NealKleimanMD

Cardiology • Houston, TX

Adult Congenital Heart Disease, Cardiac Electrophysiology, Interventional Cardiology

Adjunct Professor, Cardiology, Baylor College of Medicine

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Office
6550 Fannin Street
Suite 1901
Houston, TX 77030
Phone+1 713-441-1100

Fax+1 713-790-2643
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Education & Training

Baylor College of MedicineFellowship, Cardiovascular Disease, 1984 - 1987
Baylor College of MedicineResidency, Internal Medicine, 1981 - 1984
Columbia University Vagelos College of Physicians and SurgeonsClass of 1981

Certifications & Licensure

TX State Medical License 1982 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease
American Board of Internal Medicine Interventional Cardiology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
Top Doctors:SE Texas Castle Connolly, 2013
Men's Health Castle Connolly, 2007
Super Doctor SuperDoctors.com
Fellow (FACC) American College of Cardiology
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Clinical Trials

Role of CYP2C19 Polymorphism in the Drug Interaction Between Clopidogrel and Omeprazole Start of enrollment: 2010 Jan 01
Completed
Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement Start of enrollment: 2010 Dec 10
Completed
Not Applicable
Diagnostic Study of Rapid Regadenoson Stress Cardiovascular Magnetic Resonance (CMR) to Detect Coronary Artery Disease Start of enrollment: 2011 Aug 01
Unknown status
Phase 4
Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Severe, Symptomatic Aortic Stenosis in Intermediate Risk Subjects Who Need Aortic Valve Replacement (SURTAVI). Start of enrollment: 2012 Apr 01
Active, not recruiting
Not Applicable
A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System Start of enrollment: 2012 Dec 01
Terminated
Phase 3
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS Start of enrollment: 2012 Aug 01
Active, not recruiting
Not Applicable
Safety & Efficacy Study of the Medtronic CoreValve® System-Treatment of Symptomatic Severe Aortic Stenosis With Significant Comorbidities in Extreme Risk Subjects Who Need Aortic Valve Replacement Start of enrollment: 2012 Aug 01
Active, not recruiting
SHIELD II Clinical Investigation Start of enrollment: 2015 Aug 01
Terminated
Not Applicable
ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement Start of enrollment: 2019 Jun 10
Recruiting
Not Applicable
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Percutaneous coronary intervention before transcatheter aortic valve implantation: A propensity score matched analysis.
Amro Agalan, Sumanth Khadke, Hassaan B Arshad, Safi U Khan, Sourbha S Dani, Sarju Ganatra, Talha Ahmed, Siddharth Agarwal, Syed Zaid, Salman Zahid, Alpesh R Shah, Sach...> ;Cardiovascular Revascularization Medicine. 2024 Mar 22
1 citations
Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis.
Daniel O'Hair, Paul Mahoney, Nicolas M Van Mieghem, Stephan Windecker, Mathew R Williams, Andrew D Althouse, Kendra J Grubb, John C Lisko, William Merhi, John K Forres...> ;JACC. Cardiovascular Interventions. 2024 Mar 7
Optimizing Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Older Adults.
Safi U Khan, Neal S Kleiman> ;JAMA Network Open. 2024 Mar 4
Characteristics and Outcomes of Patients Ineligible for Tricuspid Transcatheter Edge-to-Edge Repair.
Rody G Bou Chaaya, Sahar Samimi, Fatima Qamar, Nadeen Faza, Stephen H Little, Michael J Reardon, Neal S Kleiman, William A Zoghbi, Ashrith Guha, Syed Zaid, Sachin S Go...> ;Structural Heart. 2024 Mar 1
Impact of transcatheter heart valve type on outcomes of surgical explantation after failed transcatheter aortic valve replacement: the EXPLANT-TAVR international regis...
Zaid, S., Kleiman, N., Goel, S., Szerlip, M., Mack, M., Marin-Cuartas, M., Mohammadi, S., Nazif, T., Unbehaun, A., Andreas, M., Brinster, D., Robinson, N., Wang, L., R...> ;Eurointervention. 2024 Jan 15
Five-Year Follow-Up from the CoreValve Expanded Use Transcatheter Aortic Valve-in-Surgical Aortic Valve Study.
Bajwa, T., Laham, R., Khabbaz, K., Dauerman, H., Waksman, R., Weiss, E., Allaqaband, S., Badr, S., Caskey, M., Byrne, T., Applegate, R., Kon, N., Li, S., Kleiman, N., ...> ;The American Journal of Cardiology. 2024 Mar 1
1 citations
Intravascular imaging guided versus coronary angiography guided percutaneous coronary intervention: systematic review and meta-analysis.
Safi U Khan, Siddharth Agarwal, Hassaan B Arshad, Usman Ali Akbar, Mamas A Mamas, Shilpkumar Arora, Usman Baber, Sachin S Goel, Neal S Kleiman, Alpesh R Shah> ;BMJ. 2023 Nov 16
Characteristics and Outcomes of Patients Ineligible for Transcatheter Mitral Valve Replacement.
Taha Hatab, Syed Zaid, Priscilla Wessly, Nadeen Faza, Stephen H Little, Marvin D Atkins, Michael J Reardon, Neal S Kleiman, William A Zoghbi, Sachin S Goel> ;Structural Heart. 2023 Nov 1
Outcomes With Intravascular Ultrasound and Optical Coherence Tomography Guidance in Percutaneous Coronary Intervention.
Shilpkumar Arora, Rahul Jaswaney, Tasveer Khawaja, Akhil Jain, Safi U Khan, Umesh K Gidwani, Mohammed Najeeb Osman, Sachin Goel, Alpesh R Shah, Neal S Kleiman> ;The American Journal of Cardiology. 2023 Nov 15
Edge to Edge Mitral Valve Repair After Transcatheter Valve Implantation: Jumping the Gun or Doing What Needs to Be Done?
Neal S Kleiman> ;The American Journal of Cardiology. 2024 Jan 1
1 citations
TAV-in-TAV in Failed Homograft: Redo TAVI in a Patient With 3 Previous Sternotomies.
Syed Zaid, Priscilla Wessly, Michael J Reardon, Marvin D Atkins, Nadeen Faza, Stephen H Little, Neal S Kleiman, Sachin S Goel, Taha Hatab> ;JACC. Case Reports. 2023 Sep 20
Aortic Valve Calcium Score in Addition to Dobutamine Stress Echocardiography for Low-Flow, Low-Gradient Aortic Stenosis Assessment.
Kristian Kragholm, Ola Abdelkarim, Abhiraj Sinha, Salma Zook, Min-Fang Chao, Nadeen Faza, Sachin Goel, Michael Reardon, Neal Kleiman, Stephen Little, Su Min Chang> ;Journal of the American Society of Echocardiography. 2023 Dec 1
Now You See Me Now You Don't: Subaortic Membrane Causing a Diagnostic Dilemma.
Syed Zaid, Saleem Toro, Priscilla Wessly, Maan Malahfji, Nadeen Faza, Stephen H Little, Neal S Kleiman, Michael J Reardon, Sachin S Goel, Taha Hatab> ;JACC. Case Reports. 2023 Jul 19
An Updated Meta-Analysis on Cerebral Embolic Protection in Patients Undergoing Transcatheter Aortic Valve Intervention Stratified by Baseline Surgical Risk and Device ...
Safi U Khan, Salman Zahid, Mohamad A Alkhouli, Usman Ali Akbar, Syed Zaid, Hassaan B Arshad, Stephen H Little, Michael J Reardon, Neal S Kleiman, Sachin S Goel> ;Structural Heart. 2023 Jul 1
When Echocardiography Is Challenging in Localizing Bioprosthetic Aortic Regurgitation: Dye Don't Lie.
Priscilla Wessly, Syed Zaid, Nadeen Faza, Su Min Chang, Neal S Kleiman, Stephen H Little, Sachin S Goel, Taha Hatab> ;JACC. Case Reports. 2023 Jun 7
20 citations
Explant vs Redo-TAVR After Transcatheter Valve Failure: Mid-Term Outcomes From the EXPLANTORREDO-TAVR International Registry.
Gilbert H L Tang, Syed Zaid, Neal S Kleiman, Sachin S Goel, Shinichi Fukuhara, Mateo Marin-Cuartas, Philipp Kiefer, Mohamed Abdel-Wahab, Ole De Backer, Lars Søndergaar...> ;JACC. Cardiovascular Interventions. 2023 Apr 24
3 citations
30-Day Clinical Outcomes of a Self-Expanding Transcatheter Aortic Valve: The International PORTICO NG Study.
Michael J Reardon, Bassem Chehab, Dave Smith, Antony S Walton, Stephen G Worthley, Ganesh Manoharan, Ibrahim Sultan, Gerald Yong, Katherine Harrington, Paul Mahoney, N...> ;JACC. Cardiovascular Interventions. 2023 Mar 27
Site-level variability in the processes of care and outcomes over time among patients with COVID-19 and myocardial injury: Insights from the American Heart Association...
Yasser M Sammour, John A Spertus, Kevin Kennedy, David A Morrow, Lori B Daniels, Phil Jones, Heather Alger, Laura Stevens, Alpesh Shah, Sachin S Goel, James A de Lemos...> ;American Heart Journal Plus. 2023 Mar 1
27 citations
3-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis.
John K Forrest, G Michael Deeb, Steven J Yakubov, Hemal Gada, Mubashir A Mumtaz, Basel Ramlawi, Tanvir Bajwa, Paul S Teirstein, Michael DeFrain, Murali Muppala, Bruce ...> ;Journal of the American College of Cardiology. 2023 May 2
3 citations
What's New with TAVR? An Update on Device Technology.
Syed Zaid, Marvin D Atkins, Neal S Kleiman, Michael J Reardon, Gilbert H L Tang> ;Methodist Debakey Cardiovascular Journal. 2023 Jan 1
Tough Crossing: A Challenging Case of Valve-in-Valve Transcatheter Tricuspid Valve Replacement.
Tanush Gupta, C Huie Lin, Neal S Kleiman, Nadeen N Faza, Moritz Wyler C von Ballmoos, Stephen H Little, Michael J Reardon, Sachin S Goel> ;Structural Heart. 2023 Jan 1
2 citations
Transcatheter Aortic Valve Implantation: Long-Term Outcomes and Durability.
Sachin S Goel, Neal S Kleiman, Michael J Reardon, Parth V Desai> ;Methodist Debakey Cardiovascular Journal. 2023 Jan 1
Assessment of Repeat Revascularization in Percutaneous Coronary Intervention Randomized Controlled Trials as a Surrogate for Mortality: A Meta-Regression Analysis.
Safi U Khan, Ahmad N Lone, Usman Ali Akbar, Hassaan B Arshad, Adeel Arshad, Shilpkumar Arora, Edo Kaluski, Joe Aoun, Sachin S Goel, Alpesh R Shah, Neal S Kleiman> ;Current Problems in Cardiology. 2023 Apr 1
28 citations
Structural Valve Deterioration After Self-Expanding Transcatheter or Surgical Aortic Valve Implantation in Patients at Intermediate or High Risk.
Daniel O'Hair, Steven J Yakubov, Kendra J Grubb, Jae K Oh, Saki Ito, G Michael Deeb, Nicolas M Van Mieghem, David H Adams, Tanvir Bajwa, Neal S Kleiman, Stanley Chetcu...> ;JAMA Cardiology. 2023 Feb 1
1 citations
Late Transcatheter Aortic Valve Thrombosis Leading to Cardiogenic Shock.
Qasim Al Abri, Lamees I El Nihum, Tomoya Hinohara, Su Min Chang, Nadeen N Faza, Sachin S Goel, Neal S Kleiman, Moritz C Wyler von Ballmoos, Marvin D Atkins, Michael J ...> ;JACC. Case Reports. 2022 Nov 16
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Journal Articles

Effect of Catheter Ablation with Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation
Akash Makkar, Rahul N Doshi, David Delurgio, Charles A Athill, Kenneth A Ellenbogen, Andrea Natale, Jayanthi Koneru, Irakli Giorgberidze, Neal S Kleiman, JAMA
Transcatheter Aortic Valve Replacement in Low-Risk Patients with Bicuspid Aortic Valve Stenosis
John K Forrest, Basel Ramlawi, Neal S Kleiman, Stanley J Chetcuti, Hector I Michelena, Abeel A Mangi, Jeffrey A Skiles, Jeffrey J Popma, Michael J Reardon, JAMA Cardiology
Original Investigation Neurological Complications After Transcatheter Versus Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Jeffrey J Popma, Thomas G Gleason, William H Ryan, Neal S Kleiman, Tanvir Bajwa, David L Brown, ScienceDirect
Original Investigation Self-Expanding Transcatheter Aortic Valve Replacement or Surgical Valve Replacement in High-Risk Patients: 5-Year Outcomes
G Michael Deeb, Steven J Yakubov, Joon S Lee, Thomas G Gleason, William Merhi, George Petrossian, G Chad Hughes, David H Adams, Neal S Kleiman, Jeffrey J Popma, Mubash..., ScienceDirect
Editorial Comment Does Orientation Matter?∗
Michael J Reardon, Neal S Kleiman, ScienceDirect
Reticulated Platelets: Changing Focus from Basics to Outcomes
Bashar Hannawi, Neal S Kleiman, Yousef Hannawi, Thrombosis and Haemostasis
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Authored Content

Featured Science and Key Takeaways from TCT 2020 (Part 2)October 2020
Focus on Stroke Risk and Prevention Editorial Comment Never so Simple: Bedside Measurement of Platelet Reactivity and the Risk of Stroke After Coronary Stenting∗July 2018
Early Experience with New Transcatheter Mitral Valve ReplacementJanuary 2018
Early Experience with New Transcatheter Mitral Valve ReplacementJanuary 2018
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Press Mentions

Pre-AVR Cardiac Damage in PARTNER Patients Linked to Poorer QoL at 1 YearSeptember 23rd, 2022
Conversations in Cardiology: Music in the Cath Lab?August 12th, 2021
Another Bioresorbable Stent Hits a SnagAugust 6th, 2021
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