PaulRichardCareyMD

PubMed

• 1 citations
  Concerted Protein and Nucleic Acid Conformational Changes Observed Prior to Nucleotide Incorporation in a Bacterial RNA Polymerase: Raman Crystallographic Evidence.
  Ioanna H. Antonopoulos, Brittany A. Warner, Paul R. Carey> ;Biochemistry. 2015 Aug 18
• 12 citations
  Measuring Propargyl-Linked Drug Populations Inside Bacterial Cells, and Their Interaction with a Dihydrofolate Reductase Target, by Raman Microscopy
  Hossein Heidari-Torkabadi, Tao Che, Michael N. Lombardo, Dennis L. Wright, Amy C. Anderson, Paul R. Carey> ;Biochemistry. 2015 May 5
• 5 citations
  Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone.
  Tao Che, Elizabeth A. Rodkey, Christopher R. Bethel, Sivaprakash Shanmugam, Zhe Ding, Marianne Pusztai-Carey, Michael D. Nottingham, Weirui Chai, John D. Buynak, Rober...> ;Biochemistry. 2015 Jan 27
• 5 citations
  Time-Resolved Raman and Polyacrylamide Gel Electrophoresis Observations of Nucleotide Incorporation and Misincorporation in RNA within a Bacterial RNA Polymerase Crystal
  Ioanna H. Antonopoulos, Yuko Murayama, Brittany A. Warner, Shun-ichi Sekine, Shigeyuki Yokoyama, Paul R. Carey> ;Biochemistry. 2015 Jan 13
• 24 citations
  Following drug uptake and reactions inside Escherichia coli cells by Raman microspectroscopy.
  Hossein Heidari Torkabadi, Christopher R. Bethel, Krisztina M. Papp-Wallace, Piet A. J. de Boer, Robert A. Bonomo, Paul R. Carey> ;Biochemistry. 2014 Jul 1
• 7 citations
  Following DNA chain extension and protein conformational changes in crystals of a Y-family DNA polymerase via Raman crystallography.
  Shirly J. Espinoza-Herrera, Vineet Gaur, Zucai Suo, Paul R. Carey> ;Biochemistry. 2013 Jul 23
• 12 citations
  Kinetic crystallography by Raman microscopy.
  Paul R. Carey, Yuanyuan Chen, Bo Gong, Matthew Kalp> ;Biochimica Et Biophysica Acta. 2011 Jun 1
• 16 citations
  Probing Adenine Rings and Backbone Linkages Using Base Specific Isotope-Edited Raman Spectroscopy: Application to Group II Intron Ribozyme Domain V
  Yuanyuan Chen, Nadukkudy V. Eldho, T. Kwaku Dayie, Paul R. Carey> ;Biochemistry. 2010 Apr 27
• 13 citations
  A quantitative Raman spectroscopic signal for metal-phosphodiester interactions in solution.
  Eric L. Christian, Vernon E. Anderson, Paul R. Carey, Michael E. Harris> ;Biochemistry. 2010 Apr 6
• 28 citations
  Competition between Co(NH3)63+ and Inner Sphere Mg2+ Ions in the HDV Ribozyme
  Bo Gong, Jui Hui Chen, Philip C. Bevilacqua, Barbara L. Golden, Paul R. Carey> ;Biochemistry. 2009 Dec 22
• 8 citations
  Role of E166 in the Imine to Enamine Tautomerization of the Clinical β-Lactamase Inhibitor Sulbactam
  Matthew Kalp, John D. Buynak, Paul R. Carey> ;Biochemistry. 2009 Nov 3
• 14 citations
  Why the Extended-Spectrum β-Lactamases SHV-2 and SHV-5 Are “Hypersusceptible” to Mechanism-Based Inhibitors
  Matthew Kalp, Christopher R. Bethel, Robert A. Bonomo, Paul R. Carey> ;Biochemistry. 2009 Oct 20
• 38 citations
  A Catalytic Metal Ion Interacts with the Cleavage Site G·U Wobble in the HDV Ribozyme†
  Jui Hui Chen, Bo Gong, Philip C. Bevilacqua, Paul R. Carey, Barbara L. Golden> ;Biochemistry. 2009 Feb 24
• 28 citations
  Carbapenems and SHV-1 β-Lactamase Form Different Acyl-Enzyme Populations in Crystals and Solution
  Matthew Kalp, Paul R. Carey> ;Biochemistry. 2008 Nov 11
• 12 citations
  Why Clinically Used Tazobactam and Sulbactam Are Poor Inhibitors of OXA-10 β-Lactamase: Raman Crystallographic Evidence†
  Monica A. Totir, Jooyoung Cha, Akihiro Ishiwata, Benlian Wang, Anjaneyulu Sheri, Vernon E. Anderson, John D. Buynak, Shahriar Mobashery, Paul R. Carey> ;Biochemistry. 2008 Mar 7
• 27 citations
  Sulbactam Forms Only Minimal Amounts of Irreversible Acrylate-Enzyme With SHV-1 β-Lactamase
  Monica A. Totir, Marion S. Helfand, M.P. Carey, Anjaneyulu Sheri, John D. Buynak, R.A. Bonomo, Paul R. Carey> ;Biochemistry. 2007 Aug 7
• 14 citations
  Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
  Marion S. Helfand, Magdalena A. Taracila, Monica A. Totir, R.A. Bonomo, John D. Buynak, Focco van den Akker, Paul R. Carey> ;Biochemistry. 2007 Jul 24
• 35 citations
  Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates.
  Monica A. Totir, Pius S. Padayatti, Marion S. Helfand, Marianne P. Carey, Robert A. Bonomo, Paul R. Carey, Focco van den Akker> ;Biochemistry. 2006 Oct 3
• 62 citations
  Structure-Specific Effects of Protein Topology on Cross-β Assembly: Studies of Insulin Fibrillation†
  Kun Huang, Nakul C. Maiti, Nelson B. Phillips, Paul R. Carey, Michael A. Weiss> ;Biochemistry. 2006 Aug 4
• 38 citations
  Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity.
  Marcel J. Lachenmann, John E. Ladbury, Jian Dong, Kun Huang, Paul R. Carey, Michael A. Weiss> ;Biochemistry. 2004 Nov 9
• 31 citations
  Following ligand binding and ligand reactions in proteins via Raman crystallography.
  Paul R. Carey, Jian Dong> ;Biochemistry. 2004 Jul 20
• 52 citations
  Tazobactam forms a stoichiometric trans-enamine intermediate in the E166A variant of SHV-1 beta-lactamase: 1.63 A crystal structure.
  Pius S. Padayatti, Marion S. Helfand, Monica A. Totir, Marianne P. Carey, Andrea M. Hujer, Paul R. Carey, Robert A. Bonomo, Focco van den Akker> ;Biochemistry. 2004 Jan 3
• 53 citations
  Following the Reactions of Mechanism-Based Inhibitors with β-Lactamase by Raman Crystallography†
  Marion S. Helfand, Monica A. Totir, Marianne P. Carey, Andrea M. Hujer, Robert A. Bonomo, Paul R. Carey> ;Biochemistry. 2003 Oct 31
• 13 citations
  The strength of dehalogenase-substrate hydrogen bonding correlates with the rate of Meisenheimer intermediate formation
  Jian Dong, Xuefeng Lu, Yansheng Wei, Lusong Luo, Debra Dunaway-Mariano, Paul R. Carey> ;Biochemistry. 2003 Jul 15
• 401 citations
  Metal Binding and Oxidation of Amyloid-β within Isolated Senile Plaque Cores: Raman Microscopic Evidence†
  Jian Dong, Craig S. Atwood, Vernon E. Anderson, Sandra L. Siedlak, Mark A. Smith, George Perry, Paul R. Carey> ;Biochemistry. 2003 Mar 18
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