Patrick A Flume MD

Pulmonology•Charleston, SC

Critical Care Medicine, Pleural Disease

Professor, Medicine, Medical University of South Carolina College of Medicine

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171 Ashley AveCharleston, SC 29425
Phone+1 843-792-1414

Education & Training

University of North Carolina HospitalsFellowship, Pulmonary Disease and Critical Care Medicine, 1990 - 1993
University of Texas Health Science Center San Antonio Joe and Teresa Lozano Long School of MedicineResidency, Internal Medicine, 1987 - 1990
The University of Texas Health Science Center at San AntonioClass of 1987

Certifications & Licensure

SC State Medical License 1993 - 2027
NC State Medical License 1990 - 1998
TX State Medical License 1988 - 1992
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Homozygous for the F508del-CFTR Mutation Start of enrollment: 2009 Sep 01
Terminated
Phase 2
MP-376 (Aeroquin™, Levofloxacin for Inhalation) in Patients With Cystic Fibrosis Start of enrollment: 2010 Nov 04
COMPLETED
PHASE3
Trial of Aeroquin Versus Tobramycin Inhalation Solution (TIS) in Cystic Fibrosis (CF) Patients
COMPLETED
PHASE3
Liposomal Amikacin for Inhalation (LAI) for Nontuberculous Mycobacteria Start of enrollment: 2012 Apr 19
Completed
Phase 2
Pilot Observational Study to Determine Feasibility of a Standardized Treatment of Pulmonary Exacerb. in Patients With CF Start of enrollment: 2014 Jan 01
Completed
Dose Escalation Study of QR-010 in Homozygous ΔF508 Cystic Fibrosis Patients Start of enrollment: 2015 Jun 01
Completed
Phase 1, Phase 2
Standardized Treatment of Pulmonary Exacerbations II Start of enrollment: 2016 Jun 01
Completed
Phase 4
An Efficacy and Safety Study of Ivacaftor in Patients With Cystic Fibrosis and Two Splicing Mutations Start of enrollment: 2016 Nov 01
Completed
Phase 3
A Proof of Concept Study of Inhaled Nitric Oxide for Adults With Pulmonary Non-Tuberculous Mycobacterial Infection Start of enrollment: 2019 Jan 28
Completed
Phase 2
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Publications & Presentations

PubMed

The Aging Patient with Cystic Fibrosis.
Lauren J Sullivan, Christina M Mingora, Patrick A Flume
Drugs & Aging. 2025-04-24
Trial Conduct, Baseline Characteristics, and Symptom Burden of Patients in the ARISE Study.
Charles L Daley, James D Chalmers, Patrick A Flume, David E Griffith, Naoki Hasegawa
Pulmonary Therapy. 2025-04-08
Roles of immunoglobulin GM and KM allotypes and Fcγ receptor 2 A genotypes in humoral immunity to a conserved microbial polysaccharide in pulmonary diseases.
Janardan P Pandey, Paul J Nietert, Aryan M Namboodiri, Christine Kimball, Patrick A Flume
Genes and Immunity. 2025-04-01

Press Mentions

New Breakthrough Treatments for Cystic FibrosisJuly 30th, 2024
Refining Your Search: A Team Approach to Identifying Patient Cohorts Using Data from the Electronic Health RecordApril 12th, 2023
A New Way to Improve Clinical Trial Enrollment and DiversityMarch 22nd, 2023
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Grant Support

South Carolina Clinical & Translational Research Institute (SCTR)MEDICAL UNIVERSITY OF SOUTH CAROLINA2015–2025

Professional Memberships

American College of Physicians - ACP
Member