ParasSinghMinhasMD

PubMed

• TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models.
  Edward N Wilson, Congcong Wang, Michelle S Swarovski, Kristy A Zera, Hannah E Ennerfelt, Qian Wang, Aisling Chaney, Esha Gauba, Javier A Ramos Benitez, Yann Le Guen, P...> ;Nature Neuroscience. 2024 Mar 27
• 20 citations
  A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation.
  Li Li, Devon M Conradson, Vinita Bharat, Min Joo Kim, Chung-Han Hsieh, Paras S. Minhas, Amanda M. Papakyrikos, Aarooran Sivakumaran Durairaj, Anthony V. Ludlam, Katrin...> ;Nature Metabolism. 2021 Sep 1
• 230 citations
  Restoring metabolism of myeloid cells reverses cognitive decline in ageing
  Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran Sivakumaran Durairaj, Qian Wang, Amanda J. Rubin, Amit Joshi, Joy Q He, Esha Gauba, Ling Liu, C...> ;Nature. 2021 Jan 20
• 1 citations
  Author Correction: Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration.
  Amit Joshi, Paras S. Minhas, Shane A. Liddelow, Bereketeab Haileselassie, Katrin I. Andreasson, Gerald W. Dorn, Daria Mochly-Rosen> ;Nature Neuroscience. 2021 Feb 1
• The Dueling Duo: IL10 and TNF Face Off in Microglial Recovery from Endotoxin Challenge.
  Paras S. Minhas, Aarooran Sivakumaran Durairaj, Katrin I. Andreasson> ;Immunity. 2020 Nov 17
• 40 citations
  Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau.
  Edward N. Wilson, Michelle S. Swarovski, Patricia Linortner, Marian Shahid, Abigail J. Zuckerman, Qian Wang, Divya Channappa, Paras S. Minhas, Siddhita D. Mhatre, Edwa...> ;Brain. 2020 Mar 1
• 79 citations
  Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy
  Bereketeab Haileselassie, Amit Joshi, Paras S. Minhas, Riddhita Mukherjee, Katrin I. Andreasson, Daria Mochly-Rosen> ;Journal of Neuroinflammation. 2020 Jan 27
• 34 citations
  Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology
  Amit Joshi, Lauren D. Van Wassenhove, Kelsey R. Logas, Paras S. Minhas, Katrin I. Andreasson, Kenneth I. Weinberg, Che-Hong Chen, Daria Mochly-Rosen> ;Acta Neuropathologica Communications. 2019 Dec 12
• 101 citations
  Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Science Translational Medicine. 2019 Nov 20
• 313 citations
  Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration
  Amit Joshi, Paras S. Minhas, Shane A. Liddelow, Bereketeab Haileselassie, Katrin I. Andreasson, Gerald W. Dorn, Daria Mochly-Rosen> ;Nature Neuroscience. 2019 Sep 23
• 91 citations
  Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity
  Qingkun Liu, Emily M. Johnson, Rachel K. Lam, Qian Wang, Hong Bo Ye, Edward N. Wilson, Paras S. Minhas, Ling Liu, Michelle S. Swarovski, Stephanie Tran, Jing Wang, Swa...> ;Nature Immunology. 2019 Jul 1
• 1 citations
  In Regard to Okonogi et al.
  Paras S. Minhas, Stephanie Tran> ;International Journal of Radiation Oncology, Biology, Physics. 2019 May 1
• 8 citations
  Corrigendum to "Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's disease" [EBioMedicine 2 (201...
  Liang Zhang, Song Zhang, Izumi Maezawa, Sergey Trushin, Paras S. Minhas, Matthew Pinto, Lee-Way Jin, Keshar Prasain, Thi D.T. Nguyen, Yu Yamazaki, Takahisa Kanekiyo, G...> ;Ebiomedicine. 2019 Apr 1
• 7 citations
  Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance.
  Peter K. Moon, Stephanie Tran, Paras S. Minhas> ;Journal of Translational Medicine. 2019 Jan 18
• 266 citations
  Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation.
  Paras S. Minhas, Ling Liu, Peter K. Moon, Amit Joshi, Christopher Dove, Siddhita D. Mhatre, Kévin Contrepois, Qian Wang, Brittany A. Lee, Michael Coronado, Daniel Bern...> ;Nature Immunology. 2019 Jan 1
• 2 citations
  Immersion medicine programme for secondary students.
  Paras S. Minhas, Nathan G. Kim, Jayson Myers, Wendy Caceres, Marina Martin, Baldeep Singh> ;The Clinical Teacher. 2018 Oct 1
• 1 citations
  Modulating kynurenine monooxygenase in microglia: The need for further characterization.
  P.K. Moon, Paras S. Minhas> ;Psychoneuroendocrinology. 2018 Aug 13
• Reexamining IFN-γ Stimulation of De Novo NAD+ in Monocyte-Derived Macrophages.
  Peter K. Moon, Paras S. Minhas> ;International Journal of Tryptophan Research. 2018 May 16
• 4 citations
  Passport to pathology: transforming the medical student pathology elective from a passive educational experience to an exciting, immersive clinical rotation.
  Paras S. Minhas, Imarhia E. Enogieru, Richard N. Mitchell, Douglas A. Mata> ;Human Pathology. 2017 Oct 1
• 2 citations
  Reevaluating the role of IDO1: Examining NAD+ metabolism in inflammation.
  Peter K. Moon, Paras S. Minhas> ;Journal of Neuroimmunology. 2017 Jun 15
• 3 citations
  Teasing apart NAD+ metabolism in inflammation: commentary on Zhou et al. (2016). Br J Pharmacol 173: 2352-2368.
  Peter K. Moon, Paras S. Minhas> ;British Journal of Pharmacology. 2017 Feb 1
• 75 citations
  Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.
  Alexi Nott, Jemmie Cheng, Fan Gao, Yuan-Ta Lin, Elizabeta Gjoneska, Tak Ko, Paras S. Minhas, Alicia V. Zamudio, Jia Meng, Feiran Zhang, Peng Jin, Li-Huei Tsai> ;Nature Neuroscience. 2016 Nov 1
• 67 citations
  Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.
  Nathaniel S. Woodling, Damien Colas, Qian Wang, Paras S. Minhas, Maharshi Panchal, Xibin Liang, Siddhita D. Mhatre, Holden D. Brown, Novie Ko, Irene Zagol-Ikapitte, Ma...> ;Brain. 2016 Jul 1
• 2 citations
  Neuropathology: bridging psychiatry and neurology in medical education
  Paras S. Minhas, YunXiang Chu, Douglas A. Mata> ;The Lancet. Psychiatry. 2016 Feb 1
• 69 citations
  Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease
  Liang Zhang, Song Zhang, Izumi Maezawa, Sergey Trushin, Paras S. Minhas, Matthew Pinto, Lee-Way Jin, Keshar Prasain, Thi D.T. Nguyen, Yu Yamazaki, Takahisa Kanekiyo, G...> ;Ebiomedicine. 2015 Apr 1
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Journal Articles

• Macrophage De Novo NAD+ Synthesis Specifies Immune Function in Aging and Inflammation  
  Ravindra Majeti, Paras S Minhas, Katrin I Andreasson, Christopher Dove, Nature