PaulHLerouMD

PubMed

• Bilirubin Measurement and Phototherapy Use After the AAP 2022 Newborn Hyperbilirubinemia Guideline.
  Leela Sarathy, Joseph H Chou, Katherine A Darci, Paul H Lerou, Giuseppina Romano-Clarke> ;Pediatrics. 2024 Apr 1
• Who Needs the NICU? Trends and Opportunities for Improvement.
  Leela Sarathy, Sergei Roumiantsev, Paul H Lerou> ;Hospital Pediatrics. 2023 Nov 1
• Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation.
  Kamakshi Bankoti, Wei Wang, Gaurang M Amonkar, Linjie Xiong, Jessica E Shui, Caiqi Zhao, Eric Van, Chimwemwe Mwase, Jin-Ah Park, Hongmei Mou, Yinshan Fang, Jianwen Que...> ;American Journal of Respiratory Cell and Molecular Biology. 2024 Jan 1
• 6 citations
  Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity.
  Yihan Zhang, Katharine Elliot Black, Thien-Khoi N Phung, Sujatha Rajeev Thundivalappil, Tian Lin, Wei Wang, Jie Xu, Cheng Zhang, Lida P Hariri, Allen Lapey, Hu Li, Pau...> ;American Journal of Respiratory Cell and Molecular Biology. 2023 Jun 1
• 3 citations
  A Tracheal Aspirate-derived Airway Basal Cell Model Reveals a Proinflammatory Epithelial Defect in Congenital Diaphragmatic Hernia.
  Richard Wagner, Gaurang M Amonkar, Wei Wang, Jessica E Shui, Kamakshi Bankoti, Wai Hei Tse, Frances A High, Jill M Zalieckas, Terry L Buchmiller, Augusto Zani, Richard...> ;American Journal of Respiratory and Critical Care Medicine. 2023 May 1
• 2 citations
  Standardizing the Evaluation and Management of Necrotizing Enterocolitis in a Level IV NICU.
  Megan Aurora, Madeline L Keyes, Julian Garcia Acosta, Kristen Swartz, Jesiel Lombay, Jason Ciaramitaro, Ariana Rudnick, Cassandra Kelleher, Suzanne Hally, Michael Gee,...> ;Pediatrics. 2022 Oct 1
• 1 citations
  Caring for our caretakers: building resiliency in NICU parents and staff.
  Victoria A Grunberg, Ana-Maria Vranceanu, Paul H Lerou> ;European Journal of Pediatrics. 2022 Sep 1
• 4 citations
  Primary culture of tracheal aspirate-derived human airway basal stem cells.
  Gaurang M Amonkar, Richard Wagner, Kamakshi Bankoti, Jessica E Shui, Xingbin Ai, Paul H Lerou> ;STAR Protocols. 2022 Jun 17
• 12 citations
  Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation
  Juan D. Matute, Benjamin Finander, David Pépin, Xingbin Ai, Neal Smith, Jonathan X. Li, Andrea G. Edlow, Alexandra-Chloé Villani, Paul H. Lerou, Brian T. Kalish> ;Pediatric Research. 2021 Nov 8
• 6 citations
  Improving Timeliness of Hepatitis B Vaccine Birth Dose Administration
  Leela Sarathy, Cheryl Cirillo, Cathleen Dehn, Paul H. Lerou, Michael Prendergast> ;Hospital Pediatrics. 2021 May 1
• 7 citations
  Single-cell immunophenotyping of the fetal immune response to maternal SARS-CoV-2 infection in late gestation
  Juan D. Matute, Benjamin Finander, David Pépin, Xingbin Ai, Neal Smith, Jonathan X. Li, Andrea G. Edlow, Alexandra-Chloé Villani, Paul H. Lerou, Brian T. Kalish> ;Research Square. 2021 Mar 16
• Reply.
  Lael M Yonker, Anne M Neilan, Yannic Bartsch, Ankit B Patel, James Regan, Puneeta Arya, Elizabeth Gootkind, Grace Park, Margot Hardcastle, Anita St John, Lori Appleman...> ;The Journal of Pediatrics. 2021 Jan 1
• Reply.
  Lael M Yonker, Anne M Neilan, Yannic Bartsch, Ankit B Patel, James Regan, Puneeta Arya, Elizabeth Gootkind, Grace Park, Margot Hardcastle, Anita St John, Lori Appleman...> ;The Journal of Pediatrics. 2021 Jan 1
• 239 citations
  Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic.
  Andrea G. Edlow, Jonathan Z. Li, Ai-ris Y. Collier, Caroline Atyeo, Kaitlyn E. James, Adeline A. Boatin, Kathryn J. Gray, Evan A. Bordt, Lydia L. Shook, Lael M. Yonker...> ;JAMA Network Open. 2020 Dec 1
• 14 citations
  Establishment of a pediatric COVID-19 biorepository: unique considerations and opportunities for studying the impact of the COVID-19 pandemic on children.
  Rosiane Lima, Elizabeth Gootkind, Denis De la Flor, Laura J. Yockey, Evan A. Bordt, Paolo D'Avino, Shen Ning, Katerina Heath, Katherine Harding, Jaclyn Zois, Grace Par...> ;BMC Medical Research Methodology. 2020 Sep 11
• 11 citations
  Rapid establishment of a COVID-19 perinatal biorepository: early lessons from the first 100 women enrolled.
  Lydia L. Shook, Jessica E. Shui, Adeline A. Boatin, Samantha Devane, Natalie Croul, Lael M. Yonker, Juan D. Matute, Rosiane Lima, Muriel Schwinn, Dana Cvrk, Laurel Gar...> ;BMC Medical Research Methodology. 2020 Aug 26
• 228 citations
  Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses.
  Lael M. Yonker, Anne M. Neilan, Yannic C. Bartsch, Ankit B. Patel, James Regan, Puneeta Arya, Elizabeth Gootkind, Grace Park, Margot Hardcastle, Anita St. John, Lori A...> ;The Journal of Pediatrics. 2020 Aug 20
• 11 citations
  Establishment of a Pediatric COVID-19 Biorepository: Unique Considerations and Opportunities for Studying the Impact of the COVID-19 Pandemic on Children
  Rosiane Lima, Elizabeth Gootkind, Denis De la Flor, Laura J. Yockey, Evan A. Bordt, Paolo D'Avino, Shen Ning, Katerina Heath, Katherine Harding, Jaclyn Zois, Grace Par...> ;Research Square. 2020 Aug 10
• 12 citations
  Rho/SMAD/mTOR triple inhibition enables long-term expansion of human neonatal tracheal aspirate-derived airway basal cell-like cells.
  Junjie Lu, Xiaobo Zhu, Jessica E. Shui, Linjie Xiong, Todd M. Gierahn, Cheng Zhang, Michael A. Wood, Suzanne Hally, J. Christopher Love, Hu Li, Benjamin C. Crawford, H...> ;Pediatric Research. 2021 Feb 1
• 7 citations
  Lung-Resident Mesenchymal Stromal Cells Reveal Transcriptional Dynamics of Lung Development in Preterm Infants.
  Ruggero Spadafora, Junjie Lu, Radhika S. Khetani, Cheng Zhang, Aimee Iberg, Hu Li, Yang Shi, Paul H. Lerou> ;American Journal of Respiratory and Critical Care Medicine. 2018 Oct 1
• 10 citations
  Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm.
  Junjie Lu, Anna Baccei, Edroaldo Lummertz da Rocha, Christelle Guillermier, Sean McManus, Lydia Finney, Cheng Zhang, Matthew L. Steinhauser, Hu Li, Paul H. Lerou> ;Stem Cell Research. 2018 Jan 31
• 251 citations
  The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity
  Wenzhang Wang, Luwen Wang, Junjie Lu, Sandra L. Siedlak, Hisashi Fujioka, Jingjing Liang, Sirui Jiang, Xiaopin Ma, Zhen Jiang, Edroaldo Lummertz da Rocha, Max Sheng, H...> ;Nature Medicine. 2016 Aug 1
• 6 citations
  Influence of ATM-Mediated DNA Damage Response on Genomic Variation in Human Induced Pluripotent Stem Cells
  Junjie Lu, Hu Li, Anna Baccei, Takayo Sasaki, David M. Gilbert, Paul H. Lerou> ;Stem Cells and Development. 2016 Mar 2
• 443 citations
  Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
  Benjamin S. Freedman, Craig R. Brooks, Albert Q. Lam, Hongxia Fu, Ryuji Morizane, Vishesh Agrawal, Abdelaziz F. Saad, Michelle Li, Michael R. Hughes, Ryan Vander Werff...> ;Nature Communications. 2015 Oct 23
• 2 citations
  Teaching Video NeuroImages: Nonepileptic myoclonus in a neonate following severe hypoxic-ischemic injury
  Brian H. Walsh, Fiona M. Baumer, Miya E. Bernson-Leung, Paul H. Lerou, Jurriaan M. Peters> ;Neurology. 2015 Mar 24
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Journal Articles

• The distribution of genomic variations in human iPSCs is related to replication-timing reorganization during reprogramming  
  Lu J, Li H, Hu M, Sasaki T, Baccei A, Gilbert DM, Liu JS, Collins JJ, Lerou PH, Cell Reports, 1/1/2014
• Rapid and Efficient Differentiation of Human Pluripotent Stem Cells into Intermediate Mesoderm That Forms Tubules Expressing Kidney Proximal Tubular Markers  
  Lam AQ, Freedman BS, Morizane R, Lerou PH, Valerius MT, Bonventre JV, J Am Soc Nephrol, 1/1/2014
• Stem cells: balancing resistance and sensitivity to DNA damage  
  Liu JC, Lerou PH, Lahav G, Trends Cell Biol, 1/1/2014
• A nontranscriptional role for Oct4 in the regulation of mitotic entry  
  Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ, Proc Natl Acad Sci USA, 1/1/2014
• High mitochondrial priming sensitizes hESCs to DNA damage-induced apoptosis  
  Liu JC, Guan X, Ryan JA, Rivera AG, Mock C, Agrawal V, Letai A, Lerou PH, Lahav G, Cell Stem Cells, 1/1/2013
• Derivation of human embryonic stem cells with NEMO deficiency  
  Guan X, Yabuuchi A, Huo H, Ginsberg E, Racowsky C, Daley GQ, Lerou PH, Stem Cell Research, 1/1/2012
• Cell cycle adaptations of embryonic stem cells  
  Ballabeni A, Park IH, Zhao R, Wang W, Lerou PH, Daley GQ, Kirschner MW, Proceedings of the National Academy of Sciences of the United States of America, 1/1/2011
• Derivation and maintenance of human embryonic stem cells from poor-quality in vitro fertilization embryos  
  Lerou PH, Yabuuchi A, Huo H, Miller JD, Boyer LF, Schlaeger TM, Daley GQ, Nat Protoc, 1/1/2008
• Generation of human-induced pluripotent stem cells  
  Park IH, Lerou PH, Zhao R, Huo H, Daley GQ, Nat Protoc, 1/1/2008
• Reprogramming of human somatic cells to pluripotency with defined factors  
  Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ, Nature, 1/1/2008
• Human embryonic stem cell derivation from poor-quality embryos  
  Lerou PH, Yabuuchi A, Huo H, Takeuchi A, Shea J, Cimini T, Ince TA, Ginsburg E, Racowsky C, Daley GQ, Nature Biotechnology, 1/1/2008
• Differentiation potential of histocompatible parthenogenetic embryonic stem cells  
  Lengerke C, Kim K, Lerou P, Daley GQ, Ann NY Acad Sci, 1/1/2007
• Histocompatible embryonic stem cells by parthenogenesis  
  Kim K, Lerou P, Yabuuchi A, Lengerke C, Ng K, West J, Kirby A, Daly MJ, Daley GQ, Science, 1/1/2007
• Therapeutic potential of embryonic stem cells  
  Lerou PH, Daley GQ, Blood Rev, 1/1/2005
• Lower respiratory tract infections in children  
  Lerou PH, Curr Opin Pediatr, 1/1/2001
• t(11;22)(q23;q112) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and veloc...  
  Megonigal MD, Rappaport EF, Jones DH, Williams TM, Lovett BD, Kelly KM, Lerou PH, Moulton T, Budarf ML, Felix CA, Proc Natl Acad Sci USA, 1/1/1998
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Books/Book Chapters

• Human Pluripotent Stem Cells: Methods and Protocols 
  Chapter: Derivation of pluripotent stem cells from human embryos. 
  Lerou PHEditors: Schwartz PH, Wesselschmidt RL.Humana Press, Totowa, NJ2011
• Methods in Bioengineering 
  Chapter: Derivation of mouse parthenogenetic embryonic stem cells. 
  Yabuuchi A, Lerou PH, Daley GQEditors: Yarmush ML, Langer RS.Artech House, Boston, MA2008

Lectures

• Exploring Cellular Heterogeneity of Pluripotent Stem Cells 
  Brigham and Women's Hospital - 1/1/2015
• Lessons Learned From Human Embryonic Stem Cell Derivation 
  Massachusetts General Hospital; Newton Wellesley Hospital - 1/1/2009
• Genomic Stability Maintenance in Human Pluripotent Stem Cells 
  1/1/2009
• Human Embryonic Stem Cell Derivation at Children’s Hospital 
  Boston Children’s Hospital - 1/1/2006
• Human Embryonic Stem Cell Derivation Using Poor Quality Embryos 
  Brigham and Women's Hospital - 1/1/2006
• Somatic Cell Nuclear Transfer at the Harvard Stem Cell Institute – An Update 
  1/1/2006
• Inside a Stem Cell Laboratory 
  Stanford University Club of New England - 1/1/2005
• Stem Cells in Regenerative Medicine and Reproductive Biology 
  1/1/2005
• Therapeutic Cloning 
  Boston Children’s Hospital - 1/1/2004
• Necrotizing Enterocolitis - An Update 
  Boston Children’s Hospital - 1/1/2003
• Necrotizing Enterocolitis 
  Boston Children’s Hospital - 1/1/2003
• Cases from the Wards 
  Boston Children’s Hospital - 1/1/2000
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