NeekeshVijayDhariaMDPhD

PubMed

• STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma.
  Nicole Prutsch, Shuning He, Alla Berezovskaya, Adam D Durbin, Kelsey A Maher, Jamie D Matthews, Lucy Hare, Suzanne D Turner, Lukas Kenner, Olaf Merkel, Brian J Abraham...> ;Cell Reports. Medicine. 2024 Mar 19
• 1 citations
  Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial.
  Desai, J., Alonso, G., Kim, S., Cervantes, A., Karasic, T., Medina, L., Shacham-Shmueli, E., Cosman, R., Falcon, A., Gort, E., Guren, T., Massarelli, E., Miller, W., P...> ;Nature Medicine. 2024 Jan 1
• 4 citations
  Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.
  Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L Downey-Kopyscinski, Geoffrey M Matthews, Benjamin G Barwick, Vikas A Gupta, Daphné Dupéré-Richer, Shizuka Yamano, ...> ;Nature Cancer. 2023 May 1
• 2 citations
  Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops.
  Taku Harada, Jérémie Kalfon, Monika W Perez, Kenneth Eagle, Flora Dievenich Braes, Rashad Batley, Yaser Heshmati, Juliana Xavier Ferrucio, Jazmin Ewers, Stuti Mehta, A...> ;Biorxiv. 2023 Mar 15
• 13 citations
  The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma.
  Diana Y Lu, Jana M Ellegast, Kenneth N Ross, Clare F Malone, Shan Lin, Nathaniel W Mabe, Neekesh V Dharia, Ashleigh Meyer, Amy Conway, Angela H Su, Julia Selich-Anders...> ;Nature Cell Biology. 2023 Feb 1
• 18 citations
  BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma.
  Eshini Panditharatna, Joana G Marques, Tingjian Wang, Maria C Trissal, Ilon Liu, Li Jiang, Alexander Beck, Andrew Groves, Neekesh V Dharia, Deyao Li, Samantha E Hoffma...> ;Cancer Discovery. 2022 Dec 2
• 5 citations
  Transcriptional Plasticity Drives Leukemia Immune Escape.
  Kenneth Eagle, Taku Harada, Jérémie Kalfon, Monika W Perez, Yaser Heshmati, Jazmin Ewers, Jošt Vrabič Koren, Joshua M Dempster, Vikram R Paralkar, Charles Y Lin, Neeke...> ;Blood Cancer Discovery. 2022 Sep 6
• 2 citations
  Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts.
  Jana M Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J Uckelmann, Philipp J Rauch, Maxim Pimkin, Linda S Ross, Neekesh V Dharia, Amanda L Robichaud, Amy Sau...> ;Cancer Discovery. 2022 Jul 6
• 9 citations
  A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia.
  Harada, T., Heshmati, Y., Kalfon, J., Perez, M., Xavier Ferrucio, J., Ewers, J., Hubbell Engler, B., Kossenkov, A., Ellegast, J., Yi, J., Bowker, A., Zhu, Q., Eagle, K...> ;Genes & Development. 2022 Mar 1
• 43 citations
  EP300 selectively controls the enhancer landscape of MYCN-amplified neuroblastoma.
  Adam D. Durbin, Tingjian Wang, Virangika K. Wimalasena, Mark W. Zimmerman, Deyao Li, Neekesh V. Dharia, Luca Mariani, Noha A.M Shendy, Stephanie Nance, Anand G. Patel,...> ;Cancer Discovery. 2021 Nov 12
• 39 citations
  TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
  Bo Kyung A. Seong, Neekesh V. Dharia, Shan Lin, Katherine A. Donovan, Shasha Chong, Amanda L. Robichaud, Amy Saur Conway, Amanda Hamze, Linda Ross, Gabriela Alexe, Bin...> ;Cancer Cell. 2021 Sep 13
• 2 citations
  Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
  Jasper E Neggers, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Annan Yang, Radha L Kalekar, John M Krill-Burger, Neekesh V Dharia, Guillaume...> ;Cell Reports. 2021 Jul 13
• 37 citations
  STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma.
  Biniam Adane, Gabriela Alexe, Bo Kyung A. Seong, Diana Lu, Elizabeth Hwang, Denes Hnisz, Caleb A. Lareau, Linda Ross, Shan Lin, Filemon S. Dela Cruz, Melissa Richardso...> ;Cancer Cell. 2021 Jun 14
• 5 citations
  Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival.
  Riaz Gillani, Bo Kyung A. Seong, Jett Crowdis, Jake Conway, Neekesh V. Dharia, Saif Alimohamed, Brian J. Haas, Kyuho Han, Jihye Park, Felix Dietlein, Meng Xiao He, Alm...> ;Cancer Research. 2021 Jun 7
• 5 citations
  Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Cancer Discovery. 2021 Jun 1
• 64 citations
  Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia
  Yoshihiro Gocho, Jingjing Liu, Jianzhong Hu, Wentao Yang, Neekesh V. Dharia, Jingliao Zhang, Hao Shi, Guoqing Du, August John, Ting Nien Lin, Jeremy Hunt, Xin Huang, B...> ;Nature Cancer. 2021 Jan 21
• 20 citations
  An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML.
  , , , , , , , , , , , , , , , , , , , , > ;Cancer Discovery. 2021 Jan 1
• 14 citations
  Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
  Jasper E Neggers, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Annan Yang, Radha L Kalekar, John M Krill-Burger, Neekesh V Dharia, Guillaume...> ;Cell Reports. 2020 Dec 15
• 21 citations
  Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors.
  Elaine M. Oberlick, Matthew G. Rees, Brinton Seashore-Ludlow, Francisca Vazquez, Geoffrey M. Nelson, Neekesh V. Dharia, Barbara A. Weir, Aviad Tsherniak, Mahmoud Ghand...> ;Cell Reports. 2019 Aug 27
• 31 citations
  Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.
  Pratiti Bandopadhayay, Federica Piccioni, Ryan O’Rourke, Patricia Ho, Elizabeth Gonzalez, Graham Buchan, Kenin Qian, Gabrielle Gionet, Emily J. Girard, Margo Coxon, Ma...> ;Nature Communications. 2019 Jun 3
• 35 citations
  MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
  , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Cancer Research. 2019 May 1
• 53 citations
  A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma.
  Lillian M. Guenther, Neekesh V. Dharia, Linda Ross, Amy Saur Conway, Amanda L. Robichaud, Jerrel L Catlett, Caroline Wechsler, Elizabeth S. Frank, Amy Goodale, Alanna ...> ;Clinical Cancer Research. 2019 Feb 15
• 13 citations
  Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
  Rachel M. Guerra, Gregory H. Bird, Edward P. Harvey, Neekesh V. Dharia, Kyle J. Korshavn, Michelle S. Prew, Kimberly Stegmaier, Loren D. Walensky> ;Cell Reports. 2018 Sep 25
• 155 citations
  Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry.
  Adam D. Durbin, Mark W. Zimmerman, Neekesh V. Dharia, Brian J. Abraham, Amanda Balboni Iniguez, Nina Weichert-Leahey, Shuning He, John M. Krill-Burger, David E. Root, ...> ;Nature Genetics. 2018 Aug 20
• 37 citations
  Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.
  Hanibal Bohnenberger, Lars Kaderali, Philipp Ströbel, Diego Yepes, Uwe Plessmann, Neekesh V. Dharia, Sha Yao, Carina Heydt, Sabine Merkelbach-Bruse, Alexander Emmert, ...> ;EMBO Molecular Medicine. 2018 Sep 1
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Journal Articles

• Selective Gene Dependencies in MYCN-Amplified Neuroblastoma Include the Core Transcriptional Regulatory Circuitry  
  William C Hahn, Todd R Golub, A Thomas Look, Adam D Durbin, Neekesh V Dharia, Kimberly Stegmaier, Nature

Abstracts/Posters

• Core Transcriptional Regulatory Circuitries in AML
  Neekesh Vijay Dharia, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019