NikolausSebastianTredeMDBS, PhD Immunology

Pediatric Hematology & Oncology • Salt Lake City, UT

Associate Professor, Pediatrics, University of Utah School of Medicine

Join to view full profile

Dr. Trede is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Trede's full profile

Already have an account?

Office
2000 Circle Of Hope Dr
Dept Of Neurosurgery 3b409
Salt Lake City, UT 84112
Phone+1 801-585-0199
Is this information wrong?

Education & Training

Children's Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 1995 - 1997
Children's Hospital/Boston Medical CenterResidency, Pediatrics, 1993 - 1995
Albert Ludwigs University Faculty of MedicineClass of 1987

Certifications & Licensure

UT State Medical License 2004 - 2026

Clinical Trials

A Study to Evaluate the Safety and Efficacy of JCAR017 in Pediatric Subjects With Relapsed/Refractory (r/r) B-cell Acute Lymphoblastic Leukemia (B-ALL) and B-cell Non-Hodgkin Lymphoma (B-NHL) Start of enrollment: 2018 Oct 17
Recruiting
Phase 1, Phase 2

Publications & Presentations

PubMed

4 citations
Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia.
David Spencer Mangum, Julia Meyer, Clinton C. Mason, Soheil Shams, Luke Maese, Jamie D. Gardiner, Jonathan M. Downie, Deqing Pei, Cheng Cheng, Adam Gleason, Minjie Luo...> ;JAMA Oncology. 2021 Oct 1
5 citations
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
Bergithe E Oftedal, Stefano Maio, Adam E. Handel, White Mpj., Duncan Howie, Simon J. Davis, N Prevot, Ioanna A. Rota, Mary E. Deadman, Benedikt M. Kessler, Roman Fisch...> ;Communications Biology. 2021 Jun 3
87 citations
Neuropathology of a Case With Fatal CAR T-Cell-Associated Cerebral Edema.
Matthew Torre, Isaac H. Solomon, Claire L Sutherland, Sarah Nikiforow, Daniel J. DeAngelo, Richard Stone, Henrikas Vaitkevicius, Ilene Galinsky, Robert F. Padera, Niko...> ;Journal of Neuropathology and Experimental Neurology. 2018 Oct 1
17 citations
Trim33 is essential for macrophage and neutrophil mobilization to developmental or inflammatory cues.
Doris Lou Demy, Muriel Tauzin, Mylene Lancino, Véronique Le Cabec, Michael J. Redd, Emi Murayama, Isabelle Maridonneau-Parini, Nikolaus S. Trede, Philippe Herbomel> ;Journal of Cell Science. 2017 Sep 1
33 citations
NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation
Emi Murayama, Milka Sarris, Michael J. Redd, Dorothée Le Guyader, Catherine Vivier, Wyatt Horsley, Nikolaus S. Trede, Philippe Herbomel> ;Nature Communications. 2015 Sep 28
11 citations
Targeting insulin-like growth factor 1 leads to amelioration of inflammatory demyelinating disease.
Matthew F. Cusick, Jane E. Libbey, Nikolaus S. Trede, Robert S. Fujinami> ;Plos One. 2014 Apr 9
28 citations
VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.
D. S. Mangum, Jonathan M. Downie, Clinton C. Mason, Mona S. Jahromi, D. Joshi, Vladimir Rodic, Markus Müschen, Nathan D. Meeker, Nikolaus S. Trede, John Kimble Frazer,...> ;Leukemia. 2014 Jan 1
129 citations
Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia.
Alexandre Bolze, Nizar Mahlaoui, Minji Byun, Bridget Turner, Nikolaus S. Trede, Steven R. Ellis, Avinash Abhyankar, Yuval Itan, Etienne Patin, Samuel Brebner, Paul Sac...> ;Science. 2013 May 24
27 citations
DiGeorge syndrome gene tbx1 functions through wnt11r to regulate heart looping and differentiation.
Priya Choudhry, Nikolaus S. Trede> ;Plos One. 2013 Mar 22
3 citations
Discovery of Biologically Active Oncologic and Immunologic Small Molecule Therapies using Zebrafish: Overview and Example of Modulation of T Cell Activation
Nikolaus S. Trede, William L. Heaton, Suzanne Ridges, Hossein Sofla, Matthew F. Cusick, David J. Bearss, David A. Jones, Robert S. Fujinami> ;Current Protocols in Pharmacology. 2013 Mar 1
13 citations
Tbl3 regulates cell cycle length during zebrafish development
Sarah A. Hutchinson, Erin Tooke-Locke, Jindong Wang, Schickwann Tsai, Tammisty Katz, Nikolaus S. Trede> ;Developmental Biology. 2012 Aug 15
112 citations
Zebrafish screen identifies novel compound with selective toxicity against leukemia
Suzanne Ridges, William L. Heaton, Deepa Joshi, Henry Choi, Anna M. Eiring, Lance Batchelor, Priya Choudhry, Elizabeth J. Manos, Hossein Sofla, Ali Sanati, Seth Welbor...> ;Blood. 2012 Jun 14
10 citations
Genomic Amplification of an Endogenous Retrovirus in Zebrafish T-Cell Malignancies
J. Kimble Frazer, Lance Batchelor, Diana F. Bradley, Kim H. Brown, Kimberly P. Dobrinski, Charles Lee, Nikolaus S. Trede> ;Advances in Hematology. 2012 Jun 13
53 citations
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency
Jessica S. Blackburn, Sali Liu, D M Raiser, Sarah Martinez, Hui Feng, N D Meeker, J Gentry, Donna Neuberg, A T Look, Sridhar Ramaswamy, Andre Bernards, Nikolaus S. Tre...> ;Leukemia. 2012 Apr 27
17 citations
Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen.
Matthew F. Cusick, Jane E. Libbey, Nikolaus S. Trede, David D. Eckels, Robert S. Fujinami> ;Journal of Neuroimmunology. 2012 Mar 1
248 citations
A model 450 million years in the making: zebrafish and vertebrate immunity.
Stephen A. Renshaw, Nikolaus S. Trede> ;Disease Models & Mechanisms. 2012 Jan 1
32 citations
Shared acquired genomic changes in zebrafish and human T-ALL
Lynnie A. Rudner, Kim H. Brown, Kimberly P. Dobrinski, Diana F. Bradley, Martha Iveth Garcia, Alexandra C.H. Smith, Jonathan M. Downie, Nathan D. Meeker, A T Look, Jam...> ;Oncogene. 2011 Oct 13
10 citations
Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis.
Priya Choudhry, Deepa Joshi, Birgit Funke, Nikolaus S. Trede> ;Developmental Biology. 2011 Jan 15
4 citations
Trans-centromere Effects on Meiotic Recombination in the Zebrafish
Bradley L. Demarest, Wyatt Horsley, Erin E. Locke, Kenneth M. Boucher, David Grunwald, Nikolaus S. Trede> ;Genetics. 2011 Jan 1
83 citations
The zebrafish as a model for cancer.
Maria Caterina Mione, Nikolaus S. Trede> ;Disease Models & Mechanisms. 2010 Sep 1
36 citations
Characterization of the zebrafish T cell receptor β locus
Nathan D. Meeker, Alexandra C.H. Smith, J. Kimble Frazer, Diana F. Bradley, Lynnie A. Rudner, Cynthia Love, Nikolaus S. Trede> ;Immunogenetics. 2010 Jan 7
15 citations
Disease Modeling in Zebrafish: Cancer and Immune Responses—A Report on a Workshop Held in Spoleto, Italy, July 20–22, 2009
Marina Mione, Annemarie H. Meijer, B. Ewa Snaar-Jagalska, Herman P. Spaink, Nikolaus S. Trede> ;Zebrafish. 2009 Dec 1
38 citations
The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish.
Julio D. Amigo, Gabriele E. Ackermann, John J. Cope, Ming Yu, Jeffrey D. Cooney, Dongdong Ma, Nathaniel B. Langer, Ebrahim Shafizadeh, George C. Shaw, Wyatt Horsely, N...> ;Blood. 2009 Nov 19
203 citations
Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II.
Klaus Schwarz, Achille Iolascon, Fatima Verissimo, Nikolaus S. Trede, Wyatt Horsley, Wen Chen, Barry H. Paw, Karl-Peter Hopfner, Karlheinz Holzmann, Roberta Russo, Mar...> ;Nature Genetics. 2009 Aug 1
55 citations
Heritable T Cell Malignancy Models Established in a Zebrafish Phenotypic Screen
J K Frazer, Nathan D. Meeker, Lynnie A. Rudner, Diana F. Bradley, Alexandra C.H. Smith, Bradley L. Demarest, Deepa Joshi, Erin E. Locke, Sarah A. Hutchinson, Sheryl R....> ;Leukemia. 2009 Jun 11
Join now to see all

Press Mentions

Simultaneous B and T Cell Acute Lymphoblastic Leukemias in Zebrafish Driven by Transgenic MYC: Implications for Oncogenesis and LymphopoiesisAugust 15th, 2018

Grant Support

Genetic Analysis Of Primary Immunodeficiency Using Transgenic ZebrafishEunice Kennedy Shriver National Institute Of Child Health &Human Development2008–2009
Screen For Lymphoid MutantsNational Heart, Lung, And Blood Institute2004
Screen For Lymphoid MutantsNational Heart, Lung, And Blood Institute2000–2004