NeilKowallMD

Neurology • Boston, MA

"Professor of Neurology and Pathology, Director of the NIH-funded Boston University Alzheimer’s Disease Center."

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Office
Boston University Medical Center
72 East Concord Street, B7800
Boston, MA 02118
Phone+1 857-891-7119
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Education & Training

Brigham and Women's Hospital/Massachusetts General Hospital/Harvard Medical SchoolResidency, Neurology, 1981 - 1986
Beth Israel Deaconess Medical CenterResidency, Internal Medicine, 1979 - 1981
University of British ColumbiaClass of 1979

Certifications & Licensure

MA State Medical License 1980 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Psychiatry and Neurology Neurology

Publications & Presentations

PubMed

Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE.
Alexander, A., Alvarez, V., Huber, B., Alosco, M., Mez, J., Tripodis, Y., Nicks, R., Katz, D., Dwyer, B., Daneshvar, D., Martin, B., Palmisano, J., Goldstein, L., Crar...> ;Acta Neuropathologica. 2024 Feb 26
Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy.
Alosco, M., White, M., Bell, C., Faheem, F., Tripodis, Y., Yhang, E., Baucom, Z., Martin, B., Palmisano, J., Dams-O'Connor, K., Crary, J., Goldstein, L., Katz, D., Dwy...> ;Molecular Neurodegeneration. 2024 Feb 6
Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study.
Laia Montoliu-Gaya, Michael L Alosco, Eukyung Yhang, Yorghos Tripodis, Daniel Sconzo, Madeline Ally, Lana Grötschel, Nicholas J Ashton, Juan Lantero-Rodriguez, Mathias...> ;Acta Neuropathologica. 2023 Dec 30
Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer's disease.
Madeline Ally, Michael A Sugarman, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashton, Thomas K Karikari, Hugo J Aparicio, Brandon Frank, Yorghos Tripodis, Brett Martin...> ;Alzheimer's & Dementia. 2023 Oct 25
10 citations
Neuropathologic and Clinical Findings in Young Contact Sport Athletes Exposed to Repetitive Head Impacts.
Ann C McKee, Jesse Mez, Bobak Abdolmohammadi, Morgane Butler, Bertrand Russell Huber, Madeline Uretsky, Katharine Babcock, Jonathan D Cherry, Victor E Alvarez, Brett M...> ;JAMA Neurology. 2023 Oct 1
1 citations
Biomarkers of Alzheimer's disease in Black and/or African American Alzheimer's Disease Neuroimaging Initiative (ADNI) participants.
Renée C Groechel, Yorghos Tripodis, Michael L Alosco, Jesse Mez, Wei Qiao Qiu, Lee Goldstein, Andrew E Budson, Neil W Kowall, Leslie M Shaw, Michael Weiner, Clifford R...> ;Neurobiology of Aging. 2023 Nov 1
11 citations
Leveraging football accelerometer data to quantify associations between repetitive head impacts and chronic traumatic encephalopathy in males.
Uretsky, M., Daniel H Daneshvar, Evan S Nair, Zachary H Baucom, Abigail Rasch, Bobak Abdolmohammadi, Madeline Uretsky, Nicole Saltiel, Arsal Shah, Johnny Jarnagin, Chr...> ;Nature Communications. 2023 Jun 20
Annualized changes in rate of amyloid deposition and neurodegeneration are greater in participants who become amyloid positive than those who remain amyloid negative.
Renée C Groechel, Yorghos Tripodis, Michael L Alosco, Jesse Mez, Wei Qiao Qiu, Gustavo Mercier, Lee Goldstein, Andrew E Budson, Neil W Kowall, Ronald J Killiany> ;Neurobiology of Aging. 2023 Jul 1
3 citations
Decreased myelin proteins in brain donors exposed to football-related repetitive head impacts.
Michael L Alosco, Monica Ly, Sydney Mosaheb, Nicole Saltiel, Madeline Uretsky, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Lisa Delano-Wood, Mark W Bondi, Gaoyua...> ;Brain Communications. 2023 Jan 1
2 citations
Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS.
Seung-Hye Choi, Ali Yousefian-Jazi, Seung Jae Hyeon, Phuong Thi Thanh Nguyen, Jiyeon Chu, Sojung Kim, Suhyun Kim, Hannah L Ryu, Neil W Kowall, Hoon Ryu, Junghee Lee> ;Journal of Biomedical Science. 2022 Dec 20
Utility of the ALSFRS-R for predicting ALS and comorbid disease neuropathology: The Veterans Affairs Biorepository Brain Bank.
Leigh E Colvin, Zachariah W Foster, Thor D Stein, Manisha Thakore-James, Mohammad Kian Salajegheh, Kendall Carr, Keith R Spencer, Nazifa Abdul Rauf, Latease Adams, Jam...> ;Muscle & Nerve. 2022 Aug 1
18 citations
Association of APOE Genotypes and Chronic Traumatic Encephalopathy.
Kathryn Atherton, Xudong Han, Jaeyoon Chung, Jonathan D Cherry, Zachary Baucom, Nicole Saltiel, Evan Nair, Bobak Abdolmohammadi, Madeline Uretsky, Mohammed Muzamil Kha...> ;JAMA Neurology. 2022 Aug 1
9 citations
Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease.
Brandon Frank, Madeline Ally, Yorghos Tripodis, Christian Puzo, Caroline Labriola, Landon Hurley, Brett Martin, Joseph Palmisano, Lawrence Chan, Eric Steinberg, Kather...> ;Neurology. 2022 Jun 14
12 citations
Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy.
Madeline S Morrison, Hugo J Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Thomas K Karikari, Yorghos Tripodis, Brett Martin, Joseph N Palmisano, Michael...> ;Brain. 2022 Oct 21
12 citations
A comparison between tau and amyloid-β cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease.
Katherine W Turk, Alexandra Geada, Victor E Alvarez, Weiming Xia, Jonathan D Cherry, Raymond Nicks, Gaoyuan Meng, Sarah Daley, Yorghos Tripodis, Bertrand R Huber, Andr...> ;Alzheimer's Research & Therapy. 2022 Feb 9
6 citations
MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis.
Marcela Alvia, Nurgul Aytan, Keith R Spencer, Zachariah W Foster, Nazifa Abdul Rauf, Latease Guilderson, Ian Robey, James G Averill, Sean E Walker, Victor E Alvarez, B...> ;Frontiers in Neuroscience. 2022 Jan 1
17 citations
Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE.
Michael L Alosco, Asim Z Mian, Karen Buch, Chad W Farris, Madeline Uretsky, Yorghos Tripodis, Zachary Baucom, Brett Martin, Joseph Palmisano, Christian Puzo, Ting Fang...> ;Alzheimer's Research & Therapy. 2021 Dec 7
14 citations
Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau.
Brandon Frank, Madeline Ally, Bailee Brekke, Henrik Zetterberg, Kaj Blennow, Michael A. Sugarman, Nicholas J. Ashton, Thomas K. Karikari, Yorghos Tripodis, Brett Marti...> ;Alzheimer's & Dementia. 2021 Dec 2
13 citations
Association Between Antemortem FLAIR White Matter Hyperintensities and Neuropathology in Brain Donors Exposed to Repetitive Head Impacts.
Madeline Uretsky, Sylvain Bouix, Ronald J. Killiany, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Asim Mian, Karen Buch, Chad Farris, Daniel H. Daneshvar, Brigid ...> ;Neurology. 2021 Nov 24
2 citations
The Department of Veterans Affairs Gulf War Veterans' Illnesses Biorepository: Supporting Research on Gulf War Veterans' Illnesses.
Christopher B Brady, Ian Robey, Thor D. Stein, Bertrand R. Huber, Jessica Riley, Nazifa Abdul Rauf, Keith R Spencer, Latease Adams, James G Averill, Sean E. Walker, An...> ;Brain Sciences. 2021 Oct 14
25 citations
Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project.
Michael L. Alosco, Megan L. Mariani, Charles H. Adler, Laura J. Balcer, Charles Bernick, Rhoda Au, Sarah J. Banks, William B. Barr, Sylvain Bouix, Robert C. Cantu, Mic...> ;Alzheimer's Research & Therapy. 2021 Aug 12
8 citations
Dysfunction of X-linked inhibitor of apoptosis protein (XIAP) triggers neuropathological processes via altered p53 activity in Huntington's disease.
Seung Jae Hyeon, Jinyoung Park, Junsang Yoo, Su-Hyun Kim, Yu Jin Hwang, Seung-Chan Kim, Tian Liu, Hyun Soo Shim, Y. S. Kim, Yakdol Cho, Jiwan Woo, Key-Sun Kim, Richard...> ;Progress in Neurobiology. 2021 Jun 21
2 citations
Near-Infrared Optical Spectroscopy In Vivo Distinguishes Subjects with Alzheimer's Disease from Age-Matched Controls.
Frank A. Greco, Ann C. McKee, Neil W. Kowall, Eugene B. Hanlon> ;Journal of Alzheimer's Disease. 2021 Jan 1
39 citations
Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology.
Jesse Mez, Michael L. Alosco, Daniel H. Daneshvar, Nicole Saltiel, Zachary H. Baucom, Bobak Abdolmohammadi, Madeline Uretsky, Raymond Nicks, Brett M. Martin, Joseph Pa...> ;Alzheimer's & Dementia. 2021 Apr 7
106 citations
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis
Brian W. Kunkle, Michael A. Schmidt, Hans-Ulrich Klein, Adam C. Naj, Kara L. Hamilton-Nelson, Eric B. Larson, Denis A. Evans, Phil De Jager, Paul K. Crane, Joe D. Buxb...> ;JAMA Neurology. 2021 Jan 1
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Other

Genetics of Alzheimer disease
Kowall NW, Sherva R
http://www.uptodate.com/contents/genetics-of-alzheimer-disease
UpToDate, Wolters Kluwer Health - 2013-01-31

Press Mentions

A Novel Age-Informed Approach for Genetic Association Analysis in Alzheimer’s DiseaseApril 1st, 2021
Uniform Data Set Language Measures for bvFTD and PPA Diagnosis and MonitoringFebruary 20th, 2021
Recent Consanguinity and Outbred Autozygosity Are Associated with Increased Risk of Late-Onset Alzheimer’s DiseaseJanuary 29th, 2021
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Hospital Affiliations

Veterans Affairs Boston Healthcare System - Jamaica PlainJamaica Plain, Massachusetts