P. DavidMozleyMD

PubMed

• [1-C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects.
  Neel H Mehta, Xiuyuan Wang, Samantha A Keil, Ke Xi, Liangdong Zhou, Kevin Lee, Wanbin Tan, Edward Spector, Amirhossein Goldan, James Kelly, Nicolas A Karakatsanis, P D...> ;Fluids and Barriers of the CNS. 2024 Apr 2
• Choroid Plexus Calcification Correlates with Cortical Microglial Activation in Humans: A Multimodal PET, CT, MRI Study.
  T Butler, X H Wang, G C Chiang, Y Li, L Zhou, K Xi, N Wickramasuriya, E Tanzi, E Spector, I Ozsahin, X Mao, Q R Razlighi, E K Fung, J P Dyke, T Maloney, A Gupta, A Raj...> ;AJNR. American Journal of Neuroradiology. 2023 Jul 1
• 5 citations
  The RSNA QIBA Profile for Amyloid PET as an Imaging Biomarker for Cerebral Amyloid Quantification.
  Anne M Smith, Nancy A Obuchowski, Norman L Foster, Gregory Klein, P David Mozley, Adriaan A Lammertsma, Richard L Wahl, John J Sunderland, Jean-Luc Vanderheyden, Tammi...> ;Journal of Nuclear Medicine. 2023 Feb 1
• 3 citations
  Positron Emission Tomography reveals age-associated hypothalamic microglial activation in women.
  Tracy Butler, Lidia Glodzik, Xiuyuan Hugh Wang, Ke Xi, Yi Li, Hong Pan, Liangdong Zhou, Gloria Chia-Yi Chiang, Simon Morim, Nimmi Wickramasuriya, Emily Tanzi, Thomas M...> ;Scientific Reports. 2022 Aug 3
• 36 citations
  Decreased CSF clearance and increased brain amyloid in Alzheimer's disease.
  Li, Y., Rusinek, H., Butler, T., Glodzik, L., Pirraglia, E., Babich, J., Mozley, P., Nehmeh, S., Pahlajani, S., Wang, X., Tanzi, E., Zhou, L., Strauss, S., Carare, R.,...> ;Fluids and Barriers of the CNS. 2022 Mar 14
• 39 citations
  Riluzole, a glutamate modulator, slows cerebral glucose metabolism decline in patients with Alzheimer's disease.
  Dawn C. Matthews, Xiangling Mao, Kathleen Dowd, Diamanto Tsakanikas, Caroline S. Jiang, Caroline Meuser, Randolph D. Andrews, Ana S. Lukic, Jihyun Lee, Nicholas Hampil...> ;Brain. 2021 Jun 18
• 3 citations
  Population-based input function for TSPO quantification and kinetic modeling with [11C]-DPA-713.
  Mercy I. Akerele, Sara A. Zein, Sneha Pandya, Anastasia Nikolopoulou, Susan A. Gauthier, Ashish Raj, Claire Henchcliffe, P. David Mozley, Ajay Gupta, John W. Babich, S...> ;EJNMMI Physics. 2021 Apr 29
• 23 citations
  Neurophysiological Biomarkers of Parkinson's Disease.
  Shani Waninger, Chris Berka, Marija Stevanović Karić, Stephanie Korszen, P. David Mozley, Claire Henchcliffe, Yeona Kang, Jacob Hesterman, Tomer Mangoubi, Ajay Verma> ;Journal of Parkinson's Disease. 2020 Jan 1
• 19 citations
  Intrathecal 99mTc-DTPA imaging of molecular passage from lumbar cerebrospinal fluid to brain and periphery in humans.
  Ajay Verma, Jacob Hesterman, J. Levi Chazen, Robert W. Holt, Patrick Connolly, Laura L. Horky, Shankar Vallabhajosula, P. David Mozley> ;Alzheimer's & Dementia. 2020 Jan 1
• 24 citations
  Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury
  Esteban A. Fridman, Joseph R. Osborne, Paul Mozley, Jonathan D. Victor, Nicholas D. Schiff> ;Brain. 2019 Jul 1
• 14 citations
  18F-FPEB PET/CT Shows mGluR5 Upregulation in Parkinson's Disease.
  Yeona Kang, Claire Henchcliffe, Ajay Verma, Shankar Vallabhajosula, Bin He, Paresh J. Kothari, Kane O. Pryor, P. David Mozley> ;Journal of Neuroimaging. 2019 Jan 1
• 12 citations
  Statistical Considerations for Planning Clinical Trials with Quantitative Imaging Biomarkers.
  Nancy A. Obuchowski, P. David Mozley, Dawn C. Matthews, Andrew J. Buckler, Jennifer Bullen, Edward F. Jackson> ;Journal of the National Cancer Institute. 2019 Jan 1
• 22 citations
  Noninvasive PK11195-PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease.
  Yeona Kang, P. David Mozley, Ajay Verma, David J. Schlyer, Claire Henchcliffe, Susan A. Gauthier, Ping C. Chiao, Bin He, Anastasia Nikolopoulou, Jean Logan, Jenna M. S...> ;Journal of Neuroimaging. 2018 Sep 1
• 8 citations
  [11 C]arachidonic acid incorporation measurement in human brain: Optimization for clinical use.
  Francesca Zanderigo, Yeona Kang, Dileep Kumar, Anastasia Nikolopoulou, P. David Mozley, Paresh J. Kothari, Bin He, David J. Schlyer, Stanley I. Rapoport, Maria A. Oque...> ;Synapse. 2018 Feb 1
• 24 citations
  Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation
  Ulrike W. Kaunzner, Yeona Kang, Elizabeth Monohan, Paresh J. Kothari, Nancy Nealon, Jai Perumal, Timothy Vartanian, Amy Kuceyeski, Shankar Vallabhajosula, P. David Moz...> ;Multiple Sclerosis and Related Disorders. 2017 Jul 1
• 23 citations
  Automated segmentation of MR imaging to determine normative central nervous system cerebrospinal fluid volumes in healthy volunteers
  J. Levi Chazen, Jonathan P. Dyke, Robert W. Holt, Laura L. Horky, Rachel Pauplis, Jacob Hesterman, David P. Mozley, Ajay Verma> ;Clinical Imaging. 2017 May 1
• 5 citations
  Three-Dimensional Dosimetry for Radiation Safety Estimates from Intrathecal Administration.
  Jacob Hesterman, Susan D. Kost, Robert W. Holt, Howard Dobson, Ajay Verma, P. David Mozley> ;Journal of Nuclear Medicine. 2017 Mar 1
• 1 citations
  Yttrium-90 microsphere radioembolotherapy in a patient with spontaneously ruptured hepatocellular carcinoma.
  Ronald S. Winokur, Adam D. Talenfeld, P. David Mozley, David C. Madoff> ;Clinical Imaging. 2016 Jan 1
• 75 citations
  Repeatability of 18F-FDG PET/CT in Advanced Non–Small Cell Lung Cancer: Prospective Assessment in 2 Multicenter Trials
  Wolfgang A. Weber, Constantine Gatsonis, P. David Mozley, Lucy Hanna, Anthony F. Shields, Denise R. Aberle, Ramaswamy Govindan, Drew A. Torigian, Joel S. Karp, Jian Q....> ;Journal of Nuclear Medicine. 2015 Aug 1
• 31 citations
  Repeatability of quantitative FDG-PET/CT and contrast-enhanced CT in recurrent ovarian carcinoma: test-retest measurements for tumor FDG uptake, diameter, and volume.
  Andrea Rockall, Norbert Avril, Raymond Lam, Robert Iannone, P David Mozley, Christine Parkinson, Donald Bergstrom, Evis Sala, Shah-Jalal Sarker, Iain A. McNeish, James...> ;Clinical Cancer Research. 2014 May 15
• 82 citations
  18F-FPEB, a PET Radiopharmaceutical for Quantifying Metabotropic Glutamate 5 Receptors: A First-in-Human Study of Radiochemical Safety, Biokinetics, and Radiation Dosi...
  Dean F. Wong, Rikki N. Waterhouse, Hiroto Kuwabara, Jongho Kim, James Robert Brašić, Wichana Chamroonrat, Michael Stabins, Daniel P. Holt, Robert F. Dannals, Terence G...> ;Journal of Nuclear Medicine. 2013 Mar 1
• 78 citations
  Measurement of Tumor Volumes Improves RECIST-Based Response Assessments in Advanced Lung Cancer
  P. David Mozley, Claus Bendtsen, Binsheng Zhao, Lawrence H. Schwartz, Matthias Thorn, Yuanxin Rong, Luduan Zhang, Andrea Perrone, Rene Korn, Andrew J. Buckler> ;Translational Oncology. 2012 Feb 1
• 63 citations
  Quantitative Imaging Test Approval and Biomarker Qualification: Interrelated but Distinct Activities
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Radiology. 2011 Jun 1
• 67 citations
  Change in lung tumor volume as a biomarker of treatment response: a critical review of the evidence
  P. D. Mozley, Lawrence H. Schwartz, Claus Bendtsen, Binsheng Zhao, Nicholas Petrick, Andrew J. Buckler> ;Annals of Oncology. 2010 Sep 1
• 11 citations
  Data sets for the qualification of volumetric CT as a quantitative imaging biomarker in lung cancer
  Andrew J. Buckler, Lawrence H. Schwartz, Nicholas Petrick, Michael F. McNitt-Gray, Binsheng Zhao, Charles Fenimore, Anthony P. Reeves, P. D. Mozley, Ricardo Scott Avila> ;Optics Express. 2010 Jul 5
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Journal Articles

• Cortical Laminar Binding of PET Amyloid and Tau Tracers in Alzheimer Disease  
  J Nucl Med, 1/1/2015
• 11C-MK-8278 PET as a tool for pharmacodynamic brain occupancy of histamine 3 receptor inverse agonists  
  J Nucl Med, 1/1/2014
• Repeatability of quantitative FDG-PET/CT and contrast enhanced CT in recurrent ovarian carcinoma: test retest measurements for tumor FDG uptake, diameter and volume  
  Clinical Cancer Res, 1/1/2014
• 18F-FPEB, a PET radiopharmaceutical for quantifying metabotropic glutamate 5 receptors: a first-in-human study of radiochemical safety, biokenitics, and radiation dosi...  
  J Nucl Med, 1/1/2013
• Measurement of tumor volumes improves RECIST-based response assessments in advanced lung cancer  
  Translational Oncology, 1/1/2012
• PET imaging shows equivalent dynamic human brain NK1-receptor occupancy following single-dose administration of IV fosaprepitant versus oral aprepitant  
  Clin Pharmacol Ther, 1/1/2012
• X-Ray computed tomography: Semiautomated volumetric analysis of late-stage lung tumors as a basis for response assessments  
  International J Biomed Imaging, 1/1/2011
• A collaborative enterprise for multi-stakeholder participation in the advancement of quantitative imaging  
  Radiology, 1/1/2011
• Biodistribution and radiation dosimetry of a positron emission tomographic ligand, [18F]-SP203, to image metabotropic glutamate subtype 5 receptors in humans  
  Eur J Nucl Med Molecular Imaging, 1/1/2010
• Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder  
  Eur Neuropsychopharmacol, 1/1/2010
• The use of volumetric CT as an imaging biomarker in lung cancer  
  Academic Radiol, 1/1/2010
• Volumetric CT in lung cancer: an example for the qualification of imaging as a biomarker  
  Academic Radiol, 1/1/2010
• Data sets for the qualification of volumetric CT as a quantitative imaging biomarker in lung cancer  
  Optics Express, 1/1/2010
• Change in lung tumor volume as a biomarker of treatment response: A critical review of the evidence  
  Annals Oncology, 1/1/2010
• Report of Task Force II: Best Practices in the Use of Medical Imaging Techniques in Clinical Trials  
  Drug Information Journal, 1/1/2008
• Human Biodistribution and Radiation Dosimetry of the Tachykinin NK1 Antagonist Radioligand [18F]SPA-RQ: Comparison of Thin -Slice, Bisected, and 2-D Planar Image Analysis  
  J Nucl Med, 1/1/2007
• Dopamine transporter binding in smokers and nonsmokers  
  Clinical Nuclear Medicine, 1/1/2007
• Comparison of region-of-interest analysis and human observers in the diagnosis of Parkinson's disease using [(99m)Tc]TRODAT-1 and SPECT  
  Phys Med Biol, 1/7/2006
• Molecular imaging: A tool for developing central nervous system drugs  
  J Nucl Med, 1/1/2006
• Whole-body biodistribution, radiation dosimetry estimates for the PET norepinephrine transporter probe (S,S)-[18F]FMeNER-D2 in non-human primates  
  Nucl Med Comm, 1/1/2005
• Differences in [99mTc] TRODAT-1 SPECT Binding to Dopamine Transporters in Patients With Multiple System Atrophy and Parkinson's Disease  
  Eur J Nucl Med Biol, 1/1/2005
• Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease  
  J Nucl Med, 1/1/2005
• Characterization of dose dependent norepinephrine transporter blockade by atomoxetine in human brain using 11C MeNER PET  
  J Cerebral Blood Flow Metab, 1/1/2005
• Weaving single photon imaging into new drug development  
  J Molec Imaging Biol, 1/1/2005
• Nuclear imaging in the pharmaceutical industry: the cost-value-benefit-risk equation  
  Am Pharma Rev, 1/1/2005
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Books/Book Chapters

• Radiology 
  Chapter: PET of the Musculoskeletal System 
  Editors: Taveras J, Ferrucci J.Lippincott, Williams & Wilkins, Philadelphia, PA2001
• Refractory Depression: Current Strategies and Future Directions 
  Chapter: Assessment of adrenocortical activity in refractory depressin: Steroid suppression with ketoconazole 
  Page 199 - 210Editors: Nolen WA, Zohar J, Roose SP, Amsterdam JD.John Wiley & Sons, Chichester, England1994
• Biological Basis of Schizophrenic Disorders 
  Chapter: Midlatency auditory evoked responses and neuroimaging in schizophrenia 
  Page 43 - 59Editors: Nakazawa T.Japan Scientific Societies Press, Tokyo, Japan1991