OmarYusufMianMDPhD

PubMed

• Alignment of molecular subtypes across multiple bladder cancer subtyping classifiers.
  Moritz J Reike, Joep J de Jong, Tarek A Bismar, Stephen A Boorjian, Omar Y Mian, Jonathan L Wright, Marc A Dall'Era, Hristros Z Kaimakliotis, Yair Lotan, Joost L Boorm...> ;Urologic Oncology. 2024 Mar 12
• Emerging Insights in Small-Cell Carcinoma of the Genitourinary Tract: From Diagnosis to Novel Therapeutic Horizons.
  Ruan, H., Huynh, M., Nadal Rios, R., Barata, P., Liao, R., Jang, A., Hoffman-Censits, J., Wei, S., Mian, O., Jang, A.> ;American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 2024 Jan 1
• Withdraw or Deposit?
  Mian, O., Tendulkar, R.> ;International Journal of Radiation Oncology, Biology, Physics. 2024 Jan 1
• Optimization and experimental characterization of the innovative thermo-brachytherapy seed for prostate cancer treatment.
  Taghizadeh, S., Shvydka, D., Shan, A., Parsai, E., Mian, O.> ;Medical Physics. 2024 Feb 1
• Novel therapies for metastatic prostate cancer.
  Albert Jang, Sree M Lanka, Hui Ting Ruan, Hamsa L S Kumar, Angela Y Jia, Jorge A Garcia, Omar Y Mian, Pedro C Barata, Jang, A.> ;Expert Review of Anticancer Therapy. 2023 Dec 8
• 1 citations
  Transperineal ultrasound is a good alternative for intra-fraction motion monitoring for prostate stereotactic body radiotherapy.
  Bingqi Guo, Kevin Stephans, Andrew Godley, Matt Kolar, Anthony Magnelli, Rahul Tendulkar, Omar Mian, David Majkszak, Ping Xia> ;Journal of Applied Clinical Medical Physics. 2023 Oct 1
• 1 citations
  Disparities in Prostate Cancer Diagnoses Among Persons Experiencing Homelessness.
  Zachary S Mayo, Sean M Parker, Sarah S Kilic, Jeremy Weleff, Michael Phelan, Omar Y Mian, Kevin L Stephans, John H Suh, Rahul D Tendulkar> ;European Urology. 2023 Jul 1
• The combination of prostate MRI PI-RADS scoring system and a genomic classifier is associated with pelvic lymph node metastasis at the time of radical prostatectomy.
  Jane K Nguyen, Ryan Ward, Martin Hofmann, Eric A Klein, Omar Y Mian, Christopher J Weight, Andrei S Purysko, Tarik Benidir, Zaeem Lone> ;The British Journal of Radiology. 2023 Mar 1
• 2 citations
  Lineage plasticity and treatment resistance in prostate cancer: the intersection of genetics, epigenetics, and evolution.
  Jarrell Imamura, Shinjini Ganguly, Andrew Muskara, Ross S Liao, Jane K Nguyen, Christopher Weight, Christopher E Wee, Shilpa Gupta, Omar Y Mian> ;Frontiers in Endocrinology. 2023 Jan 1
• 85 citations
  NCCN Guidelines® Insights: Bladder Cancer, Version 2.2022.
  Thomas W Flaig, Philippe E Spiess, Michael Abern, Neeraj Agarwal, Rick Bangs, Stephen A Boorjian, Mark K Buyyounouski, Kevin Chan, Sam Chang, Terence Friedlander, Rich...> ;Journal of the National Comprehensive Cancer Network. 2022 Aug 1
• 6 citations
  Transcriptomic Features of Cribriform and Intraductal Carcinoma of the Prostate.
  Magdalena Rainey, Monica Nair, Elai Davicioni, Ewan A Gibb, Sean Williamson, Shilpa Gupta, Moshe Chaim Ornstein, Rahul Tendulkar, Christopher Weight, Jane K Nguyen, Er...> ;European Urology Focus. 2022 Nov 1
• 4 citations
  Prostate Cancer Screening Disparities in Persons Experiencing Homelessness.
  Zachary S Mayo, Sarah S Kilic, Jeremy Weleff, Sean M Parker, Colleen Strzalka, Michael Phelan, Omar Y Mian, Kevin L Stephans, John H Suh, Rahul D Tendulkar> ;JCO Oncology Practice. 2022 Nov 1
• PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin.
  Reem Elagooz, Anita R Dhara, Rose M Gott, Sarah E Adams, Rachael A White, Arnab Ghosh, Shinjini Ganguly, Yuncheng Man, Amma Owusu-Ansah, Omar Y Mian, Umut A Gurkan, An...> ;Blood Advances. 2022 Dec 13
• 11 citations
  Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia.
  Yihong Guan, Metis Hasipek, Dongxu Jiang, Anand D Tiwari, Dale R Grabowski, Simona Pagliuca, Sunisa Kongkiatkamon, Bhumika Patel, Salendra Singh, Yvonne Parker, Thomas...> ;The Journal of Clinical Investigation. 2022 Feb 15
• 8 citations
  Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor.
  Peter M Anderson, Matteo M Trucco, Rohinton S Tarapore, Stacey Zahler, Stefanie Thomas, Janette Gortz, Omar Mian, Martin Stoignew, Varun Prabhu, Sara Morrow, Joshua E ...> ;Clinical Cancer Research. 2022 May 2
• 8 citations
  The Nexus of Endocrine Signaling and Cancer: How Steroid Hormones Influence Genomic Stability.
  Shinjini Ganguly, Divya Naik, Andrew Muskara, Omar Y. Mian> ;Endocrinology. 2021 Jan 1
• The landscape of early carcinogenesis revealed through the lens of integrative genomics, epigenomics, and transcriptomics
  Aysegul Balyimez, Kevin L. Stephans, Mohamed E. Abazeed, Omar Y. Mian> ;Journal of Thoracic Disease. 2019 Jun 1
• 6 citations
  The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
  Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed> ;Translational Cancer Research. 2017 Dec 1
• 2 citations
  125I Interstitial brachytherapy with or without androgen deprivation therapy among unfavorable-intermediate and high-risk prostate cancer.
  Timothy D. Smile, M.C. Tom, Ahmed Halima, Jay P. Ciezki, Chandana A. Reddy, Kevin L. Stephans, Omar Y. Mian, Ryan X. Zhang, Eric A. Klein, Steven C. Campbell, James Ul...> ;Brachytherapy. 2021 Oct 14
• 27 citations
  Patients With Muscle Invasive Bladder Cancer with Non-luminal Subtype Derive Greatest Benefit from Platinum Based Neoadjuvant Chemotherapy.
  Yair Lotan, Joep J. de Jong, Vinnie Y. T. Liu, Tarek A. Bismar, Stephen A. Boorjian, Huei-Chung Huang, Elai Davicioni, Omar Y. Mian, Jonathan L. Wright, Andrea Necchi,...> ;The Journal of Urology. 2021 Oct 13
• 3 citations
  Current Landscape and Future Directions on Bladder Sparing Approaches to Muscle-Invasive Bladder Cancer.
  James R. Broughman, Winston Vuong, Omar Y. Mian> ;Current Treatment Options in Oncology. 2021 Jan 1
• 3 citations
  Responses to the 2018 and 2019 'One Big Discovery' Question: ASTRO membership's opinions on the most important research question facing radiation oncology…where are we...
  Michael M. Dominello, Tim Sanders, Mitchell S. Anscher, John E. Bayouth, Kristy K. Brock, David J. Carlson, Geoffrey D. Hugo, Sabrina Joseph, Jonathan P.S. Knisely, Ma...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Jan 1
• 3 citations
  A Therapeutic Strategy for Preferential Targeting of TET2 Mutant and TET-dioxygenase Deficient Cells in Myeloid Neoplasms.
  Yihong Guan, Anand D Tiwari, James G Phillips, Metis Hasipek, Dale R Grabowski, Simona Pagliuca, Priyanka Gopal, Cassandra M Kerr, Vera Adema, Tomas Radivoyevitch, Yvo...> ;Blood Cancer Discovery. 2021 Mar 1
• 8 citations
  Management of Oligometastatic Prostate Cancer.
  James R. Broughman, C.W. Fleming, Omar Y. Mian, Kevin L. Stephans, Rahul D. Tendulkar> ;Applied Radiation Oncology. 2020 Sep 9
• 55 citations
  Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures
  Robert Vander Velde, Nara Yoon, Viktoriya Marusyk, Arda Durmaz, Andrew Dhawan, Daria Miroshnychenko, Diego Lozano-Peral, Bina Desai, Olena Balynska, Jan Poleszhuk, Liu...> ;Nature Communications. 2020 May 14
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Journal Articles

• Use of 5-alpha-reductase inhibitors as alternatives to luteinizinghormone releasing hormone (LHRH) analogs or anti-androgens for prostate downsizing before brachytherapy  
  Bae HJ, Mian Omar Y, Vaidya D, DeWeese TL, Song DY, Pract Radiat Oncol, 1/10/2017
• Current controversies in prostate brachytherapy for prostate cancer  
  Ibrahim Abu-Gheida, Christopher Fleming, Paul Ramia, Omar Mian, Rahul Tendulkar and Jay Ciezki, MD, Applied Radiation Oncology, 1/1/2017
• The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin  
  Mian OY, Tendulkar RD, Abazeed ME., Transl Cancer Res, 1/1/2017
• An imageguidance system for dynamic dose calculation in prostate brachytherapy using ultrasound and fluoroscopy  
  Kuo N, Dehghan E, Deguet A, Omar Y. Mian., Le Y, Burdette EC, Fichtinger G, Prince JL, Song DY, Lee J., Med Phys, 1/1/2014
• The human sodium-dependent ascorbic acid transporters SLC23A1 and SLC23A2 do not mediate ascorbic acid release in the proximal renal epithelial cell  
  Eck P, Kwon O, Chen S, Omar Y. Mian, Levine M, Physiol Rep, 1/1/2013
• Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells  
  Omar Y. Mian, Shou Zhen Wang, Sheng Zu Zhu, Merlin Gnanapragasam, Laura Graham, Harry Bear, Gordon D. Ginder, Mol. Cancer Res, 1/1/2011
• Atherosclerotic Plaque Macrophage Transcriptional Regulators Are Expressed in Blood and Modulated by Tristetraprolin  
  Willmar D. Patino, Ju-Gyeong Kang, Satoaki Matoba, Omar Y. Mian, Bernadette R. Gochuico, and Paul M. Hwang, Circ. Res, 1/1/2006
• Circulating transcriptome reveals markers of atherosclerosis  
  Willmar D. Patino, Omar Y. Mian, Ju-Gyeong Kang, Satoaki Matoba, Linda D. Bartlett, Brenda Holbrook, Hugh H. Trout III, Louis Kozloff, and Paul M. Hwang, PNAS, 1/1/2005
• Current and Future Applications of SAGE to Cardiovascular Medicine  
  Patino W.D., Omar Y. Mian, Shizukuda Y., Hwang P.M, Trends Cardiovasc. Med., 1/1/2003
• Serial Analysis of Gene Expression: Technical Considerations and Applications to Cardiovascular Biology  
  Patino W., Omar Y. Mian, Hwang P., Circ. Res, 1/1/2002
• Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice  
  Shizukuda Y, Matoba S, Omar Y. Mian, Nguyen T, Hwang PM, Mol. Cell Biochem
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Books/Book Chapters

• Pocket Guide to Radiation Oncology 
  Chapter: Chapter 14: Occult Primary Cancer of the Head and Neck 
  Omar Y. Mian and Ana KiessDemos Medical Publishing2017
• Essentials of Clinical Radiation Oncology 
  Chapter: Chapter 41: Penile Cancer 
  Rupesh Kotecha, Omar Y. Mian, Rahul D. TendulkarDemos Medical Publishing2017
• Advances in Developmental Biology 
  Chapter: The Role of the Epigenetic Signal, DNA Methylation, in Gene Regulation During Erythroid Development, Red Cell Development 
  Gordon D. Ginder, Merlin Gnanapragasam, Omar Y. MianElsevier2008

Abstracts/Posters

• DNA Methylation and H3K27M Mutant Allele Frequency as a biomarker of therapeutic response in DIPG
  Adam DeLong, Peter Anderson, Stephen Dombrowski, Erin Murphy, and Omar Mian, Lepow Day Research Presentation, CWRU SOM, 1/1/2017
• Genetic and Epigenetic Profiling of Small Cell Bladder Cancer (SCBC).
  Petros Grivas, Vadim S. Koshkin, Jordan Reynolds, Paul Elson, Cristina Magi-Galluzzi, Jesse McKenney, Karen Streator Smith, Bonnie Shadrach, Kumiko Isse, Laura R. Saun..., ASTRO Annual Meeting, 1/1/2017
• Molecular Profiling of Small Cell Bladder Cancer (SCBC) Reveals Gene Expression Determinants of an Aggressive Phenotype
  Vadim S. Koshkin, Jordan Reynolds, Paul Elson, Cristina Magi-Galluzzi, Jesse McKenney, Karen Streator Smith, Bonnie Shadrach, Kumiko Isse, Laura R. Saunders, Ming Hu, ..., ASCO Annual Meeting, 1/1/2017
• A Prospective Study of 80 patients Evaluating Registered Ultrasound and Fluoroscopy (RUF) For Intraoperative Dose Calculation: Improved Accuracy Compared To Convention...
  Omar Y. Mian, Carol Gergis, Adam Ferro, Yi Le, Scott Robertson, Robert Hobbs, Jerry L. Prince, Todd McNutt, Theodore L. DeWeese, Junghoon Lee, Daniel Y. Song, American Society of Therapeutic Radiation Oncology Annual Meeting., 1/1/2016
• Neoadjuvant Stereotactic Body Radiation Therapy Dosimetric Parameters Predict for Pathologic Outcomes and Survival in Pancreas Adenocarcinoma
  L Chen, Y Cao, A Narang, Z Cheng, LM Rosati, OY Mian, SP Robertson, et al, and JM Herman, International journal of radiation oncology, biology, physics, American Society of Therapeutic Radiation Oncology Annual Meeting, 1/1/2016
• Reductions in Prostatic and Urethral Doses Are Associated With Less Acute Morbidity in Patients Undergoing Pd-103 Brachytherapy: Substantiation of the Rationale for Fo...
  A Ferro, H Bae, SP Robertson, Y Le, TR McNutt, OY Mian, C Gergis, et al, and DY Song, International journal of radiation oncology, biology, physics, American Society of Therapeutic Radiation Oncology Annual Meeting, 1/1/2016
• SU-FR-47: Quantitative Shape Relationship Analysis of PTV Modification for Critical Anatomy Sparing and Its Impact On Pathologic Response for Neoadjuvant Stereotactic ...
  Z Cheng, L Rosati, L Chen, S Robertson, J Moore, L Peng, O Mian, ... T McNutt, Medical Physics, AAPM Annual Meeting, 1/1/2016
• Pancreas Stereotactic Body Radiation Therapy Demonstrates Minimal Acute Treatment-Related Toxicity.
  Y Cao, L Chen, ZD Guss, J Moore, OY Mian, CC Hsu, SP Robertson, ...JM Herman, International journal of radiation oncology, biology, physics, American Society of Therapeutic Radiation Oncology Annual Meeting, 1/1/2016
• Preference to Spare Critical Anatomy Near Gross Tumor Volume Is Associated With Poor Pathologic Complete Response With Breath HoldBased Neoadjuvant Stereotactic Body R...
  Z Cheng, LM Rosati, L Chen, SP Robertson, J Moore, LC Peng, OY Mian, ... JM Herman, T McNutt, International journal of radiation oncology, biology, physics, American Society of Therapeutic Radiation Oncology Annual Meeting, 1/1/2016
• Volumetric Assessment of Tumor Vessel Interaction Is a Predictor of Surgical Candidacy in Patients With Borderline Resectable and Locally Advanced Pancreatic Cancer Tr...
  Z Cheng, LM Rosati, L Chen, OY Mian, A Narang, Y Cao, J Moore, ... T McNutt, International journal of radiation oncology, biology, physics, American Society of Therapeutic Radiation Oncology Annual Meeting, 1/1/2016
• Partial Agonist Activity of Hydroxyflutamide Induces AR-and TOP2B-dependent DNA Double Strand Breaks and Radiosensitizes Prostate Cancer Cells
  JB Coulter, MC Haffner, OY Mian, K Kim, M Hedayati, Y Zhang, H Zhou, ... TL DeWeese, International journal of radiation oncology, biology, physics, American Society of Therapeutic Radiation Oncology Annual Meeting, 1/1/2016
• Prostate Volume Reduction Prior to Brachytherapy Using 5-alpha Reductase Inhibition Alone without Androgen Blockade
  HJ Bae, O Mian, Y Le, T DeWeese, D Song, Brachytherapy, American Brachytherapy Society Annual Meeting, 1/1/2016
• A Novel Technology for Noninvasive Detection of Prostate Cancer (PCa) DNA in the Blood and Urine of Men With High Risk Pca Receiving Radiation Therapy and Androgen Sup...
  Omar Y. Mian, Michael Haffner, Jonathan Coulter, David Esopi, Jennifer Meyers, Carol Gergis, Ryan Assadi, William Nelson, Srinivasan Yegnasubramanian, Theodore DeWeese, American Society of Therapeutic Radiation Oncology Annual Meeting, San Antonio, TX, 1/1/2015
• Total Lesion Glycolysis as a Predictor of Pathologic Outcomes Locally Advanced and Borderline Resectable Patients Undergoing Surgery after Preoperative Stereotactic Bo...
  Omar Y. Mian, Linda Chen, Amol Narang, Jeffrey Leal, Steven Rowe, Avani Dholakia, Shalini Moningi, Lauren Rosati, Joseph Herman., American Society of Therapeutic Radiation Oncology Annual Meeting, San Antonio, TX, 1/1/2015
• Dosimetric predictors of sexual function decline following LDR brachytherapy for prostate cancer (PCa)
  Omar Y. Mian, Scott Robertson, Amol Narang, Sameer Agarwal, Hee Joon Bae, Todd McNutt, Phuoc Tran, Theodore L. DeWeese, Danny Y. Song, ASCO/Genitourinary Meeting, San Francisco, CA, 1/1/2015
• A retrospective review of 366 patients treated with LDR prostate brachytherapy at a single institution: histopathologic, biochemical, and dosimetric predictors of outc...
  Omar Y. Mian, MD, PhD, Scott Robertson PhD, Amol Narang MD, Hee Joon Bae BS, Phuoc Tran MD, PhD, Theodore L. DeWeese MD, Danny Y. Song, MD, American Brachytherapy Society Annual Meeting, Orlando, FL, 1/1/2015
• Reduced lymphocytopenia following stereotactic body radiation therapy (SBRT) for spine metastases compared with conventional radiation therapy (CRT).
  Omar Y. Mian, Uri Hadelsberg, Kubra Gokce, Sara Alcorn, Susannah Ellsworth, Michael Lim, Jean Paul Wolinsky, Chetan Bettegowda, Daniel Sciubba, Ziya Gokaslan, Stuart G..., American Society of Therapeutic Radiation Oncology Annual Meeting, San Francisco, CA, 1/1/2014
• Timely Radiosurgery for Spine Metastases per RTOG 0613 Guidelines using a Rapidly Deployable Automated Planning Script (FastPlan)
  Omar Y. Mian, O. Thomas, Y. Le, T. McNutt, M. Lim, D. Rigamonti, K. Redmond, L. Kleinberg, American Society of Therapeutic Radiation Oncology Annual Meeting, Atlanta, GA, 1/1/2013
• Methyl Binding Domain Protein 2 (MBD2) Promotes Epithelial Dedifferentiation in Breast Cancer.
  Omar Y. Mian and Gordon D. Ginder, American Association for Cancer Research, Joint National Meeting, Washington, DC, 1/1/2010
• Methyl Binding Domain Proteins Maintain Epithelial Dedifferentiation and Therapeutic Resistance in Breast Cancer
  Omar Y. Mian, Shou Zhen Wang, Sheng Zu Zhu, Merlin N. Gnanapragasam, Gordon D. Ginder, American College of Physicians, Virginia Chapter Meeting, McLean, VA, 1/1/2009
• MBD2 Mediates Epigenetic Silencing Of Maspin In MCF-7 Cells And Contributes To Elevated Tumor Grade In 3D Culture
  Omar Y. Mian, Shou Zhen Wang, Sheng Zu Zhu, Merlin N. Gnanapragasam, Gordon D. Ginder, Keystone Symposia on Epigenetics in Health and Disease, Keystone, CO, 1/1/2009
• MBD2 inhibits migration, differentiation, and tumor suppressor expression in the breast cancer cell line, MCF7.
  Omar Y. Mian, Shou Zhen Wang, Sheng Zu Zhu, Merlin N. Gnanapragasam, Gordon D. Ginder, American Society for Clinical investigation/Association of American Physicians (ASCI/AAP) Joint Meeting, Chicago, IL, 1/1/2008
• Methyl Binding Domain Protein 2 (MBD2) Mediates Epigenetic Silencing of Maspin in MCF7 Cells and Contributes to Elevated Tumor Grade in 3D Culture.
  Omar Y. Mian, Shou Zhen Wang, Sheng Zu Zhu, Merlin N. Gnanapragasam, Gordon D. Ginder, ICAMS Retreat, Molecular Biology and Genetics, Richmond, VA, 1/1/2008
• Inter-individual Gene Expression Variation Assessed by SAGE in Human Monocytes.
  Omar Y. Mian, Willmar D. Patino, Andrew Wragg, Satoaki Matoba, Ju-Gyeong Kang, Paul M. Hwang, Keystone Symposia: The Cellular Biology of Atherosclerosis., Keystone CO, 1/1/2005
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Lectures

• Circulating tumor DNA (ctDNA) as a precision tool in radiotherapy. 
  Washington, DC - 1/4/2017
• Controversies in the contemporary management of prostate cancer: Emerging role of biomarkers 
  Sheraton Hotel, Cordoba, Argentina - 1/2/2017
• Dosimetric Predictors of Sexual Function Decline Following LDR Brachytherapy for Prostate Cancer (PCa) 
  San Antonio, TX - 1/1/2015
• Non-invasive Detection of Prostate Cancer-Specific DNA in Blood and Urine 
  James Buchanan Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD - 1/1/2014
• A Prospective Study of Registered Ultrasound and Fluoroscopy (RUF) for Intraoperative Dose Calculation: Improved Accuracy Compared To Current Ultrasound-based Intraope... 
  San Diego, CA - 1/1/2014
• Methyl Binding Domain Proteins Maintain Epithelial Dedifferentiation and Therapeutic Resistance in Breast Cancer 
  Richmond, VA - 1/1/2009
• Methyl Binding Domain Proteins Maintain Epithelial Dedifferentiation and Therapeutic Resistance in Breast Cancer. 
  Charlottesville, VA - 1/1/2009
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Other

• Integrated Molecular Profiling of GU Tumors: Applications for Personalized Therapy 
  Nature Webinar
  Nature.com
  1/28/2017
• Thesis, The Role of the Methyl DNA Binding Domain Protein 2 (MBD2) in Breast Cancer