Paul Lindholm MD

Pathology•Chicago, IL

Blood Banking & Transfusion Medicine, Hematopathology, Transplantation Immunology, Clinical Pathology

Professor of Pathology, Northwestern University Medical School

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251 E Huron StChicago, IL 60611
Phone+1 312-926-7450
Fax+1 312-926-5500

Summary

As a seasoned medical doctor and clinical educator, I have dedicated my professional career to not only patient-centered outcomes, but to making significant contributions to research and teaching in the areas of hemostasis and coagulation.

Currently, as the Medical Director Northwestern Medicine Hemostasis and Coagulation Laboratory where I oversee research and patient outcomes while also interpreting patient coagulation and platelet function assays for our physicians. Additionally, I co-direct the NMH Blood Bank and Molecular Diagnostic Laboratories. In both of these situations, I strive to teach and provide safest transfusion practices and optimal service and quality in laboratory hemostasis and coagulation testing.

My special clinical and academic interest concerns thrombosis and thrombophilia or the pathologic development of blood clots. I am interested in the etiology and pathogenesis of thrombosis and in the methods for providing therapeutic monitoring for anticoagulation therapies, with a special interest in pathological thrombosis that develops in many cancer patients, in an effort to understand the major causes of patient morbidity and mortality and then design successful therapies to prevent and treat these adverse outcomes for patients.

While my research often takes center stage, my responsibilities also include extensive teaching and administrative responsibilities. I excel in situations that require structured teamwork with individuals with diverse intellectual and personal perspectives. I also take great pride in my work, and strike to adhere to the standards, protocols, and regulations surrounding research projects of this magnitude.

Education & Training

National Cancer InstituteFellowship, Molecular Virology, 1988 - 1994
University of MinnesotaResidency, Pathology-Anatomic and Clinical, 1983 - 1988
University of Minnesota Medical SchoolClass of 1983
University of Minnesota MinneapolisB.A, Biometry, Summa cum laude, 1979
University of MinnesotaB.A., Biometry, Summa cum laude, 1979

Certifications & Licensure

IL State Medical License 2002 - 2026
WI State Medical License 1994 - 2003
MN State Medical License 1984 - 1994
American Board of Pathology Anatomic Pathology & Clinical Pathology
American Board of Pathology Blood Banking/Transfusion Medicine

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2011
PEDF regulation of adipogenesis and leptin in prostate cancer Co-Investigator, Main Project, Northwestern University Robert H. Lurie Cancer Center Prostate S.P.O.R.E, 2009, 2014
RhoA and Transcription Factor Regulation of Prostate Cancer Cell Invasion Career Development Project, Northwestern University Robert H. Lurie Cancer Center Prostate S.P.O.R.E, 2003, 2006
The Roles of γ-PAK, RhoA and NF-κB in Prostate Cancer Cell Invasion Cancer Center of the Medical College of Wisconsin and the American Cancer Society, 2002
NF-κB, and Prostate Cancer Cell Invasion Department of Defense Congressionally Directed Medical Research Program, 2001, 2005
Endothelial Cell Activation by HIV-1 Viral Tat Protein American Heart Association, 1999, 2001
Screening Environmental Mixtures for Effects on Prostate Cancer Invasion Properties United States Environmental Protection Agency STAR Grant, 1998, 2001
Ethanol-Induced Break of HIV-1 Latency State Alcoholic Beverage Medical Research Foundation, 1998-1999
Phosphorylation Regulates Tax1 Induction of NF-κB MCW Research Affairs Committee, 1997
VA Merit Awards 1995, 1997, 1999
Characterization of HTLV-I Tax1 Induced Signals Effecting NF-κB Release and NF-κB Activation Cancer Center of the Medical College of Wisconsin and the American Cancer Society, 1995-1996
Phi Kappa Phi, Minneapolis Chapter 1979
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Publications & Presentations

PubMed

Red Blood Cell Transfusion Practices.
Paul F Lindholm, Rasleen K Saluja, Thomas Long, Suzanne Coulter, Barbara J Blond
Archives of Pathology & Laboratory Medicine. 2024-11-20
P2Y12 inhibitor use predicts hematoma expansion in patients with intracerebral hemorrhage.
Ethan J Houskamp, Yuzhe Liu, Juliana Silva Pinheiro do Nascimento, Babak S Jahromi, Paul F Lindholm
Annals of Clinical and Translational Neurology. 2024-06-01
Weak or discrepant RhD phenotypes: Laboratory management strategies for local patient populations.
Christina M Barriteau, Paul F Lindholm, Karyn Hartman, Johnathon Pugh, Ricardo D Sumugod
Transfusion. 2024-04-01

Journal Articles

Three-stage ex vivo expansion of high-ploidy megakaryocytic cells: towards large-scale platelet production.
S Panuganti, AC Schlinker, PF Lindholm, ET Papoutsakis and WM Miller, Tissue Engineering, 1/1/2013
Early Platelet Transfusion Improves Platelet Activity and May Reduce Final Hematoma Size.
AM Naidech, SM Liebling, NF Rosenberg, PF Lindholm, RA Bernstein, H Batjer, MJ Alberts and HC Kwaan, Neurocritical Care, 1/1/2012
Zhang Q, Helfand BT, Jang TL, Zhu LJ, Chen L, Yang XJ, Kozlowski J, Smith N, Kundu SD, Yang G, Raji AA, Javonovic B, Pins M, Lindholm P, Guo Y, Catalona WJ, Lee C, Clin Cancer Res, 5/15/2009
Reduced platelet activity is more common than anti-platelet medication use in patients with intracerebral hemorrhage.
Naidech AM, Bassin SL, Bernstein RA, Batjer HH, Alberts MJ, Lindholm PF, Bleck TP, Neurocrit Care, 1/1/2009
Yemelyanov A, Gasparian A, Lindholm PF, Dang L, Pierce J, Karsaladze A and Budunova I, Oncogene, 1/19/2006
Hwang YS, Sivapurapu N, Hodge, JC and Lindholm, PF, Molecular Carcinogenesis, 1/1/2006
Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients.
Shidham V, Chang CC, Shidham G, Ghazala F, Lindholm P, Kampalath B, George V and Komorowski R, BMC Gastroenterology, 1/1/2003
Shi X-Z, Lindholm PF, Sarna SK, Gastroenterology, 1/1/2003
Hodge J, Kaul S, Bub J, Kajdacsy-Balla A and Lindholm PF, Cancer Research, 1/1/2003
Pieper GM, Olds CL, Bub J, Lindholm PF, American Journal of Physiology: Heart and Circulatory Physiology, 1/1/2002
A Novel Multiparametric Approach for Analysis of Cytoplasmic Immunoglobulin Light Chains by Flow Cytometry.
Chang C-C, Schur BC, Kampalath B, Lindholm P, Becker CG, Vesole DH, Modern Pathology, 1/1/2001
Lindholm PF, Kaul S, Bub J, Shidham VS, and Kajdacsy-Balla A, Clinical & Experimental Metastasis, 1/1/2001
Antioxidant Treatment Inhibits Activation of Myocardial Nuclear Factor kappa B and Inhibits Nitrosylation of Myocardial Heme Protein in Cardiac Transplant Rejection.
Pieper GM, Olds C, Hilton G, Lindholm PF, Adams MB, Roza AM, Antioxidants and Redox Signaling, 1/1/2001
NOX1000, a nitric oxide scavenger enhances cardiac allograft survival and promotes long-term graft acceptance.
Roza AM, Cooper M, Pieper GM, Hilton G, Dembny K, Lai CS, Lindholm P, Komorowski R, Felix C, Johnson C, Adams M, Transplantation, 1/1/2000
Methods of Cytology Smear Preparation and Fixation: Effect on the Immunoreactivity of Commonly Used AntiCytokeratin Antibody AE1/AE3.
Shidham VB, Lindholm PF, Kajdacsy-Balla A, Chang C-C, Komorowski R, Acta Cytologica, 1/1/2000
Prostate-Specific Antigen Expression and Lipochrome Pigment Granules in the Differential Diagnosis of Prostatitis adenocarcinoma versus Seminal Vesicle-Ejaculatory Duc...
Shidham VS, Lindholm PF, Basir Z, Kajdacsy-Balla A and Komorowski R, Archives of Pathology and Laboratory Medicine, 1/1/1999
Cooper M, Lindholm P, Pieper GM, Seibel R, Moore G, Nakanishi A, Dembny K, Komorowski R, Johnson C, Adam M, Roza AM, Transplantation, 1/1/1998
Tamami M, Lindholm P, Brady JN, J Biol Chem, 1/1/1996
Stabilization of wild-type p53 in HTLV-I transformed human lymphocytes.
Reid RL, PF Lindholm, A Mireskandari, J Dittmer, JN Brady, Oncogene, 1/1/1993
Sequences downstream of the RNA initiation site regulate HTLV-I basal gene expression.
Kashanchi F, JF Duvall, PF Lindholm, MF Radonovich, JN Brady, J Virol, 1/1/1993
Lindholm PF, RL Reid, JN Brady, J Virol, 1/1/1992
Extracellular HTLV-I Tax1 protein stimulates proliferation of competent human peripheral blood lymphocytes.
Marriott SJ, PF Lindholm, R Reid, JN Brady, New Biol, 1/1/1991
A transdominant HTLV-I Tax1 mutant that fails to localize to the nucleus.
Gitlin SD, PF Lindholm, SJ Marriott, JN Brady, J Virol, 1/1/1991
Differential precipitation and zinc chelate chromatography purification of biologically active HTLV-I Tax1 expressed in E coli.
Lindholm PF, SJ Marriott, SD Gitlin, JN Brady, J Biochem and Biophys Methods, 1/1/1991
Lindholm PF, SJ Marriott, SD Gitlin, CA Bohan, JN Brady, New Biol, 1/1/1990
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Books/Book Chapters

Infect Disorders Drug Targets.
Chapter: Approaches to Minimize Infection Risk in Blood Banking and Transfusion Practice.
Page 45 - 56PF Lindholm, K Annen, G Ramsey2011
Metal Ions in Biology and Medicine
Chapter: The effect of iron on prostate and breast cancer cell invasion.
Page 617 - 620Kajdacsy-Balla AA, S Kaul, C Chitambar, PF LindholmEditors: L Khassanova, P Collery, I Maymard, Z Khassanova, J-C Etienne.John Libbey Eurotext, Paris2002
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury
Chapter: Determination of Cyclooxygenase and Arachidonic Acid Metabolites in Invasive Human Prostate Cancer Cells.
Nithipatikom K, Borscheid CL, Kajdacsy-Balla A, Kaul S, Lindholm PF, Pytynia KB, Campbell WBEditors: Honn KV, Marnett LJ, Nigam S, Dennis E, Serhan C.Kluwer Academic/Plenum Publishers, New York, NY2002
Semin Virol
Chapter: Transcriptional regulation in the human retrovirus HTLV-I.
Page 53 - 60Lindholm PF, F Kashanchi, JN Brady1993
Human Retroviruses, UCLA Symposia on Molecular and Cellular Biology
Chapter: Molecular analysis of trans-activation in the HTLV-I LTR.
Page 13 - 22Marriott SJ, PF Lindholm, SD Gitlin, KM Brown, MF Radonovich, JF Duvall, JN BradyEditors: JE Groopman, I Chen, M Essex, R Weiss.Alan R. Liss, Inc., New York, NY1990
Approaches to Minimize Infection Risk in Blood Banking and Transfusion Practice.
PF Lindholm, K Annen, G RamseyInfect Disorders Drug Targets
Human Retroviruses, UCLA Symposia on Molecular and Cellular Biology.
Chapter: Molecular analysis of trans-activation in the HTLV-I LTR
Page 13 - 22. Marriott SJ, PF Lindholm, SD Gitlin, KM Brown, MF Radonovich, JF Duvall, JN BradyEditors: JE Groopman, I Chen, M Essex, R Weiss. Alan R.Liss, Inc, New York, N.Y
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury.
Chapter: Determination of Cyclooxygenase and Arachidonic Acid Metabolites in Invasive Human Prostate Cancer Cells
Nithipatikom K, Borscheid CL, Kajdacsy-Balla A, Kaul S, Lindholm PF, Pytynia KB, Campbell WBEditors: Honn KV, Marnett LJ, Nigam S, Dennis E, Serhan C.Kluwer Academic/Plenum Publishers, New York
Metal Ions in Biology and Medicine.
Chapter: The effect of iron on prostate and breast cancer cell invasion
Page 617 - 620Kajdacsy-Balla AA, S Kaul, C Chitambar, PF LindholmEditors: L Khassanova, P Collery, I Maymard, Z Khassanova, J-C Etienne.John Libbey Eurotext, Paris
Infect Disorders Drug Targets.
Chapter: Approaches to Minimize Infection Risk in Blood Banking and Transfusion Practice
Page 45 - 56PF Lindholm, K Annen, G Ramsey
Transcriptional regulation in the human retrovirus HTLV-I.
Page 53 - 60Lindholm PF, F Kashanchi, JN BradySemin Virol
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Abstracts/Posters

Production of high-ploidy megakaryocytic cells and functional platelets in culture using a 3-phase process.
AC Schlinker, S Panuganti, PF Lindholm, ET Papoutsakis, WM Miller, Gordon Research Conference Cell Biology of Megakaryocytes & Platelets in Galveston, TX, 3/9/2013
Production of high-ploidy megakaryocytic cells and functional platelets in culture using a 3-phase process.
AC Schlinker, S Panuganti, PF Lindholm, ET Papoutsakis, WM Miller, ECI cell-based therapies conference Scale-Up and Manufacturing of Cell Based Therapies II, San Diego, 1/21/2013
G Ramsey, Mroz, P, Thompson AA, Williams LM, Lindholm PF, Crowley, Horn JT, Keller, MA, American Association of Blood Banks 2012 Annual Meeting in Boston, MA, 10/6/2012
Cadmium activates Translationally Controlled Tumor Protein (TCTP) and p38 MAPK as possible pathways for prostate cancer cell aggressiveness.
G Munirathinam, A Kajdacsy-Balla, S Kaul, A Scumpu, T Kucynda, P Patel, M Zheng and PF Lindholm, American Association for Cancer Research 103rd Annual meeting in Chicago, IL, 3/31/2012
Role of a Wristband-Coded Mechanical Barrier System in the Interception of Misidentified Blood Bank Specimens.
Garcia-Godos N, Sumugod RD, Garland FD, Masarik SR, Lindholm PF, Ramsey G, American Association of Blood Banks 2011 Annual Meeting in San Diego, CA, 10/22/2011
Prostate cancer cell invasion is stimulated by cross communication with human monocyte-lineage cells.
N Sivapurapu, B Jovanovic, SE Crawford and PF Lindholm, American Association for Cancer Research 102th Annual meeting in Orlando, FL, 4/18/2011
Modeling The Potential For False-Negative A1 RBC Typings In Organ Donors After Emergency Group O RBC Transfusions
G Ramsey, P Bochey, P Lindholm, RD Sumugod, American Association of Blood Banks 2010 Annual Meeting in Baltimore, MD, 10/4/2010
Obese (ob/ob) mice develop prostate epithelial hyperplasia.
JA Doll, SM Wcislak, PS. Fitchev, ML. Cornwell, C Lee, CB Brendler, P Lindholm, MA. Quinn, L Huang, SE Crawford, AUA Annual meeting. San Francisco, CA, 5/31/2010
Adjuvant AntiCoagulant Treatment Reduces Mortality from Severe Sepsis in Carriers of a Functional Tissue Factor Pathway Inhibitor Polymorphism.
AHW Bruns, J Chen, HK Donnelly, G Hayes, PF Lindholm, RG Wunderink, American Thoracic Society, New Orleans, LA, 5/14/2010
Leptin Deficient Mice Develop Prostate Epithelial Hyperplasia.
JA Doll, SM Wcislak, P Fitchev, M Cornwell, C Lee, CB Brendler, P Lindholm and SE Crawford, 2009 NCI Translational Science Meeting (TSM 2), 11/5/2009
Evaluation of Eluates on the Galileo Automated Instrument.
K Wolniak, P Lindholm and G Ramsey, Ibarra, R Sumugod, American Association of Blood Banks 2009 Annual Meeting in New Orleans, LA, 10/24/2009
Acquisition of hemoglobin substitute for compassionate use case study.
Lindholm, Paul F, LifeSource User Group Meeting, Glenview, IL, 4/30/2009
Human monocytoid cells stimulate prostate cancer cell invasion involving IL-8 and MCP-1 cytokines and NF-kB Activity.
N Sivapurapu, Y Lu, B Jovanovic and PF Lindholm, American Association for Cancer Research 100th Annual meeting in Denver, CO, 4/18/2009
Tissue Factor (TF) Expression in Prostate Cancer (PCa) Using a Matched Case-Control Outcome-Based TMA Design Set.
V Macias, Y Lu, W Liang, W Gao, CA Beam, A Balla and PF Lindholm, The United States and Canadian Academy of Pathology's 98th Annual Meeting, Boston, MA, 3/7/2009
Rh Immune Globulin Therapy in IgA Deficiency.
G Ramsey, AM Peaceman, PA Greenberger, PF Lindholm, American Association of Blood Banks 2008 Annual Meeting in Montreal, Quebec, 10/4/2008
Northwestern University and Northwestern Memorial Hospital. IgM and IgG ABO Antibody Titers in ABO-Incompatible Kidney Transplants with Rituximab and Alemtuzumab Induc...
G Ramsey, JJ Friedewald, RD Sumugod, PF Lindholm, JR Leventhal, American Association of Blood Banks 2008 Annual Meeting in Montreal, Quebec, 10/4/2008
Human monocytes and proinflammatory cytokines stimulate breast and prostate cancer cell invasion.
PF Lindholm, Y Lu, BD Jovanovic, N Sivapurapu and C Lee, Platform Presentation at American Society for Investigative Pathology 2008 Annual Meeting in San Die, 4/5/2008
Monocyte-prostate cancer cell intercellular communication: a new approach to the effects of inflammation on prostate cancer invasion and progression.
N Sivapurapu, Y Lu, YS Hwang, B Jovanovic and PF Lindholm, Department of Defense Congressionally Directed Medical Research Program Innovative Minds in Prostate, 9/5/2007
Aspirin and Clopidigrel Resistance in Patients with Cerebrovascular Disease.
MJ Alberts, P Campbell, D Bergman, R Bernstein, A Naidech and P Lindholm, American Heart Association 32nd International Stroke Conference in San Francisco, CA, 2/7/2007
Q Zhang, SD Kundu1, M Pins, X Yang, J Zhu, L Liao, P Lindholm, B Javonovic, B Helfand and C Lee, Society for Basic Urologic Research Annual meeting Phoenix, AZ, 11/16/2006
Supernatant Potassium (K+) Values of Stored Irradiated Red Blood Cells (RBC): A pilot study prompted by a request to keep Irradiated RBC in a Neonatal Intensive Care U...
RD Sumugod, S Sassounes, G Ramsey, PF Lindholm, SR Masarik, F Garland, American Association of Blood Banks 2006 Annual Meeting in Miami Beach, FL, 10/21/2006
A Coded Mechanical Barrier System for Preventing Mistransfusions: Analysis and Quality Improvement.
KE Hedley, F Garland, SR Masarik, PF Lindholm, RD Sumugod, G Ramsey, American Association of Blood Banks 2006 Annual Meeting in Miami Beach, FL, 10/21/2006
Monocyte-cancer cell co-cultures stimulate in vitro cancer cell chemotactic invasion.
N Sivapurapu and PF Lindholm, American Association for Cancer Research 97th Annual meeting in Washington, D.C., 4/1/2006
Tissue Factor (TF) expression in primary invasive breast cancer correlates with tumor size and grade but not with outcome.
V Macias, J Geynisman, S Frkovic-Grazio, M Bracko, B Susnik, Y Lu, AA Kajdacsy-Balla and PF Lindholm, American Association for Cancer Research 97th Annual meeting in Washington, D.C., 4/1/2006
L Zhu, JC Hodge, B Jovanovic, N Sivapurapu, N Jafari and PF Lindholm, Prostate Inter-SPORE Meeting, Houston, TX, 2/4/2006
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