PaulThomasKotzbauerMD

Neurology • Saint Louis, MO

Professor at Department of Neurology, Washington University School of Medicine St. Louis

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Office
517 S Euclid Ave
Saint Louis, MO 63110
Phone+1 314-362-6908

Fax+1 314-747-3258
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Education & Training

University of Pennsylvania Health SystemResidency, Neurology, 1998 - 2001
Washington University in St. Louis School of MedicineClass of 1997

Certifications & Licensure

MO State Medical License 2005 - 2025
PA State Medical License 1998 - 2006
American Board of Psychiatry and Neurology Neurology

Publications & Presentations

PubMed

VCP Inhibition Augments NLRP3 Inflammasome Activation.
Ankita Sharma, Dhruva D Dhavale, Paul T Kotzbauer, Conrad C Weihl> ;Inflammation. 2024 Apr 2
Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Dhruva D Dhavale, Alexander M Barclay, Collin G Borcik, Katherine Basore, Deborah A Berthold, Isabelle R Gordon, Jialu Liu, Moses H Milchberg, Jennifer Y O'Shea, Micha...> ;Nature Communications. 2024 Mar 29
1 citations
C andN resonance assignments of alpha synuclein fibrils amplified from Lewy Body Dementia tissue.
Alexander M Barclay, Dhruva D Dhavale, Collin G Borcik, Moses H Milchberg, Paul T Kotzbauer, Chad M Rienstra> ;Biomolecular NMR Assignments. 2023 Dec 1
2 citations
A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy.
Ho Young Kim, Wai Kit Chia, Chia-Ju Hsieh, Dinahlee Saturnino Guarino, Thomas J A Graham, Zsofia Lengyel-Zhand, Mark Schneider, Cosette Tomita, Marshall G Lougee, Hee ...> ;Journal of Medicinal Chemistry. 2023 Sep 14
13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue.
Alexander M Barclay, Dhruva D Dhavale, Collin G Borcik, Moses H Milchberg, Paul T Kotzbauer, Chad M Rienstra> ;Research Square. 2023 Feb 24
2 citations
Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Dhruva D Dhavale, Alexander M Barclay, Collin G Borcik, Katherine Basore, Isabelle R Gordon, Jialu Liu, Moses H Milchberg, Jennifer O'shea, Michael J Rau, Zachary Smit...> ;Biorxiv. 2023 Jan 10
2 citations
Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells.
Frank Bearoff, Dhruva Dhavale, Paul Kotzbauer, Sandhya Kortagere> ;Molecular Immunology. 2023 Feb 1
15 citations
Neocortical Lewy Body Pathology Parallels Parkinson's Dementia, but Not Always.
W R Wayne Martin, John R Younce, Meghan C Campbell, Brad A Racette, Scott A Norris, Mwiza Ushe, Susan Criswell, Albert A Davis, Isabel Alfradique-Dunham, Baijayanta Ma...> ;Annals of Neurology. 2023 Jan 1
4 citations
Proteinopathy and Longitudinal Cognitive Decline in Parkinson Disease.
Peter S Myers, John L O'Donnell, Joshua J Jackson, Christina N Lessov-Schlaggar, Rebecca L Miller, Erin R Foster, Carlos Cruchaga, Bruno A Benitez, Paul T Kotzbauer, J...> ;Neurology. 2022 Jul 5
15 citations
VCP suppresses proteopathic seeding in neurons.
Jiang Zhu, Sara Pittman, Dhruva Dhavale, Rachel French, Jessica N Patterson, Mohamed Salman Kaleelurrrahuman, Yuanzi Sun, Jaime Vaquer-Alicea, Gianna Maggiore, Christo...> ;Molecular Neurodegeneration. 2022 Apr 12
20 citations
Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.
Rebecca L Miller, Dhruva D Dhavale, Jennifer Y O'Shea, Kristin M Andruska, Jialu Liu, Erin E Franklin, Chandana Buddhala, Susan K Loftin, John R Cirrito, Richard J Per...> ;Annals of Clinical and Translational Neurology. 2022 Feb 1
23 citations
Is Levodopa Response a Valid Indicator of Parkinson's Disease?
W.R. Wayne Martin, Michael Miles, Qiaonan Zhong, Johanna M Hartlein, Brad A. Racette, Scott A. Norris, Mwiza Ushe, Baijayanta Maiti, Susan R. Criswell, Albert A. Davis...> ;Movement Disorders. 2021 Apr 1
6 citations
Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease.
Laura Ibanez, Jorge A. Bahena, Chengran Yang, Umber Dube, Fabiana H.G. Farias, John P. Budde, Kristy Bergmann, Carol Brenner-Webster, John C. Morris, Richard J. Perrin...> ;Acta Neuropathologica Communications. 2020 Nov 19
52 citations
Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid.
Nicolas R. Barthélemy, Haiyan Liu, William Lu, Paul T. Kotzbauer, Randall J. Bateman, Brendan P. Lucey> ;Annals of Neurology. 2020 Feb 27
91 citations
APOE genotype regulates pathology and disease progression in synucleinopathy
, , , , , , , , , , , , , , , > ;Science Translational Medicine. 2020 Feb 5
20 citations
Proteinopathy and longitudinal changes in functional connectivity networks in Parkinson disease
Meghan C. Campbell, Joshua J. Jackson, Jonathan M. Koller, Abraham Z. Snyder, Paul T. Kotzbauer, Joel S. Perlmutter> ;Neurology. 2020 Feb 18
67 citations
Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation
Rachel L. French, Zachary R. Grese, Himani Aligireddy, Dhruva Dhavale, Ashley N. Reeb, Niraja Kedia, Paul T. Kotzbauer, Jan Bieschke, Yuna M. Ayala> ;The Journal of Biological Chemistry. 2019 Apr 26
112 citations
Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics
Tritia R. Yamasaki, Brandon B. Holmes, Jennifer L. Furman, Dhruva Dhavale, Bryant W. Su, Eun Suk Song, Nigel J. Cairns, Paul T. Kotzbauer, Marc I. Diamond> ;The Journal of Biological Chemistry. 2019 Jan 18
41 citations
Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules
Chia-Ju Hsieh, John J. Ferrie, Kuiying Xu, Iljung Lee, Thomas J. A. Graham, Zhude Tu, Jennifer Yu, Dhruva Dhavale, Paul T. Kotzbauer, E. James Petersson, Robert H. Mach> ;ACS Chemical Neuroscience. 2018 May 11
23 citations
Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro.
Chia-Ju Hsieh, Kuiying Xu, Iljung Lee, Thomas J. A. Graham, Zhude Tu, Dhruva Dhavale, Paul T. Kotzbauer, Robert H. Mach> ;ACS Omega. 2018 Apr 24
13 citations
Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation
Xuyi Yue, Dhruva Dhavale, Junfeng Li, Zonghua Luo, Jialu Liu, Hao Yang, Robert H. Mach, Paul T. Kotzbauer, Zhude Tu> ;Bioorganic & Medicinal Chemistry Letters. 2018 Apr 1
8 citations
Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strength.
Alexander M. Barclay, Dhruva Dhavale, Joseph M. Courtney, Paul T. Kotzbauer, Chad M. Rienstra> ;Biomolecular NMR Assignments. 2018 Feb 23
17 citations
A sensitive assay reveals structural requirements for α-synuclein fibril growth.
Dhruva Dhavale, Christina Tsai, Devika P. Bagchi, Laura A. Engel, Jonathan M Sarezky, Paul T. Kotzbauer> ;The Journal of Biological Chemistry. 2017 Jun 2
27 citations
Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer's Disease
G. S. M. Sundaram, Dhruva Dhavale, Julie L. Prior, Ping Yan, John R. Cirrito, Nigam P. Rath, Richard Laforest, Nigel J. Cairns, Jin-Moo Lee, Paul T. Kotzbauer, Vivek S...> ;Scientific Reports. 2016 Nov 2
72 citations
Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway.
Dennis Y. Chuang, Agnes Simonyi, Paul T. Kotzbauer, Zezong Gu, Grace Y. Sun> ;Journal of Neuroinflammation. 2015 Oct 31
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Journal Articles

Parkinson’s Disease and Multiple System Atrophy Have Distinct Α-synuclein Seed Characteristics
Brandon B. Holmes, Tritia R. Yamasaki, Marc I. Diamond, Nigel J. Cairns, Paul T. Kotzbauer, The Journal of Biological Chemistry

Press Mentions

Social Impact Heroes: How Emily Rogath Steckler Is Raising Awareness and Funds to Treat and Cure Infantile Neuroaxonal Dystrophy (INAD)August 1st, 2019

Grant Support

Therapeutic Approaches For Neurodegeneration Caused By PLA2G6 MutationsNational Institute Of Neurological Disorders And Stroke2011
Neurodegenerative Consequences Of PANK2 MutationsNational Institute Of Neurological Disorders And Stroke2005–2008
Neurodegenerative Consequences Of PANK2 MutationsNational Institute Of Neurological Disorders And Stroke2004