NicholasChiorazziMD

PubMed

• 1 citations
  Mutation-specific CAR T cells as precision therapy for IGLV3-21expressing high-risk chronic lymphocytic leukemia.
  Florian Märkl, Christoph Schultheiß, Murtaza Ali, Shih-Shih Chen, Marina Zintchenko, Lukas Egli, Juliane Mietz, Obinna Chijioke, Lisa Paschold, Sebastijan Spajic, Anne...> ;Nature Communications. 2024 Feb 2
• Complete miRNA-15/16 loss in mice promotes hematopoietic progenitor expansion and a myeloid-biased hyperproliferative state.
  Anita Ng, Francesca Lovat, Andrew J Shih, Yuhong Ma, Yuri Pekarsky, Frank DiCaro, Lita Crichton, Esha Sharma, Xiao Jie Yan, Daqian Sun, Tengfei Song, Yong-Rui Zou, Bri...> ;Proceedings of the National Academy of Sciences of the United States of America. 2023 Oct 24
• 1 citations
  Characterization of the Intraclonal Complexity of Chronic Lymphocytic Leukemia B Cells: Potential Influences of B-Cell Receptor Crosstalk with Other Stimuli.
  Andrea N Mazzarello, Mark Fitch, Martina Cardillo, Anita Ng, Sabreen Bhuiya, Esha Sharma, Davide Bagnara, Jonathan E Kolitz, Jacqueline C Barrientos, Steven L Allen, K...> ;Cancers. 2023 Sep 25
• 2 citations
  The role of CD180 in hematological malignancies and inflammatory disorders.
  Kurtis Edwards, Peter M Lydyard, Nino Kulikova, Tamar Tsertsvadze, Emanuela V Volpi, Nicholas Chiorazzi, Nino Porakishvili> ;Molecular Medicine. 2023 Jul 17
• 1 citations
  Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model.
  Shih-Shih Chen, Jacqueline C Barrientos, Gerardo Ferrer, Morgan King-Richards, Yu-Ju Chen, Priyadarshini Ravichandran, Michael Ibrahim, Yasmine Kieso, Sheila Waters, J...> ;Clinical Cancer Research. 2023 May 15
• 1 citations
  CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral t...
  Stefano Vergani, Davide Bagnara, Andreas Agathangelidis, Anita Kar Yun Ng, Gerardo Ferrer, Andrea N Mazzarello, Florencia Palacios, Sophia Yancopoulos, Xiao-Jie Yan, J...> ;Frontiers in Oncology. 2023 Jan 1
• 2 citations
  Activated CLL cells regulate IL-17F-producing Th17 cells in miR155-dependent and outcome-specific manners.
  Byeongho Jung, Gerardo Ferrer, Pui Yan Chiu, Rukhsana Aslam, Anita Ng, Florencia Palacios, Michael Wysota, Martina Cardillo, Jonathan E Kolitz, Steven L Allen, Jacquel...> ;JCI Insight. 2022 Jun 22
• Correction to: Intraclonal Complexity in Chronic Lymphocytic Leukemia: Fractions Enriched in Recently Born/Divided and Older/Quiescent Cells.
  Carlo Calissano, Rajendra N Damle, Sonia Marsilio, Xiao-Jie Yan, Sophia Yancopoulos, Gregory Hayes, Claire Emson, Elizabeth J Murphy, Marc K Hellerstein, Cristina Siso...> ;Molecular Medicine. 2022 Mar 15
• 2 citations
  Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia.
  Matthew Kaufman, Xiao-Jie Yan, Wentian Li, Emanuela M Ghia, Anton W Langerak, Laura Z Rassenti, Chrysoula Belessi, Neil E Kay, Frederic Davi, John C Byrd, Sarka Pospis...> ;Frontiers in Oncology. 2022 Jan 1
• 2 citations
  Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal Antibody.
  Pedram Mahmoudi Aliabadi, Ruth Teuber, Peter K Jani, Landon Wilson, Philipp Enghard, Stephen Barnes, Nicholas Chiorazzi, Andreas Radbruch, Fritz Melchers, Hiromi Kubagawa> ;Frontiers in Immunology. 2022 Jan 1
• 8 citations
  B-cell receptor isotypes differentially associate with cell signaling, kinetics, and outcome in chronic lymphocytic leukemia
  Andrea Nicola Mazzarello, Eva Gentner-Göbel, Marcus Dühren-von Minden, Tatyana N. Tarasenko, Antonella Nicolò, Gerardo Ferrer, Stefano Vergani, Yun Liu, Kanti R. Rai, ...> ;The Journal of Clinical Investigation. 2021 Nov 23
• AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.
  Pablo Elías Morande, Xiao-Jie Yan, Julieta Sepulveda, Noé Seija, María Elena Marquez, Natalia Sotelo, Cecilia Abreu, Martina Crispo, Gabriel Fernández-Graña, Natalia R...> ;Blood. 2021 Jul 22
• 6 citations
  Potential Relevance of B-cell Maturation Pathways in Defining the Cell(s) of Origin for Chronic Lymphocytic Leukemia.
  Anita Ng, Nicholas Chiorazzi> ;Hematology/oncology Clinics of North America. 2021 Jun 2
• 12 citations
  Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course
  Davide Bagnara, Catherine Tang, Jennifer R. Brown, Siddha Kasar, Stacey M. Fernandes, Monica Colombo, Stefano Vergani, Andrea Nicola Mazzarello, Fabio Ghiotto, Silvia ...> ;Frontiers in Oncology. 2021 May 25
• 15 citations
  AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression.
  Pablo Oppezzo, Marcelo A. Navarrete, Nicholas Chiorazzi> ;Frontiers in Oncology. 2021 May 10
• 22 citations
  Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL.
  Gerardo Ferrer, Byeongho Jung, Pui Yan Chiu, Rukhsana Aslam, Florencia Palacios, Andrea Nicola Mazzarello, Stefano Vergani, Davide Bagnara, Shih-Shih Chen, Sophia Yanc...> ;Leukemia. 2021 May 2
• 1 citations
  AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms.
  Pablo Elías Morande, Xiao-Jie Yan, Julieta Haydee Sepulveda-Yanez, Noé Seija, Maria Elena Marquez, Natalia Sotelo, Cecilia Abreu, Martina Crispo, Gabriel Fernández-Gra...> ;Blood. 2021 Mar 2
• 11 citations
  Chronic Lymphocytic Leukemia.
  Nicholas Chiorazzi, Shih-Shih Chen, Kanti R. Rai> ;Cold Spring Harbor Perspectives in Medicine. 2021 Feb 1
• 19 citations
  Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target.
  Florencia Palacios, Xiao-Jie Yan, Gerardo Ferrer, Shih-Shih Chen, Stefano Vergani, Xuejing Yang, Jeffrey Gardner, Jaqueline C. Barrientos, Philip J Rock, Richard Burac...> ;Leukemia. 2021 Jan 27
• 6 citations
  Chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis exhibits an increased inflammatory signature that is reduced in early-stage chronic lymphocytic leuke...
  Gonzalo Blanco, Anna Puiggros, Barbara Sherry, Lara Nonell, Xavier Calvo, Eulàlia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, Gerardo Ferrer, Florencia Palacios, Magdale...> ;Experimental Hematology. 2021 Mar 1
• 6 citations
  A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice.
  Piers E.M. Patten, Gerardo Ferrer, Shih Shih Chen, Jonathan E. Kolitz, Kanti R. Rai, Steven L. Allen, Jacqueline C. Barrientos, Nikolaos Ioannou, Alan G. Ramsay, Nicho...> ;Frontiers in Immunology. 2021 Mar 9
• 12 citations
  CXCL13 plasma levels function as a biomarker for disease activity in patients with chronic lymphocytic leukemia.
  Mariela Sivina, Lianchun Xiao, Ekaterina Kim, Alicia Vaca, Shih-Shih Chen, Michael J. Keating, Alessandra Ferrajoli, Zeev Estrov, Nitin Jain, William G. Wierda, Xuelin...> ;Leukemia. 2021 Jun 1
• 64 citations
  Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL.
  Andreas Agathangelidis, Anastasia Chatzidimitriou, Katerina Gemenetzi, Véronique Giudicelli, Maria Karypidou, Karla Plevová, Zadie Davis, Xiao-Jie Yan, Sabine Jeromin,...> ;Blood. 2021 Mar 11
• Expression and function of cathelicidin hCAP18/LL-37 in chronic lymphocytic leukemia.
  Enrique Podaza, Florencia Palacios, Diego O Croci, Denise Risnik, Xiao J Yan, María Belén Almejún, Ana Colado, Esteban E Elías, Mercedes Borge, Pablo E Morande, Raimun...> ;Haematologica. 2020 Sep 1
• 13 citations
  AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes.
  Catherine Tang, Davide Bagnara, Nicholas Chiorazzi, Matthew D. Scharff, Thomas MacCarthy> ;Frontiers in Immunology. 2020 Apr 30
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Journal Articles

• miRNAs Involvement in the Pathogenesis of Richter’s Syndrome  
  Nicholas Chiorazzi, Alessandra Ferrajoli, Haematologica
• BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia  
  Chen S-S, Chang BY, Chang S, Tong T, Ham S, Sherry BA, Burger JA, Rai KR, Leukemia, 1/1/2016
• Recurrent RPS15 mutations in chronic lymphocytic leukemia: a novel biomarker of clinical aggressiveness  
  Ljungström V, Cortese D, Young E, Pandzic T, Mansouri L, Plevova K, Ntoufa S, Baliakas P, Clifford, Sutton L-A, Blakemore S, Stavroyianni N, Agathangelidis A, Rossi D,..., Blood, 1/1/2016
• Targeting stereotyped B cell receptors from chronic lymphocytic leukemia patients with synthetic antigen surrogates  
  Sarkar M, Liu Y, Qi J, Peng H, Morimoto J, Rader C, Chiorazzi N, Kodadek T, J Biol Chem, 1/1/2016
• Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors  
  Sutton L-A, Young E, Baliakas P, Hazidimitriou A, Moysiadis T, Plevova K, Rossi D, Kminkova J, Stalika E, Pedersen LB, Malcikova J, Agathangelidis A, Davis Z, Mansouri..., Haematologica, 1/1/2016
• Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a non-classical Th1-dependent, Bcl-6-deficient process  
  Patten PEM, Ferrer G, Chen S-S, Simone R, Marsilio S, Yan X-J, Gitto Z, Yuan C, Kolitz JE, Barrientos J, Allen SL, Rai KR, MacCarthy T, Chu CC, JCI Insight, 1/1/2016
• Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status  
  Hatzi K, Catera R, Moreno Atanasio C, Fischetti VA, Allen SL, Kolitz JE, Rai KR, Chu CC, Clin Immunol, 1/1/2016
• Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukemia  
  Xochelli1 A, Agathangelidis A, Kavakiotis J, Minga E, Sutton LA, Baliakas P, Chouvarda I, Giudicelli V, Vlahavas I, Maglaveras N, Bonello L, Trentin L, Tedeschi A, Pan..., Immunogenetics, 1/1/2015
• Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations  
  Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton LA, Minga E, Tsanousa A, Scarfo L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M..., Blood, 1/1/2015
• Rewiring of sIgM-mediated intracellular signaling through the CD180 Toll-like receptor  
  Porakishvili N, Vispute K, Steele AJ, Rajakaruna N, Kulikova N, Tsertsvadze T, Nathwani A, Damle RN, Clark EA, Rai KR, Chiorazzi N, Lydyard PM, Mol Med, 1/1/2015
• Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8  
  Gounari M, Ntoufa S, Apollonio B, Papakonstantinou N, Ponzoni M, Chu CC, Rossi D, Gaidano G, Chiorazzi N, Stamatopoulos K, Ghia P, Blood, 1/1/2015
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  Mansouri L, Sutton L-A, Ljungström V, Bondza S, Arngården L, Bhoi S, Larsson J, Cortese D, Kalushkova A, Plevova K, Young E, Gunnarsson R, Falk-Sörqvist E, Lönn P, Mug..., J Exp Med, 1/1/2015
• Anti-CD20CD3 T cell-independent bispecific antibody for the treatment of B cell malignancies  
  Sun LL, Ellerman D, Mathieu M, Hristopoulos M, Chen X, Li Y, Yan X, Clark R, Reyes A, Stefanich E, Mai E, Young J, Johnson C, Huseni M, Wang G, Wang X, Chen Y, Wang P,..., Sci Trans Med, 1/1/2015
• A spoonful of sugar helps lymphoma cells go up  
  Chiorazzi N, Blood, 1/1/2015
• TLR-9 and IL-15 synergy promotes in vitro B-CLL clonal expansion  
  Mongini PKA Gupta R, Boyle E, Nieto J, Lee H, Stein J, Bandovic J, Stankovic T, Barrientos J, Kolitz JE, Allen SL, Rai K, Chu CC, J Immunol, 1/1/2015
• A 7-gene expression panel distinguishing clonal expansions of pre-leukemic and chronic lymphocytic leukemia B cells from normal B lymphocytes  
  McCarthy BA, Yancopoulos S, Tipping M, Yan X-J, Wang XP, Bennett F, Li W, Lesser M, Paul S, Boyle E, Moreno C, Catera R, Messmer BT, Cutrona G, Ferrarini M, Kolitz JE,..., Immunol Res, 1/1/2015
• Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes  
  Sherry B, Jain P, Chiu PY, Leung L, Allen SL, Kolitz JE, Rai KR, Barrientos J, Liang S, Hawtin R, Immunol Res, 1/1/2015
• Genomic imbalance defines three prognostic groups for risk stratification of chronic lymphocytic leukemia patients  
  Houldsworth J, Guttapalli A, Thodima V, Yan XJ, Mendiratta G, Zielonka T, Nanjangud G, Chen W, Patil S, Mato A, Brown JR, Rai K, Chiorazzi N, Chaganti RSK, Leuk Lymphoma, 1/1/2014
• Effects of prostaglandin E2 on p53 mRNA transcription and p5 mutagenesis during T cell-independent human B cell clonal expansion  
  Haque S, Yan XJ, Rosen L, McCormick S, Chiorazzi N, Mongini PKA, FASEB J, 1/1/2014
• Murine genetically engineered and human xenograft models of chronic lymphocytic leukemia  
  Chen SS, Chiorazzi N, Semin Hematol, 1/1/2014
• Recognition of antigen-specific B-cell receptors from chronic lymphocytic leukemia patients by synthetic antigen surrogates  
  Sarkar M, Liu Y, Morimoto J, Peng H, Aquino C, Rader C, Chiorazzi N, Kodadek T, Chem Biol, 1/1/2014
• B cell receptor signaling in chronic lymphocytic leukemia  
  Burger JA, Chiorazzi N, Trends Immunol, 1/1/2013
• Chronic lymphocytic leukemia monitoring with a lamprey idiotype-specific antibody  
  Nakahara H, Herrin BR, Alder MN, Catera R, Yan X-J, Chiorazzi N, Cooper MD, Cancer Immunol Res, 1/1/2013
• Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies  
  Cesano A, Perbellini O, Evensen E, Chu CC, Cioffi F, Ptacek J, Damle RN, Chignola R, Cordeiro J, Yan XJ, Hawtin RE, Nichele I, Ware JR, Cavallini C, Lovato O, Zanotti ..., Haematologica, 1/1/2013
• Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling  
  Chen S-S, Batliwalla F, Holodick N, Yan X-J, Yancopoulos S, Croce CM, Rothstein TL, Proc Natl Acad Sci USA, 1/1/2013
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Books/Book Chapters

• Non-Hodgkin Lymphomas: Advanced Diagnostics & Personalized Therapies 
  Chapter: B-cell chronic lymphocytic leukemia/lymphoma 
  Patten PEM, Chu CCEditors: Carbone, A., and Younes, A.Future Medicine Ltd, London2013
• Chronic Lymphocytic Leukemia 
  Chapter: Origin and nature of chronic lymphocytic leukemia B cells 
  Chiorazzi N, Ferrarini MEditors: S. O’Brien and J. G. Gribben.Informa Health Care, Inc.2008
• Essential Clinical Immunology 
  Chapter: Chronic lymphocytic leukemia 
  Chiorazzi N, Ferrarini MEditors: J. B. Zabriskie.Cambridge University Press2008
• Immune Mechanisms and Disease 
  Lahita RG, Capra JD, Ferrarini M., Zabriskie JAnnals of the New York Academy of Sciences2003
• Chronic Lymphocytic Leukemia 
  Chapter: Immunoglobulin variable region gene characteristics and surface membrane phenotype define distinct subgroups of chronic lymphocytic leukemia cases with different clinical courses 
  Chiorazzi N, Ferrarini MEditors: B. Cheson.Marcel Dekker, Inc.Edition 2nd,2001
• The Antibodies 
  Chapter: Immunoglobulin V gene sequence analyses distinguish two subsets of chronic lymphocytic leukemia B cells 
  Franco F, Ghiotto F, Hashimoto S, Dono M, Valetto A, Allen SL, Schulman P, Vinciguerra VP, Rai KR, Ferrarini MEditors: Zanetti M and Capra JD.Harwood Academic Publishers2000
• Textbook of the Autoimmune Diseases 
  Lahita RG, Chiorazzi N, Reeves WHLippincott Williams and Wilkins, Philadelphia, PA2000
• Textbook of the Autoimmune Diseases 
  Chapter: Antibodies 
  Chiorazzi NEditors: Lahita RG, Chiorazzi N, Reeves WH.Lippincott Williams and Wilkins, Philadelphia, PA2000
• B1 Lymphocytes in B Cell Neoplasia 
  Chapter: Chronic lymphocytic leukemia: A proliferation of B cells at two distinct stages of differentiation 
  Damle RN, Fais F, Ghiotto F, Valetto A, Albesiano E, Wasil T, Batliwalla FM, Allen SL, Schulman P, Vinciguerra VP, Rai KR, Gregersen PK, Ferrarini MEditors: M. Potter and F. Melchers.Springer-Verlag2000
• Chemical Immunology 
  Chapter: Subepithelial B cells of the human tonsil 
  Dono M, Zupo S, Grossi CE, Chiorazzi N, Ferrarini MEditors: M. Ferrarini and F. Caligaris-Cappio, eds.S. Karger AG1997
• Clinical and Experimental Aspects of Fanconi Anemia 
  Chapter: Complementation studies in Fanconi anemia 
  Auerbach AD, Koorse RE, Ghosh R, Venkatraj VS, Zhang MEditors: Schroeder TM, Auerbach AD, Obe G.Springer Verlag, Heidelberg1988
• The Molecular Basis of B Cell Differentiation and Function 
  Chapter: Private and shared idiotypic determinants of the human T cell antigen receptor 
  Bigler RD, Chiorazzi NEditors: Ferrarini M and Pernis B.Plenum Press, New York1987
• Systemic Lupus Erythematosus 
  Chapter: An overview of cellular immune function in systemic lupus erythematosus 
  Chiorazzi NEditors: Lahita R.J. Wiley & Sons, New York1987
• Methods in Enzymology 
  Chapter: Activation of lymphocytes by antibodies to membrane-bound antigen receptors 
  Chiorazzi NEditors: DiSabato G.1987
• Leucocyte Typing II. Volume I. Human T Lymphocytes 
  Chapter: A novel disulfide-linked cell surface molecule present on resting and activated human T lymphocytes 
  Bigler RD, Chiorazzi NEditors: Reinherz EL, Haynes BF, Nadler LM, Bernstein ID.Springer-Verlag, New York1986
• Leucocyte Typing. Human Leucocyte Differentiation Antigens Detected by Monoclonal Antibodies 
  Chapter: Distinct human leucoctye activation antigens defined by murine monoclonal antibodies AA1 and AA2 
  Chiorazzi N, Bigler RD, Hatzfeld J, McCune JMEditors: Bernard A, Boumsell L, Dausett J, Milstein C, Scholssman SF, eds.Springer-Verlag, New York1984
• Human B Lymphocyte Function 
  Chapter: The influences of antibodies to cell surface immunoglobulins on human B lymphocyte activation 
  Chiorazzi NEditors: Fauci T, Ballieux R.Raven Press, New York1982
• Proceedings of the Fifth Congress of the Italian Society of Immunology and Immunopathology 
  Chapter: T-cell dependent and T-cell independent activation of human B lymphocytes. Some applications for the study of disease 
  Chiorazzi N1981
• Regulatory T Lymphocytes 
  Chapter: Activation of human B lymphocytes by MLR-derived helper factors and anti-immunoglobulins 
  Fu SM, Kunkel HGEditors: Pernis B, Vogel HJ.Academic Press, New York1980
• Antibody Production in Man: In Vitro Synthesis and Clinical Implications 
  Chapter: Generation of plaque-forming cells. Allogeneic effect and significance of monocyte removal 
  Chiorazzi N, Ferrarini M, Montazeri G, Hoffman T, Fu SMEditors: Fauci AS, Ballieux RE.Academic Press, New York1979
• Cells of Immunoglobulin Synthesis 
  Chapter: Differentiation of leukemic B lymphocytes in man 
  Fu SM, Chiorazzi N, Hurley JN, Halper JP, Kunkel HGEditors: Vogel HJ, Pernis B.Academic Press, New York1979
• B lymphocytes in the Immune Response 
  Chapter: Differentiation in vitro of human B-type leukemia cells 
  Fu SM, Hurley J, Chiorazzi N, Kunkel HGEditors: Cooper M, Mosier D, Scher I, Vitetta E, eds.Elsevier-North Holland, New York1979
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Abstracts/Posters

• Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia
  Nicholas Chiorazzi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?
  Nicholas Chiorazzi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By BrutonÍs Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrut...
  Nicholas Chiorazzi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

• CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Move... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Extended Survival in CLL Patients Who Discontinued Idelalisib Because of Colitis Correlates with Higher Th17 Levels in Blood and Colon Tissue 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Detection of de novo IGHV mutations by ultra-deep sequencing from in vitro activated B-cell chronic lymphocytic leukemia cells: evidence for activation induced deamina... 
  Milan, Italy - 1/23/2013
• Chronic Lymphocytic Leukemia: New Concepts for Future Therapy 
  1/1/2010
• The CD38 ectoenzyme family: advances in basic science and clinical practice 
  1/1/2006
• B-cell chronic lymphocytic leukemia, a clonal disease of B lymphocytes that vary in specificity for (auto)antigens 
  1/1/2005
• Distinct sets of stereotyped antigen receptors indicate a limited primary structural diversity in antigen-binding sites of CLL B cells 
  Montreal, CA - 1/1/2004
• B Cell Chronic Lymphocytic Leukemia. Distinct phenotypic features and replicative histories among subgroups 
  1/1/2003
• Preface. Immune Mechanisms and Disease 
  1/1/2003
• The human marginal zone B cell 
  1/1/2003
• Facets of Dendritic Cell Maturation: Environmental instructions lead to distinct transcriptional patterns in myeloid dendritic cells 
  1/1/2003
• Chronic lymphocytic leukemia: a proliferation of B cells with distinct genetic and phenotypic features 
  1/1/2002
• Autoimmunity update 
  1/1/1999
• The accessory cell function of B-CLL B cells 
  1/1/1997
• Evidence for B cell oligoclonality in the blood and joints of patients with rheumatoid arthritis 
  1/1/1997
• Human B cell subsets in health and disease: Phenotypic, functional, and genetic analyses 
  1/1/1996
• In vivo isotype class switching in CD5+ chronic lymphocytic leukemia B cells 
  1/1/1995
• Clonal heterogeneity in membrane expression of CD5 in a patient with chronic lymphocytic leukemia 
  1/1/1995
• Biased usage of variable and constant region Ig genes by IgG+ CD5+ human leukemic B cells 
  1/1/1992
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