PatrickAFlumeMD

Pulmonology • Charleston, SC

Critical Care Medicine, Pleural Disease

Professor, Medicine, Medical University of South Carolina College of Medicine

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Office
171 Ashley Ave
Charleston, SC 29425
Phone+1 843-792-1414
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Education & Training

University of North Carolina HospitalsFellowship, Pulmonary Disease and Critical Care Medicine, 1990 - 1993
University of Texas Health Science Center San Antonio Joe and Teresa Lozano Long School of MedicineResidency, Internal Medicine, 1987 - 1990
The University of Texas Health Science Center at San AntonioClass of 1987

Certifications & Licensure

SC State Medical License 1993 - 2025
NC State Medical License 1990 - 1998
TX State Medical License 1988 - 1992

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Homozygous for the F508del-CFTR Mutation Start of enrollment: 2009 Sep 01
Terminated
Phase 2
MP-376 (Aeroquin™, Levofloxacin for Inhalation) in Patients With Cystic Fibrosis Start of enrollment: 2010 Nov 01
Completed
Phase 3
Trial of Aeroquin Versus Tobramycin Inhalation Solution (TIS) in Cystic Fibrosis (CF) Patients Start of enrollment: 2011 Jan 01
Completed
Phase 3
Liposomal Amikacin for Inhalation (LAI) for Nontuberculous Mycobacteria Start of enrollment: 2012 Apr 19
Completed
Phase 2
Pilot Observational Study to Determine Feasibility of a Standardized Treatment of Pulmonary Exacerb. in Patients With CF Start of enrollment: 2014 Jan 01
Completed
Dose Escalation Study of QR-010 in Homozygous ΔF508 Cystic Fibrosis Patients Start of enrollment: 2015 Jun 01
Completed
Phase 1, Phase 2
Standardized Treatment of Pulmonary Exacerbations II Start of enrollment: 2016 Jun 01
Completed
Phase 4
An Efficacy and Safety Study of Ivacaftor in Patients With Cystic Fibrosis and Two Splicing Mutations Start of enrollment: 2016 Nov 01
Completed
Phase 3
A Proof of Concept Study of Inhaled Nitric Oxide for Adults With Pulmonary Non-Tuberculous Mycobacterial Infection Start of enrollment: 2019 Jan 28
Completed
Phase 2
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Publications & Presentations

PubMed

The impact of switching to race-neutral reference equations on FEVpercent predicted among people with cystic fibrosis.
Margaret Rosenfeld, Elizabeth A Cromwell, Michael S Schechter, Rhonda D Szczesniak, Clement Ren, Patrick A Flume, Wayne J Morgan, Raksha Jain> ;Journal of Cystic Fibrosis. 2024 Mar 30
1 citations
Adjunctive Systemic Corticosteroids for Pulmonary Exacerbations of Cystic Fibrosis.
Heltshe, S., Odem-Davis, K., West, N., Sanders, D., Fogarty, B., VanDevanter, D., Goss, C., McElvaney, O., Flume, P.> ;Annals of the American Thoracic Society. 2023 Dec 14
Prevalence and Clinical Impact of Respiratory Viral Infections from the STOP2 Study of Cystic Fibrosis Pulmonary Exacerbations.
Christina S Thornton, Lindsay J Caverly, Linda M Kalikin, Lisa A Carmody, Scott McClellan, William LeBar, Don B Sanders, Natalie E West, Christopher H Goss, Patrick A ...> ;Annals of the American Thoracic Society. 2024 Apr 1
Nontuberculous mycobacterial pulmonary disease and the potential role of SPR720.
Kevin L Winthrop, Patrick Flume, Kamal A Hamed> ;Expert Review of Anti-Infective Therapy. 2023 Nov 8
Characteristics associated with cystic fibrosis-related pulmonary exacerbation treatment location.
Laura S Gold, Ryan N Hansen, Sonya L Heltshe, Patrick A Flume, Christopher H Goss, Natalie E West, Don B Sanders, Larry Kessler> ;Journal of Cystic Fibrosis. 2023 Oct 5
Experiences of cystic fibrosis newborn screening and genetic counseling.
Kimberly Foil, Lillian Christon, Cheryl Kerrigan, Patrick A Flume, Jaclyn Drinkwater, Sylvia Szentpetery> ;Journal of Community Genetics. 2023 Dec 1
Impact of lumacaftor/ivacaftor and tezacaftor/ivacaftor on treatment response in pulmonary exacerbations of F508del/F508del cystic fibrosis.
Oliver J McElvaney, Sonya L Heltshe, Katherine Odem-Davis, Natalie E West, Don B Sanders, Barbra Fogarty, Donald R VanDevanter, Patrick A Flume, Christopher H Goss> ;Journal of Cystic Fibrosis. 2023 Sep 1
4 citations
Long-term Safety and Tolerability of Omadacycline for the Treatment ofInfections.
Christina M Mingora, Wendy Bullington, Paige E Faasuamalie, Adrah Levin, Gabriella Porter, Ryan Stadnick, Cara D Varley, Doreen Addrizzo-Harris, Charles L Daley, Kenne...> ;Open Forum Infectious Diseases. 2023 Jul 1
Pulmonary exacerbations in insured patients with bronchiectasis over 2 years.
Patrick A Flume, Joseph Feliciano, Matthew Lucci, Jasmanda Wu, Sebastian Fucile, Mariam Hassan, Anjan Chatterjee> ;ERJ Open Research. 2023 Jul 1
1 citations
Reporting Standards for Diagnostic Testing: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals.
David E Ost, David J Feller-Kopman, Anne V Gonzalez, Horiana B Grosu, Felix Herth, Peter Mazzone, John E S Park, José M Porcel, Samira Shojaee, Ioana Tsiligianni, Anil...> ;Journal of Bronchology & Interventional Pulmonology. 2023 Jul 1
5 citations
Association between unplanned pregnancies and maternal exacerbations in cystic fibrosis.
Giselle Peng, Jennifer L Taylor-Cousar, MinJae Lee, Ashley Keller, Natalie E West, Traci M Kazmerski, Jennifer L Goralski, Moira L Aitken, Andrea H Roe, Denis Hadjilia...> ;Journal of Cystic Fibrosis. 2023 Sep 1
1 citations
Complications and Practice Variation in the Use of Peripherally Inserted Central Venous Catheters in People With Cystic Fibrosis: The Prospective Study of Peripherally...
Alex H Gifford, Alexandra C Hinton, Shijing Jia, Samya Z Nasr, Joel D Mermis, Thomas Lahiri, Edith T Zemanick, Charlotte C Teneback, Patrick A Flume, Emily A DiMango, ...> ;Chest. 2023 Sep 1
2 citations
Towards development of evidence to inform recommendations for the evaluation and management of bronchiectasis.
Patrick A Flume, Ashwin Basavaraj, Bryan Garcia, Kevin Winthrop, Emily Di Mango, Charles L Daley, Julie V Philley, Emily Henkle, Anne E O'Donnell, Mark Metersky> ;Respiratory Medicine. 2023 May 1
1 citations
Combined Aerobic Exercise and Virtual Reality-Based Upper Extremity Rehabilitation Intervention for Chronic Stroke: Feasibility and Preliminary Effects on Physical Fun...
Ryan E Ross, Emerson Hart, Ewan R Williams, Chris M Gregory, Patrick A Flume, Christina M Mingora, Michelle L Woodbury> ;Archives of Rehabilitation Research and Clinical Translation. 2023 Mar 1
Preparing clinicians to be site investigators in multicenter clinical trials: A training program at an academic medical center.
Tammy L Loucks, Diana Lee-Chavarria, Jillian Harvey, Rechelle Paranal, Signe Denmark, Patrick A Flume, Marc Chimowitz, Turan, T. N., Turan, T. N., Turan, T. N., Tanya ...> ;Journal of Clinical and Translational Science. 2023 Jan 1
1 citations
Enhancing study recruitment through implementation of an opt-out, cold contact process with consideration for autonomy, beneficence and justice.
Tara Pittman, Leslie Bell, Stedman Jones, Kimberly Brown, Katie Kirchoff, Patrick Flume> ;Journal of Clinical and Translational Science. 2023 Jan 1
1 citations
Long-term tezacaftor/ivacaftor safety and efficacy in people with cystic fibrosis and an F508del-CFTR mutation: 96-week, open-label extension of the EXTEND trial.
Patrick A Flume, R Scott Harris, Hildegarde Paz-Diaz, Neil Ahluwalia, Mark Higgins, Daniel Campbell, Indrias Berhane, Judy L Shih, Gregory Sawicki> ;Journal of Cystic Fibrosis. 2023 May 1
2 citations
Factors associated with receiving CF care and use of telehealth in 2020 among persons with Cystic Fibrosis in the United States.
J M Collaco, D Albon, J S Ostrenga, P Flume, M S Schechter, E A Cromwell> ;Journal of Cystic Fibrosis. 2023 May 1
6 citations
Inhaled nitric oxide for adults with pulmonary non-tuberculous mycobacterial infection.
Patrick A Flume, Bryan A Garcia, Dulaney Wilson, Lisa Steed, Susan E Dorman, Kevin Winthrop> ;Respiratory Medicine. 2023 Jan 1
1 citations
Not all phenotypes are created equal: covariates of success in e-phenotype specification.
Bashir Hamidi, Patrick A Flume, Kit N Simpson, Alexander V Alekseyenko> ;Journal of the American Medical Informatics Association. 2023 Jan 18
5 citations
Antipseudomonal treatment decisions during CF exacerbation management.
D R VanDevanter, N E West, D B Sanders, M Skalland, C H Goss, P A Flume, S L Heltshe> ;Journal of Cystic Fibrosis. 2022 Sep 1
2 citations
Abdominal Surgical Procedures in Adult Patients With Cystic Fibrosis: What Are the Risks?
Melissa A Hite, Wolfgang B Gaertner, Bryan Garcia, Patrick A Flume, Pinckney J Maxwell 4th, Virgilio V George, Thomas Curran> ;Diseases of the Colon and Rectum. 2022 Aug 1
8 citations
Telehealth and CFTR modulators: Accelerating innovative models of cystic fibrosis care.
Michelle H Prickett, Patrick A Flume, Kathryn A Sabadosa, Quynh T Tran, Bruce C Marshall> ;Journal of Cystic Fibrosis. 2023 Jan 1
8 citations
C-reactive protein (CRP) as a biomarker of pulmonary exacerbation presentation and treatment response.
D R VanDevanter, S L Heltshe, M Skalland, N E West, D B Sanders, C H Goss, P A Flume> ;Journal of Cystic Fibrosis. 2022 Jul 1
2 citations
Health care costs in a randomized trial of antimicrobial duration among cystic fibrosis patients with pulmonary exacerbations.
Laura S Gold, Ryan N Hansen, Donald L Patrick, Ashley Tabah, Sonya L Heltshe, Patrick A Flume, Christopher H Goss, Natalie E West, Don B Sanders, Donald R VanDevanter,...> ;Journal of Cystic Fibrosis. 2022 Jul 1
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Press Mentions

Refining Your Search: A Team Approach to Identifying Patient Cohorts Using Data from the Electronic Health RecordApril 12th, 2023
A New Way to Improve Clinical Trial Enrollment and DiversityMarch 22nd, 2023
COVID-19 Vaccine Trials in SC Resume After Safety TimeoutNovember 2nd, 2020
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