PRenaeGriffinMD

PubMed

• Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration.
  Pettersson-Klein, A. T.,Izadi, M.,Ferreira, DMS.,Cervenka, I.,Correia, J. C.,Martinez-Redondo, V.,Southern, M.,Cameron, M.,Kamenecka, T.,Agudelo, L. Z.,Porsmyr-Palmert...> ;Mol Metab. 2018 Feb 13
• 22 citations
  Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis
  Erika Darrah, AeRyon Kim, Xi Zhang, Tatiana Boronina, Robert N. Cole, Andrea Fava, Jon T. Giles, Clifton O. Bingham, Michael J. Chalmers, Patrick R. Griffin, Scheheraz...> ;Journal of Proteome Research. 2017 Jan 6
• Full antagonism of the estrogen receptor without a prototypical ligand side chain.
  Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou H, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen ...> ;Nat. Chem. Biol.. 2017-01-01
• Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.
  Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec J, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA> ;J. Biol. Chem.. 2016-12-02
• A Residue Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand...
  Saltzberg DJ, Broughton HB, Pellarin R, Chalmers MJ, Espada A, Dodge JA, Pascal BD, Griffin PR, Humblet C, Sali A> ;J Phys Chem B. 2016-11-03
• Two-Site Evaluation of the Repeatability and Precision of an Automated Dual-Column Hydrogen/Deuterium Exchange Mass Spectrometry Platform.
  Cummins DJ, Espada A, Novick SJ, Molina-Martin M, Stites RE, Espinosa JF, Broughton H, Goswami D, Pascal BD, Dodge JA, Chalmers MJ, Griffin PR> ;Anal. Chem.. 2016-06-21
• The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
  Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M> ;ACS Chem. Biol.. 2016-05-20
• The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.
  Tavares CDJ, Sharabi K, Dominy JE, Lee Y, Isasa M, Orozco JM, Jedrychowski MP, Kamenecka TM, Griffin PR, Gygi SP, Puigserver P> ;J. Biol. Chem.. 2016-05-13
• Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3.
  Zhao L, Zhou XE, Yi W, Wu Z, Liu Y, Kang Y, Hou L, de Waal PW, Li S, Jiang Y, Scaffidi A, Flematti GR, Smith SM, Lam VQ, Griffin PR, Wang Y, Li J, Melcher K, Xu HE> ;Cell Res.. 2015-11-01
• Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
  Zhang F, Yao J, Ke J, Zhang L, Lam VQ, Xin X, Zhou XE, Chen J, Brunzelle J, Griffin PR, Zhou M, Xu HE, Melcher K, He SY> ;Nature. 2015-09-10
• Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.
  Kojetin DJ, Matta-Camacho E, Hughes TS, Srinivasan S, Nwachukwu JC, Cavett V, Nowak J, Chalmers MJ, Marciano DP, Kamenecka TM, Shulman AI, Rance M, Griffin PR, Bruning...> ;Nat Commun. 2015-08-20
• Conformational states of the full-length glucagon receptor.
  Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, Carragher B, Yan...> ;Nat Commun. 2015-07-31
• Differential isotopic enrichment to facilitate characterization of asymmetric multimeric proteins using hydrogen/deuterium exchange mass spectrometry.
  Goswami D, Tuske S, Pascal BD, Bauman JD, Patel D, Arnold E, Griffin PR> ;Anal. Chem.. 2015-04-07
• Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14).
  Brown NE, Goswami D, Branch MR, Ramineni S, Ortlund EA, Griffin PR, Hepler JR> ;J. Biol. Chem.. 2015-04-03
• A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.
  Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M> ;J. Biol. Chem.. 2014-09-19
• HDX reveals unique fragment ligands for the vitamin D receptor.
  Carson MW, Zhang J, Chalmers MJ, Bocchinfuso WP, Holifield KD, Masquelin T, Stites RE, Stayrook KR, Griffin PR, Dodge JA> ;Bioorg. Med. Chem. Lett.. 2014-08-01
• Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry.
  Goswami D, Callaway C, Pascal BD, Kumar R, Edwards DP, Griffin PR> ;Structure. 2014-07-08
• Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles.
  Kirschke E, Goswami D, Southworth D, Griffin PR, Agard DA> ;Cell. 2014-06-19
• Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway.
  Armstrong EH, Goswami D, Griffin PR, Noy N, Ortlund EA> ;J. Biol. Chem.. 2014-05-23
• Nitric oxide-induced conformational changes in soluble guanylate cyclase.
  Underbakke ES, Iavarone AT, Chalmers MJ, Pascal BD, Novick S, Griffin PR, Marletta MA> ;Structure. 2014-04-08
• Identification of a small molecular insulin receptor agonist with potent antidiabetes activity.
  Qiang G, Xue S, Yang JJ, Du G, Pang X, Li X, Goswami D, Griffin PR, Ortlund EA, Chan CB, Ye K> ;Diabetes. 2014-04-01
• Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.
  Wang Y, Lonard DM, Yu Y, Chow D, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BW> ;Cancer Res.. 2014-03-01
• The therapeutic potential of nuclear receptor modulators for treatment of metabolic disorders: PPARγ, RORs, and Rev-erbs.
  Marciano DP, Chang MR, Corzo CA, Goswami D, Lam VQ, Pascal BD, Griffin PR> ;Cell Metab.. 2014-02-04
• Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain.
  Boerma LJ, Xia G, Qui C, Cox BD, Chalmers MJ, Smith CD, Lobo-Ruppert S, Griffin PR, Muccio DD, Renfrow MB> ;J. Biol. Chem.. 2014-01-10
• An antibody with a variable-region coiled-coil "knob" domain.
  Zhang Y, Goswami D, Wang D, Wang TA, Sen S, Magliery TJ, Griffin PR, Wang F, Schultz PG> ;Angew. Chem. Int. Ed. Engl.. 2014-01-03
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