
Nicole L Simone MD
Breast Cancer
Professor and Vice Chair of Research, Faculty Affairs, Radiation Oncology, SKCCC Associate Director, Cancer Research Education and Training, Director, Breast Radiation Oncology, Thomas Jefferson University
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111 S. 11th StreetBodine Center For Cancer TreatmentPhiladelphia, PA 19107
Phone+1 215-955-6702
Fax+1 215-955-5331
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Summary
- Dr. Nicole Simone is the Margaret Q. Landenberger Professor and Vice Chair of Research and Faculty Development of Radiation Oncology, Associate Director of Cancer Research Training and Education at the Sidney Kimmel Cancer Center at Jefferson Health, and radiation lead for the Jefferson Breast Care Center. She received her undergraduate degree in Bioengineering from the University of Pennsylvania, her MD from Rutgers – New Jersey Medical School and did her radiation oncology training at the National Cancer Institute. She stayed on as staff at the National Cancer Institute where she investigated the long term toxicity caused by cancer treatment. Since that time, she has been a Physician-Scientist at Thomas Jefferson University. Her NCI funded laboratory focuses on how caloric restriction, or a reduction in overall calories can augment the response of chemotherapy and radiation to inhibit tumor growth and metastases while improving survival in breast, prostate and lung cancer models. She incorporates the knowledge gained in the laboratory directly to patients and currently has 2 open clinical trials using diet for breast cancer, and brain metastases. She has authored over 100 research publications, sits on many national review committees, is a Councilor at Radiation Research Society, Chair of the Scientific Education Committee in ASTRO, Co-Chair of the Curriculum committee for CABTRAC, and serves on the Physician Leadership Committee for the American Association of Cancer Institutes. Her long term goal is to find creative ways to ensure each cancer patient has access to nutritional counseling.
Education & Training
National Capital ConsortiumResidency, Radiation Oncology, 2004 - 2008
Rutgers Health/New Jersey Medical SchoolInternship, Internal Medicine, 2003 - 2004
Rutgers New Jersey Medical SchoolClass of 2003
Certifications & Licensure
PA State Medical License 2010 - 2026
NJ State Medical License 2017 - 2021
MD State Medical License 2004 - 2011
American Board of Radiology Radiation Oncology
Awards, Honors, & Recognition
- CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2013
- CMS Meaningful Use Stage 1 Certification MOSAIQ EMR, Elekta, 2012
Clinical Trials
- Comparison of Surgeries, With or Without Radiation Therapy, in Treating Women With Stage I or Stage II Breast Cancer Start of enrollment: 1979 Sep 01
- Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy Start of enrollment: 2013 Mar 08
- Measuring Biomarker Response to AMP-514 in Blood Samples From Patients With Solid Tumors Undergoing Radiotherapy Start of enrollment: 2013 Nov 11
Publications & Presentations
PubMed
- Standardizing caloric restriction for preclinical cancer research.Jenna L Jacoby, Ali Calderon Aparicio, Noëlle B François, Mehek Thapar, Sara E Burke
Biotechniques. 2025-10-24 - Benchmarking the Current Landscape: Insights From an Association of American Cancer Institutes Survey on Academic Cancer Service Lines.Paula M Fracasso, Nicole L Simone, Stephanie J Si Lim, Karen L Reckamp, Julie Ann Sosa
JCO Oncology Practice. 2025-09-24 - Enhancing Radiation Oncology Training through Patient Advocate Integration.Christina A Simone-Soule, Sara E Burke, Dema Abul-Enin, Charita Kunta, Adeseye Adekeye
Medrxiv. 2025-07-28
Press Mentions
Personalized Automated Nutrition Guidance for Cancer Patients Revolutionizes CareJune 18th, 2025
Nutritional Interventions Have Potential to Improve Cancer OutcomesApril 15th, 2025
Low-Calorie Diet Helps Prevent Aggressive Breast Cancer from SpreadingMay 28th, 2014
Grant Support
- Radiation Oncology-Biology Integration Network on Oligometastasis (ROBIN OligoMET) CenterUNIVERSITY OF MARYLAND BALTIMORE2022–2027
- Mechanism of lung cancer resistance to tyrosine kinase inhibitor and radiation treatmentsTHOMAS JEFFERSON UNIVERSITY2018–2025
- (11) Diet Modification to Augment Radiation for Breast Cancer Brain MetastasesTHOMAS JEFFERSON UNIVERSITY2018–2025
- Underlying Cause Of Radiation-Induced FibrosisNational Cancer Institute2010–2011
- Mechanism Of Radiation Affects On MicrornaNational Cancer Institute2010–2011
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