NirmishShahMD

Medicine/Pediatrics • Durham, NC

Associate Professor at Duke University

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Office
40 Medicine Circle
Durham, NC 27710
Phone+1 919-684-8111
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Education & Training

Duke University HospitalFellowship, Pediatric Hematology/Oncology, 2010
Vidant Medical Center/East Carolina UniversityResidency, Internal Medicine/Pediatrics, 2000 - 2004
American University of the Caribbean School of MedicineClass of 2000

Certifications & Licensure

NC State Medical License 2000 - 2024

Clinical Trials

Evaluation of the Duration of Therapy for Thrombosis in Children Start of enrollment: 2008 Mar 01
Completed
Phase 3
Treatment of Sickle Cell Patients Hospitalized in Pain Crisis With Prophylactic Dose Low-molecular-weight Heparin (LMWH) Versus Placebo Start of enrollment: 2011 May 01
Completed
Phase 2
A Phase II Trial of Regadenoson in Sickle Cell Anemia Start of enrollment: 2013 Jul 01
Completed
Phase 2
Use of a Mobile-based App for SCD Patients Start of enrollment: 2012 Jun 01
Completed
Use of Mobile Technology for Intensive Training in Medication Management Start of enrollment: 2014 May 01
Completed
Not Applicable
Apixaban in Patients With Sickle Cell Disease Start of enrollment: 2015 Jan 01
Terminated
Phase 3
Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD) Start of enrollment: 2018 Feb 05
Terminated
Not Applicable
Ketamine Infusion for Sickle Cell Pain Crisis Start of enrollment: 2022 Jan 01
Withdrawn
Phase 4
Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell Via Mobile Applications Start of enrollment: 2020 Aug 12
Completed
Not Applicable
Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease Start of enrollment: 2020 Oct 27
Completed
Not Applicable
A Study to Assess the Safety and Efficacy of Inclacumab in Participants With Sickle Cell Disease Experiencing Vaso-occlusive Crises Start of enrollment: 2021 Oct 26
Active, not recruiting
Phase 3
Roles: Principal Investigator
Patient-Empowered Mobile Technology in Hospitalized Patients (TRU-PAIN) Start of enrollment: 2016 Aug 01
Recruiting
Not Applicable
Roles: Contact, Principal Investigator
Patient-Empowered Mobile Technology in Hospitalized Patients (TRU-PAIN) Start of enrollment: 2016 Aug 01
Recruiting
Not Applicable
Roles: Contact, Principal Investigator
Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain Start of enrollment: 2021 Nov 24
Recruiting
Phase 2
Roles: Contact
AB1 in Adult Patients With Sickle Cell Disease (SCD) Start of enrollment: 2022 Dec 05
Recruiting
Phase 1, Phase 2
Roles: Contact, Principal Investigator, Sponsor-Investigator
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers Start of enrollment: 2018 Apr 06
Completed
Phase 2
Roles: Contact
Predictors of Pain in Sickle Cell Disease Start of enrollment: 2024 Apr 01
Not yet recruiting
Not Applicable
Roles: Contact
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Publications & Presentations

PubMed

Recruitment Strategies in the Integration of Mobile Health Into Sickle Cell Disease Care to Increase Hydroxyurea Utilization Study (meSH): Multicenter Survey Study.
Chinonyelum Nwosu, Hamda Khan, Rita Masese, Judith M Nocek, Siera Gollan, Taniya Varughese, Sarah Bourne, Cindy Clesca, Sara R Jacobs, Ana Baumann, Lisa M Klesges, Jan...> ;JMIR Formative Research. 2024 Apr 16
Opioid Use Among Children and Adults With Sickle Cell Disease in North Carolina Medicaid Enrollees in the Era of Opioid Harm Reduction.
Nancy Crego, Christian Douglas, Emily Bonnabeau, Kern Eason, Marian Earls, Paula Tanabe, Nirmish Shah> ;Journal of Pediatric Hematology/oncology. 2024 May 1
Mortality in adults with sickle cell disease: Results from the sickle cell disease implementation consortium (SCDIC) registry.
Franklin Njoku, Norma Pugh, Donald Brambilla, Barbara Kroner, Nirmish Shah, Marsha Treadwell, Robert Gibson, Lewis L Hsu, Victor R Gordeuk, Jeffrey Glassberg, Jane S H...> ;American Journal of Hematology. 2024 May 1
Mental health, pain and likelihood of opioid misuse among adults with sickle cell disease.
Jonassaint, C., Parchuri, E., O'Brien, J., Lalama, C., Lin, J., Badawy, S., Hamm, M., Stinson, J., Lalloo, C., Carroll, C., Saraf, S., Gordeuk, V., Cronin, R., Shah, N...> ;British Journal of Haematology. 2024 Mar 1
Supporting data driven translational patient-centered care using network analysis to visualize symptom distress in children with serious illness.
Ford, S., Vaughn, J., Subramaniam, A., Gundala, A., Hensley, E., Shah, N.> ;Journal for Specialists in Pediatric Nursing. 2024 Jan 1
1 citations
Preferences for potential benefits and risks for gene therapy in the treatment of sickle cell disease.
Juan Marcos Gonzalez Sepulveda, Jui-Chen Yang, Shelby D Reed, Ting-Hsuan Lee, Xinyi Ng, Telba Irony, Martin Ho, Carolyn Rowley, Kaiwen Li, Marilyn J Telen, Rothman, J....> ;Blood Advances. 2023 Dec 12
Monitoring and responding to signals of suicidal ideation in pragmatic clinical trials: Lessons from the GRACE trial for Chronic Sickle Cell Disease Pain.
Eric S Swirsky, Andrew D Boyd, Carol Gu, Larisa A Burke, Ardith Z Doorenbos, Miriam O Ezenwa, Mitchell R Knisely, Jonathan W Leigh, Hongjin Li, Molly W Mandernach, Rob...> ;Contemporary Clinical Trials Communications. 2023 Dec 1
Characterizing epigenetic aging in an adult sickle cell disease cohort.
Brandon M Lê, Qing Yang, Nirmish Shah, Melanie E Garrett, Allison E Ashley-Koch, Daniel Hatch, Faith S Luyster, Paula Tanabe, Mitchell R Knisely> ;Blood Advances. 2024 Jan 9
A multilevel mHealth intervention boosts adherence to hydroxyurea in individuals with sickle cell disease.
Jane S Hankins, Donald Brambilla, Michael B Potter, Abdullah Kutlar, Robert Gibson, Allison A King, Ana A Baumann, Cathy Melvin, Victor R Gordeuk, Lewis L Hsu, Chinony...> ;Blood Advances. 2023 Dec 12
1 citations
Feasibility of Implementation of a Mobile Digital Personal Health Record to Coordinate Care for Children and Youth With Special Health Care Needs in Primary Care: Prot...
David Y Ming, Willis Wong, Kelley A Jones, Richard C Antonelli, Nitin Gujral, Sarah Gonzales, Ursula Rogers, William Ratliff, Nirmish Shah, Heather A King> ;JMIR Research Protocols. 2023 Sep 20
Outcomes of End-User Testing of a Care Coordination Mobile App With Families of Children With Special Health Care Needs: Simulation Study.
Willis Wong, David Ming, Sara Pateras, Casey Holmes Fee, Cara Coleman, Michael Docktor, Nirmish Shah, Richard Antonelli> ;JMIR Formative Research. 2023 Aug 28
Biopsychosocial Factors Associated With Pain and Pain-Related Outcomes in Adults and Children With Sickle Cell Disease: A Multivariable Analysis of the GRNDaD Multicen...
Martha O Kenney, Samuel Wilson, Nirmish Shah, Andrey Bortsov, Wally R Smith, Jane Little, Sophie Lanzkron, Julie Kanter, Susan Padrino, Amma Owusu-Ansah, Alice Cohen, ...> ;The Journal of Pain. 2024 Jan 1
Burden of Aging: Health Outcomes Among Adolescents and Young Adults With Sickle Cell Disease.
Kristen E Howell, Norma Pugh, Jennifer Longoria, Nirmish Shah, Abdullah Kutlar, Victor R Gordeuk, Allison A King, Jeffrey Glassberg, Mariam Kayle, Cathy Melvin, Marsha...> ;Hemasphere. 2023 Aug 1
1 citations
Developing an Implementation Blueprint for the NIH HEAL Initiative GRACE Trial: Perspectives on Acupuncture and Guided Relaxation for Chronic Sickle Cell Disease Pain.
Mitchell R Knisely, Eleanor Rivera, Victoria A deMartelly, Aisha Abdulkadir, Ardith Z Doorenbos, Miriam O Ezenwa, Robert E Molokie, Hongjin Li, Nirmish Shah, Judith M ...> ;Journal of Integrative and Complementary Medicine. 2023 Oct 1
1 citations
Infertility and treatment-seeking practices among females and males with sickle cell disease in the Sickle Cell Disease Implementation Consortium registry.
Eleanor Stevenson, Paula Tanabe, Mitchell Knisely, Rita Masese, Dominique Bulgin, Liliana Preiss, Jane S Hankins, Allison A King, Victor Gordeuk, Nirmish Shah> ;Pediatric Blood & Cancer. 2023 Jul 1
5 citations
Hybrid effectiveness-implementation trial of guided relaxation and acupuncture for chronic sickle cell disease pain (GRACE): A protocol.
Ardith Z Doorenbos, Judith M Schlaeger, Victoria A deMartelly, Larisa A Burke, Andrew D Boyd, Mitchell R Knisely, Jonathan W Leigh, Hongjin Li, Molly W Mandernach, Rob...> ;Contemporary Clinical Trials Communications. 2023 Apr 1
1 citations
Predicting Pain in People With Sickle Cell Disease in the Day Hospital Using the Commercial Wearable Apple Watch: Feasibility Study.
Rebecca Sofia Stojancic, Arvind Subramaniam, Caroline Vuong, Kumar Utkarsh, Nuran Golbasi, Olivia Fernandez, Nirmish Shah> ;JMIR Formative Research. 2023 Mar 14
3 citations
Evaluating Associations between Average Pain Intensity and Genetic Variation in People with Sickle Cell Disease: An Exploratory Study.
Mitchell R Knisely, Qing Yang, Nic Stauffer, Martha Kenney, Allison Ashley-Koch, John Myers, Julia K L Walker, Paula J Tanabe, Nirmish R Shah> ;Pain Management Nursing. 2023 Feb 1
Intrahepatic cholestasis in sickle cell disease: A review of diagnostic criteria, treatments, and case reports.
Christopher L Edwards, Sharena Scott, Michaela Boggan, Jordan Meek, Kiera Alston, Aiden Pearson, Alexandria McDougald, McKenzie Broadnax, Mary Wood, Camela S Barker, J...> ;Journal of the National Medical Association. 2023 Feb 1
Use of consumer wearables to monitor and predict pain in patients with sickle cell disease.
Caroline Vuong, Kumar Utkarsh, Rebecca Stojancic, Arvind Subramaniam, Olivia Fernandez, Tanvi Banerjee, Daniel M Abrams, Karin Fijnvandraat, Nirmish Shah> ;Frontiers in Digital Health. 2023 Jan 1
Characterising the prevalence of overweight and obese status among adults with sickle cell disease.
Stephanie O Ibemere, Charity I Oyedeji, Liliana Preiss, Laura E Van Althuis, Jane S Hankins, Melissa Azul, Ebony N Burns, Jeffrey Glassberg, Ward Hagar, Faiz Hussain, ...> ;British Journal of Haematology. 2023 Mar 1
4 citations
Pharmacokinetics, pharmacodynamics, safety, and efficacy of crizanlizumab in patients with sickle cell disease.
Julie Kanter, R Clark Brown, Cynthia Norris, Santosh M Nair, Abdullah Kutlar, Deepa Manwani, Nirmish Shah, Chiaki Tanaka, Shankaranand Bodla, Gessami Sanchez-Olle, Urs...> ;Blood Advances. 2023 Mar 28
4 citations
Impact of the COVID-19 Pandemic on the Implementation of Mobile Health to Improve the Uptake of Hydroxyurea in Patients With Sickle Cell Disease: Mixed Methods Study.
Sherif M Badawy, Lisa DiMartino, Donald Brambilla, Lisa Klesges, Ana Baumann, Ebony Burns, Terri DeMartino, Sara Jacobs, Hamda Khan, Chinonyelum Nwosu, Nirmish Shah, J...> ;JMIR Formative Research. 2022 Oct 14
Transitioning Adolescents With Sickle Cell Disease From Pediatric to Adult Care: Results From a New Survey of Health Care Professionals.
Nirmish R Shah, Marsha J Treadwell, Elliott Vichinsky> ;Journal of Pediatric Hematology/oncology. 2022 Oct 1
1 citations
A clinician's view of voxelotor.
Ifeyinwa Osunkwo, Alan Anderson, R Clark Brown, Nirmish Shah, Jeremie H Estepp> ;British Journal of Haematology. 2022 Nov 1
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Journal Articles

Effects of Red Blood Cell (RBC) Transfusion on Sickle Cell Disease Recipient Plasma and RBC Metabolism
Nirmish Shah, Ian Welsby, Reed Kamyszek, Andrea Ansari, Transfusion
Transition to Adult Care in Sickle Cell Disease: A Longitudinal Study of Clinical Characteristics and Disease Severity
Nirmish Shah, Gary Maslow, Pediatric Blood & Cancer

Press Mentions

GBT Presents Positive New Data on Oxbryta® (Voxelotor) in Patients with Sickle Cell Disease at ASH Annual Meeting and ExpositionDecember 12th, 2021
Development of a Severity Classification System for Sickle Cell DiseaseOctober 28th, 2020
Treating Sickle Cell Disease with HSCTFebruary 19th, 2020
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