PaulDenisLegerMD

PubMed

• Bothersome Hot Flashes Following Neoadjuvant Androgen Deprivation Therapy and Stereotactic Body Radiotherapy for Localized Prostate Cancer.
  Sarthak Shah, Abigail Pepin, Jessica Hsueh, Lindsey Gallagher, Malika T Danner, Alan Zwart, Marilyn Ayoob, Thomas M Yung, Deepak Kumar, Suy Simeng, Sean P Collins, Nim...> ;Cureus. 2024 Mar 1
• Impact of neoadjuvant relugolix on patient-reported sexual function and bother.
  Jessica Y Hsueh, Lindsey Gallagher, Min Ji Koh, Shaine Eden, Sarthak Shah, Markus Wells, Malika Danner, Alan Zwart, Marilyn Ayoob, Deepak Kumar, Simeng Suy, Sean P Col...> ;Frontiers in Oncology. 2024 Jan 1
• Early biochemical outcomes following neoadjuvant/adjuvant relugolix with stereotactic body radiation therapy for intermediate to high risk prostate cancer.
  Lindsey Gallagher, Jerry Xiao, Jessica Hsueh, Sarthak Shah, Malika Danner, Alan Zwart, Marilyn Ayoob, Thomas Yung, Tiffany Simpson, Mark Fallick, Deepak Kumar, Paul Le...> ;Frontiers in Oncology. 2023 Jan 1
• 5 citations
  Rationale for Involved Field Stereotactic Body Radiation Therapy-Enhanced Intermittent Androgen Deprivation Therapy in Hormone-Sensitive Nodal Oligo-Recurrent Prostate...
  , , , , , , , , , , , , , , , , > ;Frontiers in Oncology. 2021 Jan 18
• 3 citations
  Race/ethnicity difference in the pharmacogenetics of bilirubin-related atazanavir discontinuation.
  Paul Leger, Sanika Chirwa, Jacinta N. Nwogu, Megan Turner, Danielle M. Richardson, Paxton Baker, Michael Leonard, Husamettin Erdem, Lana M. Olson, David W. Haas> ;Pharmacogenetics and Genomics. 2018 Jan 1
• 1 citations
  A Case Report of Severe Type B Lactic Acidosis Following First Dose of Nivolumab in a VHL-Mutated Metastatic Renal Cell Carcinoma.
  Erica Nakajima, Paul Leger, Ingrid A. Mayer, Michael N. Neuss, David D. Chism, W. Kimryn Rathmell> ;Kidney Cancer. 2017 Jul 26
• 21 citations
  Pulmonary Toxicities from Conventional Chemotherapy.
  Paul Leger, Andrew H. Limper, Fabien Maldonado> ;Clinics in Chest Medicine. 2017 Jun 1
• 36 citations
  Clinical features of acquired resistance to anti–PD-1 therapy in advanced melanoma
  Daniel Y. Wang, Zeynep Eroglu, Alpaslan Özgün, Paul Leger, Shilin Zhao, Fei Ye, Jason J. Luke, Richard W. Joseph, Rizwan Haq, Patrick A. Ott, F. Stephen Hodi, Jeffrey ...> ;Cancer Immunology Research. 2017 Apr 10
• 16 citations
  Pharmacogenetics of efavirenz discontinuation for reported central nervous system symptoms appears to differ by race.
  Paul Leger, Sanika Chirwa, Megan Turner, Danielle M. Richardson, Paxton Baker, Michael Leonard, Husamettin Erdem, Lana M. Olson, David W. Haas> ;Pharmacogenetics and Genomics. 2016 Oct 1
• 59 citations
  Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomis...
  Mina C. Hosseinipour, Gregory P. Bisson, Sachiko Miyahara, Xin Sun, Agnes Moses, Cynthia Riviere, Fredrick Kirui, Sharla. Badal-Faesen, David K. Lagat, Mulinda Nyirend...> ;Lancet. 2016 Mar 19
• 62 citations
  Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa
  Phumla Sinxadi, Paul Leger, Helen McIlleron, Pete Smith, Joel A. Dave, Naomi S. Levitt, Gary Maartens, David W. Haas> ;British Journal of Clinical Pharmacology. 2015 Jul 1
• 12 citations
  Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384
  Paul Leger, Daniel H. Johnson, Gregory K. Robbins, Robert W. Shafer, David B. Clifford, Jun Li, Paul J. McLaren, David W. Haas> ;Journal of Neurovirology. 2014 Feb 20
• 27 citations
  Multiple genetic variants predict steady-state nevirapine clearance in HIV-infected Cambodians.
  Julie Bertrand, Monidarin Chou, Danielle M. Richardson, Céline Verstuyft, Paul Leger, Anne-Marie Taburet, David W. Haas> ;Pharmacogenetics and Genomics. 2012 Dec 1
• 23 citations
  Virologic, clinical and immunologic responses following failure of first-line antiretroviral therapy in Haiti
  Macarthur Charles, Paul Leger, Patrice Severe, Colette Guiteau, Alexandra Apollon, Roy M. Gulick, Warren D. Johnson, Jean W. Pape, Daniel W. Fitzgerald> ;Journal of the International AIDS Society. 2012 Jun 14
• 4 citations
  AIDS diarrhea and antiretroviral drug concentrations: a matched-pair cohort study in Port au Prince, Haiti.
  Rebecca Dillingham, Paul Leger, Carole Anne Beauharnais, Erica O Miller, Angela D. M. Kashuba, Steven H. Jennings, Kathryn M. Dupnik, Amidou Samie, Etna Eyma, Richard ...> ;The American Journal of Tropical Medicine and Hygiene. 2011 Jun 1
• 19 citations
  Clinical Impact and Cost of Monitoring for Asymptomatic Laboratory Abnormalities among Patients Receiving Antiretroviral Therapy in a Resource-Poor Setting
  Serena P. Koenig, Bruce R. Schackman, Cynthia Riviere, Paul Leger, Macarthur Charles, Patrice Severe, Charlene Lastimoso, Nicole Colucci, Jean W. Pape, Daniel W. Fitzg...> ;Clinical Infectious Diseases. 2010 Sep 1
• 39 citations
  Rates and Reasons for Early Change of First HAART in HIV-1-Infected Patients in 7 Sites throughout the Caribbean and Latin America
  Carina Cesar, Bryan E. Shepherd, Alejandro J. Krolewiecki, Valeria Fink, Mauro Schechter, Suely H. Tuboi, Marcelo Wolff, Jean W. Pape, Paul Leger, Denis Padgett, Juan ...> ;Plos One. 2010 Jun 1
• 36 citations
  CYP2B6 Variants and Plasma Efavirenz Concentrations during Antiretroviral Therapy in Port-au-Prince, Haiti
  Paul Leger, Rebecca Dillingham, Carole Anne Beauharnais, Angela D. M. Kashuba, Naser L. Rezk, Daniel W. Fitzgerald, Jean W. Pape, David W. Haas> ;The Journal of Infectious Diseases. 2009 Sep 1
• 21 citations
  High Early Mortality in Patients with Chronic Acquired Immunodeficiency Syndrome Diarrhea Initiating Antiretroviral Therapy in Haiti: A Case-Control Study
  Rebecca Dillingham, Relana Pinkerton, Paul Leger, Patrice Severe, Richard L. Guerrant, J. William Pape, Daniel W. Fitzgerald> ;The American Journal of Tropical Medicine and Hygiene. 2009 Jun 1
• 51 citations
  High mortality among patients with AIDS who received a diagnosis of tuberculosis in the first 3 months of antiretroviral therapy.
  Serena P. Koenig, Cynthia Riviere, Paul Leger, Patrice Joseph, Patrice Severe, Kea Parker, Sean E Collins, Erin Lee, Jean W. Pape, Daniel W. Fitzgerald> ;Clinical Infectious Diseases. 2009 Mar 15
• 31 citations
  Survival, plasma HIV-1 RNA concentrations and drug resistance in HIV-1-infected Haitian adolescents and young adults on antiretrovirals
  Macarthur Charles, Francine Noel, Paul Leger, Patrice Severe, Cynthia Riviere, Carole Anne Beauharnais, Erica O Miller, John Rutledge, Heejung Bang, Wesley Shealey, Ri...> ;Bulletin of the World Health Organization. 2008 Dec 1
• 23 citations
  The cost of antiretroviral therapy in Haiti
  Serena P. Koenig, Cynthia Riviere, Paul Leger, Patrice Severe, Sidney Atwood, Daniel W. Fitzgerald, Jean W. Pape, Bruce R. Schackman> ;Cost Effectiveness and Resource Allocation. 2008 Feb 14
• 226 citations
  Antiretroviral Therapy in a Thousand Patients with AIDS in Haiti
  Patrice Severe, Paul Leger, Macarthur Charles, Francine Noel, Gerry Bonhomme, Gyrlande Bois, Erik George, Stefan Kenel-Pierre, Peter F. Wright, Roy M. Gulick, Warren D...> ;The New England Journal of Medicine. 2005 Dec 1
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Journal Articles

• Race/ethnicity difference in the pharmacogenetics of bilirubin-related atazanavir discontinuation  
  1) Leger P., Chirva S., Nwogu J., Tuner M., Richardson D., Baker P., Leonard M., Erdem H., Olson L., Haas D., Pharmacogent Genomics, 1/28/2018
• A Case Report of Severe Type B Lactic Acidosis Following First Dose of Nivolumab in a VHL-Mutated Metastatic Renal Cell Carcinoma.  
  2) Nakajima E., Leger P., Mayer I., Neuss M., Chism D., Rathmell K, Kidney Cancer, 7/2017
• Clinical features of acquired resistance in anti-PD-1 therapy  
  3) Wang D., Zeynep E., Ozgun A., Leger P., Zhao S., Ye F., Luke J., Joseph R., Sosman J., Johnson D., Buchbinder E, Cancer Immunology Research, 5/2017
• Pharmacogenetics of Efavirenz Discontinuation for Reported Central Nervous System Symptoms Appears to Differ by Race  
  4) Leger P., Chirwa S., Turner M., Richardson D., Baker P., Leonard M., Erdem H., Olson L., Haas D.., Pharmacogenetics and Genomics, 10/2016
• Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multi-country open-label randomi...  
  1) Hosseinipour M., Bisson G., Miyahara S. Leger P., Gupta A., The Lancet, 3/2016
• Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa  
  5) Sinxadi P., Leger P., McIleron H., Smith P., Dave J., Levitt N., Maartens G., Haas D.., Br J Clin Pharmacol, 7/2015
• Multiple Genetic Variants Predict Steady-State Nevirapine Clearance in HIV-infected Cambodians  
  7) Bertrand J., Chou M., Richardson D., Verstuyft C., Leger P., Mentre F., Taburet A., Haas D., Pharmacogenet Genomics., 12/2012
• Virologic, Clinical and Immunologic Responses following Failure of First-line Antiretroviral Therapy in Haiti  
  2) Charles M., Leger P., Severe P., Guiteau C., Apollon A., Gulick R., Johnson W., Pape J., Fitzgerald D, Journal of the International AIDS Society, 6/2012
• 5-Year Survival of Patients with AIDS Receiving Antiretroviral Therapy in Haiti  
  6) Leger P., Charles M., Severe P., Riviere C., Pape J., Fitzgerald D, New England Journal of Medicine, 8/2009
• Antiretroviral Therapy in a Thousand Patients with AIDS in Haiti  
  12) Severe P., Leger P.,Charles M., Noel F., Bonhomme J., Bois G.,George E., Kenel-Pierre S.,Wright P., Gulick R., Johnson W., Pape J.,Fitzgerald D, New England Journal of Medicine, 12/2005
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