Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial.
Jason N Kennedy, Chung-Chou H Chang, Kevin Delucchi, David T Huang, Max S Kravitz, Derek C Angus, Kimberley M DeMerle, Nathan I Shapiro, Donald M Yealy, Carolyn S Calf...> ;Scientific Reports. 2024 Mar 14
The Interaction of Acute Kidney Injury with Resuscitation Strategy in Sepsis: A Secondary Analysis of a Multicenter, Phase 3, Randomized Clinical Trial (CLOVERS).
Ayesha Khader, Leila R Zelnick, Neha A Sathe, Bryan R Kestenbaum, Jonathan Himmelfarb, Nicholas J Johnson, Nathan I Shapiro, Ivor S Douglas, Catherine L Hough, Pavan K...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Dec 15
Characterizing malpractice cases involving emergency department advanced practice providers, physicians in training, and attending physicians.
Peter S Antkowiak, Shin-Yi Lai, Ryan C Burke, Margaret Janes, Tarek Zawi, Nathan I Shapiro, Carlo L Rosen> ;Academic Emergency Medicine. 2023 Dec 1
13 citations
Changing Severity and Epidemiology of Adults Hospitalized With Coronavirus Disease 2019 (COVID-19) in the United States After Introduction of COVID-19 Vaccines, March ...
Noah Kojima, Katherine Adams, Wesley H Self, Manjusha Gaglani, Tresa McNeal, Shekhar Ghamande, Jay S Steingrub, Nathan I Shapiro, Abhijit Duggal, Laurence W Busse, Mat...> ;Clinical Infectious Diseases. 2023 Aug 22
2 citations
Total and Subgenomic RNA Viral Load in Patients Infected With SARS-CoV-2 Alpha, Delta, and Omicron Variants.
Dimcheff, D., Blair, C., Zhu, Y., Chappell, J., Gaglani, M., McNeal, T., Ghamande, S., Steingrub, J., Shapiro, N., Duggal, A., Busse, L., Frosch, A., Peltan, I., Hager...> ;The Journal of Infectious Diseases. 2023 Aug 11
2 citations
Comparison of mRNA vaccine effectiveness against COVID-19-associated hospitalization by vaccination source: Immunization information systems, electronic medical record...
Surie, D., Bonnell, L., DeCuir, J., Gaglani, M., McNeal, T., Ghamande, S., Steingrub, J., Shapiro, N., Busse, L., Prekker, M., Peltan, I., Brown, S., Hager, D., Ali, H...> ;Vaccine. 2023 Jun 29
2 citations
Effect of intravenous fluid volume on biomarkers of endothelial glycocalyx shedding and inflammation during initial resuscitation of sepsis.
Stephen Macdonald, Erika Bosio, Gerben Keijzers, Sally Burrows, Moira Hibbs, Helen O'Donoghue, David Taylor, Ashes Mukherjee, Frances Kinnear, Lisa Smart, Juan-Carlos ...> ;Intensive Care Medicine Experimental. 2023 Apr 17
63 citations
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
, Nathan I Shapiro, Ivor S Douglas, Roy G Brower, Samuel M Brown, Matthew C Exline, Adit A Ginde, Michelle N Gong, Colin K Grissom, Douglas Hayden, Catherine L Hough, ...> ;The New England Journal of Medicine. 2023 Feb 9
3 citations
Absolute and Relative Vaccine Effectiveness of Primary and Booster Series of COVID-19 Vaccines (mRNA and Adenovirus Vector) Against COVID-19 Hospitalizations in the Un...
Nathaniel M Lewis, Nancy Murray, Katherine Adams, Diya Surie, Manjusha Gaglani, Adit A Ginde, Tresa McNeal, Shekhar Ghamande, David J Douin, H Keipp Talbot, Jonathan D...> ;Open Forum Infectious Diseases. 2023 Jan 1
5 citations
Lopinavir/ritonavir for treatment of non-hospitalized patients with COVID-19: a randomized clinical trial.
Alexander M Kaizer, Nathan I Shapiro, Jessica Wild, Samuel M Brown, B Jessica Cwik, Kimberly W Hart, Alan E Jones, Michael S Pulia, Wesley H Self, Clay Smith, Stephani...> ;International Journal of Infectious Diseases. 2023 Mar 1
4 citations
Comparison of test-negative and syndrome-negative controls in SARS-CoV-2 vaccine effectiveness evaluations for preventing COVID-19 hospitalizations in the United States.
Caitlin Turbyfill, Katherine Adams, Mark W Tenforde, Nancy L Murray, Manjusha Gaglani, Adit A Ginde, Tresa McNeal, Shekhar Ghamande, David J Douin, H Keipp Talbot, Jon...> ;Vaccine. 2022 Nov 15
6 citations
Vaccine Effectiveness Against Influenza A(H3N2)-Associated Hospitalized Illness: United States, 2022.
Mark W Tenforde, Manish M Patel, Nathaniel M Lewis, Katherine Adams, Manjusha Gaglani, Jay S Steingrub, Nathan I Shapiro, Abhijit Duggal, Matthew E Prekker, Ithan D Pe...> ;Clinical Infectious Diseases. 2023 Mar 21
6 citations
Neutralizing antibody responses in patients hospitalized with SARS-CoV-2 Delta or Omicron infection.
Susanne L Linderman, Lilin Lai, Estefany L Bocangel Gamarra, Max Sy Lau, Srilatha Edupuganti, Diya Surie, Mark W Tenforde, James D Chappell, Nicholas M Mohr, Kevin W G...> ;The Journal of Clinical Investigation. 2022 Dec 1
Comparison of clinical note quality between an automated digital intake tool and the standard note in the emergency department.
Ron Eshel, Fernanda Bellolio, Andy Boggust, Nathan I Shapiro, Aidan F Mullan, Heather A Heaton, Bo E Madsen, James L Homme, Benjamin W Iliff, Kharmene L Sunga, Cameron...> ;The American Journal of Emergency Medicine. 2023 Jan 1
44 citations
Vaccine effectiveness of primary series and booster doses against covid-19 associated hospital admissions in the United States: living test negative design study.
Katherine Adams, Jillian P Rhoads, Diya Surie, Manjusha Gaglani, Adit A Ginde, Tresa McNeal, H Keipp Talbot, Jonathan D Casey, Anne Zepeski, Nathan I Shapiro, Kevin W ...> ;BMJ. 2022 Oct 11
2 citations
Diagnostic Accuracy of a Bacterial and Viral Biomarker Point-of-Care Test in the Outpatient Setting.
Nathan I Shapiro, Michael R Filbin, Peter C Hou, Michael C Kurz, Jin H Han, Tom P Aufderheide, Michael A Ward, Michael S Pulia, Robert H Birkhahn, Jorge L Diaz, Teena ...> ;JAMA Network Open. 2022 Oct 3
15 citations
Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized With COVID-19: A Blinded, Randomized, Placebo-Controlled Trial.
Wesley H Self, Allison P Wheeler, Thomas G Stewart, Harry Schrager, Jason Mallada, Christopher B Thomas, Vince D Cataldo, Hollis R O'Neal Jr, Nathan I Shapiro, Conor H...> ;Chest. 2022 Nov 1
Characterization of older adults with cancer seeking acute emergency department care: A prospective observational study.
Jason J Bischof, Mohamed I Elsaid, John F P Bridges, Ashley E Rosko, Carolyn J Presley, Beau Abar, David Adler, Aveh Bastani, Christopher W Baugh, Steven L Bernstein, ...> ;Journal of Geriatric Oncology. 2022 Sep 1
3 citations
Palliative Care Needs and Clinical Outcomes of Patients with Advanced Cancer in the Emergency Department.
Sule Yilmaz, Corita R Grudzen, Danielle D Durham, Caroline McNaughton, Isabelle Marcelin, Beau Abar, David Adler, Aveh Bastani, Christopher W Baugh, Steven L Bernstein...> ;Journal of Palliative Medicine. 2022 Jul 1
6 citations
Trial of Early Antiviral Therapies during Non-hospitalized Outpatient Window (TREAT NOW) for COVID-19: a summary of the protocol and analysis plan for a decentralized ...
Alexander M Kaizer, Jessica Wild, Christopher J Lindsell, Todd W Rice, Wesley H Self, Samuel Brown, B Taylor Thompson, Kimberly W Hart, Clay Smith, Michael S Pulia, Na...> ;Trials. 2022 Apr 8
15 citations
mRNA Vaccine Effectiveness Against Coronavirus Disease 2019 Hospitalization Among Solid Organ Transplant Recipients.
Jennie H Kwon, Mark W Tenforde, Manjusha Gaglani, H Keipp Talbot, Adit A Ginde, Tresa McNeal, Shekhar Ghamande, David J Douin, Jonathan D Casey, Nicholas M Mohr, Anne ...> ;The Journal of Infectious Diseases. 2022 Sep 13
355 citations
Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observa...
Adam S Lauring, Mark W Tenforde, James D Chappell, Manjusha Gaglani, Adit A Ginde, Tresa McNeal, Shekhar Ghamande, David J Douin, H Keipp Talbot, Jonathan D Casey, Nic...> ;BMJ. 2022 Mar 9
3 citations
Observation Unit Use Among Patients with Cancer Following Emergency Department Visits: Results of a Multicenter Prospective Cohort from CONCERN.
Adam Klotz, Jeffrey M. Caterino, Danielle D. Durham, Juan Felipe Rico, Daniel J. Pallin, Corita Grudzen, Caroline McNaughton, Isabelle Marcelin, Beau Abar, David H. Ad...> ;Academic Emergency Medicine. 2021 Nov 22
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Journal Articles

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients with COVID-19
Matthew W Semler, Lindsay M Leither, Derek C Angus, Roy G Brower, Steven Y Chang, John C Eppensteiner, Michael R Filbin, Adit A Ginde, Michelle N Gong, Douglas L Hayde..., JAMA

Press Mentions

For Septic Shock, Another Toss-up Between Emphasizing Vasopressors vs FluidsJanuary 21st, 2023
Symptoms and Recovery Among Adult Outpatients with and Without COVID‐19 at 11 Healthcare Facilities—July 2020, United StatesJanuary 6th, 2021
More About COVID-19: Where Are We Now and Where Are We Headed?November 10th, 2020
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