OralAlpanMD

Allergy & Immunology • Fairfax, VA

Associate Professor, Pediatrics, Virginia Commonwealth University, Medical College of Virginia School of Medicine

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Office
11212 Waples Mill Rd
Ste 10
Fairfax, VA 22030
Phone+1 571-308-1900

Fax+1 571-308-1919
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Education & Training

National Institutes of Health Clinical CenterFellowship, Allergy and Immunology, 1996 - 1999
Stony Brook Medicine/University HospitalResidency, Pediatrics, 1993 - 1996
Hacettepe University FOMClass of 1990

Certifications & Licensure

MD State Medical License 1997 - 2024
VA State Medical License 2005 - 2024
American Board of Allergy and Immunology Allergy & Immunology

Awards, Honors, & Recognition

Top MD Consumers Checkbook
Super Doctor SuperDoctors.com

Clinical Trials

Development, Validation and Evaluation of an Adult and Pediatric Eosinophilic Esophagitis Activity Index Start of enrollment: 2011 Jan 01
Unknown status
Treatment Protocol of Replagal for Patients With Fabry Disease
No longer available
Identifying Responders to Xolair (Omalizumab) Using Eosinophilic Esophagitis as a Disease Model Start of enrollment: 2009 Jun 01
Completed
Phase 1
Exploration of Immunity in Gaucher Disease Start of enrollment: 2011 Apr 01
Completed
Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency Diseases Start of enrollment: 2014 Feb 01
Completed
Phase 3
Investigation of Immune Disorders and Deficiencies Start of enrollment: 2012 Dec 01
Unknown status
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Publications & Presentations

PubMed

STAT4 Phosphorylation of T-helper Cells predicts surgical outcomes in Refractory Chronic Rhinosinusitis.
Upchurch, Z., Michael R Abidin, Oral Alpan, Matthew Plassmeyer, Lina Kozhaya, Denise Loizou, Mikail Dogan, Zachary Upchurch, Nathan P Manes, Aleksandra Nita-Lazar, Der...> ;Medrxiv. 2023 Dec 13
Towards standardizing basophil identification by flow cytometry.
Soren Ulrik Sonder, Matthew Plassmeyer, Denise Loizou, Oral Alpan> ;Frontiers in Allergy. 2023 Jan 1
5 citations
Mammalian Target of Rapamycin Pathway Assessment in Antiphospholipid Antibody-Positive Patients with Livedo.
Ecem Sevim, Salma Siddique, Madhavi Latha S Chalasani, Susan Chyou, William D Shipman, Orla O'Shea, Joanna Harp, Oral Alpan, Stéphane Zuily, Theresa T Lu, Doruk Erkan> ;The Journal of Rheumatology. 2022 Sep 1
8 citations
Efficacy, safety, and tolerability of lebrikizumab in adolescent patients with uncontrolled asthma (ACOUSTICS).
Stanley J Szefler, Graham Roberts, Adalberto S Rubin, Stefan Zielen, Piotr Kuna, Oral Alpan, Judith Anzures-Cabrera, Qiang Chen, Cécile T J Holweg, Janusz Kaminski, We...> ;Clinical and Translational Allergy. 2022 Jul 1
3 citations
Towards an FDA-cleared basophil activation test.
Oral Alpan, Richard L Wasserman, Theodore Kim, Amy Darter, Atul Shah, Douglas Jones, Donald McNeil, Henry Li, Laura Ispas, Melinda Rathkopf, Elena Perez, Dareen Siri, ...> ;Frontiers in Allergy. 2022 Jan 1
12 citations
Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed Therapies.
Thomas A Premeaux, Stephen T Yeung, Scott Bowler, Oral Alpan, Raavi Gupta, Lishomwa C Ndhlovu, Zaheer Bukhari> ;Frontiers in Immunology. 2022 Jan 1
2 citations
Efficacy, Safety and Tolerability of a New 10% Intravenous Immunoglobulin for the Treatment of Primary Immunodeficiencies.
Elena E. Perez, Jacques Hébert, Anne K. Ellis, Oral Alpan, William R. Lumry, Ralph Shapiro, Daniel Suez, J. Fernando Mandujano, Richard L. Wasserman> ;Frontiers in Immunology. 2021 Jul 8
31 citations
Caspases and therapeutic potential of caspase inhibitors in moderate-severe SARS CoV2 infection and long COVID.
Matthew Plassmeyer, Oral Alpan, Michael J. Corley, Thomas A. Premeaux, Kimberleigh Lillard, Paige Coatney, Tina Vaziri, Suzan Michalsky, Alina P.S. Pang, Zaheer Bukhar...> ;Allergy. 2021 May 15
3 citations
Basophil activation test: A diagnostic, predictive and monitoring assay for allergen immunotherapy.
Oral Alpan, Janice A. Layhadi, Søren Ulrik Sønder, Henry Li, Mohamed H. Shamji> ;Allergy. 2021 May 1
98 citations
Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice.
Alexandra F. Santos, Oral Alpan, Hans Jürgen Hoffmann> ;Allergy. 2021 Feb 27
6 citations
Validation of inducible basophil biomarkers: Time, temperature and transportation.
Theodore Kim, Jing Yu, Henry Li, Mark D. Scarupa, Richard L. Wasserman, Athena Economides, Martha V. White, Carla Ward, Atul Shah, Douglas H. Jones, Melinda Rathkopf, ...> ;Cytometry. Part B, Clinical Cytometry. 2021 Feb 4
81 citations
CCR5 Inhibition in Critical COVID-19 Patients Decreases Inflammatory Cytokines, Increases CD8 T-Cells, and Decreases SARS-CoV2 RNA in Plasma by Day 14.
Patterson, B. K., Bruce K. Patterson, Harish Seethamraju, Kush Dhody, Michael J. Corley, Kazem Kazempour, Jay Lalezari, Alina P.S. Pang, Christopher Sugai, Eisa Mahyar...> ;International Journal of Infectious Diseases. 2021 Feb 1
71 citations
SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus.
Mikail Dogan, Lina Kozhaya, Lindsey Placek, Courtney Gunter, Mesut Yigit, Rachel Hardy, Matthew Plassmeyer, Paige Coatney, Kimberleigh Lillard, Zaheer Bukhari, Michael...> ;Communications Biology. 2021 Jan 29
24 citations
Inflammasome activation and pyroptosis in lymphopenic liver patients with COVID-19.
Alexander Kroemer, Khalid Khan, Matthew Plassmeyer, Oral Alpan, M A Haseeb, Raavi Gupta, Thomas M. Fishbein> ;Journal of Hepatology. 2020 Jul 6
6 citations
Impact of immune work-up on outcomes and the cost of care in patients with Chronic Rhinosinusitis.
Oral Alpan, Denise Loizou, Ivan Santos, Bernard Ness, Joseph Plandowski> ;Allergy. 2019 May 3
6 citations
Altered immune phenotypes in subjects with Fabry disease and responses to switching from agalsidase alfa to agalsidase beta.
Renuka P. Limgala, Tabitha Jennelle, Matthew Plassmeyer, Michel Boutin, Pamela Lavoie, Mona Abaoui, Christiane Auray-Blais, Khan Nedd, Oral Alpan, Ozlem Goker-Alpan> ;American Journal of Translational Research. 2019 Mar 15
6 citations
Improved panels for clinical immune phenotyping: Utilization of the violet laser.
Mark Ryherd, Matthew Plassmeyer, Connor Alexander, Ines Eugenio, Yuliya Kleschenko, Ariel Badger, Raavi Gupta, Oral Alpan, Søren Ulrik Sønder> ;Cytometry. Part B, Clinical Cytometry. 2018 Sep 1
6 citations
A 6-month, multicenter, open-label study of fixed dose naproxen/esomeprazole in adolescent patients with juvenile idiopathic arthritis
Daniel J. Lovell, Jason Dare, Megan Francis-Sedlak, Julie Ball, Brian LaMoreaux, Emily von Scheven, Adam L Reinhardt, Rita Jerath, Oral Alpan, Ramesh Gupta, Donald P. ...> ;Pediatric Rheumatology Online Journal. 2018 Jun 26
5 citations
Enzyme replacement therapy reverses B lymphocyte and dendritic cell dysregulations in patients with Gaucher Disease
Renuka P. Limgala, Chandni Jani, Chidima Ioanou, Oral Alpan, Ozlem Goker-Alpan> ;Blood Cells, Molecules & Diseases. 2018 Feb 1
22 citations
Time of Initiating Enzyme Replacement Therapy Affects Immune Abnormalities and Disease Severity in Patients with Gaucher Disease.
Renuka P. Limgala, Chidima Ioanou, Matthew Plassmeyer, Mark Ryherd, Lina Kozhaya, Lauren Austin, Cem Abidoglu, Derya Unutmaz, Oral Alpan, Ozlem Goker-Alpan> ;Plos One. 2016 Dec 12
17 citations
Persistent immune alterations and comorbidities in splenectomized patients with Gaucher disease.
Søren Ulrik Sønder, Renuka P. Limgala, Margarita M. Ivanova, Chidima Ioanou, Matthew Plassmeyer, Gerald E. Marti, Oral Alpan, Ozlem Goker-Alpan> ;Blood Cells, Molecules & Diseases. 2016 Jul 1
97 citations
A Pilot Study of Omalizumab in Eosinophilic Esophagitis
Denise Loizou, Benjamin Enav, Edina Komlodi-Pasztor, Pamela Hider, Julie J. Kim-Chang, Laura E. Noonan, Tabitha Taber, Suhasini Kaushal, Renuka P. Limgala, Margaret Br...> ;Plos One. 2015 Mar 19
209 citations
Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis.
Marc E. Rothenberg, Ting Wen, Allison B Greenberg, Oral Alpan, Benjamin Enav, Ikuo Hirano, Kari C. Nadeau, Sergio Kaiser, Thomas Peters, Antonio Perez, Ieuan Jones, Jo...> ;The Journal of Allergy and Clinical Immunology. 2015 Feb 1
140 citations
Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on H1 antihistamines: a randomized, placebo-controll...
Sarbjit S Saini, Carsten Bindslev-Jensen, Marcus Maurer, Jean-Jacques Grob, Emel Bülbül Baskan, Mary S Bradley, Janice Canvin, Abdelkader Rahmaoui, Panayiotis Georgiou...> ;The Journal of Investigative Dermatology. 2015 Jan 1
2 citations
Diffuse Cutaneous Mastocytosis, Bullous Variant, Presenting in a Six-Month-Old Infant
Lauren Kinneman, Barbara Molloy, Viet Nguyen, Denise Loizou, Robert A. Silverman, Noel Mensah-Bonsu, Benjamin Enav, Jasbir Johal, Matthew Plassmeyer, Mark Ryherd, Laur...> ;The Journal of Allergy and Clinical Immunology. in Practice. 2014 May 1
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Hospital Affiliations

Reston Hospital CenterReston, Virginia