NicoleLSimoneMD

Breast Cancer

Professor and Vice Chair of Research, Faculty Affairs and DEI, Radiation Oncology, SKCC Program Leader, Cancer Risk and Control Program, Director, Breast Radiation Oncology, Thomas Jefferson University

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Office
111 S. 11th Street
Bodine Center For Cancer Treatment
Philadelphia, PA 19107
Phone+1 215-955-6702

Fax+1 215-955-5331
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Summary

Adding a healthy diet to the fight against cancer

Absolutely. We know that some foods in our diet have been shown to actually promote cancer growth, such as processed sugars and fats. There's something about th

Education & Training

National Capital ConsortiumResidency, Radiation Oncology, 2004 - 2008
Rutgers Health/New Jersey Medical SchoolInternship, Internal Medicine, 2003 - 2004
Rutgers New Jersey Medical SchoolClass of 2003

Certifications & Licensure

PA State Medical License 2010 - 2024
NJ State Medical License 2017 - 2021
MD State Medical License 2004 - 2011
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2013
CMS Meaningful Use Stage 1 Certification MOSAIQ EMR, Elekta, 2012

Clinical Trials

Comparison of Surgeries, With or Without Radiation Therapy, in Treating Women With Stage I or Stage II Breast Cancer Start of enrollment: 1979 Sep 01
Caloric Restriction in Treating Patients With Stage 0-I Breast Cancer Undergoing Surgery and Radiation Therapy Start of enrollment: 2013 Mar 08
Completed
Not Applicable
Measuring Biomarker Response to AMP-514 in Blood Samples From Patients With Solid Tumors Undergoing Radiotherapy Start of enrollment: 2013 Nov 11
Completed
Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer Start of enrollment: 2014 Jul 22
Completed
Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer Start of enrollment: 2015 Feb 05
Completed
Phase 1
Telehealth in Improving Quality of Life in Patients During Post Radiation Therapy Visits Start of enrollment: 2016 Mar 23
Completed
Not Applicable
CAREFOR: Precision Medicine Driving Precision Nutrition for the Treatment of NeoAdjuvant Breast Cancer Start of enrollment: 2016 Jun 16
Completed
Not Applicable
Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer Start of enrollment: 2016 Jun 08
Active, not recruiting
Phase 2
Prospective Breast Cancer Biospecimen Collection Start of enrollment: 2018 May 10
Recruiting
Not Applicable
SABR-CaRe in Early Stage Breast Cancer Start of enrollment: 2021 Aug 23
Recruiting
Phase 2
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Publications & Presentations

PubMed

Temporal Considerations in Brain Metastases Radiation Therapy: The Intersection of Chronobiology and Patient Profiles.
Nicolas G Nelson, Sara E Burke, Lauren E Matlack, Alexandria P Smith, Noelle Francois, Joseph F Lombardo, Yash B Shah, Kuang-Yi Wen, Ayesha A Shafi, Louis Cappelli, Ni...> ;Clocks & Sleep. 2024 Mar 21
Novel Functional Radiomics for Prediction of Cardiac Positron Emission Tomography Avidity in Lung Cancer Radiotherapy.
Wookjin Choi, Yingcui Jia, Jennifer Kwak, Maria Werner-Wasik, Adam P Dicker, Nicole L Simone, Eugene Storozynsky, Varsha Jain, Yevgeniy Vinogradskiy> ;JCO Clinical Cancer Informatics. 2024 Mar 1
ELK1/MTOR/S6K1 Pathway Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer.
Zhao, L., Wang, Y., Sun, X., Zhang, X., He, J., Simone, N.> ;International Journal of Molecular Sciences. 2024 Feb 17
A Proof-of-Concept Pilot Test of a Behavioral Intervention to Improve Adherence to Dietary Recommendations for Cancer Prevention.
Meghan L Butryn, Charlotte J Hagerman, Nicole T Crane, Marny M Ehmann, Evan M Forman, Brandy-Joe Milliron, Nicole L Simone> ;Cancer Control. 2023 Nov 11
TP53 structure-function relationships in metastatic castrate-sensitive prostate cancer and the impact of APR-246 treatment.
Tung Hoang, Philip Sutera, Triet Nguyen, Jinhee Chang, Shreya Jagtap, Yang Song, Amol C Shetty, Dipanwita D Chowdhury, Aaron Chan, Francesca A Carrieri, Lara Hathout, ...> ;The Prostate. 2024 Jan 1
Physician Perceptions on Cancer Screening for LGBTQ+ Patients.
Nicolas G Nelson, Joseph F Lombardo, Ayako Shimada, Marissa L Ruggiero, Alexandria P Smith, Kevin Ko, Amy E Leader, Edith P Mitchell, Nicole L Simone> ;Cancers. 2023 Jun 1
A novel method for measuring the burden of breast cancer in neighborhoods.
Russell K McIntire, Hee-Soon Juon, Scott W Keith, Nicole L Simone, Dexter Waters, Eleanor Lewis, Charnita Zeigler-Johnson> ;Preventive Medicine Reports. 2023 Jun 1
Gender Composition in Biomedical Research Grant Submissions and Grant Review Panels Before Versus During the COVID-19 Pandemic.
Danielle Roubinov, Kent A Griffith, Nicole L Simone, Sindy Escobar Alvarez, Marilyn Thomas, Christina Mangurian, Reshma Jagsi> ;Journal of Women's Health. 2023 Apr 1
Markers and associations of nutrition identified in a senior adult oncology clinic.
Joseph Lombardo, Abigail M Schmucker, Scott W Keith, Ashwini Ronghe, Alexandria Smith, Ayesha S Ali, Muneeb Niazi, Melissa Denton, Kristine Swartz, Andrew Chapman, Nic...> ;Journal of Geriatric Oncology. 2023 Jan 1
Optimizing an mHealth Intervention to Change Food Purchasing Behaviors for Cancer Prevention: Protocol for a Pilot Randomized Controlled Trial.
Olivia Z Horgan, Nicole T Crane, Evan M Forman, Brandy-Joe Milliron, Nicole L Simone, Fengqing Zhang, Meghan L Butryn> ;JMIR Research Protocols. 2022 Jun 24
14 citations
Perceptions of and barriers to cancer screening by the sexual and gender minority community: a glimpse into the health care disparity.
Joseph Lombardo, Kevin Ko, Ayako Shimada, Nicolas Nelson, Christopher Wright, Jerry Chen, Alisha Maity, Marissa L Ruggiero, Scott Richard, Dimitrios Papanagnou, Edith ...> ;Cancer Causes & Control. 2022 Apr 1
2 citations
A comparative study using time-driven activity-based costing in single-fraction breast high-dose rate brachytherapy: An integrated brachytherapy suite vs. decentralize...
Gabriella C Squeo, Courtney M Lattimore, Nicole L Simone, Greg Suralik, Sunil W Dutta, Michael D Schad, Lucy Su, Bruce Libby, Einsley-Marie Janowski, Shayna L Showalte...> ;Brachytherapy. 2022 Feb 4
8 citations
Chronoradiobiology of Breast Cancer: The Time Is Now to Link Circadian Rhythm and Radiation Biology.
Nicolas Nelson, Joseph Lombardo, Lauren Matlack, Alexandria Smith, Kamryn Hines, Wenyin Shi, Nicole L Simone> ;International Journal of Molecular Sciences. 2022 Jan 25
6 citations
Spatial Metrics of Interaction between CD163-Positive Macrophages and Cancer Cells and Progression-Free Survival in Chemo-Treated Breast Cancer.
Brenton A Maisel, Misung Yi, Amy R Peck, Yunguang Sun, Jeffrey A Hooke, Albert J Kovatich, Craig D Shriver, Hai Hu, Marja T Nevalainen, Takemi Tanaka, Nicole Simone, L...> ;Cancers. 2022 Jan 8
4 citations
Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer.
Anuradha A Shastri, Joseph Lombardo, Samantha C Okere, Stephanie Higgins, Brittany C Smith, Tiziana DeAngelis, Ajay Palagani, Kamryn Hines, Daniel A Monti, Stella Volp...> ;International Journal of Molecular Sciences. 2021 Dec 24
3 citations
An Ex Vivo Brain Slice Model to Study and Target Breast Cancer Brain Metastatic Tumor Growth.
Lorela Ciraku, Rebecca A. Moeller, Emily M. Esquea, Wiktoria A. Gocal, Edward J. Hartsough, Nicole L. Simone, Joshua G. Jackson, Mauricio J. Reginato> ;Journal of Visualized Experiments. 2021 Sep 22
8 citations
A Pilot Trial Using Telemedicine in Radiation Oncology: The Future of Health Care Is Virtual
Ryan C Miller, Brittany A. Simone, Joseph Lombardo, James M. Taylor, Kamila Nowak-Choi, Kevin Ko, Linda Ferguson, Ann Donnelly, Ayesha S Ali, Wenyin Shi, Adam P. Dicke...> ;Telemedicine Reports. 2021 Jun 14
18 citations
Caloric Restriction Impairs Regulatory T cells Within the Tumor Microenvironment After Radiation and Primes Effector T cells.
Gregor Manukian, Charles Kivolowitz, Tiziana DeAngelis, Anuradha A. Shastri, Jason E. Savage, Kevin Camphausen, Ulrich Rodeck, Jelani C. Zarif, Nicole L. Simone> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Aug 1
20 citations
miR-21 Plays a Dual Role in Tumor Formation and Cytotoxic Response in Breast Tumors.
Tu Dan, Anuradha A. Shastri, Ajay Palagani, Simone Buraschi, Thomas Neill, Jason E. Savage, Aastha Kapoor, Tiziana DeAngelis, Sankar Addya, Kevin Camphausen, Renato V....> ;Cancers. 2021 Feb 20
Dosimetric Comparisons of Simulation Techniques for Left-Sided Breast Cancer in the COVID-19 Era: Techniques to Reduce Viral Transmission and Respect the Therapeutic R...
James M. Taylor, Andrew Song, K. Nowak, Tu Dan, Brittany A. Simone, Amy S. Harrison, Laura Doyle, Virginia Lockamy, Pramila R. Anne, Nicole L. Simone> ;Cureus. 2021 Feb 15
10 citations
Exercise Therapy and Radiation Therapy for Cancer: A Systematic Review.
Nicholas G. Zaorsky, Taylor H. Allenby, John Lin, Jennifer Rosenberg, Nicole L. Simone, Kathryn H. Schmitz> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Jul 15
3 citations
A systematic review of home-based dietary interventions during radiation therapy for cancer
Taylor H. Allenby, Megan L. Crenshaw, Katlynn M. Mathis, Colin E. Champ, Nicole L. Simone, Kathryn H. Schmitz, Leila T. Tchelebi, Nicholas G. Zaorsky> ;Technical Innovations & Patient Support in Radiation Oncology. 2020 Sep 14
2 citations
Is Host Metabolism the Missing Link to Improving Cancer Outcomes
Christopher M. Wright, Anuradha A. Shastri, Emily K. Bongiorno, Ajay Palagani, Ulrich Rodeck, Nicole L. Simone> ;Cancers. 2020 Aug 19
10 citations
Toxicity and cosmetic outcomes after treatment with a novel form of breast IORT.
Max O. Meneveau, Gina R. Petroni, Nikole Varhegyi, Anneke T. Schroen, David R. Brenin, Einsley M. Janowski, Adam C. Berger, Melissa Lazar, Nicole L. Simone, Timothy N....> ;Brachytherapy. 2020 Jun 20
185 citations
COVID-19 medical papers have fewer women first authors than expected.
Jens Peter Andersen, Mathias Wullum Nielsen, Nicole L. Simone, Resa E. Lewiss, Reshma Jagsi> ;Elife. 2020 Jun 15
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Press Mentions

Low-Calorie Diet Helps Prevent Aggressive Breast Cancer from SpreadingMay 28th, 2014
Fighting Cancer with Dietary ChangesMay 26th, 2014
Dieting on Radiation Therapy May Improve Outcomes for Breast Cancer Patients: New Clinical Trial to BeginFebruary 4th, 2013

Grant Support

Underlying Cause Of Radiation-Induced FibrosisNational Cancer Institute2010–2011
Mechanism Of Radiation Affects On MicrornaNational Cancer Institute2010–2011
Underlying Cause Of Radiation-Induced FibrosisDivision Of Basic Sciences - Nci2009
Mechanism Of Radiation Affects On MicrornaDivision Of Basic Sciences - Nci2009
Underlying Cause Of Radiation-Induced FibrosisNational Cancer Institute2008