Nathan Ivan Shapiro MD
Associate Professor, Medicine-Beth Israel Deaconess Medical Center, Harvard Medical School
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330 Brookline AveCC2WBoston, MA 02215
Phone+1 617-754-2343
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Education & Training
Massachusetts General Hospital/Brigham and Women’s Hospital/Harvard Medical SchoolResidency, Emergency Medicine, 1997 - 2000
Lewis Katz School of Medicine at Temple UniversityClass of 1996
Certifications & Licensure
MA State Medical License 1999 - 2027
PA State Medical License 2002 - 2006
RI State Medical License 2005 - 2006
American Board of Emergency Medicine Emergency Medicine
Clinical Trials
Publications & Presentations
PubMed
- A whole-blood cryopreservation method streamlines clinical sample collection for multimodal single-cell immune profiling in sepsis.Alyssa K DuBois, Pierre O Ankomah, Alexis C Campbell, Renee Hua, Olivia K Nelson
JCI Insight. 2026-08-24 - Modeling treatment effects on absorbing outcomes in clinical trials: Leveraging longitudinal and ordinal data for efficiency gains.Chiara Di Gravio, Ran Tao, Yunbi Nam, Eric P Schmidt, Nathan Shapiro
Statistical Methods in Medical Research. 2026-08-01 - 1 citationsMachine Learning to Identify Physician Actions Associated with Patient Experience of Compassion.Clifford M Marks, Patrice Baptista, Cameron Gaines, Christopher W Jones, Lauren Remboski
Journal of General Internal Medicine. 2026-08-01
Journal Articles
- Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients with COVID-19Matthew W Semler, Lindsay M Leither, Derek C Angus, Roy G Brower, Steven Y Chang, John C Eppensteiner, Michael R Filbin, Adit A Ginde, Michelle N Gong, Douglas L Hayde..., JAMA
Press Mentions
Immune Cell ‘Signatures’ Could Help Guide Treatment for Critically Ill PatientsSeptember 30th, 2025- For Septic Shock, Another Toss-up Between Emphasizing Vasopressors vs FluidsJanuary 21st, 2023
Symptoms and Recovery Among Adult Outpatients with and Without COVID‐19 at 11 Healthcare Facilities—July 2020, United StatesJanuary 6th, 2021
Grant Support
- Genetically Linked Metabolites of Sepsis Severity and MortalityUNIVERSITY OF MICHIGAN AT ANN ARBOR2025–2027
- Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsisMASSACHUSETTS GENERAL HOSPITAL2023–2027
- Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection effortsMASSACHUSETTS GENERAL HOSPITAL2023–2026
- Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsisMASSACHUSETTS GENERAL HOSPITAL2023–2025
- The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic ShockBETH ISRAEL DEACONESS MEDICAL CENTER2019–2025
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