PaulEHughesMD

PubMed

• 74 citations
  AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small Cell Lung Cancer
  Giffin Michael John, Keegan Cooke, Edward K. Lobenhofer, Juan Estrada, Jinghui Zhan, Petra Deegen, Melissa Thomas, Christopher Murawsky, Jonathan Werner, Siyuan Liu, F...> ;Clinical Cancer Research. 2021 Mar 1
• 111 citations
  Targeting MCL-1 in hematologic malignancies: Rationale and progress
  Andrew H. Wei, Andrew W. Roberts, Andrew Spencer, Aaron S. Rosenberg, David S. Siegel, Roland B. Walter, Sean Caenepeel, Paul E. Hughes, Zach McIver, Khalid Mezzi, Phu...> ;Blood Reviews. 2020 Feb 21
• 8 citations
  Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an alpha-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.
  Gwenaella Rescourio, Ana Z. Gonzalez, Salman Jabri, Brian Belmontes, Gordon Moody, Doug Whittington, Xin Huang, Sean Caenepeel, Mario G. Cardozo, Alan C. Cheng, David ...> ;Journal of Medicinal Chemistry. 2019 Nov 18
• Volatile aroma composition of distillates produced from fermented sweet and acid whey.
  Risner, D.,Tomasino, E.,Hughes, P.,Meunier-Goddik, L.> ;J. Dairy Sci.. 2018 Nov 06
• 59 citations
  Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer.
  Varuna Nangia, Faria M. Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J. Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L. Archibald, Chendi Li, Cameron Frase...> ;Cancer Discovery. 2018 Dec 1
• 247 citations
  AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
  Sean Caenepeel, Sean P. Brown, Brian Belmontes, Gordon Moody, Kathleen S. Keegan, Danny Chui, Douglas A. Whittington, Xin Huang, Leszek Poppe, Alan C. Cheng, Mario G. ...> ;Cancer Discovery. 2018 Dec 1
• Fermentation and distillation of cheese whey: Carbon dioxide-equivalent emissions and water use in the production of whey spirits and white whiskey.
  Risner, D.,Shayevitz, A.,Haapala, K.,Meunier-Goddik, L.,Hughes, P.> ;J. Dairy Sci.. 2018 Feb 06
• 31 citations
  MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor.
  Sean Caenepeel, Keegan Cooke, Sarah Wadsworth, Guo Huang, Lidia Robert, Blanca Homet Moreno, Giulia Parisi, Elaina Cajulis, Richard Kendall, Pedro J. Beltran, Antoni R...> ;Oncotarget. 2017 Jan 27
• 201 citations
  Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer
  Paul E. Hughes, Sean Caenepeel, Lawren C. Wu> ;Trends in Immunology. 2016 Jul 1
• 39 citations
  In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models
  Paul E. Hughes, Karen Rex, Sean Caenepeel, Yajing Yang, Yihong Zhang, Martin A. Broome, Hue T. Kha, Teresa L. Burgess, Benny Amore, Paula Kaplan-Lefko, Jodi Moriguchi,...> ;Molecular Cancer Therapeutics. 2016 Jan 1
• 15 citations
  The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors.
  Markian Stec, Kristin L. Andrews, Yunxin Bo, Sean Caenepeel, Hongyu Liao, John D. McCarter, Erin L. Mullady, Tisha San Miguel, Raju Subramanian, Nuria A. Tamayo, Dougl...> ;Bioorganic & Medicinal Chemistry Letters. 2015 Oct 1
• 3 citations
  Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
  Brian A. Lanman, Anthony B. Reed, Victor J. Cee, Fang-Tsao Hong, Liping H. Pettus, Ryan Wurz, Kristin L. Andrews, Jian Jiang, John D. McCarter, Erin L. Mullady, Tisha ...> ;Bioorganic & Medicinal Chemistry Letters. 2014 Dec 15
• 41 citations
  MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways
  Anne Y. Saiki, Sean Caenepeel, Dongyin Yu, Julie A. Lofgren, Tao Osgood, Rebecca Robertson, Jude Canon, Cheng Su, Adrie Jones, Xiaoning Zhao, Chetan Deshpande, Marc Pa...> ;Oncotarget. 2014 Apr 23
• 15 citations
  Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
  Ryan Wurz, Longbin Liu, Kevin Yang, Nobuko Nishimura, Yunxin Bo, Liping H. Pettus, Sean Caenepeel, Daniel J. Freeman, John D. McCarter, Erin L. Mullady, Tisha San Migu...> ;Bioorganic & Medicinal Chemistry Letters. 2012 Sep 1
• 33 citations
  Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
  Mark H. Norman, Kristin L. Andrews, Yunxin Y. Bo, Shon Booker, Sean Caenepeel, Victor J. Cee, Noel D'angelo, Daniel J. Freeman, Bradley J. Herberich, Fang-Tsao Hong, C...> ;Journal of Medicinal Chemistry. 2012 Aug 30
• 29 citations
  Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Journal of Medicinal Chemistry. 2012 May 23
• 31 citations
  Structure–Activity Relationships of Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Investigations of Various 6,5-Heterocycles t...
  Markian Stec, Kristin L. Andrews, Shon Booker, Sean Caenepeel, Daniel J. Freeman, Jian Jiang, Hongyu Liao, John McCarter, Erin L. Mullady, Tisha San Miguel, Raju Subra...> ;Journal of Medicinal Chemistry. 2011 Jun 29
• 43 citations
  Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and qui...
  Nobuko Nishimura, Aaron C. Siegmund, Longbin Liu, Kevin Yang, Marian C. Bryan, Kristin L. Andrews, Yunxin Bo, Shon Booker, Sean Caenepeel, Daniel J. Freeman, Hongyu Li...> ;Journal of Medicinal Chemistry. 2011 Jun 20
• 21 citations
  Anti-tumor activity of motesanib in a medullary thyroid cancer model.
  Angela Coxon, James Bready, Steve Kaufman, Juan Estrada, Tao Osgood, Jude Canon, Ling Wang, Robert Radinsky, Rick Kendall, Paul E. Hughes, Anthony Polverino> ;Journal of Endocrinological Investigation. 2012 Feb 1
• 73 citations
  Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors
  Noel D'angelo, Tae-Seong Kim, Kristin L. Andrews, Shon Booker, Sean Caenepeel, Kui Chen, Derin C. D'amico, Daniel J. Freeman, Jian Jiang, Longbin Liu, John D. McCarter...> ;Journal of Medicinal Chemistry. 2011 Feb 18
• 116 citations
  Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Pep...
  Angela Coxon, James Bready, Hosung Min, Stephen J. Kaufman, Juan Leal, Dongyin Yu, Tani Ann Lee, Ji-Rong Sun, Juan Estrada, Brad Bolon, James M. McCabe, Ling Wang, Kar...> ;Molecular Cancer Therapeutics. 2010 Oct 1
• 16 citations
  Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors
  Sean Caenepeel, Lisa Renshaw-Gegg, Angelo Baher, Tammy L. Bush, Will Baron, Todd Juan, Raffi Manoukian, Andrew Tasker, Anthony Polverino, Paul E. Hughes> ;Journal of Experimental & Clinical Cancer Research. 2010 Jul 15
• 35 citations
  Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.
  Victor J. Cee, Alan C. Cheng, Karina Romero, Steve Bellon, Christopher Mohr, Douglas A. Whittington, Annette Bak, James Bready, Sean Caenepeel, Angela Coxon, Holly L. ...> ;Bioorganic & Medicinal Chemistry Letters. 2009 Jan 15
• 32 citations
  Broad Antitumor Activity in Breast Cancer Xenografts by Motesanib, a Highly Selective, Oral Inhibitor of Vascular Endothelial Growth Factor, Platelet-Derived Growth Fa...
  Angela Coxon, Tammy L. Bush, Douglas Saffran, Stephen Kaufman, Brian Belmontes, Karen Rex, Paul E. Hughes, Sean Caenepeel, James B. Rottman, Andrew Tasker, Vinod F. Pa...> ;Clinical Cancer Research. 2009 Jan 1
• 27 citations
  Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors
  Brian L. Hodous, Stephanie D. Geuns-Meyer, Paul E. Hughes, Brian K. Albrecht, Steve Bellon, Sean Caenepeel, Victor J. Cee, Stuart C. Chaffee, Maurice Emery, Jenne Fret...> ;Bioorganic & Medicinal Chemistry Letters. 2007 May 15
• Join now to see all