NilsW.G.LambrechtMD

PubMed

• 2 citations
  Single-cell dissection of Merkel cell carcinoma heterogeneity unveils transcriptomic plasticity and therapeutic vulnerabilities.
  Bhaba K Das, Aarthi Kannan, Graham J Velasco, Mikaela D Kunika, Nils Lambrecht, Quy Nguyen, Haibo Zhao, Jie Wu, Ling Gao> ;Cell Reports. Medicine. 2023 Jul 18
• 1 citations
  Typhimurium Infection Reduces the Ascorbic Acid Uptake in the Intestine.
  Trevor Teafatiller, Sandeep B Subramanya, Nils Lambrecht, Veedamali S Subramanian> ;Mediators of Inflammation. 2023 Jan 1
• IGF-1/IGFBP-3 Serum Ratio as a Robust Measure to Determine GH Deficiency and Guide Human Recombinant GH Therapy.
  Nils Lambrecht> ;The Journal of Clinical Endocrinology and Metabolism. 2023 Mar 10
• 6 citations
  Circulating tumor DNA as a predictive biomarker in Merkel cell carcinoma.
  Soo J Park, Aarthi Kannan, Jeremy P Harris, Curtis Lacy, Gregory A Daniels, Steve P Lee, Nils Lambrecht, Nicole Hook, Perry Olshan, Paul R Billings, Alexey Aleshin, Li...> ;Journal of the American Academy of Dermatology. 2022 Nov 1
• 10 citations
  Spatiotemporal Alterations in Gait in Humanized Transgenic Sickle Mice.
  Stacy B Kiven, Ying Wang, Anupam Aich, Donovan A Argueta, Jianxun Lei, Varun Sagi, Madhushan Tennakoon, Saad J Bedros, Nils Lambrecht, Kalpna Gupta> ;Frontiers in Immunology. 2020 Oct 15
• 27 citations
  NUCB2/nesfatin-1 - Inhibitory effects on food intake, body weight and metabolism.
  Martha A. Schalla, Suraj Unniappan, Nils Lambrecht, Masatomo Mori, Yvette Taché, Andreas Stengel> ;Peptides. 2020 Jun 1
• 14 citations
  Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-κB, NLRP3, and gut microbiota.
  Subrata Sabui, Jonathan Skupsky, Rubina Kapadia, Kyle Cogburn, Nils Lambrecht, Anshu Agrawal, Hamid M. Said> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2019 Oct 1
• 21 citations
  Biotin and pantothenic acid oversupplementation to conditional SLC5A6 KO mice prevents the development of intestinal mucosal abnormalities and growth defects
  Subrata Sabui, Rubina Kapadia, Abhisek Ghosal, Michael Schneider, Nils Lambrecht, Hamid M. Said> ;American Journal of Physiology. Cell Physiology. 2018 Apr 18
• 38 citations
  Biotin Deficiency Induces Th1- and Th17-Mediated Proinflammatory Responses in Human CD4+ T Lymphocytes via Activation of the mTOR Signaling Pathway.
  Asif Elahi, Subrata Sabui, Nell N. Narasappa, Sudhanshu Agrawal, Nils Lambrecht, Anshu Agrawal, Hamid M. Said> ;Journal of Immunology. 2018 Apr 15
• 7 citations
  Prostate cancer diagnosis using epigenetic biomarkers, 3D high-content imaging and probabilistic cell-by-cell classifiers.
  Darko Stefanovski, George Tang, Kolja Wawrowsky, Raymond C. Boston, Nils Lambrecht, Jian Tajbakhsh> ;Oncotarget. 2017 Jul 5
• 19 citations
  Role of the sodium-dependent multivitamin transporter (SMVT) in the maintenance of intestinal mucosal integrity
  Subrata Sabui, Jennifer Ann Bohl, Rubina Kapadia, Kyle Cogburn, Abhisek Ghosal, Nils Lambrecht, Hamid M. Said> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2016 Sep 1
• 18 citations
  Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption.
  Veedamali S. Subramanian, Nils Lambrecht, Christian Lytle, Hamid M. Said> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2016 Feb 15
• Corrigendum. The binding selectivity of vonoprazan (TAK-438) to the gastric H+,K+-ATPase.
  David R. Scott, Keith Munson, Elizabeth A. Marcus, Nils Lambrecht, George Sachs> ;Alimentary Pharmacology & Therapeutics. 2016 Jan 1
• 61 citations
  The binding selectivity of vonoprazan (TAK‐438) to the gastric H+,K+‐ATPase
  David R. Scott, Keith Munson, Elizabeth A. Marcus, Nils Lambrecht, George Sachs> ;Alimentary Pharmacology & Therapeutics. 2015 Dec 1
• 1 citations
  Changes in tumor-antigen expression profile as human small-cell lung cancers progress
  Lisheng Ge, Neil Hoa, Nils Lambrecht, Maria Dacosta-Iyer, Yi Ouyang, Amir Abolhoda, Martin R. Jadus> ;Cancer Biology & Medicine. 2015 Jun 30
• 7 citations
  HCA519/TPX2: a potential T-cell tumor-associated antigen for human hepatocellular carcinoma.
  Ahmed M. Aref, Neil Hoa, Lisheng Ge, Anshu Agrawal, Maria Dacosta-Iyer, Nils Lambrecht, Yi Ouyang, Andrew N. Cornforth, Martin R. Jadus> ;Oncotargets and Therapy. 2014 Jun 13
• 15 citations
  Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease.
  Neil Hoa, Lisheng Ge, Rajeev B. Tajhya, Christine Beeton, Andrew N. Cornforth, Amir Abolhoda, Nils Lambrecht, Maria Dacosta-Iyer, Yi Ouyang, Anthony Mai, Erin Hong, Ju...> ;American Journal of Translational Research. 2014 May 15
• 53 citations
  Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease
  Shobha H. Ganji, Gary D. Kukes, Nils Lambrecht, Moti L. Kashyap, Vaijinath S. Kamanna> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2014 Feb 15
• 48 citations
  The ghrelin activating enzyme ghrelin-O-acyltransferase (GOAT) is present in human plasma and expressed dependent on body mass index.
  Miriam Goebel-Stengel, Tobias Hofmann, Ulf Elbelt, Pauline Teuffel, Anne Ahnis, Peter Kobelt, Nils Lambrecht, Burghard F. Klapp, Andreas Stengel> ;Peptides. 2013 May 1
• 58 citations
  Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects
  Andreas Stengel, Tobias Hofmann, Miriam Goebel-Stengel, Vanessa Lembke, Anne Ahnis, Ulf Elbelt, Nils Lambrecht, Jürgen Ordemann, Burghard F. Klapp, Peter Kobelt> ;Histochemistry and Cell Biology. 2013 Mar 21
• 48 citations
  Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption.
  Abhisek Ghosal, Nils Lambrecht, Sandeep B. Subramanya, Rubina Kapadia, Hamid M. Said> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2013 Jan 1
• 36 citations
  Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention
  Martin R. Jadus, Josephine Natividad, Anthony Mai, Yi Ouyang, Nils Lambrecht, Sandor Szabo, Lisheng Ge, Neil Hoa, Maria Dacosta-Iyer> ;Clinical & Developmental Immunology. 2012 Jul 29
• 3 citations
  Excessive therapeutic response in a case of blastic plasmacytoid dendritic cell neoplasm.
  Shieh Mp, Reisian N, Walavalkar, Slater Lm, Nils Lambrecht> ;Clinical Advances in Hematology & Oncology. 2012 Jan 1
• 25 citations
  Ménétrier's disease of the stomach: a clinical challenge.
  Nils Lambrecht> ;Current Gastroenterology Reports. 2011 Sep 20
• 27 citations
  Lipopolysaccharide increases gastric and circulating NUCB2/nesfatin-1 concentrations in rats.
  Andreas Stengel, Miriam Goebel-Stengel, Janusz Jawien, Peter Kobelt, Yvette Taché, Nils Lambrecht> ;Peptides. 2011 Sep 1
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Journal Articles

• Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of non-alcoholic fatty liver disease  
  SH. Ganji, G.D. Kukes, N. Lambrecht, ML. Kashyap, VS. Kamanna, Am J Physiol Gastrointest Liver Physiol, 2/1/2014
• Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects  
  A. Stengel, T. Hofmann, M. Goebel-Stengel, V. Lembke, A. Ahnis, U. Elbelt, N. Lambrecht, J. Ordemann, B.F. Klapp, P. Kobelt, Histochem Cell Biol, 1/1/2013
• The ghrelin activating enzyme ghrelin-O-acyltransferase (GOAT) is present in human plasma and expressed dependent on body mass index  
  M. Goebel-Stengel, T. Hofmann, U. Elbelt, P. Teuffel, A. Ahnis, P. Kobelt, N. Lambrecht, B. Klapp, A. Stengel, Peptides, 1/1/2013
• Excessive therapeutic response in a case of blastic plasmacytoid dendritic cell neoplasm  
  M.P. Shieh, N. Reisian, V. Walavalkar, L.M. Slater, N. Lambrecht, Clin Adv Hematol Oncol, 1/1/2012
• Lung Cancer: a classic example of tumor escape and progression while providing opportunities for immunological intervention  
  MR. Jadus, J. Natividad, A. Mai1, Y. Ouyang, N. Lambrecht, S. Szabo, L. Ge, N. Hoa, and MG. Dacosta-Iyer, Clinical and Developmental Immunology, 1/1/2012
• Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2  
  A. Stengel, M. Goebel-Stengel, L. Wang, A. Shaikh, N. Lambrecht, J. Rivier, Y. Tache, American Journal of Physiology - Gastrointestinal and Liver Physiology, 1/1/2011
• Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa  
  A. Stengel, M. Goebel, L. Wang, Y. Tache, G. Sachs, N. Lambrecht, Biochemical and Biophysical Research Communications, 1/1/2010
• Impaired Intestinal Vitamin B(1) (Thiamin) Uptake in Thiamin Transporter-2-Deficient Mice  
  J.C. Reidling, N. Lambrecht, M. Kassir, H.M. Said, Gastroenterology, 1/1/2010
• Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin acylating enzyme GOAT  
  A. Stengel, M. Goebel, L. Wang, J.R. Reeve Jr., Y. Tache, N. Lambrecht, Peptides, 1/1/2010
• Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei  
  M. Goebel, A. Stengel, N. Lambrecht, L. Wang, Y. Tache, Neuroscience Letters, 1/1/2009
• The transcriptomes of purified gastric ECL and parietal cells: identification of a novel pathway regulating acid secretion  
  N. Lambrecht, I. Yakubov, C. Zer, G. Sachs, Physiol Genomics, 1/1/2006
• Identification of the K efflux channel coupled to the gastric H,K ATPase during acid secretion  
  N. Lambrecht, I. Yakubov, D. Scott, G. Sachs, Physiol Genomics, 1/1/2005
• The control of gastric acid and Helicobacter pylori eradication  
  G. Sachs, J.M. Shin, K. Munson, O. Vagin, N. Lambrecht, D.R. Scott, D.L. Weeks, K. Melchers, Aliment Pharmacol Ther, 1/1/2000
• Structural aspects of the gastric H,K ATPase: The M5/M6 domain and alpha-beta association  
  D. Melle-Milovanovic, N. Lambrecht, G. Sachs, J.M. Shin, Acta Physiol Scand, 1/1/1998
• Identification of the site of inhibition by omeprazole of alpha-beta fusion protein of the HK-ATPase using site directed mutagenesis  
  N. Lambrecht, Z. Corbett, D. Bayle, S.J.D. Karlish, G. Sachs, J Biol Chem, 1/1/1998
• Muller:Functional ablation of sensory neurons impairs the healing of acute gastric mucosal damage in rats  
  B.M. Peskar, N. Lambrecht, Th. Stroff, M. Respondek, K.-M, Dig Dis Sci, 1/1/1995
• Nitric oxide as mediator of the gastroprotection by cholecystokinin-8 and pentagastrin  
  Th. Stroff, N. Lambrecht, B.M. Peskar, Europ J Pharmacol, 1/1/1994
• Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin  
  N. Lambrecht, M. Burchert, M. Respondek, K. M. Müller, B. M. Peskar, Gastroenterology, 1/1/1993
• Effect of prostaglandins and capsaicin on gastric vascular flow and mucosal injury in endothelin-1-treated rats  
  B. M. Peskar, P. Nowak, N. Lambrecht, Agents and Actions, 1/1/1992
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Abstracts/Posters

• Calpain-1 Contributes to Pain and Organ Damage in Sickle Cell Disease
  Nils Lambrecht, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• An Intimal Cardiac Sarcoma with Overexpression of MDM2, first presented as intestinal obstruction, a case report and review of literature.
  N. Lambrecht, ASCP Online Case Reports; American Society for Clinical Pathology, Chicago, IL, 1/1/2014
• A Case Of Unsuspected Hereditary Hemochromatosis And The Important Role Of Autopsy
  Ali Nael, Sasan Setoodeh, M. DaCosta-Iyer, SA. Deshmukh-Rane, Y. Ouyang, N. Lambrecht, Arch Pathol Lab Med, 1/1/2014
• Mechanisms of Preprandial Ghrelin Release From Mouse Gastric X/A-like Cells - Molecular Basis for Regulation by Insulin.
  Michelle Giffin, Janusz Jawien, Andreas Stengel, Miriam Goebel-Stengel, Nils W. Lambrecht, Gastroenterology, 1/1/2013
• The ghrelin activating enzyme ghrelin-O-acyltransferase (GOAT) is present in the human circulation and expressed dependent on body weight.
  Andreas Stengel, Miriam Goebel-Stengel, Tobias Hofmann, Peter Kobelt, Nils W. Lambrecht, Burghard F. Klapp, Gastroenterology, 1/1/2012
• Lipopolysaccharide increases Gastric and Circulating NUCB2/Nesfatin-1 Concentrations in Rats
  Andreas Stengel, Miriam Goebel, Janusz Jawien, Yvette Tache, Nils Lambrecht, Gastroenterology, 1/1/2011
• Abdominal Surgery Inhibits Circulating Acyl Ghrelin and Ghrelin-O-Acyltransferase Levels in Rats: Role of the Somatostatin Receptor 2
  Andreas Stengel, Miriam Goebel, Lixin Wang, Nils W. Lambrecht, Almaas Shaikh, Burghard F. Klapp, Jean E. Rivier, Yvette Tache, Gastroenterology, 1/1/2011
• Exploration of Selective Gene Expression by Rat Gastric Corpus Epithelium
  Miriam Goebel, Andreas Stengel, George Sachs, Nils W. Lambrecht, Gastroenterology, 1/1/2011
• Blastic Plasmacytoid Dendritic Cell Neoplasm
  Niloufar Reisian, Nils W. Lambrecht, Vignesh Walavalkar, Marie Shieh, Lewis Slater, Arch Pathol Lab Med, 1/1/2010
• Differential Distribution of Ghrelin-O-Acyltransferase (Goat) Immunoreactive Cells in the Mouse and Rat Gastric Oxyntic Mucosa
  Miriam Goebel, Andreas Stengel, Lixin Wang, Yvette Tache, George Sachs, Nils W. Lambrecht, Gastroenterology, 1/1/2010
• Comparative Gene Expression Analysis of the Rat Gastrointestinal Tract Epithelia
  Nils W. Lambrecht, Andreas Stengel, Miriam Goebel, George Sachs, Gastroenterology, 1/1/2010
• Fasting Decreases Nesfatin-1/NUCB2 Serum Levels in Rats
  Miriam Goebel, Andreas Stengel, Yvette Tache, George Sachs, Nils W. Lambrecht, Gastroenterology, 1/1/2009
• Isolation and Transcriptomal Characterization of Endocrine Cells of the Rat Ileum
  Nils W. Lambrecht, Andreas Stengel, Miriam Goebel, Yvette Tache, George Sachs, Gastroenterology, 1/1/2009
• Changes in Rat ECL Cell Gene Expression Due to 24 hr Fasting
  Nils W. Lambrecht, Iskandar Yakubov, George Sachs, Gastroenterology, 1/1/2007
• Identification of a Novel Negative Feedback Regulation of the ECL Cell During Acid Secretion By the Parietal Cell Using Subtractive Hybridization Microarray Gene Expre...
  Nils W. Lambrecht, Iskandar Yakubov, Cindy Zer, George Sachs, Gastroenterology, 1/1/2006
• Pacap Activation of Secretory and Proliferative Signaling Pathways in Bon Cells Is Mediated Through PKA, Calmodulin and RAS
  Sandy N. Lieu, David S. Oh, Nils W. Lambrecht, Iskandar Yakubov, George Sachs, Joseph R. Pisegna, Patrizia M. Germano, Gastroenterology, 1/1/2006
• Expression, Localization and Function of the K Channel Complex [kcnq1, Kcne2] in Parietal Cells
  Nils W. Lambrecht, Iskandar Yakubov, George Sachs, Gastroenterology, 1/1/2005
• Physiological Genomics of the Gastric Parietal Cell
  Nils W. Lambrecht, Iskandar Yakubov, George Sachs, Gastroenterology, 1/1/2004
• The binding region of a novel class of anti-ulcer drugs, the imidazo[1,2 alpha] pyridines, on the gastric H,K-ATPase
  Olga Vagin, Keith Munson, Nils W. Lambrecht, George Sachs, Gastroenterology, 1/1/2001
• Mutational analysis of glutamate 820 of the alpha subunit of the rabbit H,K-ATPase
  Nils W. Lambrecht, Keith Munson, George Sachs, Gastroenterology, 1/1/1999
• Identification of the loop region between TM5 and TM6 of the H,K ATPase using cysteine mutagenesis
  N. Lambrecht, Z. Corbett, D. Bayle, S.J.D. Karlish, G. Sachs, Gastroenterology, 1/1/1998
• Prostagalndins involved in mild irritant-evoked gastroprotection are derived via the cyclooxygenase 2 pathway.
  Britta Gretzer, Nils W. Lambrecht, Karlheinz Ehrlich, M. Chantrain, Brigitta M Peskar, Gastroenterology, 1/1/1997
• Functional expression of the gastric H,K-ATPase as an alpha-beta fusion protein.
  Nils W. Lambrecht, Denis Bayle, Steve J. D. Karlish and George Sachs, Gastroenterology, 1/1/1996
• Is omeprazole resistance due to mutations of cysteine 813 or 822 in the acid pump?
  Luis P. Leite, Nils W. Lambrecht, George Sachs, Donald O. Castell, Per-Olaf Lagerstrom, Gastroenterology, 1/1/1995
• Nitric oxide participates in the regulation of gastric emptying but is not involved in the inhibitory effects of cholecystokinin (CCK)-8 on gastric motility in rats.
  Susanne Plate, Nils W. Lambrecht, Brigitta M Peskar, Gastroenterology, 1/1/1994
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