Nicholas Chiorazzi MD

PubMed

• IGLV3-21-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia.
  Claudia Fischer, Shih-Shih Chen, Johanna Nimmerfroh, Anne Eugster, Simon Stücheli
  Haematologica. 2025-09-11
• Chronic lymphocytic leukemia often arises by a multiclonal selection process.
  Davide Bagnara, Andrea N Mazzarello, Niccolò Cardente, Stefano Vergani, Siddha Kasar
  Haematologica. 2025-08-01
• CLL crosstalk with naïve T cells enhances the differentiation of IL-22-producing T cells and CLL -cell survival.
  Gerardo Ferrer, Florencia Palacios, Pui Yan Chiu, Kelly Wong, Alberto Bueno-Costa
  Leukemia. 2025-02-01

Journal Articles

• miRNAs Involvement in the Pathogenesis of Richter’s Syndrome  
  Nicholas Chiorazzi, Alessandra Ferrajoli, Haematologica
• BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia  
  Chen S-S, Chang BY, Chang S, Tong T, Ham S, Sherry BA, Burger JA, Rai KR, Leukemia, 1/1/2016
• Recurrent RPS15 mutations in chronic lymphocytic leukemia: a novel biomarker of clinical aggressiveness  
  Ljungström V, Cortese D, Young E, Pandzic T, Mansouri L, Plevova K, Ntoufa S, Baliakas P, Clifford, Sutton L-A, Blakemore S, Stavroyianni N, Agathangelidis A, Rossi D,..., Blood, 1/1/2016

Books/Book Chapters

• Non-Hodgkin Lymphomas: Advanced Diagnostics & Personalized Therapies 
  Chapter: B-cell chronic lymphocytic leukemia/lymphoma 
  Patten PEM, Chu CCEditors: Carbone, A., and Younes, A.Future Medicine Ltd, London2013
• Essential Clinical Immunology 
  Chapter: Chronic lymphocytic leukemia 
  Chiorazzi N, Ferrarini MEditors: J. B. Zabriskie.Cambridge University Press2008
• Chronic Lymphocytic Leukemia 
  Chapter: Origin and nature of chronic lymphocytic leukemia B cells 
  Chiorazzi N, Ferrarini MEditors: S. O’Brien and J. G. Gribben.Informa Health Care, Inc.2008

Abstracts/Posters

• Deciphering the CXCL9-CXCL10-CXCL11/CXCR3 Axis in CLL-like Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia: A New Target for Immune Activation?
  Nicholas Chiorazzi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia
  Nicholas Chiorazzi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By BrutonÍs Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrut...
  Nicholas Chiorazzi, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Lectures

• CLL Intraclonal Fractions Defined By Time Since Cell Birth/Division Promote a Leukemia-Supportive, Immune-Tolerant Microenvironment By Distinct Mechanisms 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Ibrutinib Treatment Reduces Myeloid Derived Suppressor Cell Numbers and Function in Chronic Lymphocytic Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Move... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018