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Nestoras Mathioudakis, MD, Endocrinology, Baltimore, MD

Nestoras Nicolas Mathioudakis MD MHS (He/him)

Endocrinology•Baltimore, MD

Diabetes, Lipid Metabolism

Associate Professor, Endocrinology, Diabetes, & Metabolism; Co-Medical Director, Baltimore Metropolitan Diabetes Regional Partnership

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  • 601 North Caroline StreetFloor 2Baltimore, MD 21287

  • Phone+1 410-955-9270

  • Fax+1 410-367-2042

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Summary

  • Dr. Nestoras Mathioudakis is an endocrine specialist based in Baltimore, MD, with subspecialties in diabetes and lipid metabolism. He completed his medical education and training, including a residency in Internal Medicine and a fellowship in Endocrinology, Diabetes, and Metabolism, at Johns Hopkins University. He is an Associate Professor and Clinical Director at Johns Hopkins Hospital, where he has been employed since 2012. Dr. Mathioudakis has notable experience in conditions such as insulinoma, diabetes mellitus, obesity, lipid metabolism disorders, and hypoglycemia. His recent publications focus on diabetes-related research, utilizing technologies like AI and machine learning. He has played key roles as a principal investigator in clinical trials focusing on diabetes prevention and management. He has been recognized as a Baltimore Top Doc in his field and holds certifications in meaningful use by Epic Systems Corporation.

Education & Training

  • Johns Hopkins University
    Johns Hopkins UniversityFellowship, Endocrinology, Diabetes, and Metabolism, 2009 - 2012
  • Johns Hopkins University
    Johns Hopkins UniversityResidency, Internal Medicine, 2006 - 2009
  • Johns Hopkins University School of Medicine
    Johns Hopkins University School of MedicineClass of 2006
  • Johns Hopkins University
    Johns Hopkins UniversityBA, French, 1997 - 2001

Certifications & Licensure

  • FL State Medical License
    FL State Medical License 2021 - Present
  • VA State Medical License
    VA State Medical License 2021 - 2028
  • MD State Medical License
    MD State Medical License 2012 - 2027
  • Endocrinology, Diabetes and Metabolism
    American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

  • Baltimore Top Doc - Diabetes Care Baltimore Magazine, 2020-2021
  • Baltimore Top Doc - Endocrinology Baltimore Magazine, 2018
  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2013-2014, 2016-2017

Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Development and Validation of a Machine Learning Model to Predict near-Term Risk of Iatrogenic Hypoglycemia in Hospitalized Patients  
    Nestoras N Mathioudakis, Mihail Zilbermint, JAMA Network Open
  • ACTH-secreting pituitary microadenomas are associated with a higher prevalence of central hypothyroidism compared to other microadenoma types  
    Mathioudakis N, Thapa S, Wand GS, Salvatori R, Clin Endocrinol (Oxf.), 5/15/2012
  • A lifelong smoker with hypopituitarism: rethinking the hypothesis of a tumore in the hypophysis  
    Mathioudakis N, Quinones-Hinojosa A, Salvatori R, Basaria S, Case Report Med, 1/1/2012

Books/Book Chapters

  • Neurosurgery Clinics of North America 
    Chapter: Management Options for Persistent Postoperative Acromegaly 
    Page 621 - 638Mathioudakis N, Salvatori REditors: Aghi and Blevins.2012
  • Schmidek & Sweet's Operative Neurosurgical Techniques: Indications, Methods, and Results. 
    Chapter: Medical therapy of hormone-secreting pituitary adenomas. 
    Mathioudakis N, Salvatori REditors: A Quinones-Hinojosa.2012

Lectures

  • "Thyroid Nodules and Thyroid Cancer" 
    Johns Hopkins School of Medicine - 12/1/2013
  • "Thyroid Disorders" 
    Johns Hopkins School of Nursing - 11/1/2013
  • "Diabetes: A Cardiovascular Disease" 
    Trinidad and Tobago - 10/1/2013

Other

  • U-500 insulin. 
    Mathioudakis N, The Johns Hopkins Diabetes Guide POC-IT Center (Johns Hopkins Point of Care Technology Center)
    Baltimore, MD - 8/1/2013
  • Insulin Pumps. 
    Mathioudakis N, The Johns Hopkins Diabetes Guide POC-IT Center (Johns Hopkins Point of Care Technology Center)
    Baltimore, MD - 8/1/2013
  • Global Health and Diabetes. 
    Mathioudakis N, The Johns Hopkins Diabetes Guide POC-IT Center (Johns Hopkins Point of Care Technology Center)
    Baltimore, MD - 8/1/2013

Authored Content

  • The Society for Vascular Surgery Wound, Ischemia, and Foot Infection (WIfI) Classification System Predicts Wound Healing Better Than Direct Angiosome Perfusion in Diabetic Foot WoundsJanuary 2018

Press Mentions

  • AI-Directed Diabetes Prevention Program as Effective as Human Coaching
    AI-Directed Diabetes Prevention Program as Effective as Human CoachingNovember 28th, 2025
  • AI-Powered App Matches Human Coaching Effectiveness for Diabetes Prevention with Higher Engagement Rates
    AI-Powered App Matches Human Coaching Effectiveness for Diabetes Prevention with Higher Engagement RatesNovember 20th, 2025
  • AI Diabetes Prevention Program Yields Similar Results as Human-Led Program
    AI Diabetes Prevention Program Yields Similar Results as Human-Led ProgramNovember 13th, 2025

Grant Support

  • Implementation of a diabetes navIgator to Mitigate disPArities and improve CGM upTake and sustained use across the lifespan of T1D (IMPACT T1D)JOHNS HOPKINS UNIVERSITY2022–2026
  • Supplement to Effectiveness of Digital Versus In-Person Diabetes Prevention ProgramsJOHNS HOPKINS UNIVERSITY2020–2025
  • Supplement to Effectiveness of Digital Versus In-Person Diabetes Prevention ProgramsJOHNS HOPKINS UNIVERSITY2020–2025
  • Effectiveness of Digital Versus In-Person Diabetes Prevention ProgramsNIDDK2020–2025
  • Implementation and Evaluation of a Real-Time Informatics Alert to Prevent Insulin-Associated Hypoglycemia in the Hospital.NIH- NIDDK2016–2020

Committees

  • Clinical Director, Division of Endocrinology, Diabetes, & Metabolism 2016 - Present
  • Chair, Glucose Steering Committee 2015 - Present
  • Associate Director, Inpatient Diabetes Management Service, Johns Hopkins Hospital 2012 - 2016

Research History

  • Co-principal investigatorDiabetes Prevention Program Outcomes Study (Johns Hopkins site)2012 - Present
  • Postdoctoral FellowStudied the role of pituitary stem cells in pituitary tumorigenesis (Lab of Dr. Alfredo Quinones-HInojosa)2009 - 2012

Professional Memberships

Other Languages

  • Greek, French

Industry Relationships

  • Principle investigator, Sweetch Health LTDPersonalized Smartphone-assisted Coaching System to Improve Glucose Homeostasis in Adults With PrediabetesDisclosure: None2015 - Present

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