NezamHAfdhalMD

Gastroenterology • Boston, MA

Hepatology & Liver Transplantation

Professor, Medicine-Beth Israel Deaconess Medical Center, Harvard Medical School

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Office
BIDMC
110 Francis St., Ste 8e
Boston, MA 02215
Phone+1 617-632-1069
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Education & Training

Boston University Medical CenterFellowship, Gastroenterology, 1987 - 1989
Royal College of Surgeons IrelandClass of 1981

Certifications & Licensure

MA State Medical License 1989 - 2024

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012
Super Doctor SuperDoctors.com
Fellow (FACG) American College of Gastroenterology
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Clinical Trials

FibroScan in Patients With Hepatitis B and C Presenting for Liver Biopsy Start of enrollment: 2005 Mar 01
Completed
Not Applicable
Cerebral Effects of Pegylated Interferon in Hepatitis C Positive Subjects Start of enrollment: 2004 Mar 01
Completed
Study of Long-term Peg Intron vs. Colchicine in Non-responders. Start of enrollment: 2000 Jan 15
Completed
Phase 4
Timing and Duration of Acute Hepatitis C Treatment Start of enrollment: 2002 Jan 01
Completed
Phase 4
Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding Start of enrollment: 2006 May 01
Completed
Phase 3
Phase I Trial of Silymarin for Chronic Liver Diseases Start of enrollment: 2006 Nov 01
Completed
Phase 1
Study of Nitazoxanide, Peginterferon Alfa-2a and Ribavirin in Treatment-Naive Hepatitis C Patients Start of enrollment: 2008 Mar 01
Completed
Phase 2
Phase II Trial of Silymarin for Patients With Chronic Hepatitis C Who Have Failed Conventional Antiviral Treatment Start of enrollment: 2008 Apr 01
Completed
Phase 2
Phase II Trial of Silymarin for Non-Cirrhotic Patients With Non-Alcoholic Steatohepatitis Start of enrollment: 2008 Apr 01
Completed
Phase 2
HCV-TARGET- Hepatitis C Therapeutic Registry and Research Network Start of enrollment: 2011 Nov 01
Completed
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Publications & Presentations

PubMed

Velacur ACE outperforms FibroScan CAP for diagnosis of MASLD.
Alnoor Ramji, Eric M Yoshida, Emily Pang, Caitlin Schneider, Rohit Loomba, Tarek Hassanein, Michael P Curry, Nezam H Afdhal> ;Hepatology Communications. 2024 Apr 1
The Use of Noninvasive Velacur® for Discriminating between Volunteers and Patients with Chronic Liver Disease: A Feasibility Study.
Tam, E., Schneider, C., Hassanien, T., Curry, M., Abdelgelil, N., Afdhal, N.> ;International Journal of Hepatology. 2024 Jan 1
Case report and mini-review: Sarcina ventriculi in the stomach of an 80-year-old female.
Kirmaier, A., Kubiak, J., Mahler, L., Qian, X., Wu, L., Ono, Y., Riedel, S., Medline, A., Yang, X., Elamin, S., Afdhal, N., Arnaout, R.> ;Diagnostic Microbiology and Infectious Disease. 2024 Feb 1
18 citations
Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis.
Rohit Loomba, Daniel Q Huang, Arun J Sanyal, Quentin Mark Anstee, Michael Trauner, Eric J Lawitz, Dora Ding, Lily Ma, Catherine Jia, Andrew Billin, Ryan S Huss, Chuhan...> ;Gut. 2023 Mar 1
8 citations
A phase 2, open-label, randomized, multiple-dose study evaluating Inarigivir in treatment-naïve patients with chronic hepatitis B.
Man-Fung Yuen, Chi-Yi Chen, Chun-Jen Liu, Wen-Juei Jeng, Magdy Elkhashab, Carla S Coffin, Won Kim, Susan Greenbloom, Alnoor Ramji, Young S Lim, Yoon J Kim, Scott K Fun...> ;Liver International. 2023 Jan 1
5 citations
First-line therapies for hepatitis B in the United States: A 3-year prospective and multicenter real-world study after approval of tenofovir alefenamide.
Calvin Q Pan, Nezam H Afdhal, Victor Ankoma-Sey, Ho Bae, Michael P Curry, Douglas Dieterich, Lynn Frazier, Andrew Frick, Hie-Won Hann, W Ray Kim, Paul Kwo, Scott Milli...> ;Hepatology Communications. 2022 Aug 1
25 citations
Fibrosis-4 Index as an Independent Predictor of Mortality and Liver-Related Outcomes in NAFLD.
Joana Vieira Barbosa, Scott Milligan, Andrew Frick, Jeremy Broestl, Zobair Younossi, Nezam H Afdhal, Michelle Lai> ;Hepatology Communications. 2022 Apr 1
23 citations
Fibrosis-4 Index Can Independently Predict Major Adverse Cardiovascular Events in Nonalcoholic Fatty Liver Disease.
Joana Vieira Barbosa, Scott Milligan, Andrew Frick, Jeremy Broestl, Zobair Younossi, Nezam Afdhal, Michelle Lai> ;The American Journal of Gastroenterology. 2022 Mar 1
2 citations
Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease
Shilpa Tiwari-Heckler, Eric U. Yee, Yusuf Yalcin, Jiwoon Park, Duc-Huy T. Nguyen, Wenda Gao, Eva Csizmadia, Nezam H. Afdhal, Kenneth J. Mukamal, Simon C. Robson, Miche...> ;Cell Reports. 2021 Oct 26
2 citations
Lipoprotein Z, A novel hepatotoxic lipoprotein, predicts outcome in alcoholic hepatitis.
Kunpeng Hu, Maria Camila Perez-Matos, Josepmaria Argemi, Eduardo Vilar, Irina Shalaurova, Esther Bullitt, Lee Landeen, Go Sugahara, Huiyan Deng, Karan Mathur, Stephani...> ;Hepatology. 2021 Oct 18
39 citations
Cirrhosis Regression is Associated with Improved Clinical Outcomes in Patients with Nonalcoholic Steatohepatitis.
Arun J. Sanyal, Quentin M. Anstee, Michael Trauner, Eric Lawitz, Manal F. Abdelmalek, D. Ding, Ling Han, Catherine Jia, Ryan S Huss, Chuhan Chung, Vincent Wai-Sun Wong...> ;Hepatology. 2021 Oct 18
18 citations
A Machine Learning Approach to Liver Histological Evaluation Predicts Clinically Significant Portal Hypertension in NASH Cirrhosis
Jaime Bosch, Chuhan Chung, Oscar Carrasco-Zevallos, Stephen A. Harrison, Manal F. Abdelmalek, Mitchell L. Shiffman, Don C. Rockey, Zahil Shanis, Dinkar Juyal, Harsha P...> ;Hepatology. 2021 Aug 1
8 citations
Genetic variation in the mitochondrial glycerol-3-phosphate acyltransferase is associated with liver injury
Aaron Hakim, Matthew Moll, Joseph Brancale, Jiangyuan Liu, Jessica Lasky-Su, Edwin K. Silverman, Silvia Vilarinho, Z. Gordon Jiang, Yered Pita-Juarez, Ioannis S. Vlach...> ;Hepatology. 2021 Jul 3
6 citations
Prevalence of drug-drug interactions with pangenotypic direct-acting antivirals for hepatitis C and real-world care management in the United States: a retrospective ob...
Michael P. Curry, Scott Milligan, Naoky Tsai, Nicole Wick, Zobair M. Younossi, Nezam H. Afdhal> ;Journal of Managed Care & Specialty Pharmacy. 2021 Jun 9
18 citations
A Dynamic Aspartate-to-Alanine Aminotransferase Ratio Provides Valid Predictions of Incident Severe Liver Disease.
Fredrik Åberg, Christopher J. Danford, Maja Thiele, Mats Talbäck, Ditlev Nytoft Rasmussen, Z. Gordon Jiang, Niklas Hammar, Patrik Nasr, Mattias Ekstedt, Anna But, Paul...> ;Hepatology Communications. 2021 Mar 8
5 citations
Bleeding events in lusutrombopag-treated thrombocytopenic patients.
Edoardo G. Giannini, Takeshi Kano, Toshimitsu Ochiai, Roy Bentley, Pomy Shrestha, Nezam H. Afdhal> ;European Journal of Clinical Investigation. 2021 Feb 1
20 citations
Differential Associations of Circulating MicroRNAs With Pathogenic Factors in NAFLD
Ghideon Ezaz, Hirsh D. Trivedi, Margery A. Connelly, Claudia Filozof, Kellie Howard, Mark L.Parrish, Mark A. Herman, Imad Nasser, Nezam H. Afdhal, Z. Gordon Jiang, Mic...> ;Hepatology Communications. 2020 Mar 13
183 citations
The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials.
Arun J. Sanyal, Stephen A. Harrison, Vlad Ratziu, Manal F. Abdelmalek, Anna Mae Diehl, Stephen H. Caldwell, Mitchell L. Shiffman, Raul Aguilar Schall, Catherine Jia, B...> ;Hepatology. 2019 Dec 1
168 citations
Noninvasive Tests Accurately Identify Advanced Fibrosis due to NASH: Baseline Data From the STELLAR Trials
Quentin M. Anstee, Eric Lawitz, Naim Alkhouri, Vincent Wai-Sun Wong, Manuel Romero-Gómez, Takeshi Okanoue, Michael Trauner, Kathryn Kersey, Georgia Li, Ling Han, Cathe...> ;Hepatology. 2019 Nov 1
92 citations
Lusutrombopag for the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Invasive Procedures (L-PLUS 2)
Markus Peck-Radosavljevic, Krzysztof Simon, A. Iacobellis, Tarek Hassanein, Zeid Kayali, Albert Tran, Mihaly Makara, Ziv Ben Ari, Marius Braun, Paul Mitrut, Sheng-Shun...> ;Hepatology. 2019 Oct 1
25 citations
Three Years of Progress Toward Achieving Hepatitis C Elimination in the Country of Georgia, April 2015–March 2018
Tengiz Tsertsvadze, Amiran Gamkrelidze, Nikoloz Chkhartishvili, Akaki Abutidze, Lali Sharvadze, Vakhtang Kerashvili, Maia Butsashvili, David Metreveli, Lia Gvinjilia, ...> ;Clinical Infectious Diseases. 2020 Aug 22
4 citations
Changing demographics among populations prescribed HCV treatment, 2013-2017.
Naoky Tsai, Bruce R. Bacon, Michael P. Curry, Scott Milligan, Nicole Wick, Zobair M. Younossi, Nezam H. Afdhal> ;The American Journal of Managed Care. 2019 Jul 1
15 citations
Safety and effectiveness of lusutrombopag in Japanese chronic liver disease patients with thrombocytopenia undergoing invasive procedures: Interim results of a postmar...
Ritsue Sasaki, Chikako Shiino, Michio Imawari, Roy Bentley, Bin Cai, Manami Yoshida, Nezam H. Afdhal> ;Hepatology Research. 2019 Jul 22
48 citations
Liver Fibrosis Determination.
Michelle Lai, Nezam H. Afdhal> ;Gastroenterology Clinics of North America. 2019 Apr 1
103 citations
Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease
Andrew J. Muir, Cynthia Levy, Harry L.A. Janssen, Aldo J. Montano-Loza, Mitchell L. Shiffman, Stephen H. Caldwell, Velimir A. Luketic, D. Ding, Catherine Jia, B. Mccol...> ;Hepatology. 2019 Feb 1
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Lectures

MRI 2012: Clinical Update and Practical Applications
Harvard Medical School, Duck Key, Florida - 2/20/2012
Update in Internal Medicine
Harvard Medical School & Beth Israel Deacones Medical Center, Boston, Massachusetts - 12/4/2011

Other

Management of the side effects of peginterferon and ribavirin being used for treatment of chronic hepatitis C virus infection
Afdhal NH, Kelleher TB
http://www.uptodate.com/contents/management-of-the-side-effects-of-peginterferon-and-ribavirin-being
UpToDate, Wolters Kluwer Health - 2012-09-28
Acute cholangitis
Afdhal NH
http://www.uptodate.com/contents/acute-cholangitis
UpToDate, Wolters Kluwer Health - 2011-12-21
Pathogenesis, clinical features, and diagnosis of acute cholecystitis
Afdhal NH, Zakko SF
http://www.uptodate.com/contents/pathogenesis-clinical-features-and-diagnosis-of-acute-cholecystitis
UpToDate, Wolters Kluwer Health - 2012-12-18
Treatment of acute cholecystitis
Afdhal NH, Vollmer CM, Zakko SF
http://www.uptodate.com/contents/treatment-of-acute-cholecystitis
UpToDate, Wolters Kluwer Health - 2012-09-25
Complications of laparoscopic cholecystectomy
Afdhal NH, Vollmer CM
http://www.uptodate.com/contents/complications-of-laparoscopic-cholecystectomy
UpToDate, Wolters Kluwer Health - 2012-08-08
Gallstone ileus
Afdhal NH, Keaveny AP, Bowers S
http://www.uptodate.com/contents/gallstone-ileus
UpToDate, Wolters Kluwer Health - 2012-06-11
Neuropsychiatric side effects associated with interferon-alfa plus ribavirin therapy: Recognition and risk factors
Afdhal NH, Raison CL
http://www.uptodate.com/contents/neuropsychiatric-side-effects-associated-with-interferon-alfa-plus-
UpToDate, Wolters Kluwer Health - 2012-03-28
Neuropsychiatric side effects associated with interferon-alfa plus ribavirin therapy: Treatment and prevention
Afdhal NH, Raison CL
http://www.uptodate.com/contents/neuropsychiatric-side-effects-associated-with-interferon-alfa-plus-
UpToDate, Wolters Kluwer Health - 2012-08-29
Noninvasive assessment of hepatic fibrosis
Afdhal NH, Curry MP
http://www.uptodate.com/contents/noninvasive-assessment-of-hepatic-fibrosis
UpToDate, Wolters Kluwer Health - 2012-12-18
Acalculous cholecystitis
Afdhal NH
http://www.uptodate.com/contents/acalculous-cholecystitis
UpToDate, Wolters Kluwer Health - 2013-01-02
Approach to the patient with incidental gallstones
Afdhal NH
http://www.uptodate.com/contents/approach-to-the-patient-with-incidental-gallstones
UpToDate, Wolters Kluwer Health - 2012-10-11
Epidemiology of and risk factors for gallstones
Afdhal NH
http://www.uptodate.com/contents/epidemiology-of-and-risk-factors-for-gallstones
UpToDate, Wolters Kluwer Health - 2012-10-11
Hepatic adenoma
Afdhal NH, Curry MP
http://www.uptodate.com/contents/hepatic-adenoma
UpToDate, Wolters Kluwer Health - 2012-12-18
Clinical manifestations and diagnosis of cholangiocarcinoma
Afdhal NH, Anderson CD, Lowe RC
http://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-cholangiocarcinoma
UpToDate, Wolters Kluwer Health - 2012-12-06
Epidemiology, pathogenesis, and classification of cholangiocarcinoma
Afdhal NH, Anderson CD, Lowe RC
http://www.uptodate.com/contents/epidemiology-pathogenesis-and-classification-of-cholangiocarcinoma
UpToDate, Wolters Kluwer Health - 2012-05-14
AIDS cholangiopathy
Afdhal NH
http://www.uptodate.com/contents/aids-cholangiopathy
UpToDate, Wolters Kluwer Health - 2012-11-01
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Press Mentions

GI Leader to Know: Dr. Harvey Lefton of the Jefferson Health Torresdale HospitalJuly 1st, 2019
10 GI Physicians Featured in JuneJune 28th, 2019
Spring Bank Pharmaceuticals Hosts R&D Day on Pipeline of Novel Immunomodulatory TherapeuticsDecember 6th, 2018
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Grant Support

Clinical Center For Phase I/II Trials Of Silymarin In Chronic Liver DiseaseNational Center For Complementary &Alternative Medicine2006–2010
Clinical CoreNational Institute Of Allergy And Infectious Diseases2005–2009
Clinical Trial: Phase I Study Of Silymarin In Chronic Hepatitis C Or Fatty LiverNational Center For Research Resources2008
Phase I Study Of Silymarin In Chronic Hepatitis C Or Fatty Liver DiseaseNational Center For Research Resources2007
Antiviral Therapy In African Americans With HCVNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2005
NO Inhibition In Systemic/Renal Hemodynamics In Patients With CirrhosisNational Center For Research Resources2004
Proteomics And Biomarkers For Hepatocellular CancerNational Cancer Institute2003–2004
Protein Lipid Interactions In Gallstone PathogenesisNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2002
Protein Lipid Interactions In Gallstone PathogenesisNational Institute Of Diabetes And Digestive And Kidney Diseases1999
Protein-Lipid Interactions In Gallstone PathogenesisNational Institute Of Diabetes And Digestive And Kidney Diseases1993–1995