NathanielMyerWeathingtonMD

PubMed

• An answered call for aid? Cannabinoid clinical framework for the opioid epidemic.
  Krista Hammaker, Nathaniel Weathington, Joseph Maroon, Lawton W Tang, Brian Donohue, Rachel Yehuda, Kenneth M Ford, Myro Figura, Ben Kelmendi, Belinda Tan, Matthew W C...> ;Harm Reduction Journal. 2023 Aug 16
• 4 citations
  β-Agonist exposure preferentially impacts lung macrophage cyclic AMP-related gene expression in asthma and asthma COPD overlap syndrome
  Kaveh Moghbeli, Eleanor Valenzi, Rachel Naramore, John Sembrat, Kong Chen, Mauricio Rojas, Sally E. Wenzel, Robert Lafyatis, Brian D. Modena, Nathaniel M. Weathington> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2021 Sep 8
• 38 citations
  Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1
  Yuan Liu, Travis Lear, Manish Verma, Kent Z.Q. Wang, P. Anthony Otero, Alison C. McKelvey, Sarah R. Dunn, Erin Steer, Nicholas W. Bateman, Christine C. Wu, Yu Jiang, N...> ;JCI Insight. 2020 Jun 4
• 9 citations
  Tumor Necrosis Factor Alpha Regulates Skeletal Myogenesis by Inhibiting SP1 Interaction with cis-Acting Regulatory Elements within the Fbxl2 Gene Promoter
  Michael E. O’Brien, James D. Londino, Marcus McGinnis, Nathaniel M. Weathington, Jessica Adair, Tomeka Suber, Valerian E. Kagan, Kong Chen, Chunbin Zou, Bill B. Chen, ...> ;Molecular and Cellular Biology. 2020 May 28
• 55 citations
  Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome.
  Georgios D Kitsios, L. Yang, Dimitris V. Manatakis, Mehdi Nouraie, John Evankovich, William Bain, Daniel G. Dunlap, Faraaz Ali Shah, Ian J. Barbash, Sarah F. Rapport, ...> ;Critical Care Medicine. 2019 Dec 1
• 26 citations
  BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications.
  Nathaniel M. Weathington, Michael E. O’Brien, Josiah E. Radder, Thomas Whisenant, Eugene R. Bleecker, William W. Busse, Serpil C. Erzurum, Benjamin Gaston, Annette T. ...> ;American Journal of Respiratory and Critical Care Medicine. 2019 Oct 1
• 22 citations
  The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.
  Lian Li, Jianxin Wei, Shuang Li, Anastasia M. Jacko, Nathaniel M. Weathington, Rama K. Mallampalli, Jing Zhao, Yutong Zhao> ;Ebiomedicine. 2019 Jun 14
• 32 citations
  IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription
  Sarah K. Whitley, Anand Balasubramani, Carlene L. Zindl, Ranjan Sen, Yoichiro Shibata, Gregory E. Crawford, Nathaniel M. Weathington, Robin D. Hatton, Casey T. Weaver> ;The Journal of Biological Chemistry. 2018 Oct 12
• 18 citations
  Ex vivo lung perfusion as a human platform for preclinical small molecule testing
  Nathaniel M. Weathington, Diana Alvarez, John Sembrat, Josiah E. Radder, Nayra Cardenes, Kentaro Noda, Qiaoke Gong, Hesper Wong, Jay K. Kolls, Jonathan D'Cunha, Rama K...> ;JCI Insight. 2018 Oct 4
• 27 citations
  Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells.
  Dan Wang, Jing Zhao, Shuang Li, Jianxin Wei, Ling Nan, Rama K. Mallampalli, Nathaniel M. Weathington, Haichun Ma, Yutong Zhao> ;Journal of Molecular Cell Biology. 2018 Feb 1
• 24 citations
  The deubiquitinating enzyme USP48 stabilizes TRAF2 and reduces E-cadherin-mediated adherens junctions
  Shuang Li, Dan Wang, Jing Zhao, Nathaniel M. Weathington, Dong Shang, Yutong Zhao> ;FASEB Journal. 2018 Jan 1
• 22 citations
  Post-translational modification of the interferon-gamma receptor alters its stability and signaling.
  James D. Londino, Dexter L. Gulick, Travis Lear, Tomeka Suber, Nathaniel M. Weathington, Luke S. Masa, Bill B. Chen, Rama K. Mallampalli> ;The Biochemical Journal. 2017 Oct 15
• 6 citations
  IL-4 Induces IL17Rb Gene Transcription in Monocytic Cells with Coordinate Autocrine IL-25 Signaling.
  Nathaniel M. Weathington, Shreya M. Kanth, Qiaoke Gong, James D. Londino, Akihiko Hoji, Mauricio Rojas, John B. Trudeau, Sally E. Wenzel, Rama K. Mallampalli> ;American Journal of Respiratory Cell and Molecular Biology. 2017 Sep 1
• 37 citations
  Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation
  Elizabeth A. Lendermon, Tiffany A. Coon, Joseph S. Bednash, Nathaniel M. Weathington, John F. McDyer, Rama K. Mallampalli> ;Respiratory Research. 2017 Jun 28
• 41 citations
  Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity.
  Joseph S. Bednash, Nathaniel M. Weathington, James D. Londino, Mauricio Rojas, Dexter L. Gulick, Robert Fort, SeungHye Han, Alison C. McKelvey, Bill B. Chen, Rama K. M...> ;Nature Communications. 2017 May 11
• 72 citations
  Bioactive extracellular matrix fragments in lung health and disease
  Amit Gaggar, Nathaniel M. Weathington> ;The Journal of Clinical Investigation. 2016 Sep 1
• 5 citations
  APO-9'-Fucoxanthinone Extracted from Undariopsis peteseniana Protects Oxidative Stress-Mediated Apoptosis in Cigarette Smoke-Exposed Human Airway Epithelial Cells
  Jun-Ho Jang, Ji-Hyeok Lee, Hitendra S. Chand, Jong-Soo Lee, Yong Lin, Nathaniel M. Weathington, Rama K. Mallampalli, You-Jin Jeon, Toru Nyunoya> ;Marine Drugs. 2016 Jul 21
• 35 citations
  Aging and Lung Disease. Clinical Impact and Cellular and Molecular Pathways.
  Mauricio Rojas, Ana L. Mora, Maria G. Kapetanaki, Nathaniel M. Weathington, Mark T. Gladwin, Oliver Eickelberg> ;Annals of the American Thoracic Society. 2015 Dec 11
• 22 citations
  Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia
  Chunbin Zou, Jin Li, Sheng Xiong, Yan Chen, Qin Wu, Xiuying Li, Nathaniel M. Weathington, SeungHye Han, Courtney Snavely, Bill B. Chen, Rama K. Mallampalli> ;Science Translational Medicine. 2015 Oct 28
• 38 citations
  The proinflammatory role of HECTD2 in innate immunity and experimental lung injury
  Tiffany A. Coon, Alison C. McKelvey, Travis Lear, Shristi Rajbhandari, Sarah R. Dunn, William Connelly, Joe Y. Zhao, SeungHye Han, Yuan Liu, Nathaniel M. Weathington, ...> ;Science Translational Medicine. 2015 Jul 8
• 7 citations
  The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor
  Joseph Franz, Travis Lear, Qiaoke Gong, Nathaniel M. Weathington, Jerome, J., Jacob A. Jerome> ;Journal of Immunology Research. 2015 Jun 11
• 14 citations
  CD8(+)IL-17(+) T Cells Mediate Neutrophilic Airway Obliteration in T-bet-Deficient Mouse Lung Allograft Recipients.
  Elizabeth A. Lendermon, Jeffrey M. Dodd-o, Hannah L. Miller, Sudipto Ganguly, Iulia Popescu, Christopher P. O'Donnell, Nayra Cardenes, Melanie Levine, Mauricio Rojas, ...> ;American Journal of Respiratory Cell and Molecular Biology. 2015 May 1
• 22 citations
  Lysophosphatidic acid receptor 1 antagonist ki16425 blunts abdominal and systemic inflammation in a mouse model of peritoneal sepsis
  Jing Zhao, Jianxin Wei, Nathaniel M. Weathington, Anastasia M. Jacko, Hai Huang, Allan Tsung, Yutong Zhao> ;Translational Research. 2015 Jul 1
• 19 citations
  Serum starvation regulates E-cadherin upregulation via activation of c-Src in non-small-cell lung cancer A549 cells.
  Su Dong, Andrew Khoo, Jianxin Wei, Rachel K. Bowser, Nathaniel M. Weathington, Shuqi Xiao, Lina Zhang, Haichun Ma, Yutong Zhao, Jing Zhao> ;American Journal of Physiology. Cell Physiology. 2014 Nov 1
• 24 citations
  Glycogen Synthase Kinase-3β Stabilizes the Interleukin (IL)-22 Receptor from Proteasomal Degradation in Murine Lung Epithelia
  Nathaniel M. Weathington, Courtney Snavely, Bill B. Chen, Jing Zhao, Yutong Zhao, Rama K. Mallampalli> ;The Journal of Biological Chemistry. 2014 Jun 20
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Journal Articles

• Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells  
  Wang D, Zhao J, Li S, Nan L, Weathington NM, Ma H, Zhao Y, J Mol Cell Biol, 1/1/2017
• Post-translational modification of the interferon gamma receptor alters its stability and signaling  
  Londino JD, Gullick DL, Lear TB, Suber TL, Weathington NM, Masa LS, Chen BB, Mallampalli RK, Biochem J, 1/1/2017
• APO-9'-Fucoxanthinone extracted from undariopsis peteseniana protects oxidative stress-mediated apoptosis in cigarette smoke-exposed human airway epithelial cells  
  Jang JH, Lee JH, Chand HS, Lee JS, Lin Y, Weathington NM, Mallampalli R, Jeon YJ, Nyunoya T, Marine Drugs, 1/1/2016
• Novel PDE4 inhibitors derived from Chinese medicine forsythia  
  Coon TA, McKelvey AC, Weathington NM, Birru RL, Lear T, Leikauf GD, Chen BB, PLoS One, 1/1/2014
• Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation  
  Lendermon EA, Coon TA, Bednash JS, Weathington NM, McDyer JF, Mallampalli RK, Respir Res, 1/11/2017
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Abstracts/Posters

• Small molecule inhibition of the CHIP E3 ligase stabilizes deltaf508 CFTR in HEK cell lines
  Franz J, Londino JD, Chen B, Myerburg M, Weathington NM, Straub A, Am J Respir Crit Care Med, American Thoracic Society International Scientific Meeting, Washington, DC, 1/1/2017
• IL-4 dependent IL17Rb gene transcription requires coordinate autocrine Il-25 signaling in monocytes and alveolar macrophages
  Kanth S, Gong Q, Tedrow J, Wenzel SW, Mallampalli R, Weathington NM, Am J Respir Crit Care Med, American Thoracic Society International Scientific Meeting, Washington, DC, 1/1/2017
• Azithromycin decreases NALP3 expression in THP-1 cells
  Lendermon EA, Coon TA, Bednash JS, Weathington NM, McDyer JF, Mallampalli RK, Am J Respir Crit Care Med, American Thoracic Society International Scientific Meeting, Washington, DC, 1/1/2017
• IL-4 as a driver of the IL-25 signaling axis in alveolar macrophages and monocytes
  Weathington NM, Kanth S, Gong Q, Mallampalli, RK, Pittsburgh Munich International Lung Conference, Pittsburgh, PA, 1/1/2016
• The IL-25 signaling Axis is Induced by Th2 cytokine IL-4 in Human Monocytes and Macrophages
  Kanth S, Gong Q, Mallampalli RK, and Weathington NM, University of Pittsburgh Department of Medicine Research Day, Pittsburgh, PA, 1/1/2016
• Human Ex-Vivo Lung Preparations for Testing the Anti-Inflammatory Small Molecule BC1215
  Weathington NM, Alvarez DA, Sembrat J, Cardenes N, Noda K, Mallampalli RK, D’Cuhna J, Chen BB, Rojas M, American Thoracic Society International Scientific Conference, San Francisco, CA, 1/1/2016
• Induction of Il-17rb And Il-25 In Human Monocytes and Macrophages Through the Action of Th2 Cytokine Il-4
  Kanth S, Gong Q, Mallampalli RK, and Weathington NM, American Thoracic Society International Scientific Conference, San Francisco, CA, 1/1/2016
• Inhibition of NALP7 Inflammasome Activity with A Novel Small Molecule Antagonist of The Deubiquitinase STAMBP
  Bednash JS, Weathington NM, Fort RJ, Mckelvey A, Chen BB, Mallampalli RK, American Thoracic Society International Scientific Conference, San Francisco, CA, 1/1/2016
• Human Ex Vivo Ventilated and Perfused Lung Preparations as a Platform for Drug Development
  Nathaniel Weathington, Diana Alvarez, John Sembrat, Nayra Cardenes, Kentaro Noda, Rama K Mallampalli, Jonathan D’Cuhna, Bill Chen, Mauricio Rojas, Munich Pittsburgh international lung conference, Munich, Germany, 1/1/2015
• Therapeutic targeting of the deubiquitinase STAMBP as a novel inhibitor of NALP7 inflammasome activity
  Joseph Bednash, Nathaniel Weathington, Robert Fort, Bill Chen Rama Mallampalli, Munich Pittsburgh International lung conference, Munich, Germany, 1/1/2015
• Il-22 Receptor Modulation By The E3 Ligase Subunit Fbxw12 Modulates Epithelial Proliferation And Host Defense Signaling
  Joseph Franz, Jake Jerome, Qiaoke Gong, Travis Lear, Nathaniel Weathington, American Thoracic Society International scientific meeting, Denver, CO, 1/1/2015
• Nalp7 Protein Expression Is Regulated by Ubiquitination In Response To LPS In Human Monocytes
  Joseph Bednash, Nathaniel Weathington, Robert Fort, Bill Chen Rama Mallampalli, American Thoracic Society International scientific meeting, Denver, CO, 1/1/2015
• The E3 Ligase Subunit FBXW12 Modulates the IL-22 Receptor Abundance and Host-Protective Epithelial Proliferation
  Nathaniel Weathington, Joseph Franz, Courtney Snavely, Jake Jerome, Qiaoke Gong, Travis Lear, Rama Mallampalli, American Society of Clinical Investigators Young Investigator Awards Poster Presentation, Chicago, IL, 1/1/2015
• The IL-22 Receptor is coordinately Regulated by the Ubiquitin Proteasome System and Glycogen Synthase Kinase-3beta
  Nathaniel Weathington, Courtney Snavely, Bill Chen, Jing Zhao, Yutong Zhao, Rama Mallampalli, American Thoracic Society International scientific meeting, San Diego, CA, 1/1/2014
• Interleukin 22 receptor abundance and signaling is regulated by the ubiquitin proteasome and glycogen synthase kinase 3beta
  Nathaniel Weathington, Courtney Snavely, Bill Chen, Jing Zhao, Yutong Zhao, Rama Mallampalli, IMMUNOLOGY 2014, Pittsburgh, PA, 1/1/2014
• The IL-22 Receptor, an Essential Component of Host Defense to Pneumonia, is Regulated by the Ubiquitin Proteasome System, and Stabilized by GSK-3beta
  Nathaniel Weathington, Courtney Snavely, Bill Chen, Jing Zhao, Yutong Zhao, Rama Mallampalli, Pittsburgh International Lung Conference, 1/1/2013
• Molecular and medhanistic characterization of the anti-inflammatory activity of Traditional Chinese medicinal plant Forsythia suspensa
  Tiffany A Coon, Nathaniel Weathington, Bill B Chen, Pittsburgh International Lung conference, 1/1/2013
• The IL-22 Receptor, An Essential Component of Host Defense to Pneumonia, is Regulated by the Ubiquitin-Proteasome System, and Depleted After IL22 Ligation
  Nathaniel Weathington, Courtney Snavely, Yutong Zhao, Rama Mallampalli, Meeting of the American Thoracic Society, Philadelphia, PA, 1/1/2013
• Regulation of the IL-22 Receptor by the Ubiquitin-Proteasome System with IL22 Ligation via Glycogen Synthase Kinase 3beta actitvity
  Nathaniel Weathington et al, University of Pittsburgh Department of Medicine research day, Pittsburgh, Pennsylvania, 1/1/2013
• The IL-22 receptor regulation by the ubiquitin proteasome
  Nathaniel Weathington, Mark Geraci for the pulmonary fellow’s retreat, Pittsburgh, PA, 1/1/2013
• Matrix Metalloprotease (MMP)-9 Modulates Surfactant Protein-D (SP-D) Functions In Vitro
  Preston Bratcher, Nathaniel Weathington, et al, American Thoracic Society International Scientific Conference, San Francisco, CA, 1/1/2012
• Matrix metalloproteinase-9 cleaves Surfactant Protein-D, and impairs its innate immune function in bacterial agglutination and opsonophagocytosis
  Peston Bratcher, Nathaniel Weathington, et al, Pittsburgh International Lung Conference, Pittsburgh, PA, 1/1/2011
• Matrix metalloproteinase-9 cleaves Surfactant Protein-D, impairing collectin function as a bacterial agglutinin and opsonin in vitro, and such cleavage is seen during ...
  Nathaniel M Weathington, Amit Gaggar, Xin Xu, and Robert Snelgrove, American Thoracic Society annual scientific conference, 1/1/2010
• Surfactant Protein D is cleaved by matrix metalloproteinase-9, resulting in disruption of collectin function
  Nathaniel M Weathington, Patricia L Jackson, Landon Wilson, Matthew Hardison, and Amit Gaggar, American Association of Immunologists annual scientific conference, 1/1/2009
• PGP: a peptide PMN chemoattractant derived from extracellular matrix breakdown and active on neutrophils
  Nathaniel M Weathington, J Edwin Blalock, et al, Days of Molecular Medicine meeting, Karolinska Institute, Stockholm, Sweden, 1/1/2006
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Lectures

• Pulmonary Function Tests interpretation and relevance 
  1/1/2017
• Acute Hemoptysis Management 
  1/1/2017
• Pulmonary Artery Catheterization and Interpretation 
  1/1/2017
• Hypoxemia Causes and Therapy 
  1/1/2017
• Interstitial Lung Disease 
  1/1/2017
• Understanding and Treating Shock 
  1/1/2017
• The physiologic, molecular and genetic basis of Protease-driven emphysematous COPD. From Gene SNPs to respiratory mechanics 
  1/1/2017
• Tipping Points and Moving Targets-Examining Molecular Switches and Homeostatic Control of Lung Inflammation 
  University of Pittsburgh School of Medicine - 1/1/2016
• Ex Vivo Ventilated Perfused Lungs as a relevant human system to model injury and test the novel anti-inflammatory 
  1/1/2016
• IL-4 as a driver of the IL-25 signaling axis in alveolar macrophages and monocytes 
  1/1/2016
• Mixed Signals and Molecular Switches for Innate Inflammatory Signaling in the Lung 
  Stanford University - 1/1/2016
• New molecular therapeutics targeting Integrin-TGF signaling in the pathophysiology of fibrotic disease 
  1/1/2015
• The cytokine receptor for IL22 is degraded through action of novel E3 Ubiquitin Ligase FBXW12, which acts as an epithelial growth suppressor 
  Washington, DC - 1/1/2014
• Cellular Regulation of IL-22R expression in pneumonia 
  Pittsburgh, PA - 1/1/2013
• A 56-year old man with acute onset dyspnea 
  Pittsburgh, PA - 1/1/2012
• Collagen breakdown as a driver of inflammation: PGP peptides in lung disease 
  1/1/2007
• Characterization of the molecular mechanism of the neutrophil chemoattractant PGP and its role in lung disease 
  University of Alabama Department of Medicine, Birmingham, AL - 1/1/2006
• Characterization of the CXCL activity of the collagen-liberated PGP peptide 
  University of Alabama Birmingham - 1/1/2006
• Variable EJP amplitude in stomatogastric muscles of Panulirus 
  Woods Hole, MA - 1/1/1999
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