NolanHowardSigalMDPhD

PubMed

• 17 citations
  Surfing the piperazine core of tricyclic farnesyltransferase inhibitors
  Laura L. Rokosz, Chia-Yu Huang, John C. Reader, Tara M. Stauffer, Daniel Chelsky, Nolan H. Sigal, Ashit K. Ganguly, Baldwin John J> ;Bioorganic & Medicinal Chemistry Letters. 2005 Dec 15
• 28 citations
  Heterogeneity of the BALB/c IgM anti-phosphorylcholine antibody response.
  Judith A. Owen, Nolan H. Sigal, Norman R. Klinman> ;Nature. 1982 Jan 28
• 68 citations
  The B-Cell Clonotype Repertoire
  Nolan H. Sigal, Norman R. Klinman> ;Advances in Immunology. 1978 Jan 1
• 39 citations
  Differential expression of an equivalent clonotype among BALB/c and C57BL/6 mice
  Michael P. Cancro, Nolan H. Sigal, Norman R. Klinman> ;The Journal of Experimental Medicine. 1978 Jan 1
• 34 citations
  Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells.
  R. S. Accolla, Patricia J. Gearhart, Nolan H. Sigal, Michael P. Cancro, Norman R. Klinman> ;European Journal of Immunology. 1977 Dec 1
• 71 citations
  Expression of phosphorylcholine-specific B cells during murine development
  Nolan H. Sigal, Allan R. Pickard, Eleanor S. Metcalf, Patricia J. Gearhart, Norman R. Klinman> ;The Journal of Experimental Medicine. 1977 Oct 1
• 15 citations
  The Frequency of p-Azophenylarsonate and Dimethylaminonapthalene-Sulfonyl-Specific B Cells in Neonatal and Adult BALB/c Mice
  Nolan H. Sigal> ;Journal of Immunology. 1977 Sep 1
• 3 citations
  Novel idiotypic and antigen-binding characteristics in two anti-dinitrophenyl monoclonal antibodies.
  Nolan H. Sigal> ;The Journal of Experimental Medicine. 1977 Jul 1
• 27 citations
  In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification.
  Eleanor S. Metcalf, Nolan H. Sigal, Norman R. Klinman> ;The Journal of Experimental Medicine. 1977 May 1
• 46 citations
  The monoclonal anti-phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire.
  Patricia J. Gearhart, Nolan H. Sigal, Norman R. Klinman> ;The Journal of Experimental Medicine. 1977 Apr 1
• 26 citations
  The Interplay of Evolution and Environment in B-cell Diversification
  Norman R. Klinman, Nolan H. Sigal, E. S. Metcalf, Susan K. Pierce, Patricia J. Gearhart> ;Cold Spring Harbor Symposia on Quantitative Biology. 1977 Jan 1
• 79 citations
  Assessing B cell diversification by antigen receptor and precursor cell analysis.
  Norman R. Klinman, Allan R. Pickard, Nolan H. Sigal, Patricia J. Gearhart, E. S. Metcalf, Susan K. Pierce> ;Annales D'immunologie. 1976 Jun 1
• 65 citations
  Late acquisition of a germ line antibody specificity.
  Nolan H. Sigal, Patricia J. Gearhart, Joan L. Press, Norman R. Klinman> ;Nature. 1976 Jan 1
• 106 citations
  Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.
  Patricia J. Gearhart, Nolan H. Sigal, Norman R. Klinman> ;Proceedings of the National Academy of Sciences of the United States of America. 1975 May 1
• 53 citations
  The Frequency of Phosphorylcholine-Specific B Cells in Conventional and Germfree Balb/c Mice
  Nolan H. Sigal, Patricia J. Gearhart, Norman R. Klinman> ;Journal of Immunology. 1975 Apr 1
• 101 citations
  Heterogeneity of the balb/c antiphosphorylcholine antibody response at the precursor cell level.
  Patricia J. Gearhart, Nolan H. Sigal, Norman R. Klinman> ;The Journal of Experimental Medicine. 1975 Jan 1
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Journal Articles

• A DNA-unwinding protein isolated from Escherichia coli: Its interaction with DNA and with DNA polymerases.  
  Sigal, N.H., H. Delius, T. Kornberg, M. Gefter, and B. Alberts, Proc. Natl. Acad. Sci. USA 69: 3537-3541
• Genetic recombination: The nature of a crossed strand-exchange between two homologous DNA molecules.  
  Sigal, N.H., and B. Alberts, J. Molec. Biol. 71: 789-793
• Heterogeneity of the BALB/c anti-phosphorylcholine antibody response at the precursor cell level.  
  Gearhart, P.J., N.H. Sigal, and N.R. Klinman, J. Exp. Med. 141: 56-71
• The frequency of phosphorylcholine-specific B cells in conventional and germfree BALB/c mice.  
  Sigal, N.H., P.J. Gearhart, and N.R. Klinman, J. Immunol. 68: 1354-1358
• Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.  
  Gearhart, P.J., N.H. Sigal, and N.R. Klinman, Proc. Natl. Acad. Sci. USA 72: 1707-1711
• Late acquisition of a germ line antibody specificity.  
  Sigal, N.H., P.J. Gearhart, J.L. Press, and N.R. Klinman, Nature 259: 51-52
• The monoclonal anti-phosphorylcholine antibody response in several murine strains: Genetic implications of a diverse repertoire.  
  Gearhart, P.J., N.H. Sigal, and N.R. Klinman, J. Exp. Med. 145: 876-891
• In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification.  
  Metcalf, E.S., N.H. Sigal, and N.R. Klinman, J. Exp. Med. 145: 1382-1386
• Novel idiotypic and antigen-binding characteristics in two anti-dinitrophenyl monoclonal antibodies.  
  Sigal, N.H, J. Exp. Med. 146: 282-286
• The frequency of p-azophenylarsonate and dimethylaminonaphthalene-sulfonyl-specific B cells in neonatal and adult BALB/c mice.  
  Sigal, N.H, J. Immunol. 119: 1129-1133
• Expression of phosphorylcholine-specific B cells during murine development.  
  Sigal, N.H., A.R. Pickard, E.S. Metcalf, P.J. Gearhart, and N.R. Klinman, J. Exp. Med. 146: 933-948
• Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells.  
  Accolla, R.S., P.J. Gearhart, N.H. Sigal, M.P. Cancro, and N.R. Klinman, Eur. J. Immunol. 7: 867-881
• Differential expression of an equivalent clonotype among BALB/c and C57BL/6 mice.  
  Cancro, M.P., N.H. Sigal, and N.R. Klinman, J. Exp. Med. 147: 1-12
• Heterogeneity of the BALB/c IgM anti-phosphorylcholine antibody response.  
  Owen, J.A., N.H. Sigal, and N.R. Klinman, Nature 295: 347-348
• Modulation of chronic lymphocytic leukemia cells by phorbol ester: Increase in Ia expression, IgM secretion and MLR stimulation capacity.  
  Okamura, J., M. Letarte, L.D. Stein, N.H. Sigal, and E.W. Gelfand, J. Immunol. 128: 2276-2280
• Regulation of azophenylarsonate-specific repertoire expression I: Frequency of cross-reactive idiotype-positive B cells in A/J and BALB/c mice.  
  Sigal, N.H, J. Exp. Med. 156: 1352-1365
• Patterns of isotype commitment in human B cells: Limiting dilution analysis of Epstein-Barr virus-infected cells.  
  Stein, L.D., C.J. Ledgley, and N.H. Sigal, J. Immunol. 130: 1640-1645
• Limiting dilution analysis of Epstein-Barr virus-induced immunoglobulin production.  
  Stein, L.D., and N.H. Sigal, Cell Immunol. 79: 309-319
• Regulation of azophenylarsonate-specific repertoire expression II: Fine specificity and isotype heterogeneity of anti-arsonate antibodies.  
  Sigal, N.H, J. Immunol. 131: 1889-1894
• Absence of lymphocyte ecto-5'-nucleotidase in infants with reticuloendotheliosis and immunodeficiency.  
  Gelfand, E.W., C.P. Rao, D. McCurdy, N.H. Sigal, and A. Cohen, Adv. in Exp. Med. Biol. 165: 141-146
• Heterogeneity of the human phosphocholine-specific B cell repertoire.  
  Stein, L.D., and N.H. Sigal, J. Immunol. 132: 1329-1335
• Ecto-5'-nucleotidase I: Expression in human normal and neoplastic lymphoid cell lines representing sequential stages of B-cell differentiation.  
  Sen-Gupta, S., T. Hibi, A. MacKay, V. Markovia, L.D. Stein, N.H. Sigal, E.W. Gelfand, and B.E. Chechik, J. Nat. Cancer Inst. 73: 1075-1080
• Heterogeneity of EBV-transformable human B lymphocyte populations.  
  Chan, M.A., L.D. Stein, H.-M. Dosch, and N.H. Sigal, J. Immunol. 136: 106-112
• Characterization of murine monoclonal antibodies to E. coli J5.  
  Miner, K.M., C.L. Manyak, E. Williams, J. Jackson, M. Jewell, M.T. Gammon, C. Ehrenfreund, E. Hayes, L.T. Callahan III, H. Zweerink, and N.H. Sigal, Infection and Immunity 52: 56-62
• In vitro regulation of IgA subclass production III: Selective transformation of IgAl producing cells by Epstein-Barr virus.  
  Conley, M.E., Chan, M.A., and N.H. Sigal, J. Immunol. 138: 1402-1407
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Books/Book Chapters

• The Generation of Diversity: A New Look. 
  Chapter: The acquisition of the B cell specificity repertoire: The germ-line theory of predetermined permutation of genetic information 
  Page 127 - 149Klinman, N.R., J.L. Press, N.H. Sigal, and P.J. GearhartEditors: A. J. Cunningham.Academic Press, London
• Development of Host Defenses. 
  Chapter: Functional analysis of B cell maturation at the clonotype level 
  Page 93 - 106Klinman, N.R., E.S. Metcalf, and N.H. SigalEditors: M.D. Cooper and D.H. Dayton.Raven Press, New York
• Regulation of the Immune System: Genes and the Cells in Which They Function. 
  Chapter: The significance of minor clonotypes in the dissection of B-cell diversification 
  Page 217 - 224Sigal, N.H., M.P. Cancro, and N.R. KlinmanEditors: E.E. Sercarz and L.A. Herzenberg.Academic Press, New York
• Developmental Immunobiology. 
  Chapter: Control of the expression of the B-cell specificity repertoire 
  Page 179 - 193Klinman, N.R., M.P. Cancro, S.K. Pierce, J.A. Owen, E.S. Metcalf, and N.H. SigalEditors: G.W. Siskind, S.D. Litwin, and M.E. Wecksler.Academic Press, New York
• Human B Lymphocyte Function, Activation and Immunoregulation. 
  Chapter: Parallel quantitation in individual microcultures of antigen- and class-specific immunoglobulins 
  Page 103 - 118Sigal, N.H., and H.M. DoschEditors: A.S. Fauci and R.E. Ballieux.Raven Press, New York
• Human B Lymphocyte Function, Activation and Immunoregulation. 
  Chapter: Hapten-carrier-induced PFC responses in humans 
  Page 61 - 71Dosch, H.M., N.H. Sigal, and E.W. GelfandEditors: A.S. Fauci and R.E. Ballieux.Raven Press, New York
• Regulation of the Immune System. 
  Chapter: The development and diversity of B cells 
  Page 441 - 444Sigal, N.H., and L.S. WickerEditors: H. Cantor, L. Chess, and E. Sercarz.Alan R. Liss, Inc, New York
• Investigation of Cell-Mediated Immunity. 
  Chapter: Lymphocyte activation 
  Page 135 - 146Sigal, N.HEditors: T. Yoshida.Churchill Livingstone, New York
• The Biology of the Interferon System. 
  Chapter: Antagonistic effect of alpha and beta interferon on Ia-induction by gamma interferon 
  Page 351 - 354Manyak, C.L., N.H. Sigal, H.C. Passmore, and G.C. KooEditors: W.E. Stewart II and H. Schellekens.Elsevier Science Publishers, New York
• Idiotypes and Diseases. 
  Chapter: Idiotypic analysis of the influenza virus-specific human B cell repertoire 
  Page 134 - 142Sigal, N.H., M. Chan, M.A. Reale, T. Moran, J.L. Schulman, and C. BonaEditors: M. Zanetti, C. Bona, and F. Celada.Karger, Basel
• Idiotypes and Diseases. 
  Chapter: Effects of immunization with syngeneic monoclonal anti-idiotype antibody on antibody responses to influenza viruses 
  Page 143 - 149Schulman, J.L., T.M. Moran, M. Monestier, M. Reale, Y. Beilin, N.H. Sigal, and C.A. BonaEditors: M. Zanetti, C. Bona and F. Celada.Karger, Basel
• Report of the NIAID Task Force on Immunology and Allergy.s. 
  Chapter: Nonspecific immunosuppressive drugs: CsA and FK-506 
  Page 43 - 48Sigal, N.HEditors: S. Burakoff and C. Carpenter.U.S. Department of Health and Human Services
• Adv. Medicinal Chemistry. 
  Chapter: Chemistry and biology of the immunosuppressant FK-506 
  Page 55 - 108Shinkai, I. and N.H. SigalEditors: B.E. Maryanoff and C.A. Maryanoff.JAI Press, Greenwich
• Fundamental Immunology. 
  Chapter: Immunosuppression 
  Page 903 - 916Sigal, N.H. and F.J. DumontEditors: W.E. Paul.Raven Press, New York
• Perspectives in Drug Discovery and Design: Immunosuppressive Agents. 
  Sigal, N.HEditors: Sigal, N.H. and M.J. Wyvratt.ESCOM Publishers, Leiden, Netherlands
• Immunopharmaceuticals. 
  Chapter: FK-506: Preclinical and clinical studies 
  Page 1 - 30Parsons, W.H. and N.H. SigalEditors: E.S. Kimball.CRC Press, Boca Raton
• Combinatorial Chemistry and Molecular Diversity in Drug Discovery. 
  Chapter: Approaches and technologies for screening large combinatorial libraries 
  Page 433 - 445Sigal, N.H. and D. ChelskyEditors: E.M. Gordon and J.F. Kerwin.John Wiley & Sons, New York
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Abstracts/Posters

• The interplay of evolution and environment in B-cell diversification.
  Klinman, N.R., N.H. Sigal, E.S. Metcalf, S.K. Pierce, and P.J. Gearhart, Cold Spring Harbor Symp. Quant. Biol. 41: 165-173

Other

• Novel 6-position analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin. 
  N.H. Sigal, U.S. patent number 4,914,188
• Process for identifying and assaying L-679,934 immunosuppressive agents. 
  N.H. Sigal, U.S. patent number 5,109,112