NicholasADi ProsperoMDPhD

PubMed

• 78 citations
  Mechanism of Increased LDL (Low-Density Lipoprotein) and Decreased Triglycerides With SGLT2 (Sodium-Glucose Cotransporter 2) Inhibition.
  Debapriya Basu, Lesley-Ann Huggins, Diego Scerbo, Joseph C. Obunike, Adam E. Mullick, Paul Rothenberg, Nicholas A. Di Prospero, Robert H. Eckel, Ira J. Goldberg> ;Arteriosclerosis, Thrombosis, and Vascular Biology. 2018 Sep 1
• 5 citations
  Pharmacokinetics and pharmacodynamics of canagliflozin in pediatric patients with type 2 diabetes.
  William V. Tamborlane, David Polidori, Domenick Argenti, Nicholas A. Di Prospero> ;Pediatric Diabetes. 2018 Jun 1
• 11 citations
  The Subclinical Cardiomyopathy of Friedreich's Ataxia in a Pediatric Population
  Jonathan F. Plehn, Keren Hasbani, Inez Ernst, Kenneth D. Horton, Bart Drinkard, Nicholas A. Di Prospero> ;Journal of Cardiac Failure. 2017 Oct 3
• 76 citations
  Canagliflozin: a sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes mellitus.
  Norm Rosenthal, Gary Meininger, Kirk Ways, David Polidori, Mehul Desai, Rong Qiu, Maria Alba, Frank Vercruysse, Dainius Balis, Wayne Shaw, Robert Edwards, Scott Bull, ...> ;Annals of the New York Academy of Sciences. 2015 Nov 1
• 9 citations
  Effect of food on the pharmacokinetics of canagliflozin, a sodium glucose co-transporter 2 inhibitor, and assessment of dose proportionality in healthy participants.
  Damayanthi Devineni, Prasarn Manitpisitkul, Joseph Murphy, Hans Stieltjes, Jay Ariyawansa, Nicholas A. Di Prospero, Paul Rothenberg> ;Clinical Pharmacology in Drug Development. 2015 Jul 1
• 34 citations
  Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants
  Damayanthi Devineni, Nicole Vaccaro, Joseph Murphy, Christopher R. Curtin, Rao N.V.S. Mamidi, Sveta Weiner, Shean-Sheng Wang, Jay Ariyawansa, Hans Stieltjes, Ewa Wajs,...> ;International Journal of Clinical Pharmacology and Therapeutics. 2015 Feb 1
• Implications of retinal effects observed in chronic toxicity studies on the clinical development of a CNS-active drug candidate.
  Eichenbaum, G.,Zhou, J.,Kelley, M. F.,Roosen, W.,Costa-Giomi, P.,Louden, C.,Di Prospero, N. A.,Pandina, G.,Singh, J. B.,Ford, L.,Moyer, J. A.,Nork, T. M.,Ver Hoeve, J....> ;Regul. Toxicol. Pharmacol.. 2014 Apr 01
• 31 citations
  Assessing Function and Endurance in Adults with Spinal and Bulbar Muscular Atrophy: Validity of the Adult Myopathy Assessment Tool
  Michael O. Harris-Love, Lindsay Fernández-Rhodes, Galen O. Joe, Joseph A. Shrader, Angela Kokkinis, Alison La Pean Kirschner, Sungyoung Auh, Li Li, Ellen W. Levy, Todd...> ;Rehabilitation Research and Practice. 2014 May 5
• 6 citations
  Evaluation of JNJ-26489112 in patients with photosensitive epilepsy: a placebo-controlled, exploratory study.
  Nicholas A. Di Prospero, Jay J. Gambale, Gahan Pandina, Lisa Ford, Suzette Girgis, John A. Moyer, Liwen Xi, Jeffrey S. Nye, Dorothée G.A. Kasteleijn-Nolst Trenité> ;Epilepsy Research. 2014 May 1
• CCR2 antagonism in patients with type-2 diabetes mellitus: A randomized, placebo-controlled study.
  Di Prospero, N. A.,Artis, E.,Andrade-Gordon, P.,Johnson, D. L.,Vaccaro, N.,Xi, L.,Rothenberg, P.> ;Diabetes Obes Metab. 2014 May 07
• 38 citations
  Rating disease progression of Friedreich’s ataxia by the International Cooperative Ataxia Rating Scale: analysis of a 603-patient database
  Günther Metz, N Coppard, Jonathon M. Cooper, Martin B. Delatycki, Alexandra Durr, Nicholas A. Di Prospero, Paola Giunti, David A. Lynch, Jörg B. Schulz, Christian Rumm...> ;Brain. 2013 Jan 1
• 318 citations
  Impaired mitochondrial function in psychiatric disorders.
  Husseini K. Manji, Tadafumi Kato, Nicholas A. Di Prospero, Seth Ness, M. Flint Beal, Michael Krams, Guang Chen> ;Nature Reviews. Neuroscience. 2012 May 1
• 113 citations
  Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial.
  , , , , , , , , , , , , , , , , > ;The Lancet. Neurology. 2011 Feb 1
• 73 citations
  Histone Deacetylases Suppress CGG Repeat–Induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome
  Peter K. Todd, Seok Yoon Oh, Amy Krans, Udai Bhan Pandey, Nicholas A. Di Prospero, Kyung-Tai Min, J. Paul Taylor, Henry L. Paulson> ;Plos Genetics. 2010 Dec 9
• 29 citations
  Exercise Capacity and Idebenone Intervention in Children and Adolescents With Friedreich Ataxia
  Bart Drinkard, Randall E. Keyser, Scott M. Paul, Ross Arena, Jonathan F. Plehn, Jack A. Yanovski, Nicholas A. Di Prospero> ;Archives of Physical Medicine and Rehabilitation. 2010 Jul 1
• 88 citations
  Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology.
  Astrid C. Haugen, Nicholas A. Di Prospero, Joel S. Parker, Rick D. Fannin, Jeff W. Chou, Joel N. Meyer, Christopher J. Halweg, Jennifer B. Collins, Alexandra Durr, Ken...> ;Plos Genetics. 2010 Jan 15
• 120 citations
  Clinical features of spinal and bulbar muscular atrophy.
  Lindsay E. Rhodes, Brandi K. Freeman, Sungyoung Auh, Angela Kokkinis, Alison La Pean, Tanya J. Lehky, Joseph A. Shrader, Ellen W. Levy, Michael O. Harris-Love, Nichola...> ;Brain. 2009 Dec 1
• 23 citations
  Standard and Modified Statistical MUNE Evaluations in Spinal-Bulbar Muscular Atrophy
  Tanya J. Lehky, Cheun Ju Chen, Nicholas A. Di Prospero, Lindsay E. Rhodes, Kenneth H. Fischbeck, Mary Kay Floeter> ;Muscle & Nerve. 2009 Nov 1
• Characterizing gait, locomotor status, and disease severity in children and adolescents with Friedreich ataxia.
  Croarkin, E., Maring, J., Pfalzer, L., Harris-Love, M., Siegel, K., DiProspero, N.> ;J Neurol Phys Ther. 2009 Sep
• 35 citations
  Clinical experience with high-dose idebenone in Friedreich ataxia.
  Jörg B. Schulz, Nicholas A. Di Prospero, Kenneth H. Fischbeck> ;Journal of Neurology. 2009 Mar 1
• 28 citations
  Predictors of progression in patients with Friedreich ataxia.
  Alison La Pean, Neal Jeffries, Chelsea Grow, Bernard Ravina, Nicholas A. Di Prospero> ;Movement Disorders. 2008 Oct 30
• Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation.
  Shao, J., Welch, W. J., Diprospero, N. A., Diamond, M. I.> ;Mol Cell Biol. 2008 Sep
• 29 citations
  Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics
  Barrington G. Burnett, Jaime Andrews, Srikanth Ranganathan, Kenneth H. Fischbeck, Nicholas A. Di Prospero> ;Neurobiology of Disease. 2008 Jun 1
• 193 citations
  Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial
  Nicholas A. Di Prospero, Angela Baker, Neal Jeffries, Kenneth H. Fischbeck> ;The Lancet. Neurology. 2007 Oct 1
• HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.
  Pandey, U. B., Nie, Z., Batlevi, Y., McCray, B. A., Ritson, G. P., Nedelsky, N. B., Schwartz, S. L., DiProspero, N. A., Knight, M. A., Schuldiner, O., Padmanabhan, R.,...> ;Nature. 2007 Jun 14
• Join now to see all